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Low-dose ketoconazole-fluconazole combination versus fluconazole in single doses for the treatment of vaginal candidiasis Susilo, Jan; Setiawati, Arini; Darmansjah, Iwan; Indarti, Junita; Kusuma, Fitriyadi
Medical Journal of Indonesia Vol 20, No 3 (2011): August
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (44.099 KB) | DOI: 10.13181/mji.v20i3.453

Abstract

Background: Vaginal candidiasis (VC) is one of the most common fungal diseases. Candida albicans is the most common causative fungus and has been isolated from more than 80% of specimens obtained from women with VC. Ketoconazole is the first orally active antifungal, the dosage for VC is 200 mg twice daily for 5 days. Fluconazole is the newer oral antifungal, its dosage for VC is a single oral dose of 150 mg. Since fluconazole 150 mg is considerably expensive, a single dose of 100 mg ketoconazole and 40 mg fluconazole in combination has been tested for the treatment of VC. The results showed that from 11 women with confirmed VC, 1-2 weeks after drug administration, the mycological culture was negative in 8 women, positive in 1 woman, and 2 woman lost to follow-up. This promising result led to the present study with the objective to confirm the efficacy and safety of the above combination in a formal clinical trial.Methods: A total of 165 female patients, aged 18 years or older, with the diagnosis of VC from clinical symptoms (pruritus or burning or excessive discharge) and positive microscopic smear (pseudohyphae and/or yeast cells) were randomized to receive a single dose of either keto-fluco combination (n = 85) or fluconazole (n = 80), and returnedfor follow-up visit on day 8.Results: Among these patients, 39 patients had negative baseline culture, leaving 126 patients eligible for efficacy evaluation. The mycological eradication in the keto-fluco group was 74.5% (41 patients from a total of 55 patients with available mycological culture), while that in the fluconazole group was 70.2% (40 patients from 57 patients with available culture) and this difference was not significant. The clinical favorable response (clinical cure and clinical improvement) in the keto-fluco arm (n = 60) was 98.3%, while that in the fluconazole group (n = 66) was 100%. Adverse events were found in 5 patients, 3 patients in the keto-fluco group (3/85 = 3.5%) and 2 patients in the fluconazole group (2/80 = 2.5%).Conclusion: The present study showed that the efficacy and safety of ketoconazole 100 mg and fluconazole 40 mg combination was not inferior compared to fluconazole 150 mg in single doses for the treatment of vaginal candidiasis. (Med J Indones 2011; 20:205-11)Keywords: fluconazole, low-dose ketoconazole-fluconazole combination, single dose, vaginal candidiasis
Clinical and Laboratory Predictors of Deep Vein Thrombosis in Ovarian Malignant Tumor Kusuma, Fitriyadi; Sitorus, Christina
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 3, July 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (107.312 KB) | DOI: 10.32771/inajog.v5i3.548

Abstract

Objective: To investigate the clinical and laboratory predictors of symptomatic deep vein thrombosis (DVT) in ovarian malignant tumor. Methods: One hundred sixteen patients with suspected ovarian malignant tumor were recruited. Age, body mass index (BMI); D-dimer, fibrinogen, thrombocyte level, comorbid, tumor diameter, staging, distant metastasis, ascites, histopathology, length of surgery, blood loss and transfusion were recorded. Results: Incidence of symptomatic DVT was 16.5% and 88.2% cases occurred before surgery. No case of symptomatic DVT during postoperative care was found. Predictors of DVT were distant metastasis (OR 28.99; 95% CI 3.83-219.52, BMI ≥ 22.7 kg/m2 (OR 15.52, 95% CI 2.24-107.37), D-Dimer ≥ 1700 mg/ml (OR 13.30, 95% CI 2.40- 73.84), advanced stage (OR 6.66; 95% CI 1.05-42.27), epithelial tumor (OR 6.5; 95% CI 0.34-125.75), tumor’s diameter ≥ 18.25 cm (OR 2.36, 95% CI 0.48-11.54), and comorbidity (OR 2.49, 95% CI 0.53-11.66). Prediction score of DVT were score 3 for distant metastasis, BMI ≥ 22.7 kg/m2, D-Dimer ≥ 1700 mg/ml, score 2 for advanced stage, score 1 for tumor diameter ≥ 18.25 cm, comorbid, epithelial tumor and score 0 for the absence of variables or its value less than the cut off. Total score ≥ 8 of 14 is the least score which has a good predictive value for DVT with AUC 0.92, 95% CI 0.86-0.92, probability 86.46%. Conclusion: Distant metastasis and D-dimer are independently associated with the development of DVT in ovarian malignant tumor. [Indones J Obstet Gynecol 2017; 5-3: 180-184] Keywords: deep vein thrombosis, D-dimer, ovarian malignant, tumor predictor
Management of Abnormal Cervical Cytology: Atypical Squamous Cells of Undetermined Significance (ASC-US) and Atypical Squamous Cells cannot exclude High Grade Intraepithelial Lesion (ASC-H) Kusuma, Fitriyadi; Liedapraja, Mediana s.
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (115.366 KB) | DOI: 10.32771/inajog.v1i3.359

