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All Journal Jurnal Kesehatan Cendikia Jenius Public Health Journal
Kemal Akbar Suryoadji
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Impact of Chemotherapy on Venous Thromboembolism in Cervical Cancer: Systematic Meta-Analysis Observational Studies Fitriyadi Kusuma; Kemal Akbar Suryoadji; Wulyo Rajabto; Geraldus Sigap Gung Binathara; Shuffa Chilla Mayhana; Fahrayhansyah Muhammad Faqih; Bintang Wirawan; Abdul Hafiidh Surya Putra
Jurnal Kesehatan Cendikia Jenius Vol. 3 No. 2 (2026): April 2026
Publisher : CV. CENDIKIA JENIUS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70920/jenius.v3i2.373

Abstract

Objective: Cervical cancer is associated with an increased risk of venous thromboembolism (VTE), which may be further aggravated by chemotherapy. This study aimed to assess the impact of chemotherapy on VTE incidence in patients with cervical cancer. Methods: A systematic review was conducted according to PRISMA 2020 guidelines. PubMed, the Cochrane Library, and EMBASE were searched from inception to October 2024 for observational studies reporting VTE incidence in cervical cancer patients receiving chemotherapy. Studies including women with cervical cancer treated with chemotherapy and reporting VTE outcomes were eligible, while studies evaluating radiotherapy or surgery alone were excluded. Results: Three observational studies involving 2,292 patients met the inclusion criteria. Pooled analysis showed that chemotherapy significantly increased VTE risk (RR 2.83; 95% CI: 2.05–3.90; p < 0.001), with low statistical heterogeneity. The reported incidence of chemotherapy-associated VTE ranged from 10.0% to 18.7%. Conclusion: Chemotherapy is associated with a nearly threefold increased risk of VTE in cervical cancer patients. These findings support routine VTE risk stratification prior to chemotherapy and consideration of individualized thromboprophylaxis. Further prospective studies are needed to define optimal prevention strategies.
RISK OF PANCREATITIS FOLLOWING ENDOSCOPIC ULTRASONOGRAPHY: A SYSTEMATIC REVIEW AND META-ANALYSIS Muhammad Faisal Prananda; Kemal Akbar Suryoadji; Rania Sofia Garnetta; Najma Ali; Achmad Fauzi; Dadang Makmun
Public Health Journal Vol. 3 No. 4 (2026): In Progress
Publisher : Teewan Journal Solutions

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62710/0rfn1z86

Abstract

Endoscopic ultrasonography-guided tissue sampling is widely used to diagnose pancreatic lesions, but pancreatitis remains a clinically relevant adverse event, and evidence on its risk factors is inconsistent. This systematic review and meta-analysis aimed to summarize the incidence of pancreatitis after endoscopic ultrasonography and to evaluate patient- and procedure-related risk factors. PubMed, Scopus, and the Cochrane Library were searched for studies reporting pancreatitis after endoscopic ultrasonography and evaluating risk factors. Risk factors reported in at least two studies with extractable dichotomous data were pooled as risk ratios with 95% confidence intervals using the Mantel–Haenszel fixed-effect model. Five studies were included: two cohort studies, a multicenter pooled analysis, a retrospective case–control study, and a case report. The reported incidence of pancreatitis ranged from 0.29% to 9.2%, reflecting differences in study populations and procedural risk. Only two studies provided data suitable for pooling. Pancreatitis was not significantly associated with sex (risk ratio 1.13; 95% confidence interval 0.48–2.64), history of pancreatitis (1.50; 0.60–3.75), or sampling of the pancreatic head versus other locations (1.21; 0.50–2.94), and no between-study heterogeneity was observed. In individual studies, recent acute pancreatitis and side-branch intraductal papillary mucinous neoplasm were associated with a higher risk. Pancreatitis after endoscopic ultrasonography-guided pancreatic sampling is uncommon, and its reported incidence varies with patient selection and procedural characteristics. The pooled findings are limited by the small number of studies and participants. Recent pancreatitis and needle passage through the pancreatic duct or normal parenchyma may identify patients at higher risk and warrant prospective investigation.
Co-Authors Abdul Hafiidh Surya Putra ACHMAD FAUZI Alifaturrasyid Syafaatullah Ridwan Bintang Wirawan Dadang Makmun Fahrayhansyah Muhammad Faqih Fitriyadi Kusuma Geraldus Sigap Gung Binathara Muhammad Faisal Prananda Najma Ali Rania Sofia Garnetta Shuffa Chilla Mayhana Wulyo Rajabto