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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN The Indonesian Biomedical Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Perinatology
William Alexander Setiawan
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Prenatal Diagnosis dan Penatalaksanaan Gastroskisis William Alexander Setiawan
Indonesian Journal of Obstetrics & Gynecology Science Volume 2 Nomor 2 September 2019
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (461.903 KB) | DOI: 10.24198/obgynia.v2n2.125

Abstract

Gastroskisis merupakan defek kongenital yang terjadi pada dinding abdomen janin. Kejadian yang dilaporkan di seluruh dunia berkisar antara 4-5 per 10.000 kelahiran hidup. Mortalitas pada bayi yang lahir dengan gastroschisis telah menurun selama bertahun-tahun tetapi morbiditas masih tetap tinggi. Diperlukan prenatal diagnosis yang optimal agar proses melahirkan bisa dipersiapkan sebaik mungkin. Pada prenatal diagnosis dilakukan penilaian defek kongenital lainnya agar hasil klinis lebih baik dengan manajemen lebih awal, selain itu dilakukan juga penilaian untuk menentukan adanya kelainan kromosom atau tidak. Apabila kelainan tersebut bersifat isolated, maka hasil klinis akan lebih baik dibandingkan gastroschisis dengan kelainan kromosom. Metode persalinan dan waktu persalinan yang direkomendasikan yaitu pada usia kehamilan 37 minggu dengan metode sectio caesarea. Manajemen neonatal meliputi persalinan di fasilitas kesehatan tersier dan manajemen bedah paska kelahiran yaitu penutupan bedah primer, penutupan bertahap dengan silo, atau penutupan umbilikal tanpa jahitan.Prenatal Diagnosis and Management of GastroschisisAbstractGastroskisis is a congenital defect that occurs in the fetal abdominal wall. Events reported throughout the world range from 4-5 per 10,000 live births. Mortality in infants born with Gastroskisis has declined over the years but morbidity is still high. An optimal prenatal diagnosis is needed so that the labor can be prepared as well as possible. Prenatal diagnosis is done by assessing other congenital defects so that clinical results are better with earlier management, in addition assessment is also done to determine whether there is a chromosome abnormality or not. If the abnormality is isolated, the clinical results will be better than Gastroskisis with chromosomal abnormalities. The recommended method of delivery and labor time is 37 weeks gestational age with the sectio caesarea method. Neonatal management includes delivery in tertiary health facilities and management of postnatal surgery namely primary surgical closure, staged reduction with silo and sutureless umbilical closure.Key words: Congenital Defect, Gastroskisis, Prenatal Diagnosis
Ekspresi Annexin A2 pada Kanker Ginekologi William Alexander Setiawan
Indonesian Journal of Obstetrics & Gynecology Science Volume 4 Nomor 1 Maret 2021
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v4n1.174

Abstract

Tujuan: Untuk menentukan adanya hubungan antara ekspresi ANXA2 dan berbagai aspek kanker ginekologi. Metode: Pencarian terstruktur untuk penelitian yang menyelidiki hubungan ekspresi ANXA2 dan kanker serviks, kanker endometrium dan kanker ovarium menggunakan PubMed. Pencarian terbatas pada 10 tahun terakhir dan dilakukan penyaringan dengan kriteria inklusi serta eksklusi yang telah ditetapkan. Hasil: Dari 52 penelitian didapatkan 9 penelitian yang kemudian dilakukan telaah kritis. ANXA2 diekspresikan berlebih dalam jaringan karsinoma dibandingkan dengan jaringan normal. Kesimpulan: Peningkatan ekspresi ANXA2 berperan dalam proliferasi sel kanker. Ekspresi ANXA2 berkorelasi dengan stadium lanjut dan penyakit metastasis. ANXA2 dapat digunakan untuk memprediksi progresivitas, angka kelangsungan hidup, dan resistensi terhadap rejimen pengobatan.Annexin A2 Expression in Gynecological Cancer: A Systematic ReviewAbstractObjective: To determine the relationship between ANXA2 expression and various aspects of gynecological cancer. Method: A structured search for studies involving the relationship of ANXA2 and cervical cancer, endometrial cancer and ovarian cancer using PubMed. Search is limited to the last 10 years and is screened with predetermined inclusion and exclusion criteria. Result: Of the 52 studies obtained 9 studies which were then carried out critical studies. ANXA2 is overexpressed in carcinoma tissue compared to normal tissue. Conclusion: Increased expression of ANXA2 approved in cancer cell proliferation. Expression of ANXA2 correlates with advanced stage and metastatic disease. ANXA2 can be used to predict progression, survival rates, and resistance to treatment regimens.Key words: Annexin A2, gynecological cancer, proliferation
Adenomiosis Berdampak Buruk terhadap Keberhasilan in Vitro Fertilization William Alexander Setiawan
Indonesian Journal of Obstetrics & Gynecology Science Special Issue: Article Review
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v4n2s.175

