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STANDARISASI EKSTRAK TERPURIFIKASI DAUN MANGGA ARUMANIS (Mangifera indica L.) Dewi Andini Kunti Mulangsri; Elya Zulfa; Sugar Arifin; Masduki Faqih
Jurnal Inovasi Teknik Kimia Vol 4, No 2 (2019)
Publisher : Fakultas Teknik Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/inteka.v4i2.3006

Ekstrak etanol daun mangga arumanis perlu dilakukan standarisasi untuk menjamin konsistensi mutu, keamanan dan efek yang dihasilkan. Purifikasi ekstrak dilakukan untuk menghilangkan adanya zat ballast yang tidak dapat menghasilkan efek terapi. Tujuan dari penelitian ini untuk memperoleh dan mengetahui hasil standarisasi ekstrak terpurifikasi daun mangga arumanis (ETDMA). Daun mangga arumanis disari dengan metode maserasi, pelarut etanol 96%, dilanjutkan purifikasi ekstrak dengan metode ekstraksi cair-cair menggunakan pelarut air panas-etilasetat. Standarisasi ETDMA dilakukan untuk parameter spesifik dan nonspesifik. Parameter spesifik meliputi uji organoleptis, kadar senyawa larut air dan larut etanol. Parameter nonspesifik meliputi kadar air, kadar abu total, kadar abu tidak larut asam dan uji cemaran logam. Data standarisasi dianalisis secara deskriptif yang beberapa dibandingkan dengan standar yang telah ditetapkan. Hasil uji parameter spesifik berupa ekstrak terpurifikasi daun mangga arumanis kental berwarna hijau kecoklatan, kadar senyawa larut air dan etanol masing-masing sebesar 22% dan 67,4 %. Hasil uji parameter nonspesifik berupa kadar air, susut pengeringan tidak memenuhi syarat, sedangkan kadar abu, kadar abu tidak larut asam, cemaran Pb dan Cd, cemaran mikroba memenuhi syarat. Jadi belum dapat dikatakan ekstrak terpurifikasi daun mangga arumanis terstandar. Kata kunci : Daun mangga arumanis, Mangifera indica L., Ekstrak terpurifikasi, Standarisasi Kata kunci : Daun mangga arumanis, Mangifera indica L., Ekstrak terpurifikasi, Standarisasi

OPTIMASI CMC-Na DAN KARBOMER SEBAGAI PENGIKAT PADA FORMULA PASTA GIGI TRIKLOSAN SECARA SLD Elya Zulfa; Fajar Indah; Mimiek Murukmihadi
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT CMC-Na is a hydrogel binding agent that can absorb water and carbomer. This excipient is single phase system that does not absorb but swell in the water. Extrudability, cohesiveness, and the active substance dispersed well in the mouth is an important function of the binding agent. The purpose of this study is to find the optimum formula triclosan toothpaste with a combination CMC-Na and carbomer as a binding agent. The formula was obtained based on Design Expert® 9.0.3 was, F1 (5.50%:0.50%); F2 (4.75%:1.25%); F3 (4.75%:1.25%); F4 (5.50%:0.50%); F5 (4.00%:2.00%); F6 (4.38%:1.63%); F7 (4.00%:2.00%) and F8 (5.13%:0.88%). Viscosity, pH, and the level of preference considered to decide the optimum formula. The Equations was obtained based on experiments and theoretical verified using One Sample T-test at 95% confidence level. Based on Simplex Lattice Design equation, the proportion CMC-Na:carbomer is 5.35%:0.65% shown the optimum formula. Experimental and theoretical results have the same response (p>0.05). The combination of CMC-Na and carbomer affects the physical characteristics and level of preference, which increased pH, reduces viscosity and increase the level of preference. Key words: Optimation, toothpaste formula, binding agent, CMC-Na, carbomer

EVALUASI KARAKTERISTIK FISIKA-KIMIA SEDIAAN KRIM DAN LOTION EKSTRAK KULIT BUAH NANAS (Ananas comosus L.Merr) Elya Zulfa; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTIn previous research, ethanolic extract of pineapple peel (EEPP) has activity as a sunscreen because of the content of flavonoids. EEPP can be formulated in the form of creams and lotions to facilitate use on the skin. This study aims to evaluate the physical chemistry characteristics of EEPP creams and lotions. Creams and lotions were made in 3 formulas based on variations in FI extract concentrations (15.0%), FII (17.5%), FIII (20.0%), base controls and positive controls (preparations on the market). The cream obtained was evaluated for physical chemical characteristics including organoleptic, homogeneity, adhesion and dispersion, viscosity, pH and SPF values which were analyzed descriptively. cream with varying concentrations of green, the distinctive smell of pineapple, homogeneous and in accordance with the pH of the skin. Increasing the concentration of EEPP in the preparation has an effect on increasing viscosity, adhesion but decreasing the dispersion. Whereas the lotion shows greenish color, aromatic odor and semisolid texture and is easily applied. The increase in EEPP in lotion affects the increase in pH, adhesion, but decreasing the dispersion.Keywords: Creams, lotions, sunscreen, pineapple fruit skin

