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POTENSI INTERAKSI ANTAR OBAT PADA PASIEN RAWAT INAP DIABETES MELITUS TIPE-2 DENGAN KOMORBIDITAS HIPERTENSI Geografi, Liniati; Simbolon, Octaviana Maria
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.561 KB)

Type 2 diabetes mellitus (insulin-dependent diabetes or adult-onset diabetes) is a condition caused by the ineffective use of insulin in the human body. This disease is also often accompanied by hypertension, where these comorbidities can spur severe cardiovascular complications such as heart attacks, strokes and kidney failure. Hospitalised diabetic patients with comorbid hypertension, have the potential to experience drug-related problems / Drug-Related Problems (DRPs), especially Drug-Drug Interactions (DDIs) due to a combination of therapies during the treatment period. The results obtained from the data tracking of 52 patients showed that 21 patients (40%) had the potential to experience DDIs. The types of potential DDI found in this study had 71 kinds variation with 124 events, 5% were major and 95% were moderate. The prevalence of potential interactions between drugs is quite high and varied. Inpatient monitoring of the risk is essential to avoid potential dangers inflicts on patients.  

PEMERIKSAAN KESEHATAN DAN KONSULTASI OBAT PADA PERHIMPUNAN WARAKAWURI SANTA MONIKA SAMARINDA Josepha Benciang; Martina Norsanah; Liniati Geografi
Jurnal Pengabdiaan Masyarakat Kasih (JPMK) Vol 1 No 1 (2019): October
Publisher : JPMK : Jurnal Pengabdian Masyarakat Kasih Published by Unit Penelitian dan Pengabdian Kepada Masyarakat (UPPM) STIKES Dirgahayu Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52841/jpmk.v1i1.62

Perhimpunan Warakawuri Katolik Santa Monika merupakan suatu wadah Ibu-ibu janda / wanita Katolik yang tidak menikah, dengan usia rata-rata 60 tahun. Tujuan kegiatan ini adalah: mengetahui tekanan darah, berat badan, kadar kolesterol, asam urat, glukosa darah peserta, promosi kesehatan sesuai dengan kondisi peserta, baik secara langsung maupun dengan bantuan brosur dan membuka konsultasi terkait kepatuhan peserta dalam menjalankan terapi obat. Penyuluhan dilakukan kepada peserta yang mengalami hiperkolesterolemia (kadar kolesterol ≥ 200 mg/dL) dan hipertensi (tekanan darah >140 mm Hg). Hasil rata-rata dari empat kali pemeriksaan kesehatan menunjukkan bahwa 18 orang (78%) mengalami hiperkolesterolemia, 12 orang (52%) mengalami hiperurisemia (kadar asam urat ≥ 6 mg/dL), 10 orang (42%) mengalami hipertensi, dan 2 orang (9%) memiliki kadar glukosa darah ≥ 200 mg %. Mengingat besarnya manfaat kegiatan ini, maka selanjutnya perlu diadakan penyuluhan kesehatan secara berkesinambungan agar memberikan manfaat yang lebih optimal terhadap peningkatan kualitas hidup anggota Perhimpunan Warakawuri St. Monika Samarinda

EVALUASI PENGGUNAAN ANTIBIOTIK UNTUK TERAPI INFEKSI SALURAN KEMIH PADA PASIEN SINDROM NEFROTIK PEDIATRI Liniati Geografi; Djoko Wahyono; Nanang Munif Yasin
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 4, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.249

