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All Journal BALI MEDICAL JOURNAL (BMJ) Jurnal Berkala Epidemiologi Jurnal NERS Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal Orthopaedi and Traumatology Surabaya (JOINTS) Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology Narra J The Hip and Knee Journal

Mouli Edward

Department Of Orthopaedic And Traumatology, Faculty Of Medicine, Universitas Airlangga – Dr. Soetomo General Hospital, Surabaya

Author-ID : 4339803

Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

Published : 24 Documents Claim Missing Document

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The Healing Effect of Cuttlefish Bone on Fractured Bone in Rat Model Kloping, Laskar Pradnyan; Purwati, P.; Edward, Mouli
BALI MEDICAL JOURNAL Vol 5 No 2 (2016)
Publisher : BALI MEDICAL JOURNAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.571 KB)

Background: Fractured bone healing requires three to nine months, which prolongs the patients’ morbidity. Long bone fracture is considered to be difficult due to the dependence of bodily mobility and freedom. Bone tissue engineering materials includes hydroxyapatite (HAp), titanium, alumina, and polymers. HAp is found to be heavily abundant in cuttlefish. This study is conducted to prove that the cuttlebone has an effect of accelerating the fractured long bone healing process. Methods: This is an experimental study using a total of 32 samples of Rattus norwegicus. The Treatment Group received the cuttlebone extract + 0.9% NaCl while the Control Group received only NaCL 0.9%. Both groups were fractured beforehand. On the 14th day the fractured area was harvested and assigned for histopathology and radiographic exam. Results: The Treatment Group was found to have thicker callus formation and more osteoblasts. Conclusions: The cuttlebone extract application caused thicker callus and higher osteoblast production, proving an accelerated fractured bone healing process.

Clinical Features in Metastatic Bone Disease with and without Pathological Fractures: A Comparative Study Putu Garry; Mouli Edward; Rosy Setiawati; Sjahjenny Mustokoweni; Ferdiansyah Mahyudin
Health Notions Vol 3, No 10 (2019): October
Publisher : Humanistic Network for Science and Technology (HNST)

Background: Pathological fracture complications such as impaired clinical features is suspected to increase the mortality in MBD. In Indonesia, the habit of delayed seeking of medical treatment was common and potentially led to pathological fracture. Aim: This study compared the clinical features between MBD with and without pathological fracture. Methods: This was a retrospective study of MBD at Dr. Soetomo General Hospital in 2011-2015. We compared the clinical features by pain in Visual Analog Scale (VAS); general health presentation represented by laboratory findings; and the history of non-medical treatments. Results: 64 patients had MBD were included in this study. 37 (57.8%) of them presented with pathological fractures, and 27 (42.2%) without. Pain was the most common chief complaint (76.5%). No significant difference found between the MBD with and without pathological fracture in all variables (p=0.122; p=0.64; p=0.823; p=0.417, p=1.000 for VAS, hemoglobin, albumin, calcium, and history of non-medical treatment respectively). This probably associated with the therapy and a variety of primary tumors underlying the MBD. However, 6 out of 10 patients with history non-medical treatment presented with fractures. Conclusion: There's no significant difference in clinical features of MBD from both groups, while those with fractures had worse conditions. Keywords: Metastatic bone disease, Pathological fracture, Clinical features

Femur Pathological Fracture Caused by Metastatic Bone Disease Derived from Foot Squamous Cell Carcinoma Ferdiansyah .; Mouli Edward; Muhammad Hardian Basuki; Deny Mory Aryawan
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 1, No 02 (2017)
Publisher : Universitas Muhammadiyah Surabaya

Background : Bone is an organ and the most common site that prone to metastatic cancer and cause serious morbidity. Besides, metastatic cancer to bone will limit skeletal function so that decrease quality of life and even death that most of them caused by its complication.Objective : Reporting a rare case about Squamous Cell Carcinoma that cause femur pathological fracture caused by Metastatic Bone Disease.Material and Method : Case report in women patients 55 years old with femur close fracture one-third middle caused by Metastatic Bone Disease in RSUD Soetomo Surabaya, period May 2015-March 2016.Data is taken retrospectively from medical record through interview, physical examination, radiological examination, and laboratory.Result and Discussion : Patients are treated in hospital because of femur close fracture one-third middle caused by Metastatic Bone Disease. Based on physical and radiological examination, it is decided being done by skin traction first. The next plan is surgery. Patients are treated with interlocking nail left femur. Evaluation after surgery is done with medical rehabilitation, that is ROM exercise. Until now, 9 months after surgery, patients still control routinely to be done chemotherapy and there is improvement in patient’s condition.Conclusion : Metastatic process in bone often cause pathological fracture. Bone Metastatic is common from Breast, Lung, Prostate and Kideney Cancer. There was no publication before about Bone Metastatic Disease come from Squamous Cell Cancer. Mirel’s score is used as guiding in fixation prior to the next treatment. Decision of surgery is considered through patient’s objective and subjective appraisal that can be calculated in Abdurrahman score system.

