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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Fajar Indah
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Medicine & Pharmacology

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OPTIMASI CMC-Na DAN KARBOMER SEBAGAI PENGIKAT PADA FORMULA PASTA GIGI TRIKLOSAN SECARA SLD Elya Zulfa; Fajar Indah; Mimiek Murukmihadi
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.247 KB) | DOI: 10.31942/jiffk.v0i0.1359

Abstract

ABSTRACT CMC-Na is a hydrogel binding agent that can absorb water and carbomer. This excipient is single phase system that does not absorb but swell in the water. Extrudability, cohesiveness, and the active substance dispersed well in the mouth is an important function of the binding agent. The purpose of this study is to find the optimum formula triclosan toothpaste with a combination CMC-Na and carbomer as a binding agent. The formula was obtained based on Design Expert® 9.0.3 was, F1 (5.50%:0.50%); F2 (4.75%:1.25%); F3 (4.75%:1.25%); F4 (5.50%:0.50%); F5 (4.00%:2.00%); F6 (4.38%:1.63%); F7 (4.00%:2.00%) and F8 (5.13%:0.88%). Viscosity, pH, and the level of preference considered to decide the optimum formula. The Equations was obtained based on experiments and theoretical verified using One Sample T-test at 95% confidence level. Based on Simplex Lattice Design equation, the proportion CMC-Na:carbomer is 5.35%:0.65% shown the optimum formula. Experimental and theoretical results have the same response (p>0.05). The combination of CMC-Na and carbomer affects the physical characteristics and level of preference, which increased pH, reduces viscosity and increase the level of preference. Key words: Optimation, toothpaste formula, binding agent, CMC-Na, carbomer
Co-Authors Elya Zulfa Mimiek Murukmihadi