Infeksi merupakan komplikasi yang paling umum dari anak dengan sindrom nefrotik (SN) dan infeksi yang paling sering terjadi ialah Infeksi Saluran Kemih (ISK). Penelitian ini bertujuan untuk mengetahui pola penggunaan antibiotik dari segi pemilihan jenis, rute, kombinasi danalih terapi antibiotik, mengetahui rasionalitas terapi ISK rawat inap berdasarkan kriteria tepat indikasi, tepat obat, tepat pasien dan tepat dosis (4T), serta perbedaan luaran terapi dari penggunaan antibiotik untuk terapi ISK rawat inap pasien SN pediatri di RSUP Dr. Sardjito Yogyakarta. Penelitian dilakukan secara retrospektif selama bulan Juli 2013 pada sebanyak 16 pasien dengan 22 kasus ISK. Pengambilan data berdasarkan rekam medik pasien SN pediatri dengan komplikasi ISK yang rawat inap di RSUP Dr. Sardjito Yogyakarta periode Januari 2008 sampai dengan Desember 2012. Pengolahan data dilakukan secara deskriptif. Berdasarkan adanya pemeriksaan ulang urinalisis dan mikroskopis sampel urin, hanya 16 dari 22 kasus (72%) yang dapat dievaluasi keberhasilan terapinya dan seluruhnya memiliki luaran klinis membaik. Penggunaan antibiotik yang sesuai panduan ditemukan sebesar 25% (4 kasus) sedangkan penggunaan antibiotika yang tidak sesuai ditemukan sebesar 75% (12 kasus). Kata kunci: antibiotik, infeksi saluran kemih, sindrom nefrotik, pediatri

Studi Rasionalitas Penggunaan Obat Favipiravir pada Pasien Covid-19 di RSUD Harapan Insan Sendawar Kabupaten Kutai Barat Tahun 2021 Teresia Delvi; Liniati Geografi; Clara Ritawany Sinaga
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8607

Corona Virus Disease 2019 (COVID-19) is an infectious disease caused by the SARS COV-2 virus. One of the antiviral groups that are often used worldwide for the treatment of COVID-19 is Favipiravir. Favipiravir use should be monitored because the accuracy of the drug will maximize the effect of therapy on the patient. Evaluation of Drug Use (EPO) of Favipiravir in terms of rationality needs to be done. Drugs that are not used rationally can cause side effects, the length of treatment will be longer, and even cause death effects in patients. The purpose of this study was to describe the characteristics of COVID-19 patients based on age, gender, and comorbidities and to find out the rationale for using Favipiravir inpatients at the HIS Hospital based on the criteria for the right diagnosis, the right patient, the right drug, the right dose, the right time interval for administration, appropriate duration of administration and clinical outcomes of COVID-19 patients (PCR, TCM, and antigen). This research is a type of nonexperimental research, the research was carried out in a descriptive evaluative way, and the data was collected retrospectively by looking at the medical record data. Determination of the rationale for using Favipiravir was carried out using the literature of the Indonesian COVID-19 Drug Informatorium edition 3, 100% correct patient, 100% correct drug, 100% correct diagnosis, correct dose 50.84%, correct duration of administration 61.01%, correct time interval administration of 81.35% and clinical outcomes (PCR (-) 74.57% %, TCM (-) 16.94%, and Antigen (-) 6.77%.

Correlation Compliance Antiretroviral Therapy With Levels Viral Load In HIV Patients At Poly Clinic VCT Abdoel Wahab Sjahranie Samarinda Hospital 2022 Mukhlis Agus Setiawan Putra; Liniati Geografi; Clara Ritawany Sinaga
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.47512

ABSTRACT Human Immunodeficiency Virus (HIV) is a virus which can attack and infect human white blood cells and cause a decrease in the human immune system. Antiretrovirals (ARVs) have been shown to prevent HIV transmission because ARVs have a mechanism of action to prevent the gradual replication of the HIV virus. Compliance with taking ARV is very necessary, because non-compliance can cause resistance and make the amount of virus in the blood increase. The success of ARV therapy can be determined by monitoring the levels ofviral load. The objectives of the study were to determine the relationship between the level of compliance with the level ofviral loadat 6 and 12 months on ARV. This type of research is observational analytic with research design cross-sectional. The level of adherence was measured using the MMAS-8 questionnaire and the level ofviral loadtaken from medical record data. The data analysis used was Univariate and Bivariate withChi Square. The study showed that from 60 respondents, the results showed that the category of high compliance was 63.4%, the category of moderate compliance was 13.3% and the category of low adherence was 23.3%. The results of the bivariate test showed that the significance value between the level of patient compliance and the level of viral load 6 months (p= 0.027) and 12 months (p= 0.001) <0.05. There is a significant relationship between adherence to taking antiretroviral drugs with levels of viral load HIV patients at the VCT clinic at the Abdoel Wahab Sjahranie Hospital Samarinda in 2022. Keywords: Compliance with taking medication, Viral Load 6 and 12 months, HIV.