Tumor Mimicking in Musculoskeletal System in Surabaya: A Case Series Bayu Antara Hadi; Mouli Edward
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 1 (2020)
Publisher : Universitas Muhammadiyah Surabaya

ABSTRACTMusculoskeletal tumors are potential causes of heavy morbidity and economic burdens for patients. There are often cases suspected as musculoskeletal tumors based on a specific diagnostic modality because of overlapping features upon physical examination or a tumor-like appearance from the radiological examination, the more reason for triple diagnosis to be performed for an exact diagnosis. We report 5 cases of fractures tumor-mimicking lesions. The First patient, a patient with MRI revealing a primary malignant bone tumor, but with plain thorax x-ray and FNAB, the diagnosis was tuberculosis arthritis of the elbow. The second patient shows metastatic proses with plain radiographic, but from open biopsy, the diagnoses fall to chronic osteomyelitis. The third patient had a history of papillary carcinoma thyroid with pathological fracture of proximal of the left femur, but the biopsy shows a hypercalcemic state. The fourth patient, had mass size 20x15 cm at the thigh, but the biopsy shows Non-Specific Chronic Osteomyelitis. The fifth patient with progressive swelling of the left knee for one year, 10x10 cm in size, the biopsy showed no sign of malignancy but tuberculosis of left distal femur. In conclusion, standard comprehensive diagnosis steps consisting of clinical history, imaging, laboratory and histopathological examinations are crucial to differentiate tumor-mimicking lesions from neoplasms, thus ensuring proper treatment.Keywords: Tumour mimicking, osteosarcoma, chondroma, malignancy

Profile of Diabetic Foot Ulcer Patients at Tertiary Care Hospital in Surabaya, Indonesia Arisvia Sukma Hariftyani; Hermina Novida; Mouli Edward
Jurnal Berkala Epidemiologi Vol. 9 No. 3 (2021): Jurnal Berkala Epidemiologi (PERIODIC EPIDEMIOLOGY JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V9I32021.293-302

Background: Diabetic Foot Ulcer (DFU) has been associated with a high mortality rate of Diabetes Mellitus (DM) patients. Both behavioral and biological factors cause predisposition to DFU. Purpose: This research describes the profile of hospitalized DFU patients at a tertiary care hospital in Surabaya. Methods: A retrospective descriptive study that analyzed medical records of hospitalized T2DM patients with DFU in Dr. Soetomo General Hospital. Sampled respondents were patients ≥ 21 years old who were hospitalized between 2016–2018. Demographic data, clinical characteristics, medical histories, length of hospital stay, laboratory results, precipitating factors, microorganism culture results, treatment, and outcome were analyzed. Descriptive analysis is presented in the form of narratives, tables, and diagrams. Results: 9.08% of hospitalized Type 2 DM (T2DM) cases were related to foot ulcers. The average patient age was 57.00 ± 9.83 years with no gender predominance. DM was poorly controlled (Mean HbA1C 9.78±2.83%; RBG 251.83 ± 158.15 mg/dL). The majority of patients had sepsis (68.26%) and renal function impairment (62.72%). Ulcers with Wagner grades of 4–5 were frequent (41.31%). The highest percentage of sepsis (80.49%) and the average leukocyte level (22.60±11.95 x109/L) were found in gangrenous feet. Anemia was more predominant and severe in ulcers with higher Wagner grades. Trauma and Escherichia coli were the most common precipitating factors and microorganisms isolated, respectively. Amputation was performed for 82.36% of patients who were admitted to hospital with gangrene. The Lower Extremity Amputation (LEA) and mortality rates were 14.11% and 40.93%, respectively. Conclusion: DFUs were found to have a relatively high prevalence among T2DM patients, and must never be neglected due to the high associated mortality rate.

