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All Journal Althea Medical Journal Universa Medicina
Eman Sutrisna
Department of Pharmacology, Faculty of Medicine, Universitas Jenderal Soedirman
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The protective effect of celery (Apium graveolens L.) ethanol extract on anemia in 5/6 subtotal nephrectomy rat model Afifah Afifah; Khusnul Muflikhah; Tri Lestari; Eman Sutrisna; Ajeng Kirana; Sindy Devi Prastiwi
Universa Medicina Vol. 39 No. 1 (2020)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (553.807 KB) | DOI: 10.18051/UnivMed.2020.v39.12-18

Abstract

BackgroundAnemia is a frequent complication of chronic kidney disease (CKD). Anemia in CKD is associated with reduced quality of life, increased cardiovascular disease, cognitive impairment, and mortality. Therefore it is necessary to find an alternative agent for preventing anemia in CKD. Celery is one of the natural substances that have anti-inflammatory, antioxidant, and antihypertensive pharmacological effects. Based on the mechanism of CKD and its progression, celery is thought to prevent anemia in CKD. This research was aimed at evaluating the protective effect of celery extract against anemia in a CKD rat model. MethodsThis was an experimental laboratory study using 25 male Sprague Dawley rats, aged 2-3 months, they were randomized into 5 groups, namely group A, sham operation; group B, subtotal nephrectomy; group C, D, E, subtotal nephrectomy + 250, 500, 1000 mg/kg BW ethanol extract of celery, respectively. The administration of celery extract was performed 14 days before and 14 days after induction of 5/6 subtotal nephrectomy. The hematological parameters (Hb, RBC, Ht, MCV, MCH, MCHC) and serum creatinine level were measured at the end of the study. Data were analyzed with One Way ANOVA and Kruskal-Wallis test followed by Mann-Whitney test at p<0.05. ResultsThere were no significant differences between groups in Hb, RBC, Ht, MCV (p>0.05) and significant differences between groups in MCH and MCHC (p<0.05). The highest levels of Hb, RBC, and Ht were found in group C.ConclusionCelery ethanol extract at a dose of 250 mg/kg BW/day may prevent anemia in the CKD rat model.
Cervical Cancer Chemoprevention Using Hippobroma longiflora Extract through Modulation of Ki-67 and p53 in Benzo[a]pyrene-Induced Wistar Rats Ana Bina Sari; Eman Sutrisna; Daniel Joko Wahyono
Althea Medical Journal Vol 13, No 2 (2026)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v13n2.4633

Abstract

Background: Cervical cancer remains one of the most common malignancies affecting women worldwide and is closely linked to dysregulated cell proliferation and impaired tumor suppressor responses. Herbs contain effective anticancer compounds that may be used alone or as adjuvants to existing chemotherapy regimens to improve efficacy and/or reduce drug-induced toxicity. Hippobroma longiflora (L.) G.Don a or kitolod is a medicinal plant known to contain antioxidant and anticancer compounds. This study evaluated the effect of ethanol extract of kitolod leaves on Ki-67 and p53 expression in a Benzo[a]pyrene (B[a]P)-induced cervical carcinogenesis model in female Wistar rats.Methods: This experimental study used a post-test-only control group design. Female Wistar rats (n=25) were grouped into five groups: a healthy control group without B[a]P exposure, a negative control group receiving only B[a]P (0.3 mg/kg BW/day); and three treatment groups receiving B[a]P combined with kitolod leaf extract at doses of 100, 200, or 300 mg/kg BW/day for 30 days. Phytochemical screening and gas chromatography–mass spectrometry (GC-MS) were used to characterize the extract. Cervical histopathologal and immunohistochemical examinations were performed to assess Ki-67 and p53 expression. Data were analyzed using one-way ANOVA followed by Bonferroni post hoc tests, with p<0.05 considered statistically significant.Results: Compared with the negative control, kitolod leaf extract significantly reduced Ki-67 expression and increased p53 expression (p<0.001). The greatest effect was observed at the 300 mg/kg BW/day dose. Conclusions: Kitolod leaf ethanol extract modulates Ki-67 and p53 expression in B[a]P-exposed rats, suggesting anti-proliferative activity and enhancement of tumor suppressor responses during early cervical carcinogenesis.
Co-Authors Afifah Afifah Ajeng Kirana Ana Bina Sari Daniel Joko Wahyono Khusnul Muflikhah Sindy Devi Prastiwi Tri Lestari