Abstract

AbstrakTujuan: Memaparkan etiologi dan faktor risiko, diagnosis banding, patofisiologi, pemantauan, terapi, komplikasi, rekurensi dan tindakan preventif pada kasus preeklamsia pascasalin.Metode: Tinjauan pustaka dengan berbagai referensi yang diakses melalui mesin pencarian seperti Pubmed dan Sci-Hub dengan menggunakan kata kunci preeclampsia, hypertension, postpartum, management. Sumber referensi yang digunakan yaitu guidelines, jurnal, dan buku teks yang diterbitkan dalam 15 tahun terakhir.Kesimpulan: Insiden preeklamsia di Indonesia yaitu 128.273/tahun atau sekitar 5,3%. Sebanyak 0,3 – 27,5% kasus yang dilaporkan mengalami preeklamsia atau hipertensi pascasalin. Gejala-gejala preeklamsia pascasalin muncul setelah melahirkan. Mayoritas kasus berkembang dalam 48 jam setelah persalinan, walaupun sindrom dapat muncul hingga 6 minggu setelah persalinan. Periode pascasalin merupakan waktu kritis bagi spesialis obstetri dan ginekologi untuk menjamin wanita dengan riwayat preeklamsia untuk dipantau dalam jangka waktu pendek dan panjang. Akan tetapi, pemantauan pascasalin sangatlah rendah, berkisar antara 20-60%. Pemilihan antihipertensi pasca salin yaitu berikatan kuat dengan protein dan solubilitas lipid yang rendah sehingga lebih sedikit yang masuk ke ASI. Selain itu, dipengaruhi juga oleh ionisasi, berat molekul dan konstituen ASI (kandungan lemak, protein, dan air). Agen lini pertama untuk preeklamsia pascasalin adalah labetalol dan hidralazin intravena serta nifedipin. Wanita dengan hipertensi gestasional ataupun preeklamsia biasanya dapat menghentikan antihipertensi dalam 6 minggu pasca salin.Postpartum PreeclampsiaAbstractObjective: To explain about etiologies and risk factors, differential diagnosis, pathophysiology, follow up, treatment, complications, recurrence, and prevention of preeclampsia post delivery discharged.Method: Literature review with several references accessed through search engines such as Pubmed and Sci-Hub by using keywords preeclampsia, hypertension, postpartum, management. Reference sources used are guidelines, journals, and textbooks published in the last 15 years.Conclusion: The incidence of preeclampsia in Indonesia is 128,273/year or around 5.3%. As many as 0.3-27.5% of cases reported postpartum preeclampsia or hypertension. Symptoms of postpartum preeclampsia appear after delivery. The majority of cases develop within 48 hours after delivery, although the syndrome can appear up to 6 weeks after delivery. The postpartum period is a critical time for obstetricians and gynecologists to ensure women with a history of preeclampsia are monitored in the short and long term. However, postpartum monitoring is very low, ranging from 20-60%. The choice of antihypertensive postpartum is that it is strongly bound to protein with low lipid solubility so that fewer enter breast milk. In addition, it is also influenced by ionization, molecular weight and constituents of breast milk (fat content, protein, and water). The first line agent for postpartum preeclampsia is intravenous labetolol and hydralazine and also nifedipine. Women with gestational hypertension or preeclampsia can usually stop antihypertension within 6 weeks postpartum.Key word: postpartum preeclampsia, antihypertension
Alobar holoprosencephaly: a case report Tjokorda Gde Agung Suwardewa; Ryan Saktika Mulyana; William Alexander Setiawan
Indonesian Journal of Perinatology Vol. 3 No. 1 (2022): Available online : 1 June 2022
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v3i1.23

