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Formulation and Effectiveness Test of 96% Ethanol Extract Anti-Acne Serum Cashew Leaves (Anacardium occidentale L.) Mc Seer, Raysha; Rini Dwiastuti; Eka Indra Setyawan
Scientific Journal of Dermatology and Venereology Vol. 2 No. 2 (2024): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i1.99

Introduction: Recently, the use of cosmetics to cure acne made from natural ingredients can have a good effect. Cosmetic preparations that are currently developing rapidly are serum preparations because they have better effects, and the moisturizing technology used is based on skin physiology. The natural ingredient in question is cashew leaves, which treat acne caused by Propionibacterium acnes. This research aims to obtain a serum preparation of cashew leaf extract to determine its effectiveness against P. acne and optimize the two ingredients, namely carbopol and triethanolamine (TEA) so that the serum preparation has physical stability that meets predetermined standards. Methods: This research is pure experimental research of a qualitative nature to obtain a serum preparation of cashew leaf extract with effectiveness as an anti-acne and using the factorial design method with the optimization factor for carbopol concentration comparison as a gelling agent and TEA as an alkalizing agent. The physical property parameters observed as a response to the equation are spreadability and viscosity using two-way statistical tests, ANOVA, with IBM SPSS statistics 29.0.1.0 software. Results: The research results obtained indicate the effectiveness of cashew leaf extract serum preparations against bacteria, such as Propionibacterium acnes. Apart from that, there is no significant difference between the formulas in the spreadability parameters, which means there is no influence from variations in carbopol and TEA concentrations on the physical evaluation of spreadability. Meanwhile, there are significant differences between the formulas in the viscosity parameters, there is an influence of variations in the concentration of carbopol and TEA on the physical evaluation of viscosity. Conclusion: Cashew leaf extract serum preparations are effective in treating bacteria Propionibacterium acnes, the cause of acne.

FORMULATION AND EFFECTIVENESS TEST OF THE WOUND HEALING GEL RED PIDADA FRUIT (Sonneratia Caseolaris) SKIN EXTRACT Rusdeni, Sofia; Rini Dwiastuti; Phebe Hendra; Hasyrul Hamzah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1633

Red pidada fruit peel extract gel preparation can increase the efficiency and comfort of topical use because of its activity in the healing of open wounds. The aim of this research was to determine how variations in HPMC levels affect the physical quality and stability of red pidada fruit peel extract gel preparations, using the maceration method to obtain thick extracts and formulations with different HPMC concentrations (1% HPMC, 3% and HPMC 5% formula were tested for physical quality and stability, including the Storage Stability Test for 4 weeks. Effectiveness testing was also carried out in white mice using an incision wound method with a depth of 1.5 mm and macroscopic observation. The effectiveness test concentration was set to 5%. The results of data analysis using the Spss One Way ANOVA test showed that higher HPMC levels resulted in a thicker gel, viscosity, stickiness, spreadability, and higher pH. It can be concluded that the gel formulation that meets the requirements is that formula 2 provides organoleptic test results with a thick green color typical of red pidada, good homogeneity test, spreadability test 5.52 cm, adhesion test 2.61 minutes, viscosity test 2700cCps, pH test 4.92. During storage, the gel exhibited good consistency. The longer the storage time, the closer the pH changes to alkaline values. With the Anova value, there is a significant difference in the three formulas with a value of p=0.005 Keywords: red pidada (Sonneratia caseolaris) fruit peel, wound healing, HPMC, gel

Prototipe Alat Pengekstrak Kunyit Otomatis Menggunakan Aktuator Motor DC Bernadeta Wuri Harini; Rini Dwiastuti; Y. B. Savio Surya Amanda
Widya Teknik Vol. 15 No. 1 (2016)
Publisher : Fakultas Teknik, Universitas Katolik Widya Mandala Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/wt.v15i1.1469

Di dalam kunyit terdapat kurkuminoid dengan kandungan utama berupa kurkumin. Pada penelitian sebelumnya telah dibuat alat ukur kadar kurkuminoid portabel. Sebelum kadar kurkumin diukur, kunyit harus diekstrak dahulu. Oleh karena itu dalam penelitian ini dibuat prototipe alat pengekstrak kunyit otomatis. Alat pengesktrak otomatis terdiri dari motor DC sebagai komponen utama penumbuk kunyit. Setelah kunyit selesai ditumbuk maka mikrokontroler akan mengaktifkan solenoid valve sehingga cairan etanol keluar ke tempat penumbuk kunyit sehingga kunyit larut dalam etanol. Larutan ini kemudian diukur absorbansinya menggunakan alat ukur spektrofotometer. Hasil pengukuran kemudian dibandingkan dengan hasil pengekstrakan kunyit secara manual. Sampel kunyit yang diambil adalah satu ruas kunyit pada bagian pangkal, tengah dan ujung. Dari hasil pengukuran ekstraksi secara manual, ekstrak kunyit pada bagian pangkal mempunyai absorbansi sebesar 1,083, bagian tengah 0,888 dan bagian ujung 0,62. Hasil ekstraksi secara otomatis menunjukkan semakin lama penumbukan maka error absorbansi semakin kecil. Penumbukan selama 15 detik diperoleh error absorbansi sebesar 66,76% dan penumbukan selama 3 menit 26,87%. Dengan hasil ini maka dapat diketahui bahwa proses penumbukan optimal dalam waktu 5 menit. Dengan penambahan proses pelarutan maka total waktu yang dibutuhkan adalah sekitar 8 menit. Waktu proses pengekstrakan secara otomatis ini lebih singkat daripada proses pengekstrakan secara manual (15 menit).

