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All Journal Journal Orthopaedi and Traumatology Surabaya (JOINTS)
Muhammad Hardian Basuki
Staff of Orthopaedic and Traumatology Department, Faculty of Medicine, Universitas Airlangga, Dr Soetomo General Hospital, Surabaya
Health Professions Medicine & Pharmacology

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QUALITY OF LIFE COMPARATION IN METASTATIC BONE DISEASE PATIENT BEFORE AND AFTER SURGERY IN DR. SOETOMO GENERAL HOSPITAL Ferdiansyah Mahyudin; Mouli Edward; Muhammad Hardian Basuki; Rizky Agung Satria
Journal Orthopaedi and Traumatology Surabaya Vol. 7 No. 2 (2018): October 2018
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v7i2.2018.132-138

Abstract

Background: Metastatic bone disease is bone pathologic process caused by spread of primary tumor. The incidence of metastatic bone disease varies between 20-75% corresponds to the primary site of the malignancy. Surgery in metastatic bone disease aim to cure or palliate the morbidity caused by the disease. Operative treatment could reduce pain, improve function, control metastatic focus of the malignancy, and provide mechanical stabilization. Based on those benefits, operative treatment is important to improve quality of life in patients with metastatic bone disease. Purpose:  Proved that there was a difference in the quality of life MBD patients before and after surgery.Methods: This research was a retrospective cohort on MBD patients which undergone surgery, and never given any other treatment in the course of the disease. The research was conducted in Dr. Soetomo General Hospital, Surabaya. Patient sampling was done using consecutive sampling. Karnofsky score was taken from the medical record before the procedure and direct interview via phone or completing questionnaire. Data analysis was done descriptively and analytically. Statistical tests were done using Wilcoxon test.Results: 146 patients enrolled in the research. The mean age of the sample was 48.77 ± 13.34 years. The mean of Karnofsky score before and after the procedure was 53.69±13.07 and 75.54±13.69 with statistical result of p<0.001.Conclusion: The Karnofsky score in MBD patients was higher after the surgery compared to before the surgery.
ANALYSIS OF IMMUNITY IN OSTEOSARCOMA AS A BASIS FOR DEVELOPMENT FOLLOWING THERAPY Ferdiansyah Mahyudin; Mouli Edward; Muhammad Hardian Basuki; Kadek Seta Prawira
Journal Orthopaedi and Traumatology Surabaya Vol. 7 No. 2 (2018): October 2018
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v7i2.2018.139-148

Abstract

Background: Osteosarcoma is a malignant bone disease. Predictors which used to determine osteosarcoma from non-invasive (stage IIB) to invasive (stage III), through the ratio of macrophages-1 (M-1) which are pro-inflammatory (anti-cancer) with macrophages-2 (M-2) which have anti-inflammatory characteristic (pro cancer) is not clear yet.Purpose: To elaborate the role of M-1 ratio with M-2 in the development of non-invasive osteosarcoma become invasive, in effort to obtain predictors that can be used to the selection of neoadjuvant therapy time.Methods: An observational study with cross sectional analytic study design. The sample of this research were all of paraffin blocks containing osteosarcoma patient tissue, collected within 5 years. The number of samples that met the inclusion criteria was 26 samples, and then divided into two groups, namely group-I as many as 13 stages IIB and group-II as many as 13 samples of stage III. The measured variables are the number of macrophages that express TNF-α and those that express IL-10 by immunohistochemical methods.Results: Analysis of the data using a Mann-Whitney test, and the results were obtain is the number of macrophages expressing TNF-α in group-I was greater than in group-II (p <0.05). Likewise, macrophages that expressed IL-10 in group I were smaller than in group-II (p <0.05).Conclusion: The M-1 ratio which reflected by TNF-α expression cells with M-2 as reflected by IL-10 expression cells in the non-invasive group is 5: 1.Whereas in the group that develops to invasive is 1:6.
Co-Authors Ferdiansyah Mahyudin Kadek Seta Prawira Mouli Edward Rizky Agung Satria