Abstract

Objective: To review for the management of abnormal cervical cytology: atypical squamous cells of undetermined significance (ASCUS) and atypical squamous cells cannot exclude high-grade intraepithelial lesion (ASC-H) as a treatment of cervical precancerous lesions in order to avoidexcessive treatment, reduce of unnecessary examinations and to provide cost effectively. Method: Literature study on published literatures and studies about the management of cervical cytology. Conclusion: The results of ASC-US cervical cytology and ASC-H is aninitial screening to detect precancerous cervical lesions. Definitive therapy should be done when finding a low-grade lesions (LSIL) and high degree of lesion(HSIL) squamous intraepithelial. A clinician expected to understand the natural history of HPV infection and the management of precancerous cervical lesions properly. [Indones J Obstet Gynecol 2013; 37-3: 166-170] Keywords: ASC-H, ASC-US, cervical cytology abnormalities, cervical precancerous lesion.
Survivin and Telomerase as Radiotherapeutic Response Predictors of Subjects with Stage IIIB Cervical Squamous Cell Carcinoma Fitriyadi Kusuma; Andrijono Andrijono; Ani Retno Prijanti; Laila Nuranna; Sri Mutya Sekarutami; Bambang Sutrisna; Ferry Sandra
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.813

Abstract

BACKGROUND: Cervical cancer is one of the most prevalent cancers in women. Even with similar clinicopathologic features, radiotherapy outcomes are still vary among patients. This research was conducted to measure radiotherapy responses on cervical cancer patients by using Survivin, Telomerase and Cytochrome C.METHODS: Subjects who matched the criteria were selected and requested to fill questionnaires. Subjects were then evaluated with magnetic resonance imaging (MRI) pre- and post-3D conformal radiotherapy. Histopathological study was conducted using resected tumors to determine the differentiation type. Enzyme-linked Immunosorbent Assays for detection of Survivin, Telomerase and Cytochrome C was performed using the resected tumors as well.RESULTS: There were 76 patients in this study. Mean ofage was 50 and diameter of tumor size was 5.35 cm. Mean levels of Survivin, Telomerase and Cytochrome C were 632.82 pg/mL, 5.59 pg/mL and 204.75 ng/mL, respectively. There were significant correlations between radiotherapy response and Survivin (p=0.041) or Telomerase (p=0.022). Subjects with lower Survivin level (<932 pg/mL) had higher 1-year survival rate (63%) than subjects with higher Survivin level (50%). Similar results were obtained for subjects with lower Telomerase level (<5.75 pg/mL), who had higher 1-year survival rate (60%) than subjects with higher Telomerase level (43%).CONCLUSION: Since radiotherapy response is significantly correlated with Survivin and Telomerase levels and subjects with lower Survivin or Telomerase level have higher 1-year survival rate, it can be suggested that Survivin and Telomerase could be potential predictors of radiotherapeutic response for subjects with stage IIIB cervical squamous cell carcinoma.KEYWORDS: cervical cancer, radiotherapy Survivin, Telomerase, Cytochrome C
Ovarian Malignancy Prediction by Gatot Purwoto (GP) Score, Risk Malignancy Index (RMI), and Frozen Section in Young Age: Prediksi Keganasan Ovarium dari Skor Gatot Purwoto (GP), Risk Malignancy Index (RMI), dan Potong Beku pada Usia Muda Liva Wijaya; Fitriyadi Kusuma
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 3, July 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (145.8 KB) | DOI: 10.32771/inajog.v2i3.399