Abstract

Introduction: Holoprosencephaly (HPE) is a rare congenital malformation of the brain; the incidence rate was 0.49-1.2 cases per 10,000-20,000 term births. HPE occurs due to failure of the prosencephalon division at the stage of brain development during the 4-5 weeks of pregnancy. Alobar HPE is one of the most severe types compared to other types. Most of the fetuses affected by this anomaly will die, and those born alive generally cannot survive for more than a year. This study presented a rare case of a baby with alobar HPE. Case report: A 33-year-old woman referred from Karang asem hospital Bali, G3P0020, 23 weeks gestation, has a poor obstetric history. The ultrasound examination results show no falx cerebri, even cerebellum and hypoechoic picture of the cerebrum. Ultrasound of the face was found a flat nose and hypotelorism. Termination at 28 weeks gestation, a baby boy was born 1000 g with the Apgar score 1-1. Multiple congenital abnormalities were found: flat nose, labiopalatoschizis, polydactyly manus dextra and omphalocele. Conclusion: Alobar HPE is a very rare congenital anomaly. The cause of the disease has not been fully explained. Current therapy is just supportive and has not been able to resolve the source of the problem. Alobar HPE disease has a poor prognosis.
The role of circular Ribonucleic Acid in preeclampsia: a literature review William Alexander Setiawan; A.A. Gde Marvy Khrisna Pranamartha
Indonesian Journal of Perinatology Vol. 1 No. 1 (2020): Available Online: 1 December 2020
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.952 KB) | DOI: 10.51559/inajperinatol.v1i1.4

Abstract

Circular RNAs (circRNAs) are non-coding RNAs with a covalently closed circular structure that present in a variety of organisms. The circRNAs are more stable and durable than linear RNAs due to incompatibility with the RNases. Recent studies have shown that circRNAs are expressed differently at the mother-fetal interface of women with preeclampsia compared to women with normal pregnancy. Although the evidence showed that circRNAs mediate various pathological processes in pregnancy, the mechanism of action is still unclear. In this paper, we provide a highlight of the current state of knowledge about circRNAs, its relation to preeclampsia, and the potential applications as preeclampsia biomarkers.
Use of Prophylactic Antibiotics in Third and Fourth Degree of Perineal Rupture William Alexander Setiawan
Indonesian Journal of Perinatology Vol. 3 No. 2 (2022): (Available online: 1 December 2022)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v3i2.21

Abstract

Numerous studies have demonstrated how routine episiotomies can cause additional problems like poor postpartum sexual function, ongoing perineal pain, and increased anal sphincter damage resulting in flatus or fecal incontinence. To combat the high frequency of maternal labor morbidity, antibiotic prophylaxis is recognized as a method of intervention that can be applied. . On the other hand, several studies seem to support the use of preventive antibiotics in situations of severe perineal rupture. It is not advised to use antibiotics excessively due to the rising prevalence of their use, which increases the danger of antibiotic resistance. As a result, following a serious perineal tear, the use of prophylactic antibiotics is crucial to preventing infection and determining whether a side effect is present in the mother or infant. Therefore it is necessary to assess the effectiveness of antibiotic prophylaxis to reduce maternal morbidity and side effects of third and fourth-degree perineal rupture during vaginal delivery.
Diagnosis and management of syphilis infection in pregnancy: a literature review I Gde Sastra Winata; William Alexander Setiawan; Ni Luh Wita Astari Widhusadi; DPG Jananuraga Maharddhika; Fenyta Christyani; Putu Bagus Darmayasa; Anthony Stephen Halim; Ernest TB Sianturi
Indonesian Journal of Perinatology Vol. 4 No. 1 (2023): (Available online: 1 June 2023)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i1.28

Abstract

Treponema pallidum, which causes the infectious disease syphilis, has a high rate of vertical transfer from mother to kid. Untreated maternal infection increases the risk of perinatal morbidity and mortality and unfavorable pregnancy outcomes, notably congenital syphilis. It is necessary to check for gestational syphilis during the prenatal period, and its diagnosis is straightforward. Nevertheless, this illness still affects two million pregnant women globally, indicating its significant prevalence. Congenital syphilis clinical symptoms are regulated by gestational age, maternal syphilis stage, maternal therapy, and fetus immune response. Early and late congenital syphilis have historically been used to describe it. The direct identification of treponemes, serological tests, and clinical signs all contribute to the diagnosis of maternal infection. Penicillin is typically used in the treatment, which also includes sexual partners. Fetal infection can be treated and prevented from spreading from the mother to the fetus with proper maternal infection management. To lower the prevalence of congenital syphilis, screening, early detection, and appropriate care are crucial during pregnancy and the preconception period.
Loop electrosurgical excision procedure: A Review I Nyoman Bayu Mahendra; William Alexander Setiawan
Indonesian Journal of Perinatology Vol. 4 No. 1 (2023): (Available online: 1 June 2023)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i1.34

