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All Journal Strada Jurnal Ilmiah Kesehatan (SJIK)
Awal Darmawan
Abdul Wahab Sjahranie Samarinda General Hospital
Dentistry Health Professions Public Health

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Betel Leaf Extract Efficacy on Wound Healing: A Systematic review Awal Darmawan; Saldy Yusuf; Takdir Tahir; St Syahriyani
STRADA : Jurnal Ilmiah Kesehatan Vol. 10 No. 1 (2021): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v10i1.666

Abstract

Betel leaf extract effectively accelerates wound healing. To identify the potency of betel leaf extract in the inflammatory phase, proliferation and remodeling of wound healing phases. Literature quest: PubMed, EBSCO host, Proquest, Science Direct, DOAJ and GARUDA. As many as five articles were reviewed, In acute wounds, the level of IL-1β betel leaf extract at a concentration of 3% (ρ˂ 0.002, r = 0.701) has an effect on inflammation. Diabetes mellitus ulcers, blood vessel growth and increased collagen layer thickening affect cell proliferation, increased epithelialization, more melanin, melanocyte and fibrous tissue formation (ρ<0.05), increased granulation tissue weight (ρ<0.05), hydroxyproline content increased (ρ<0.05), epidermal thickening, more lots of fibroblasts and few macrophages, and inhibiting bacterial growth (ρ<0.05). Betel leaf extract has the potential to heal wounds both acute wounds, infection wounds and diabetic ulcers.
Co-Authors Saldy Yusuf St Syahriyani Takdir Tahir