Abstract

Objective: To know the diagnostic value of a scoring system taken before surgery and frozen section in young-aged patients with suspected malignancy. Using that result, we can also investigate whether frozen section gives additional value to clinical scoring system. Method: This study is a diagnostic test. This study was carried out by accessing RSCM’s medical record from 2006-2011. From 437 patients suspected of ovarian malignancy, we included 157 patients due to age. Result: Diagnostic value of GP score are 77%, 49%, 61%, 68%, 63%, while RMI are 69%, 49%, 58%, 45%, 59%, (sensitivity, specificity, positive predictive value, negative predictive value, and accuracy respectively). Diagnostic value of frozen section in patients with suspected malignancy using GP score >4 are 81.7%, 87.2%, 90.7%, 75.6%, 83%, while in patients with RMI 200 are 81%, 87%, 89%, 77%, 83% (sensitivity, spesificity, positive predictive value, negative predictive value, and accuracy respectively). Conclusion: Gatot Purwoto score and RMI have good diagnostic value in proving malignancy in young age. Its predictive value will be increased by frozen section. Keywords: frozen section, gatot purwoto score, ovarian malignancy, RMI, young age
Postradiotherapy Outcome on Cervical Cancer Stage IIIB Patients with and without Paraaortic Lymph Nodes Enlargement: Hasil Pascadiadioterapi pada Pasien Kanker Serviks Stadium IIIB dengan dan tanpa Pembesaran Nodus Paraaorta Fitriyadi Kusuma; Sahat B. Matondang; Laila Nuranna; Gatot Purwoto; Oni Khonsa; Purnomo Hyaswicaksono
Indonesian Journal of Obstetrics and Gynecology Volume 9 No. 1 January 2021
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v9i1.1438

Abstract

Objective : To determine whether there are differences in clinical response after radiotherapy and 1 year survival in patients with advanced cervical cancer with and without enlargement of PALN.Method : An observational analytic study using a retrospective cohort method was done using consecutive sampling. The subjects of this study were all women with a primary diagnosis of stages IIB to IVB cervical cancer who came to the gynecological oncology clinic of Dr. Cipto Mangunkusumo National General Hospital and underwent MRI examination before undergoing treatment in January 2016 to May 2017Results: Among 76 subjects studied, there were 4 (5.1%) subjects who had enlarged PALN. There were no significant differences between the enlargement status of PALN and age (p = 0.829), age of first sexual intercourse (p = 0.33), parity (p = 0.642), mass diameter (p = 0.777). Patients with PALN enlargement have 2.13 times risk of having negative radiotherapy outcome (p = 0.02, OR 2.13, CI95% 1.12 – 4.07). There was no difference in 1-year survival between patients with and without enlargement of PALN (median 201 vs. 293, p = 0.072).Conclusion: Patients with PALN enlargement have increased risk of having negative radiotherapy outcome (p < 0.05). There were no differences in 1 year survival between patients with advanced cervical cancer with enlargement PALN.Keywords : cervical cancer, lymph node enlargement, paraaortic, radiotherapy. Abstrak Tujuan: Mengetahui adakah perbedaan respon klinis pascaradioterapi dan kesintasan 1 tahun pada pasien kanker serviks stadium lanjut dengan pembesaran KGB paraaorta dibandingkan tanpa pembesaran KGB paraaorta.Metode: Penelitian ini merupakan penelitian analitik observasional dengan menggunakan metode kohort retrospektif. Pengambilan sampel dilakukan dengan cara pengambilan sampel berturut-turut. Subyek penelitian ini adalah semua perempuan dengan diagnosis primer kanker serviks stadium IIB hingga IVB yang datang ke poliklinik Onkologi Ginekologi RSUPN Dr. Cipto Mangunkusumo dan menjalani pemeriksaan MRI sebelum dilakukan terapi pada bulan Januari 2016 hingga Mei 2017.Hasil: Dari 76 subjek yang diteliti, didapatkan sebanyak 4 (5,1%) subyek yang mengalami pembesaran KGB paraaorta. Tidak didapatkan perbedaan yang bermakna antara status pembesaran KGB paraaorta dan usia (p = 0,829), usia hubungan seksual pertama (p = 0,333), paritas (p = 0,642), dan diameter massa (p = 0,777). Pasien dengan pembesaran KGB paraaorta memiliki risiko 2,13 kali lipat (p = 0,02, OR 2,13, IK95% 1,12-4,07) memiliki risiko respon terapi negatif. Tidak terdapat perbedaan kesintasan 1 tahun antara pembesaran KGB paraaorta dan tidak (median 201 vs. 293, p = 0,072).Kesimpulan Pasien dengan pembesaran KGB paraaorta memiliki risiko lebih tinggi mengalami respon radioterapi negatif. (p < 0,05). Tidak terdapat kesintasan 1 tahun antara pasien kanker serviks stadium lanjut dengan dan tanpa pembesaran KGB.Kata kunci: kanker serviks, paraaorta, pembesaran KGB, radioterapi.
Socio-demographic Profiles of Cervical Cancer Patients at Cipto Mangunkusumo Hospital - 2009-2019 and Its Association with Cancer Stages at Diagnosis Fitriyadi Kusuma; Kemal Akbar Suryoadji; Michael Adrian; Tofan Widya Utami; Hariyono Winarto; Tricia Dewi Anggraeni; Kartiwa Hadi Nuryanto; Muhammad Haekal
Cermin Dunia Kedokteran Vol 49, No 5 (2022): Jantung dan Saraf
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i5.1846