FORMULASI DAN EFEK SALEP EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava,L.) DENGAN BASIS HIDROKARBON TERHADAP LUKA SAYAT PADA TIKUS JANTAN GALUR WISTAR Ririn Lispita Wulandari; Elya Zulfa; Dwara Andriani Astuti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 16, No 02 (2019): Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 02 Desember 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT The ethanol extract of guava leaves (EEGL) is proven to heal various types of wounds.This study aims to determine the physicochemical characteristics of the EEGL ointment with a hydrocarbon base formula and examine the effect of the ointment against cut wounds on wistar male rat. The EEGL was obtained by maceration using 70% ethanol solvent. The ointment made 3 formulas with a ratio of hydrocarbon base composition (cera alba:vaselin album) namely F1 (2.5:92.5)%; F2 (5:90)%; F3 (7.5:87.5)%. The physicochemical characteristics of all ointments examined included organoleptic, homogeneity, pH, viscosity, spreadability, and adhesion. Organoleptic, homogeneity and pH data were analyzed descriptively, while viscosity, spreadability and adhesion data were analyzedstatistically. Testing the effect of all ointment formulas on the wound was done by applying 0.5 gram 2x a day for 9 days compared to wound control without treatment and positive control used commercial product.The parameter of effect measured was the length of the cut wound on the 9th day, then analyzed with the Kruskall Wallis test followed by the Mann Whitney test.The physicochemical characteristics of EEGL ointment (F1, F2, F3) are known that all ointment formulas are brown in color, typical of guava, homogeneous, pH according to skin pH, viscosity and adhesion are significantly different, while the spredability is not significant.The EEGL ointment had an effect on the cut wound of the male wistar rats, ie the length of the wound on the 9th day was reduced and compared to wound controlwas differentsignificantly. Keywords :Guava leaves, ointment, cut of wound.

FORMULASI SALEP EKSTRAK ETANOLIK DAUN BINAHONG (Anrederacordifolia (Ten.) Steenis) DENGAN VARIASI BASIS SALEP Elya Zulfa; Tegar Bagus Prasetyo; Mimik Murukmihadi
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT The absorbtion-based ointment of ethanolic extract of binahong leaves (Anredera cordifolia (Ten.) Steenis) on 10% concentrate has antibacterial activity towards Staphylococcus aureus. In order to improve the activity of this ethanolic extract of binahong leaves, it is necessarily to adjust the ointment’s base of formulation. The aims of study are to determine the ointment’s physical characteristics which various base such as hydrocarbon, absorbtion and water solubility. The ethanolic extract of binahong leaves obtained from maceration method, using 70% of ethanol. The ointment was made based on the variation of its base which are hydrocarbon, absorbtion and water solubility. The obtained oinment then was examined on its physical characteristics properties including organoleptic test, pH, viscosity, stickiness, spreadability, and antibacterial activity toward Staphylococcus aureus on the agar plate medium. The organoleptic and pH test result data were analyzed descriptively. The data of stickiness, viscosity were analyzed using one-way ANOVA and Tukey with the level of confidence up to 95%, whilst the spreadability data was analyzed using Kruskal wallis and Man whitney. There were significant differences between the results of viscosity, stickiness, on each formula of ethanolic extract ointment of binahong leaves. However, there were no significant differences on the pshycal characteristic of the pH, organoleptic, homogenic, and spreadability. Keywords: Ointment, Binahong leaves, Antibacterial activity, Staphylococcus aureus.

