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All Journal Indonesian Journal of Perinatology
A.A. Gde Marvy Khrisna Pranamartha
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Udayana/Sanglah General Hospital, Denpasar, Bali, Indonesia
Health Professions Medicine & Pharmacology Nursing

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The role of circular Ribonucleic Acid in preeclampsia: a literature review William Alexander Setiawan; A.A. Gde Marvy Khrisna Pranamartha
Indonesian Journal of Perinatology Vol. 1 No. 1 (2020): Available Online: 1 December 2020
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.952 KB) | DOI: 10.51559/inajperinatol.v1i1.4

Abstract

Circular RNAs (circRNAs) are non-coding RNAs with a covalently closed circular structure that present in a variety of organisms. The circRNAs are more stable and durable than linear RNAs due to incompatibility with the RNases. Recent studies have shown that circRNAs are expressed differently at the mother-fetal interface of women with preeclampsia compared to women with normal pregnancy. Although the evidence showed that circRNAs mediate various pathological processes in pregnancy, the mechanism of action is still unclear. In this paper, we provide a highlight of the current state of knowledge about circRNAs, its relation to preeclampsia, and the potential applications as preeclampsia biomarkers.
Co-Authors William Alexander Setiawan