Studi Rasionalitas Penggunaan Obat Favipiravir pada Pasien Covid-19 di RSUD Harapan Insan Sendawar Kabupaten Kutai Barat Tahun 2021 Delvi, Teresia; Geografi, Liniati; Sinaga, Clara Ritawany
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 6 No. 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8607

Corona Virus Disease 2019 (COVID-19) is an infectious disease caused by the SARS COV-2 virus. One of the antiviral groups that are often used worldwide for the treatment of COVID-19 is Favipiravir. Favipiravir use should be monitored because the accuracy of the drug will maximize the effect of therapy on the patient. Evaluation of Drug Use (EPO) of Favipiravir in terms of rationality needs to be done. Drugs that are not used rationally can cause side effects, the length of treatment will be longer, and even cause death effects in patients. The purpose of this study was to describe the characteristics of COVID-19 patients based on age, gender, and comorbidities and to find out the rationale for using Favipiravir inpatients at the HIS Hospital based on the criteria for the right diagnosis, the right patient, the right drug, the right dose, the right time interval for administration, appropriate duration of administration and clinical outcomes of COVID-19 patients (PCR, TCM, and antigen). This research is a type of nonexperimental research, the research was carried out in a descriptive evaluative way, and the data was collected retrospectively by looking at the medical record data. Determination of the rationale for using Favipiravir was carried out using the literature of the Indonesian COVID-19 Drug Informatorium edition 3, 100% correct patient, 100% correct drug, 100% correct diagnosis, correct dose 50.84%, correct duration of administration 61.01%, correct time interval administration of 81.35% and clinical outcomes (PCR (-) 74.57% %, TCM (-) 16.94%, and Antigen (-) 6.77%.

POTENSI INTERAKSI ANTAR OBAT PADA PASIEN RAWAT INAP DIABETES MELITUS TIPE-2 DENGAN KOMORBIDITAS HIPERTENSI Liniati Geografi; Octaviana Maria Simbolon
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.331

Type 2 diabetes mellitus (insulin-dependent diabetes or adult-onset diabetes) is a condition caused by the ineffective use of insulin in the human body. This disease is also often accompanied by hypertension, where these comorbidities can spur severe cardiovascular complications such as heart attacks, strokes and kidney failure. Hospitalised diabetic patients with comorbid hypertension, have the potential to experience drug-related problems / Drug-Related Problems (DRPs), especially Drug-Drug Interactions (DDIs) due to a combination of therapies during the treatment period. The results obtained from the data tracking of 52 patients showed that 21 patients (40%) had the potential to experience DDIs. The types of potential DDI found in this study had 71 kinds variation with 124 events, 5% were major and 95% were moderate. The prevalence of potential interactions between drugs is quite high and varied. Inpatient monitoring of the risk is essential to avoid potential dangers inflicts on patients.

Antibiotic Use in Pediatric Pharyngitis at Juanda Samarinda Public Health Center from January-December 2023 -, Mardiana -; Geografi, Liniati; Simanullang, Raymon
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.529