Abstract

LEEP is a one-of-a-kind outpatient procedure for diagnosing and treating dysplastic cervical lesions. Loop diathermy treatment, loop excision of the transformation zone (LETZ), and large loop excision of the transformation zone (LLETZ) are other names. This approach yields high-quality cytologic specimens and has no negative effects on reproductive function. It also can be used to treat cervical cancer by replacing cryotherapy or laser. LEEP can be used to bypass the entire transformation zone. This is done with the help of a high-frequency, low-current electric generator and a stainless-steel loop. The LEEP procedure has a similar complication rate to cryotherapy. Bleeding is the most common complication. In addition, there may be inadequate lesion removal and cervical stenosis. LEEP has several advantages over other treatments, including removing aberrant tissue that allows cytologic examination, cheap cost, simplicity of acquiring important skills, and the potential to treat lesions with fewer visits. Patients are pleased with the surgery. LEEP is anticipated to be widely used by family physicians.
Comparison of punch biopsy and Loop Electrosurgical Excision Procedure (LEEP) on abnormal colposcopy findings in daily use which is preferable Sastra Wianta, I Gde; Marvy Khrisna Pranamartha, Anak Agung Gde; Alexander Setiawan, William
Indonesian Journal of Perinatology Vol. 4 No. 2 (2023): Available online : 1 December 2023
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i2.39

Abstract

Cervical cancer has become a global problem with high mortality and morbidity and contributed to around 311,000 deaths in 2018 which tends to rise every year. Detection of cervical cancer is very necessary to provide appropriate management to patients. Various detection and diagnosis approaches to cervical cancer continue to be developed along with advances in technology. However, comparisons of the types of methods used have not been widely reported. A biopsy is a tool used to detect a suspected malignancy that has been used for many years. One of them is a punch biopsy, a method often used to detect cervical cancer. Currently, technology is developed with the discovery of various other diagnostic tools such as Loop Electrosurgical Excision Procedure (LEEP). LEEP is an excisional procedure in high-resource settings to provide tissue for histopathology. However, the role of punch biopsy can’t be ruled out. This article discusses the differences between a punch biopsy and a LEEP procedure and the advantages and disadvantages of both.
Dilemmatic treatment of recurrent right breast mucinous carcinoma in a 34-year-old pregnant woman: a case report Widhusadi, Ni Luh Wita Astari; Setiawan, William Alexander
Indonesian Journal of Perinatology Vol. 4 No. 2 (2023): Available online : 1 December 2023
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i2.40

Abstract

Introduction: In females under 35, the incidence of mucinous carcinoma (MC), a rare form of breast carcinoma, is 1%. When pregnancy-associated breast cancer is diagnosed, it presents a challenge to strike a balance between a potentially fatal therapy for the fetus and a life-saving therapy for the mother's breast cancer. This study aimed to present an MC case in a 34-year-old female with seven weeks-old gestations. Case presentation: The 34-year-old woman presented with a lump on her right breast in 2012 and was diagnosed with giant fibroadenoma. Then, an excisional biopsy was performed, and the pathological finding showed a grade II MC. After one year of tumor regression, another mass was found on the same side of the breast. A repeated ultrasound was carried out, and then the patient was scheduled to have a radical mastectomy followed by radiotherapy. During the schedule of radiotherapy, she found out that she was 6-7 weeks pregnant. This condition brought a new problem since there was a chance that the radiotherapy may have affected the fetus. Therefore, the radiotherapy treatment was postponed until the 6-month gestational age or after the delivery of the baby. Conclusion: Our case report shows the complexity of judgments to achieve the holistic treatment of our patient's condition. Furthermore, the determination of 'wait-and-observe' could be contemplated for the characteristics of the tumor and the patient's decision.
Co-Authors A.A. Gde Marvy Khrisna Pranamartha Anom Suardika Anthony Stephen Halim Darmayasa, Putu Bagus DPG Jananuraga Maharddhika Duarsa, Vidya Saraswati Putri Ernest TB Sianturi Evert Solomon Pangkahila Fenyta Christyani Harrista, Daniel Victor I Gde Sastra Winata I Gede Mega Putra I Ketut Suwiyoga I Made Darmayasa I Nyoman Bayu Mahendra Kusuma, Anak Agung Ngurah Jaya Marvy Khrisna Pranamartha, Anak Agung Gde Ni Luh Wita Astari Widhusadi Ni Luh Wita Astari Widhusadi Nyoman Bayu Mahendra Putra, Ida Bagus Agung Widnyana Putu Bagus Darmayasa Ryan Saktika Mulyana Sastra Wianta, I Gde Tjokorda Gde Agung Suwardewa