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Kosasih Padmawinata
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology

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ISOLASI, KARAKTERISASI DAN UJI AKTIVITAS PENCEGAHAN ANTIKALKULI LUTEOLIN 7-O-GLUKOSIDA DARI DAUN Sonchus arvensis L., PADA TIKUS DENGAN METODE MATRIKS-ASAM GLIKOLAT Diah Dhianawaty; Kosasih Padmawinata; Iwang Soediro; Andreanus A -; Soemardji -
Bionatura Vol 5, No 3 (2003): Bionatura Nopember 2003
Publisher : Direktorat Sumber Daya Akademik dan Perpustakaan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (154.493 KB)

Abstract

Banyak tumbuhan yang digunakan untuk mengobati penyakit batu kandungkemih dalam pengobatan tradisional Indonesia. Diantaranya: Orthosiphonaristatus (Bl.)Miq., Sonchus arvensis L., Phyllanthus niruri L., Strobilanthus crispusL. dan Imperata cylindrica L., Sonchus arvensis L. telah diteliti efek antikalkulinyaterhadap batu oksalat kandung kemih eksperimental pada tikus jantan.Kandungan kimia yang telah diketahui yaitu asam fenolat dan turunannya,flavonoid (antara lain luteolin 7-O-glukosida), terpena, kumarin, lipid dan minyakatsiri. Senyawa luteolin 7-O-glukosida telah diisolasi dari ekstrak etanol dandikarakterisasi dengan spektrofotometri ultraviolet, inframerah, massa danresonansi magnet inti. Uji aktivitas antikalkuli luteolin 7-O-glukosida dilakukandengan metode matriks-asam glikolat. Bobot batu kandung kemih yang terjadidigunakan sebagai parameter untuk mengevaluasi aktivitas antibatu kandungkemih. Dari penelitian diperoleh, luteolin 7-O-glukosida aktif sebagai antikalkulipada dosis 0,15 mg/kg bb tikus: pada upaya pencegahan berkhasiat 51,62%(P≤0,05) dan pada upaya pengobatan, terjadi penekanan 3,77% walaupunsecara statistik tidak bermakna.
CYTOTOXIC ISOFLAVONOIDS OF PACHYRRHiUS EROSUS SEEDS Leonardus B.S. Kardono; Soefjan Tsauri; John M. Pezzuto; A. Douglas Kinghorn; Kosasih Padmawinata
Jurnal Kimia Terapan Indonesia Vol 4, No 2 (1994)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3038.221 KB) | DOI: 10.14203/jkti.v4i2.248

Abstract

By bioactivity-directed fractionation, phytochemical and cytotoxic studies of the seeds of Pachyrrhizus erosus L. resulted in the isolation of isoflavonoid-based compounds, one novel compound and eight known compounds, comprising the novel coumaronochromene, pachyrrhisomene {1}, the known pterocarpan, neodulin {2}, the known 3-arylcoumarin, pachyrrhizin {3}, the known isoflavonoid, dehydroneotenone {4}, five known rotenoids, rotenone {5}, l2a-hydroxyrotenone {6}, 12a-hydroxypachyrrhizone {7}, 12a-hydroxyerosone {8}, and 12a-hydroxymunduserone {9}. The identities of these compounds were elucidated or confirmed using combination of modern one- and two- dimensional NMR techniques, such as 1H-1H COSY, CSCMID, 1H-1H NOESY, and selective INEPT, as well as by comparison with published spectroscopic data. It is likely that the novel compound, pachyrrhisomene {1} is derived from the same biosynthetic intermediate as the pterocarpan, neodulin {2}. All of these compounds were evaluated for their anticancer potential in a battery of tumour cell lines, comprishing P-388 lymphocytic leukemia, KB-carcinoma of the nasopharynx, a multi-drug resistant variant of KB, KB-VI, and a number of human cancer cell lines derived from a variety of tumour types, namely fibrosarcoma, lung, colon, melanoma, and breast. Two compounds, rotenone {5} and 12a-hydroxyrotenone {6} were observed to exhibit potent but nonspecific activity.
Co-Authors A. Douglas Kinghorn Andreanus A - Diah Dhianawaty Iwang Soediro John M. Pezzuto Leonardus B.S. Kardono Soefjan Tsauri Soemardji -