Abstract

Objective: To determine the socio-demographic profile of cervical cancer patients at Cipto Mangunkusumo Hospital in 2009-2019 based on educational level, parity, age, residence, and employment status and their relationship to cervical cancer stage at diagnosis. Methods: Comparative analytical study was conducted retrospectively based on medical records in Cipto Mangunkusumo Hospital. The selection was based on data completeness: cervical cancer stages, sociodemographic profiles consisting of education level, parity, age, Java or non-Java Island resident, and occupation. Multivariate analysis calculated the association between socio-demographic factors and cervical cancer stages. Data were analyzed using SPSS v.22.0 and Microsoft Excel. Results: This study included 4,584 patients with complete data. Only 19.3% patients were in the early stage, 63.3% had less than three parities, 82.8% of patients had formal primary school education or less, 80.9% patients were aged 18-65 years, 88.3% patients resided in Java Island, and 80.5% didn’t have the occupation. There was a significant association (p <0.05) between cervical cancer stage and educational level (aOR= 0.86; 95% CI= 0.78-0.94) and age (aOR= 1.46; 95% CI= 1.18-1.40). There is no significant association (p >0.05) between cervical cancer stage and parity, residence, and employment status. Conclusion: Low education and old age (> 65-year-old) were associated with the advanced stage of cervical cancer at diagnosis. Tujuan: Mengetahui profil sosiodemografi pasien kanker serviks di Rumah Sakit Cipto Mangunkusumo tahun 2009-2019 berdasarkan tingkat pendidikan, jumlah paritas, usia, status kependudukan, pekerjaan, serta hubungannya terhadap stadium kanker serviks saat diagnosis. Metode: Penelitian analitik komparatif retrospektif berdasarkan data rekam medis Rumah Sakit Cipto Mangunkusumo. Pemilihan sesuai kelengkapan data: stadium kanker serviks, profil status sosiodemografi yang terdiri atas tingkat pendidikan, paritas, usia, penduduk pulau Jawa atau non-Jawa, dan status pekerjaan. Hubungan antar variabel dianalisis multivariat untukmencari hubungan berbagai faktor sosiodemografi terhadap stadium kanker serviks. Analisis data menggunakan program SPSS versi 22.0 dan Microsoft Excel.Hasil: Terdapat 4.584 pasien kanker serviks yang memenuhi kriteria inklusi. Sebanyak 19,3% pasien dengan stadium awal. Selanjutnya 82,8% pasien memiliki pendidikan formal sekolah dasar atau kurang, 63,3% pasien memiliki jumlah paritas kurang dari tiga, 80,9% pasien berusia antara 18-65 tahun, 88,3% pasien berdomisili di pulau Jawa, dan 80,5% tidak bekerja. Didapatkan asosiasi bermakna (p<0,05) antara stadium kanker serviks dan tingkat pendidikan (aOR = 0,86; 95% CI= 0,78-0,94) dan usia (aOR= 1,46; 95% CI= 1,18-1,40). Tidak ditemukan asosiasi bermakna (p>0,05) antara stadium kanker serviks dengan paritas, domisilikependudukan, dan status pekerjaan. Simpulan: Tingkat pendidikan rendah dan usia lanjut (>65 tahun) berasosiasi dengan stadium lanjut kanker serviks saat diagnosis. 
Association Between Risk of Malnutrition and Surgical Outcome in Ovarian Cancer Patients Fitriyadi Kusuma; Mutiara Riani; Fiastuti Witjaksono
eJournal Kedokteran Indonesia Vol 9, No. 3 - Desember 2021
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (119.598 KB) | DOI: 10.23886/ejki.9.71.203-7