Pharyngitis is an infection or inflammation of the pharyngeal (throat) region, primarily caused by bacteria and viruses. The most common bacterial cause is Group A Streptococcus. Management of bacterial pharyngitis involves the use of antibiotics aimed at eradicating the causative pathogen. Quantitative analysis of antibiotic use can be conducted using the Defined Daily Dose (DDD) method, which is useful for assessing both the pattern and volume of drug consumption. This study aims to quantify the use of antibiotics in pediatric pharyngitis patients using the ATC/DDD method at Juanda Samarinda Public Health Center in 2023. This research is classified as a descriptive quantitative study and employs a non-experimental, retrospective design. Data were collected from antibiotic usage reports and medical records of pediatric pharyngitis patients treated in 2023. Data processing was performed using descriptive and quantitative analysis, with all results processed using Microsoft Excel 2019 and presented in tabular format. Based on the findings, the antibiotic with the highest usage in pediatric pharyngitis patients at Juanda Samarinda Public Health Center was Amoxicillin, with an average of 38.5 DDD/1,000 patient-days (KPRJ), while the lowest was Cefadroxil, with an average of 4.9 DDD/1,000 patient-days (KPRJ).

Evaluation of Antibiotic Utilization Patterns in Community-Acquired Pneumonia Inpatients Using ATC/DDD and DU 90% Methods at Taman Husada Bontang Regional General Hospital in 2024 Lawin, Handratin; Geografi, Liniati
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.522

Community-acquired pneumonia (CAP) represents an acute infectious inflammatory condition affecting the lung parenchyma, typically contracted in non-hospital settings. Antibiotic therapy serves as the primary treatment modality for CAP. This investigation employs a dual methodological approach: quantitative assessment through the Defined Daily Dose (DDD) metric and qualitative evaluation utilizing the Drug Utilization 90% (DU 90%) analysis. The study objectives focus on characterizing antibiotic consumption patterns among CAP patients at Taman Husada Bontang Regional General Hospital during 2024, employing both ATC/DDD and DU90% analytical frameworks. This quantitative descriptive research utilized retrospective data collection from medical records of CAP inpatients admitted between January and June 2024. Following comprehensive screening, 83 eligible patient records were included for analysis. Data processing involved descriptive statistical methods with Microsoft Excel for tabular presentation of findings. Demographic analysis revealed a homogeneous age distribution (100% within 18-39 years) with male predominance (59%). Quantitative evaluation identified Ceftriaxone as the most frequently prescribed antibiotic (42.5 DDD/100 treatment days). The DU 90% analysis further delineated the therapeutic landscape, with Ceftriaxone (52.9%), Levofloxacin (23.5%), Azithromycin (11.1%), and Ceftazidime (5.3%) constituting the predominant therapeutic agents.

Study of Medicine Dosage Adjustments in Inpatients with Chronic Kidney Disease Weking, Katharina Kening; Geografi, Liniati; Sinaga, Clara Ritawany
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.88181

Background: Decreased kidney function in patients with Chronic Kidney Disease (CKD) necessitates dose adjustment, especially for medicines that have a narrow therapeutic index to avoid unwanted medicine effects.Objectives: The purpose of this study was to determine the medicine dosage adjustments in CKD patients and their therapy outcomes.Methods: This type of research is descriptive with a retrospective approach. The sample in this study is the medical records of inpatient CKD patients at Abdoel Wahab Sjahranie Samarinda Hospital for the period May to November 2022. Calculation of GFR (Glomerular Filtration Rate) uses the MDRD (Modification of Diet in Renal Disease) formula.Results: The results showed that the sex of most patients was male as many as 56.25%. The age of most patients in the range of 53-59 years old as many as 33.75%. Most CKD severity level is stage 5 as many as 91.25%. The most common comorbidities were hypertension (61 patients), diabetes mellitus (15 patients), and edema or pulmonary edema (11 patients). There were 77 patients requiring dose adjustment out of a total of 80 patients. There were 149 (34.89%) medicines requiring dose adjustment out of a total of 427 medicines, with the 5 most medicines being calcium carbonate (24.16%), furosemide (24.16%), metoclopramide (10.74%), paracetamol (10.74%), and ranitidine (7.39%). There were 128 (85.91%) medicines with doses appropriate to the Lexicomp 2023 or Renal Pharmacotherapy 2013. The therapy outcome improved in patients who required dose adjustments by 90.91%.Conclusion: It is recommended to calculate GFR using a new formula such as eGFR using CKD-EPI, and collecting data with a larger number of samples.

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