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Wachjudi Kurnia
Fakultas Kedokteran Universitas Hang Tuah
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Pengaruh Terapi Oksigen Hiperbarik terhadap Kadar Testosteron pada Tikus Model Sindroma Ovarium Polikistik dengan Resistensi Insulin Fajar Sudiono; Lunardhi Susanto; Wachjudi Kurnia
Denta Journal Kedokteran Gigi Vol 3 No 1 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 1 January - June 2020
Publisher : Universitas Hang Tuah

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Abstract

Background:Polycystic ovary syndrome (PCOS) is an endocrine disorder that has the broadest and best in women often springs reproduktif age. Factors underlying the recovery of PCOS are excessive androgens, insulin resistance, and disturbance of gonadotropin dynamics. Excessive androgen causes LH and FSH to develop. In the theory hyperbaric oxygen therapy allows to increase sensitivity tissue to insulin. The . The purpose of this research was to know effect using hyperbaric oxygen therapy 2.4 ATA 3x30 minutes for 5 sessions on testosterone levels on rats model of Polycystic Ovary Syndrome with insulin resistance.Metode:The research is experimental with post test only control group design. The total sample used as 12 rats that is divided into 2 groups. Independent variable is therapeutic oxygen hiperbarik, dependent variable testosteron level from blood sample of rats and control variables are room temperature and standard feed and control variables of androgen injection, types and specifications of experimental animals, cage size and animal care. Data analysis of this study was processed using Mann Whitney U test.Result:The results of using Mann Whitney U Test with p-value = 0,150 > α (0.05), showed no difference between testosterone levels in the experimental group given androgen injection with the group of animals given androgen injection and hyperbaric oxygen therapy.Conclusion:Therapy oxygen hyperbarik has not been effecting testosteron levels in white rats (Rattus Norvegicus) model syndroma ovarium polycystic with resistensi insulin
Pengaruh Pemberian Ekstrak Rumput Laut Cokelat (Sargassum duplicatum) terhadap Peningkatan Kadar Hematokrit pada Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Anemia yang Diinduksi NaNO2 Ayu Mayang; Liliawanti Liliawanti; Wachjudi Kurnia
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

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Abstract

Anemia is still a high prevalence disease in Indonesia, caused by a lack of iron in the body. The components from brown seaweed such as cobalamin (vitamin B12), pyridoxine (vitamin B6), chlorophyll and iron (Fe) can increase red blood cells in the body. The purpose of this research was to determine the effect of brown seaweed (Sargassum duplicatum) which can increase hematocrit levels in the blood of white male wistar strain rat (Rattus norvegicus) suffered from anemia in induction NaNO2. This research uses an experimental laboratory method with a post test only control group design. The samples were 30 male rats divided into 3 treatment groups, the negative control group (K0) without treatment, the positive control (K1) be treated anemia given NaNO2 for 18 days without Sargassum duplicatum extract and treatment group (K2) treated with anemia given NaNO2 for 18 days without Sargassum duplicatum extract at a dose of 2,45gr / kgBB. On the 40th day, a blood sample was taken, then measured the hematocrit level.The results showed that the mean number of blood hematocrit levels in K2 was higher than K1, it showed a significant difference descriptively. Based on the KruskalWallis test, a value of 0.260 was obtained that p > 0,05 showed that there were no statistically significant differences between groups of experimental animals.From the results of this research, the conclusion is the administration of brown seaweed extract (Sargassum duplicatum) descriptively increased, but not statistically significant.
Pengaruh Pemberian Ekstrak Rumput Laut Cokelat (Sargassum duplicatum) terhadap Peningkatan Kadar Hematokrit pada Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Anemia yang Diinduksi NaNO2 Emy Noviana Sandy; Liliawanti Liliawanti; Wachjudi Kurnia
Denta Journal Kedokteran Gigi Vol 4 No 1 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 1 January - June 2021
Publisher : Universitas Hang Tuah

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Abstract

Background: In Indonesia, the prevalence of iron deficiency anemia reaches 25,2 percent, it indicates that anemia is a medical condition in society that needs attention. Brown seaweed (Sargassum duplicatum) is a group of algae that contains minerals such as iron and vitamin B12. So that the content in Sargassum duplicatum can be used for anemia therapy that serves as the main forming hemoglobin. Objective: The purpose of this experimental research was to determine the administration of Sargassum duplicatum affects the increase in blood haemoglobin levels of rats that are anemia induced NaNO2..Methods: This research used the Post-test only control group design, the samples were 30 male rats divided into 3 treatment groups (K0, K1, and K2). The process of treating anemia in rats using sodium nitrite (NaNO2) at a dose of 125 mg / KgBB. K0 group is a group that is not treated. K1 group is a group that was given NaNO2 for 18 days without dieting Sargassum duplicatum. The K2 group was the group that was given NaNO2 for 18 days and received the Sargassum duplicatum diet at a dose of 2.45 g/kgBB for 14 days.Result: From this research it can be seen that K0 has an average hemoglobin level of 12,71 g/dL, K1 has an average hemoglobin level of 11.96 g / dL, and K2 has an average hemoglobin level of 12,99 g/dL which shows that descriptively there is a difference between groups K1 and K2. Based on the KruskalWallis statistical test, a value of 0,290 was obtained so that p > 0.05 showed that H0 was accepted, which means there was no difference in the administration of Sargassum duplicatum in increasing blood hemoglobin levels in anemic rats.Conclusion: From the results of this research, the conclusion in descriptively there was an increase in the blood hemoglobin level of white rats in the group receiving Sargassum duplicatum extract therapy but it was not statistically significant.
Pengaruh Terapi Oksigen Hiperbarik terhadap Kadar Testosteron pada Tikus Model Sindroma Ovarium Polikistik dengan Resistensi Insulin Fajar Sudiono; Lunardhi Susanto; Wachjudi Kurnia
Oceana Biomedicina Journal Vol 3 No 1 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 1 January - June 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i1.25