FORMULATION AND EFFECTIVENESS TEST OF THE WOUND HEALING GEL RED PIDADA FRUIT (Sonneratia Caseolaris) SKIN EXTRACT Rusdeni, Sofia; Rini Dwiastuti; Phebe Hendra; Hasyrul Hamzah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1633

Red pidada fruit peel extract gel preparation can increase the efficiency and comfort of topical use because of its activity in the healing of open wounds. The aim of this research was to determine how variations in HPMC levels affect the physical quality and stability of red pidada fruit peel extract gel preparations, using the maceration method to obtain thick extracts and formulations with different HPMC concentrations (1% HPMC, 3% and HPMC 5% formula were tested for physical quality and stability, including the Storage Stability Test for 4 weeks. Effectiveness testing was also carried out in white mice using an incision wound method with a depth of 1.5 mm and macroscopic observation. The effectiveness test concentration was set to 5%. The results of data analysis using the Spss One Way ANOVA test showed that higher HPMC levels resulted in a thicker gel, viscosity, stickiness, spreadability, and higher pH. It can be concluded that the gel formulation that meets the requirements is that formula 2 provides organoleptic test results with a thick green color typical of red pidada, good homogeneity test, spreadability test 5.52 cm, adhesion test 2.61 minutes, viscosity test 2700cCps, pH test 4.92. During storage, the gel exhibited good consistency. The longer the storage time, the closer the pH changes to alkaline values. With the Anova value, there is a significant difference in the three formulas with a value of p=0.005 Keywords: red pidada (Sonneratia caseolaris) fruit peel, wound healing, HPMC, gel

Unlocking the Bioactive Potential of Pandanus conoideus Lim: A Process-Modified Approach to Double the Oil Yield and Enhance In Vitro Radical Scavenging Activity Siti Hartinah; I Made Budi; Rini Dwiastuti
Natural Sciences Engineering and Technology Journal Vol. 5 No. 1 (2025): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v5i2.67

Pandanus conoideus Lim (Red Fruit), an indigenous plant of Papua, Indonesia, is a traditionally valued source of natural antioxidants. However, community-based oil extraction methods are often inefficient, leading to low yields and thermal degradation of bioactive compounds, thereby limiting the product's quality and standardization potential. This study aimed to develop and validate a process-modified extraction technique to improve both the yield and a key chemical quality marker—the in vitro antioxidant efficacy—of Red Fruit oil. Oil was extracted from Pandanus conoideus fruit using two methods: a traditional empiric method (aqueous boiling, manual pressing) and a novel modified method (steam distillation, mechanical screw pressing, centrifugation at 3500 x g, and controlled-temperature vacuum evaporation at 50°C). Oil yields were quantified on both wet and dry weight bases. The in vitro antioxidant capacity was determined using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, with the half-maximal inhibitory concentration (IC₅₀) calculated from scavenging activity at concentrations of 50, 100, 150, and 200 ppm. Commercial Vitamin E was used as a positive control. The process-modified extraction method produced a substantially greater oil yield (20.0% w/w) compared to the empiric method (10.8% w/w), representing an 85.2% increase in production efficiency. In the DPPH assay, the oil from the modified method exhibited significantly higher radical scavenging potency, with an IC₅₀ value of 63.94 ± 2.15 ppm. This was superior to the empiric method extract (IC₅₀ = 95.55 ± 3.41 ppm; p < 0.01) and the 300 IU Vitamin E standard (IC₅₀ = 75.48 ± 2.88 ppm). In conclusion, the integrated, process-modified extraction strategy successfully overcomes the critical limitations of traditional methods by improving process efficiency and preserving chemical integrity. It nearly doubles the oil yield and significantly enhances the in vitro radical scavenging activity by minimizing thermal degradation of bioactive compounds. This validated approach provides a robust framework for the standardized production of high-quality P. conoideus oil, establishing a scientific foundation for its development as a high-value, evidence-based natural product.

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