Abstract

Ovarian cancer is the fourth most cancer in Indonesia. Treatment of ovarian cancer is surgery. Malnutrition may complicate healing, so studying the association between malnutrition and surgical outcome in ovarian cancer patients is necessary. A cross-sectional study was conducted in Dr. Cipto Mangunkusumo General Hospital from July 2018 - March 2019. fromo 63 patients underwent surgery, four were excluded due to non-malignant ovarian pathology results. Parameters assessed were characteristic subjects and risk factors of malnutrition in ovarian cancer patients. Malnutrition was assessed using the Patient-Generated Subjective Global Assessment (PGSGA) and surgery factors assessed were the length of surgery, size of the tumor, and blood loss during surgery. The nutritional status was classified as well-nourished and malnourished. The receiver operating characteristic (ROC) curve is used to assess malnutrition, length of stay, size of the tumor, and blood loss during surgery. The result shows that the prevalence of malnutrition in ovarian cancer was 78% (moderate was 42.4% and severe was 35.6%), and the median length of stay was eight days. There is an association (chi-square test, p<0.05) between malnutrition and surgical outcome in ovarian cancer patients. Malnutrition is associated (chi-square test, p<0.05) with a length of stay and increased blood loss during surgery.
DIAGNOSIS DAN TATALAKSANA PADA KISTAA OVARIUM: LITERATURE REVIEW Kemal Akbar Suryoadji; Alifaturrasyid Syafaatullah Ridwan; Ahmad Fauzi; Fitriyadi Kusuma
Khazanah: Jurnal Mahasiswa Vol. 14 No. 1 (2022): Khazanah: Jurnal Mahasiswa
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/khazanah.vol14.iss1.art5

Abstract

Kista ovarium adalah pertumbuhan jaringan abnormal berbentuk kantong yang berisi air pada sekitar ovarium. Kista ovarium membutuhkan penegakkan diagnosis secara menyeluruh berdasarkan anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang termasuk modalitas radiologi berdasarkan USG, CT Scan, dan MRI. Setelah diagnosis ditegakkan selanjutnya dilakukan penatalaksanaan pada pada kista ovarium yang terbagi atas observasi dan operasi dengan menyesuaikan kondisi pasien.
Pendekatan Klinis Massa Ovarium di Fasilitas Kesehatan Tingkat Pertama dengan USG menggunakan penilaian IOTA Fitriyadi Kusuma; Kemal Akbar Suryoadji
Cermin Dunia Kedokteran Vol 50 No 9 (2023): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i9.835

Abstract

Massa ovarium dapat berupa kista yang merupakan kantong berisi cairan di sekitar ovarium ataupun tumor yang merupakan perkembangan sel abnormal. USG dapat menilai massa ovarium pasien berdasarkan penilaian IOTA.   Ovarial masses can be cysts or tumors. Ultrasound examination can assess ovarian mass through IOTA assessment.
Co-Authors Abdullah, Muhammad Raoul Taufiq Adiyarianni, Ghina Ahmad Fauzi Ahmad Fauzi Alexander AW Peters Alifaturrasyid Syafaatullah Ridwan Alifaturrasyid Syafaatullah Ridwan Amalia, Ginva Andi Darma Putra Andrijono Andrijono Anggaraeni, Tricia Dewi Anggraeni, Tricia Dewi Ani Retno Prijanti Aria Kekalih Arini Setiawati As’syifa, Salsa Billa Bambang Sutrisna Binathara, Geraldus Sigap Gung Darmiati, Sawitri Elfahmi, Khalida Ikhlasiya Tajdar Gefariena Faisha Rahma, Melly Ferry Sandra Fiastuti Witjaksono Gatot Purwoto Hariyono Winarto Hariyono Winarto Hariyono Winarto Iwan Darmansjah Jan Susilo Joedo Prihartono Junita Indarti Kartiwa Hadi Nuryanto Kemal Akbar Suryoadji Kemal Akbar Suryoadji Kemal Akbar Suryoadji Kemal Akbar Suryoadji Kemal Akbar Suryoadji Laila Nuranna Laila Nuranna Laila Nuranna Liedapraja, Mediana s. Lisnawati Liva Wijaya Malano, Yoarva Metasyah, Namira Michael Adrian Muhammad Haekal Muhammad Haekal Muhammad Ilyas Muhammad Raoul Taufiq Abdullah Mutiara Riani Nasution, Hiro Hidaya Danial Oktalia, Arisda Oni Khonsa Purnomo Hyaswicaksono Putra, Abdul Hafiidh Surya Ridwan, Alifaturrasyid Syafaatullah Rizky Humairah , Inas Sahat B. Matondang Sekarutami, Sri Mutya SEPTELIA INAWATI WANANDI Sini, Kieran Pasha Ivan Siregar, Trifonia Pingkan Sitorus, Christina Soloan, Garry Sri Mutya Sekarutami Surya Putra, Abdul Hafiidh Suryoadji, Kemal Akbar Tofan Widya Utami Tofan Widya Utami Tofan Widya Utami Tricia Dewi Anggraeni Tricia Dewi Anggraeni Tricia Dewi Anggraeni Utami, Tofan Widya Widya Utami, Tofan Wulandari, Anisa Saphira