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All Journal Indonesian Journal on Medical Science (IJMS)
Tia Intan Pradita
Politeknik Kesehatan Bhakti Mulia
Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Nursing Public Health

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Uji Daya Antiinflamasi Ekstrak Etanol Daun Mangkokan (Nothopanax Scutellarium Merr.) pada Mencit Yang Diinduksi Karagenin Tia Intan Pradita; Sri Rejeki
Indonesian Journal on Medical Science Vol 9 No 1 (2022): IJMS 2022
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (546.028 KB) | DOI: 10.55181/ijms.v9i1.354

Abstract

Mangkokan leaves (Nothopanax scutellarium Merr.) contain flavonoids, alkaloids, saponins, and polyphenols which are used to treat wounds, antibacterial, anti-inflammatory, and antioxidants. This study aims to determine the ethanol extract of mangkokan leaves has anti-inflammatory power in mice induced by carrageenan and to determine the effective dose of mangkokan leaf ethanol extract which provides anti-inflammatory power comparable to the positive control. This type of research is experimental. Mangkokan leaves were extracted by maceration method using 70% ethanol solvent. The test animals used were 25 mice and divided into 5 groups. All groups were induced with carrageenan. Group I was given positive control (na diclofenac), group II was given negative control (coconut oil), and groups III, IV, V were given ethanol extract of mangkokan leaves each with a dose of 100 mg / kg, 200 mg / kg, 400 mg / kgBB. The results of measuring the length of edema every 30 minutes for 6 hours were analyzed with the help of SPSS version 22.0 for windows. Results% DAI of the ethanol extract of mangkokan leaves with a dose of 400 mg was 58.88%, a dose of 200 mg was 50.49%, a dose of 100 mg was 43.67%, and a positive control was 66.71%. The conclusion of this study is that the ethanol extract of mangkokan leaves  anti-inflammatory activity in mice which is comparable to the positive control with a dose of 400 mg.The ethanol extract of mangkokan leaves has the potential to be anti-inflammatory.
Co-Authors Sri Rejeki