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All Journal Program Kreativitas Mahasiswa - Penelitian
Jusuf Salenussa
Program Studi Pendidikan Kimia, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Pattimura

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POTENSI EKSTRAK METANOL DAUN KAPUR (Harmsiopanax aculeatus, Harms) SEBAGAI OBAT ANTIMALARIA Wijaya, Jefry; Salenussa, Jusuf; Marantika, Jacky
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Kapur plant (Harmsiopanax aculeatus Harms) is traditionally used by Mollucans to treat malaria disease. Squeezed of young leaves which is dropped on the eye of sufferer is the way of its treatment. This research is aimed to assay haem polymerization inhibition activity, cytotoxic activity toward vero cells and to analysis chemical secondary metabolit of compound content on methanol extract of the old kapur leaves. Dried powder of kapur leaves (1 kg) is extracted by maceration technique using methanol solvent obtained 95,85g (9,59%) of methanol extract. Those extract which assayed haem polymerization inhibition on activity by Bassilico et al. (1998) method is shown IC50 values of 9410,93 µg/mL. Cytotoxic test toward vero cells using MTT assay, Kasugai et al. (1983) is shown that IC50 values is 9402,81 µg/mL. Phytochemical analysis by spray and visible reagent shown of flavanoids, phenolic, saponin an antraquinones compound. Keyword: Harmsiopanax acuelatus Harms, haem polymerization inhibition activity, cytotoxic activity, vero cell, phytochemical.
POTENSI EKSTRAK HEKSAN DAUN KAPUR (Harmsiopanax aculeatus, Harms) SEBAGAI OBAT ANTIMALARIA Salenussa, Jusuf; Wijaya, Jefry; Labetubun, Colincie Natalia; Belseran, Stenly Erwin
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (290.045 KB)

Abstract

Kapur plant (Harmsiopanax aculeatus, Harms) is traditionally used by Mollucans to treat malaria disease. Squeezed of young leaves which is dropped on the eye of sufferer is the way of its treatment. This research is aimed to assay haem polymerization inhibition activity, cytotoxic activity toward vero cells and to analysis chemical secondary metabolit of compound content on hexane extract of the old kapur leaves. Dried powder of kapur leaves (1 kg) is extracted by maceration technique using hexane solvent obtained 24.34g (2.43%) of hexane extract. Those extract which assayed haem polymerization inhibition on activity by Bassilico et al. (1998) method and cytotoxic test toward vero cells using MTT assay. Probit analysis has showing us that hexane extract of ripe kapur leaves were inhibit haem polymerization actively with IC50 in the amount 59.473 µg/mL and were not toxic toward normal cells with IC50 in the amount 1270.746 µg/mL. Phytochemical analysis by spray and visible reagent shown of steroid compound. Keywords:  Harmsiopanax acuelatus Harms, haem polymerization inhibition activity, cytotoxic activity, vero cell, phytochemical
Co-Authors Colincie Natalia Labetubun, Colincie Natalia Jacky Marantika Jefry Wijaya Stenly Erwin Belseran, Stenly Erwin