Abstract

Background:Polycystic ovary syndrome (PCOS) is an endocrine disorder that has the broadest and best in women often springs reproduktif age. Factors underlying the recovery of PCOS are excessive androgens, insulin resistance, and disturbance of gonadotropin dynamics. Excessive androgen causes LH and FSH to develop. In the theory hyperbaric oxygen therapy allows to increase sensitivity tissue to insulin. The . The purpose of this research was to know effect using hyperbaric oxygen therapy 2.4 ATA 3x30 minutes for 5 sessions on testosterone levels on rats model of Polycystic Ovary Syndrome with insulin resistance.Metode:The research is experimental with post test only control group design. The total sample used as 12 rats that is divided into 2 groups. Independent variable is therapeutic oxygen hiperbarik, dependent variable testosteron level from blood sample of rats and control variables are room temperature and standard feed and control variables of androgen injection, types and specifications of experimental animals, cage size and animal care. Data analysis of this study was processed using Mann Whitney U test.Result:The results of using Mann Whitney U Test with p-value = 0,150 > α (0.05), showed no difference between testosterone levels in the experimental group given androgen injection with the group of animals given androgen injection and hyperbaric oxygen therapy.Conclusion:Therapy oxygen hyperbarik has not been effecting testosteron levels in white rats (Rattus Norvegicus) model syndroma ovarium polycystic with resistensi insulin
Pengaruh Pemberian Ekstrak Rumput Laut Cokelat (Sargassum duplicatum) terhadap Peningkatan Kadar Hematokrit pada Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Anemia yang Diinduksi NaNO2 Ayu Mayang; Liliawanti Liliawanti; Wachjudi Kurnia
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.47

Abstract

Anemia is still a high prevalence disease in Indonesia, caused by a lack of iron in the body. The components from brown seaweed such as cobalamin (vitamin B12), pyridoxine (vitamin B6), chlorophyll and iron (Fe) can increase red blood cells in the body. The purpose of this research was to determine the effect of brown seaweed (Sargassum duplicatum) which can increase hematocrit levels in the blood of white male wistar strain rat (Rattus norvegicus) suffered from anemia in induction NaNO2. This research uses an experimental laboratory method with a post test only control group design. The samples were 30 male rats divided into 3 treatment groups, the negative control group (K0) without treatment, the positive control (K1) be treated anemia given NaNO2 for 18 days without Sargassum duplicatum extract and treatment group (K2) treated with anemia given NaNO2 for 18 days without Sargassum duplicatum extract at a dose of 2,45gr / kgBB. On the 40th day, a blood sample was taken, then measured the hematocrit level.The results showed that the mean number of blood hematocrit levels in K2 was higher than K1, it showed a significant difference descriptively. Based on the KruskalWallis test, a value of 0.260 was obtained that p > 0,05 showed that there were no statistically significant differences between groups of experimental animals.From the results of this research, the conclusion is the administration of brown seaweed extract (Sargassum duplicatum) descriptively increased, but not statistically significant.
Pengaruh Pemberian Ekstrak Rumput Laut Cokelat (Sargassum duplicatum) terhadap Peningkatan Kadar Hematokrit pada Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Anemia yang Diinduksi NaNO2 Emy Noviana Sandy; Liliawanti Liliawanti; Wachjudi Kurnia
Oceana Biomedicina Journal Vol 4 No 1 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 1 January - June 2021
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v4i1.51

Abstract

Background: In Indonesia, the prevalence of iron deficiency anemia reaches 25,2 percent, it indicates that anemia is a medical condition in society that needs attention. Brown seaweed (Sargassum duplicatum) is a group of algae that contains minerals such as iron and vitamin B12. So that the content in Sargassum duplicatum can be used for anemia therapy that serves as the main forming hemoglobin. Objective: The purpose of this experimental research was to determine the administration of Sargassum duplicatum affects the increase in blood haemoglobin levels of rats that are anemia induced NaNO2..Methods: This research used the Post-test only control group design, the samples were 30 male rats divided into 3 treatment groups (K0, K1, and K2). The process of treating anemia in rats using sodium nitrite (NaNO2) at a dose of 125 mg / KgBB. K0 group is a group that is not treated. K1 group is a group that was given NaNO2 for 18 days without dieting Sargassum duplicatum. The K2 group was the group that was given NaNO2 for 18 days and received the Sargassum duplicatum diet at a dose of 2.45 g/kgBB for 14 days.Result: From this research it can be seen that K0 has an average hemoglobin level of 12,71 g/dL, K1 has an average hemoglobin level of 11.96 g / dL, and K2 has an average hemoglobin level of 12,99 g/dL which shows that descriptively there is a difference between groups K1 and K2. Based on the KruskalWallis statistical test, a value of 0,290 was obtained so that p > 0.05 showed that H0 was accepted, which means there was no difference in the administration of Sargassum duplicatum in increasing blood hemoglobin levels in anemic rats.Conclusion: From the results of this research, the conclusion in descriptively there was an increase in the blood hemoglobin level of white rats in the group receiving Sargassum duplicatum extract therapy but it was not statistically significant.
Co-Authors Ayu Mayang Emy Noviana Sandy Fajar Sudiono Liliawanti Lunardhi Susanto