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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Octaviana Maria Simbolon
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Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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EVALUASI PENGGUNAAN ANTIBIOTIKA PADA PASIEN LEUKEMIA LIMFOBLASTIK AKUT DENGAN DEMAM NEUTROPENIA DI RUMAH SAKIT UMUM DAERAH ABDUL WAHAB SJAHRANIE SAMARINDA Octaviana Maria Simbolon; Liniati Geograf
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 2 (2020): Jurnal Ilmu Farmasi & Farmasi Klinik Vol. 17 N0. 02 Desember 2020
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.861 KB) | DOI: 10.31942/jiffk.v17i2.4069

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ABSTRACT The use of antibiotics is one of the management of neutropenic fever in patients with acute lymphoblastic leukemia (ALL). Irrational and excessive antibiotics can promote resistance to certain bacteria. The aim of this study was to evaluate the use of antibiotics given to ALL patients with neutropenic fever qualitatively and quantitatively. This type of observational research was conducted with a descriptive method using a cross-sectional design. Retrospective data collection from medical records of ALL patients who received antibiotics during 2017-2018. The quality of antibiotic use was analyzed using the Gyssens method, while the quantity of antibiotic use was analyzed using the DDD method per 100 bed days. Based on the results of the study of 7 ALL patients with neutropenic fever, the rational (category 0) use of antibiotics was 50% and the irrational (category I-IV) use of antibiotics was 50%. The use of inappropriate antibiotic dose (category IIA) was 25%, the use of the antibiotic inaccurate interval of use (category IIB) was 10%, and there was no indication that antibiotic use (category V) was 15%. Quantitative evaluation of the use of antibiotics using the DDD method per 100 bed days showed that the total use of antibiotics was 7 types with a DDD value of 100 patient days of 19.15. The most widely used antibiotic is the cephalosporin class, namely cefotaxime with a DDD value of 6.51. Keywords: antibiotics, leukemia, quality, quantity
POTENSI INTERAKSI ANTAR OBAT PADA PASIEN RAWAT INAP DIABETES MELITUS TIPE-2 DENGAN KOMORBIDITAS HIPERTENSI Liniati Geografi; Octaviana Maria Simbolon
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.331

Abstract

Type 2 diabetes mellitus (insulin-dependent diabetes or adult-onset diabetes) is a condition caused by the ineffective use of insulin in the human body. This disease is also often accompanied by hypertension, where these comorbidities can spur severe cardiovascular complications such as heart attacks, strokes and kidney failure. Hospitalised diabetic patients with comorbid hypertension, have the potential to experience drug-related problems / Drug-Related Problems (DRPs), especially Drug-Drug Interactions (DDIs) due to a combination of therapies during the treatment period. The results obtained from the data tracking of 52 patients showed that 21 patients (40%) had the potential to experience DDIs. The types of potential DDI found in this study had 71 kinds variation with 124 events, 5% were major and 95% were moderate. The prevalence of potential interactions between drugs is quite high and varied. Inpatient monitoring of the risk is essential to avoid potential dangers inflicts on patients.
Co-Authors Liniati Geograf Liniati Geografi