Modern and Classic Wound Dressing Comparison in Wound Healing, Comfort and Cost Ferdiansyah Mahyudin; Mouli Edward; M Hardian Basuki; Yunus Basrewan; Ansari Rahman
Jurnal Ners Vol. 15 No. 1 (2020): APRIL 2020
Publisher : Universitas Airlangga

Introduction: Wound care has also developed rapidly after the dissemination of the concept of TIME (Tissue, Infection, Moisture, and Wound Edge) in modern dressing (MD). The aim of this study was to compare modern dressings (MDs) and classic dressings (CDs) in terms of patient comfort, cost effectiveness and wound healing.Methods: A prospective study design with total of 25 participants. The sampling technique used was consecutive sampling. Patient comfort was assessed through the frequency of wound care and pain scale using the Visual Analogue Scale (VAS). Cost-effectiveness was assessed using direct and indirect costs. Wound healing was assessed using the Bates-Jensen Wound Assessment Tool (BWAT) score. The data was analyzed using the independent t and Mann-Whitney tests.Results: In terms of comfort, the mean for the number of times that wound care was performed and the pain scale in the participants using MD was (3.07 ± 0.88 times and VAS 4.59 ± 0.72, respectively), which is less compared to using CD (4.60 ± 1.84 times each and VAS 5.43 ± 0.75). Referring to the indirect and direct costs, MD (13.67 ± 6.09 and 527.63 ± 84.47, respectively) has the same cost-effectiveness as CD (14.00 ± 7.64 and 482.68 ± 98.08, respectively). In terms of healing, the mean of the BWAT score in MD (31.26 ± 1.69) was better compared to CD (33.07 ± 1.65).Conclusion: The application of MD has the same cost-effectiveness as CD with a more satisfactory outcome for the wounds in terms of comfort and healing.

DIFFERENCES OF BONE REGENERATION USING BOVINE HYDROXYAPATITE AND BOVINE HYDROXYAPATITE WITH FREEZE-DRIED PLATELET RICH PLASMA ALLOGRAFT IN BONE DEFECT OF FEMORAL WHITE RABBIT Mouli Edward; Henry Dominica; Ferdiansyah Mahyudin; Fedik Abdul Rantam
Journal Orthopaedi and Traumatology Surabaya Vol. 9 No. 2 (2020): October 2020
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v9i2.2020.34-54

Background: Hydroxyapatite is a bone graft that has osteoconductive properties for bone defects treatment. Platelet-rich plasma (PRP) has a capability of providing many bioactive molecules in physiological proportions. Hydroxyapatite given freeze-dried PRP is expected to create a graft that can strengthen the matrix while promoting osteoinduction. This study compares the effects of regeneration on the bone between bovine hydroxyapatite (BHA) and bovine hydroxyapatite with freeze-dried platelet-rich plasma (FD-PRP) as a bone graft in bone defect of the femoral white rabbit.Methods: The 12 equal New Zealand white rabbits aged 6-9 months are divided into two groups. Bone defects were made in the lower femoral meta-diaphysis with a diameter of 2.5 mm. The defects were filled with BHA with FD-PRP allograft in the treatment group and BHA in the control group. Both groups will be sacrificed in the third and sixth weeks, then evaluated histologically for microvascular structure, osteoblasts, woven bone, type-I collagen, osteocalcin, alkaline phosphatase, and immunoglobulin G.Results: During the evaluation in week 3 and 6, microvascular structure, osteoblast, and type-I collagen decreased in both groups with insignificant differences (p>0.05). Woven bone, osteocalcin, and immunoglobulin G increased in the treatment group but was not significant (p>0.05). Alkaline phosphatase increased higher in the treatment group, with a considerable difference in the sixth week (p=0.008).Conclusion: The elevation in the production of woven bone, osteocalcin, and alkaline phosphatase at the third and sixth-week evaluations highlight the possibility that administering BHA given FD-PRP may have contributed to the healing of bone defects.

GIANT CELL TUMOR OF THE RIBS: A CASE REPORT I Putu Gede Pradnyadewa Pradana; Mouli Edward
Journal Orthopaedi and Traumatology Surabaya Vol. 10 No. 1 (2021): April 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v10i1.2021.32-38

Background: Giant Cell Tumor (GCT) is a benign tumor but can be malignant and spread to other organs. Common site of GCT develops in long bone, especially in the knee. A lesion that develops in flat bone is considered rare. This case report aims to recognize GCT of bone and its predilection and help improve diagnostics and manage this case to provide better results.Case Report: A seven-year-old female came with complaints of lump and intermittent pain in left-back. The lump is gradually getting more prominent. The pain is localized in the back mid-area, worsen with any touch around the area. On examination, there is deformity and mass on the posterolateral side at the 9th rib level around 3 cm in diameter. There was tenderness on palpation and limited range of motion (ROM). The cytological and radiological finding suggests GCT of bone. The patient had resection surgery of the lesion. The histopathologic results on the operative specimens confirmed the diagnosis of GCT.Discussion: An unusual location of GCT lesions needs to be a concern because they can be underdiagnosed not to receive optimal therapy. Inadequate therapy can increase the incidence of recurrence and malignancy changes. In this case, the patient had resection surgery. Postoperatively, the patient is in good condition with no sign of local recurrence.Conclusion: GCT should be included in the differential diagnosis of rib-originated tumors. Tumor lesions in unusual places other than long bones and occurs on the immature patient should be particular concern and confirmed diagnosis.

