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All Journal Nexus Biomedika Jurnal Respirasi (JR)
Eko Setijanto
Sebelas Maret University
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Uji Efektivitas Sterilisasi dan Desinfeksi Ventilator Mekanik Di RSUD Dr. Moewardi Indraputri, Rizky Saraswati; Saptawati, Leli; Setijanto, Eko
Nexus Biomedika Vol 3, No 2 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

Abstract

Background: Mechanical ventilator is a semicritical equipment that often contacts with mucous membrane or skin. The use of mechanical ventilator for long term can cause some complication, one of them is Ventilator-Associated Pneumonia (VAP) which is the common nosocomial infection in ICU. Sterilization and disinfection of mechanical ventilator decrease microorganism infection. Every hospital has their own sterilization and disinfection procedure of mechanical ventilator. This research aims to examine the effectiveness of sterilization and disinfection of mechanical ventilator at RSUD Dr. Moewardi. Method: This was an analytic observational study using cross sectional design. Samples were taken from swab and circuit rinse of mechanical ventilator tube after sterilization and disinfection with storage and without storage process. A total of 30 samples were sampled for each tube and circuit based on the rule of thumb with consecutive sampling technique. Data were analyzed descriptively and tested using Chi Square test. Result: There were 30 samples from circuit rinse which were negative from contamination. In tube swab, there were 8 samples positive from contamination. In 15 samples of tube swab without storage process, there were 2 positive samples and 13 negative samples from contamination. In 15 samples of tube swab with storage process, there were 6 positive samples and 9 negative samples from contamination. The microorganisms of contaminants were Bacillus sp, Staphylococcus aureus, and Staphylococcus epidermidis. The statistical analyses showed no significant relationship between both storage processes either sterilization or disinfection of mechanical ventilator and microorganism contamination (p = 0.226). Conclusion: Sterilization and disinfection of ventilator circuit at RSUD Dr. Moewardi are effective. While sterilization and disinfection of mechanical ventilator are not yet effective. There is not a significant relationship between storage and the effectiveness of either sterilization or disinfection of mechanical ventilator. Keywords: sterilization, disinfection, mechanical ventilator  
Factors Associated with Outcomes of Acinetobacter baumannii Infection in Ventilator-Associated Pneumonia in the ICU of Dr. Moewardi General Hospital, Surakarta Putra, Lutfi Lafil Cahya; Saptawati, Leli; Setijanto, Eko; Maryani, Maryani; Maarif, Athok Shofiudin
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.201-207

Abstract

Introduction: Acinetobacter baumannii is a nosocomial pathogen with high mortality rates in intensive care units (ICUs) and is commonly associated with ventilator-associated pneumonia (VAP). Due to declines in physiological and immune functions, A. baumannii can trigger septic shock complications, thereby increasing mortality risk. This study aimed to identify the risk factors associated with outcomes in VAP patients in the ICU of Dr. Moewardi General Hospital, Surakarta. Methods: This retrospective cohort study was conducted at Dr. Moewardi General Hospital, Surakarta, using patient medical records. Data were analyzed with Chi-square and Mann-Whitney U tests, followed by multiple logistic and linear regression to determine correlations between risk factors and outcomes (recovery, mortality, length of stay/LOS). Results: This study included 80 patients with VAP caused by A. baumannii. Most patients were under 60 years old (52.5%), had good nutritional status (75%), were on ventilators for less than 10 days (63.75%), and had mild comorbidities (51.25%). Moderate-severe comorbidities (p=0.001) and malnutrition (p=0.005) were significantly associated with increased mortality. In addition, ventilator use ≥10 days was significantly associated with LOS (p<0.001). Conclusion: Moderate-severe comorbidities and malnutrition were risk factors for mortality in patients with A. baumannii-related VAP, while ventilator use ≥10 days was a risk factor for prolonged hospitalization. Identifying these factors can help medical personnel manage conditions that worsen VAP outcomes and reduce the risk of A. baumannii-related mortality.
Co-Authors Leli Saptawati Leli Saptawati Maarif, Athok Shofiudin Maryani Maryani Putra, Lutfi Lafil Cahya Rizky Saraswati Indraputri