UJI SITOTOKSISITAS EKSTRAK METANOL UMBI BIT (Beta vulgaris L. var. rubra L.) TERHADAP CELL LINE T47D Elya Zulfa; sri susilowati; aqnes budiarti
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTTherapy failure of breast cancer as a consequence of cell resistention has encouraged the effort to develop a cancer medicine including herbal medicine. Based on some research, it can be concluded that there is antioxydant and anticancer activity from beetroot involved with betasianin and betasantin substance that belong to flavonoid compound. The purpose of this research was to find the effect cytotoxic of methanolic extract of beetroot (Beta vulgaris L. var. rubra L.) on cell line T47D which was a breast cancer cell.This research was conducted on several experiment step namely plant determination, cell preparation, cell harvest, methanolic extraction, and cytotoxic test. The extraction of beetroot is conducted by maceration method using methanol 70 %. Cytotoxic test on cell line T47D is conducted by MTT assay using five concentration ceries were 500, 250, 125, 62,5 and 31,25 ug/ml. Data analysis uses probit analysis.Research result shows that methanolic extract of beetroot there was no cytotoxic activity on cell line T47D. It shows that five consentration series methanolic extraction of beetroot have % cell viability more than 100%.Keyword: Beetroot, Beta vulgaris L. var. rubra L, Cell line T47D, Cytotoxic, Flavonoid.

PENGARUH WAKTU ULTRASONIKASI TERHADAP KARAKTERISTIK FISIKA NANOPARTIKEL KITOSAN EKSTRAK ETANOL DAUN SUJI (Pleomele angustifolia) DAN UJI STABILITAS FISIKA MENGGUNAKAN METODE CYCLING TEST Malinda Prihantini; Elya Zulfa; Listyana Dewi Prastiwi; Ikha Dyah Yulianti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 16, No 02 (2019): Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 02 Desember 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT The nanoparticle system encapsulates and protects flavonoids of suji leaves from photolysis and oxidation instability. Chitosan is a biocompatible, biodegradable and non-toxic nanoparticles forming polymer. Ultrasonication is a materials mixing technique under high vibration energy. The ultrasonication time affects the particle size. The aim of this study was to determine the effect of the ultrasonication time on physical characteristics of chitosan nanoparticles of suji (Pleomele angustifolia) leaf ethanol extract and its physical stability after cycling test. Ethanol extract of suji leaves (EEDS) was obtained by maceration using 70% ethanol. Chitosan EEDS nanoparticles were made under ionic gelation method using an ultrasonication time of 3 minutes (FI), 6 minutes (FII), and 9 minutes (FIII). The physical characterization of nanoparticles includes particle size, polydispersity index, and zeta potential. Chitosan EEDS nanoparticles with the best physical characteristics (FIII) were tested for stability using cycling test method. The data obtained were analyzed using the Anova statistical method with a 95% confidence level. The size of EEDS chitosan nanoparticles (nm) was significantly different in all formulas, FI (374.47), FII (288.43), and FIII (233.37). The polydispersity index of FI (0.38) and FIII (0.65) were significantly different, while FII (0.41) was not significantly different. The zeta potential (mV) FI (51.70), FII (46.10), and FIII (48.60) were not significantly different in all formulas. The physical characteristics of Formula III after Cycling Test showed a particle size of 455.0 nm, a polydispersity index of 0.174, and a zeta potential of 20.1 mV. Keywords: ultrasonication, nanoparticles, chitosan, cycling test, suji leaf (Pleomele angustifolia)

Formulation of Spray Gel Containing Soybean Seed (Glycine max) Ethanolic Extract as A Sunscreen Cosmetics Ayu Shabrina; Faza Putri_Maulina Hanik; M_Rifki Pratama_Kharisma Akbar; Elya Zulfa
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 2 (2020): Jurnal Ilmu Farmasi & Farmasi Klinik Vol. 17 N0. 02 Desember 2020
Publisher : Universitas Wahid Hasyim Semarang

Skin damage caused by free radicals disturbs the health of human skin that needs protection. Soybean extract showed that its SPF value was 6,93 on concentration of 0,5%. The purpose of this study was to determine the effect of variation concentrations of Soybean Seed Ethanol Extract (SSEE) on spray gel characteristic and sunscreen activity in vitro. Soybean seeds were extracted by maceration method using 96% ethanol solvent. Extracts obtained were made into spray gel preparation with variations of SSEE concentration were 2% (F1), 4% (F2), 6% (F3). SSEE spray gel was tested for organoleptic, homogeneity, pH, viscosity, spraying pattern and sunscreen activity test. Data from organoleptic, homogeneity, viscosity, pH and spray patterns and sunscreen activity were analyzed descriptively while viscosity was analyzed using linear regression. The spray gels were homogenous with thick texture, and brownish yellow color also distinctive aroma of soybean seeds. Based on the test results, variations concentrations of SSEE did not affect the spray gel characteristics except the viscosity that decreased. Sunscreen activity test showed that SPF values were 13.82 (F1), 13.96 (F2) and 14.54 (F3) included maximal protection. Keywords: soybeans, sunscreen, spray gel, in vitro

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