A Comparison between the Effectiveness of Platelet-Rich Plasma Injection and Corticosteroid Injection in Plantar Fasciitis Patients: A Systematic Review Fikri Rasikh Pritanto; Rwahita Satyawati; Mouli Edward; Rr. Indrayuni Lukitra Wardhani
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 3 (2022): Indian Journal of Forensic Medicine and Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i3.18278

A systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses chart(PRISMA) was used in this study. About 7 articles have been included. A month post-injection, corticosteroidinjection reduced pain more than PRP injection (Mean: 1.22; 95% CI:-1.10 to 3.54; p=0.30).However, PRP injectionreduced pain significantly more than corticosteroid injection in three months after injection (Mean: -0.77, 95%CI:-1.46 to -0.96; p=0.03), and in six months later (Mean:-1.22, 95% CI:-2.02 to -0.42; p=0.003). The effectivenessdifference between Platelet-Rich Plasma injection and corticosteroid injection in patients with plantar fasciitisvaries depending on peak period and facial thickness.

OSTEOSARCOMA HAS NOT BECOME ATTENTION TO SOCIETY PROFILE OF OSTEOSARCOMA PATIENTS AT DR. SOETOMO GENERAL HOSPITAL SURABAYA “A RETROSPECTIVE STUDY” Ferdiansyah Mahyudin; Mouli Edward; Muhammad Hardian Basuki; Yunus Abdul Bari; Yesa Suwandani
Journal Orthopaedi and Traumatology Surabaya Vol. 7 No. 1 (2018): April 2018
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v7i1.2018.20-30

Background: Osteosarcoma is the most common bone neoplasm found in the community but evaluation osteosarcoma cases in RSUD Dr. Soetomo has not been updated since 1995.Purpose: This study o osteosarcoma patient characteristic as well as therapy at Dr. Soetomo General Hospital in 2007 to 2016. It expects to show survival rates of osteosarcoma patient, so it can be a reference for searching the problems in the treatment of osteosarcoma cases and helps to decide treatment for osteosarcoma.Research Methods: Descriptive retrospective study, conducted on osteosarcoma patients at Dr. Soetomo General Hospital during 2007-2016 periods. Data were obtained from Ortho tumor patient database, and contacting them by phone or home visit.Results: Osteosarcoma patients was found mostly in 2015, while the least in 2008, with trend increasing by time. Majority of the patients came with advanced stage. Osteosarcoma treated mostly by amputation, either with or without chemotherapy. The survival rate in the first, second, or the fifth year was found lower than other references. Most common cause of mortality was the metastasis.Conclusion: Awareness of the society about the cancer sign of cancer and desire to use medical treatment as a priority is still low. This causes a low early detection rate of osteosarcoma and a high rate of metastatic cases because of inappropriate early treatment. Further socialization and increased awareness of medics about the suspicion of osteosarcoma are needed to improve the success rate of treatment as well as the survival rate.

Co-Authors Abdul Bari, Yunus Akbar, Kukuh Ali Ansari Rahman Ardana, Fahrizal Novan Arifin Arisvia Sukma Hariftyani Arius Suwondo Armando, Braven Asyumaredha Asyumaredha Bayu Antara Hadi Benedicta, Steesy Buwana, Dewan S. Caesar Haryo Bimoseno Deny Mory Aryawan Desnantyo, Andre Triadi Dwikora Novembri Utomo Erfan Nasrullah Fedik Abdul Rantam Ferdiansyah Mahyudin Fikri Rasikh Pritanto Henry Dominica Heri Suroto Hermina Novida, Hermina I Putu Gede Pradnyadewa Pradana Kadek Seta Prawira Kukuh Dwiputra Hernugrahanto Laskar Pradnyan Kloping, Laskar Pradnyan Lisan, Rizal A. Lukas Widhiyanto M Hardian Basuki Manyakori, Dionysius Bramta Putra Martanto, Tri Wahyu Mohammad Hardian Basuki Muhammad Dimas Arya Candra Permana, Muhammad Dimas Arya Candra Muhammad Hardian Basuki Muhammad Hardian Basuki Muhammad Hardian Basuki Muhammad Hardian Basuki P. Purwati, P. Perwira, Ferdiansyah Danang Putu Garry Rizky Agung Satria Rwahita Satyawati Dharmanta Setiawati, Rosy Sjahjenny Mustokoweni, Sjahjenny Steesy Benedicta Suyono, Rifki Effendi Wardhana, Teddy Heri Wardhani, Indrayuni Lukitra Yesa Suwandani Yunita Purnamasari, Yunita Yunus Abdul Bari Yunus Basrewan

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