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All Journal Jurnal Online Mahasiswa (JOM) Bidang Kedokteran UMI Medical Journal Herbal Medicine Journal Jurnal Riset Multidisiplin Edukasi
Annisa Abdi Ghifari
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Other

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KUALITAS VISUM ET REPERTUM PERLUKAAN DI RSUD BANGKINANG PERIODE 1 JANUARI 2009 - 31 DESEMBER 2013 Ghifari, Annisa Abdi; Afandi, Dedi; Chandra, Fifia
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 2 (2015): Wisuda Oktober 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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ABSTRACTIn addition to treat patients , a doctor’s duty is also requested to make a written statement for justice importance that is called Visum et Repertum (VeR). VeR of injury for living victims is the most frequent form of assistance requested by investigating officers compared to other kinds of VeR. A good quality of VeR is required in view of its important role in litigation of a criminal offense. This study was aimed to understand the quality of VeR of injury in General Hospital of Bangkinang during 1st January 2009-31st December 2013. The research was an observational study using descriptive retrospective design. This study used Herkutanto’s scoring method towards 13 VeR substances. Samples of this study were all data of VeR of injury that had fulfilled inclusion criteria. The total of samples were 316 samples of VeR. This study suggested that the highest number of living victims of injury cases was 191 victims in age group 22-40 years old with the most frequent sex was male as many as 117 victims. The most frequent violence was blunt violence as many as 266 cases with the most frequent age group was 22-40 years old. The quality of VeR in preface was good quality, in body part was poor quality and in conclusion was medium quality. In general, quality of VeR of injury in General Hospital of Bangkinang during 1st january 2009-31st december 2013 was 50,93% that could be categorized as medium quality.Keywords: Visum et Repertum, injury, quality of VeR of injury
Farmakogenomik Metabolisme Obat: Menelusuri Variasi Genetik dan Dampaknya terhadap Respon terhadap Obat Syaifulanwar, Alauddin; Ghifari, Annisa Abdi; Hamidy, Muhammad Yulis
UMI Medical Journal Vol 10 No 1 (2025): UMI Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/umj.v10i1.371

Abstract

Latar belakang: Farmakogenomik merupakan studi bagaimana susunan genetic memengaruhi responsnya terhadap pengobatan yang dapat menyebabkan variasi respons pengobatan. Farmakogenomik bertujuan untuk mengoptimalkan efektivitas pengobatan sekaligus meminimalkan reaksi obat yang merugikan. Namun, terdapat tantangan yang menghambat seperti keterjangkauan uji genetik, infrastruktur, seta edukasi bagi tenaga kesehatan. Isi: Farmakogenomik menawarkan peluang besar dalam personalisasi terapi untuk penyakit kronis seperti gangguan psikiatri. Profiling genetic terhadap varian enzim cytochrome seperti CYP2C19 dan CYP2D6 telah terbukti meningkatkan pemilihan dan penyesuaian dosis obat, sehingga dapat menurunkan risiko efek samping. Pedoman klinis dari Clinical Pharmacogenetis Implementastion Consortium (CPIC) semakin memfasilitasi penerjemahan riset farmakogenomik ke dalam praktik klinis yang aplikatif, dengan menyediakan kerangka kerja terstruktur untuk integrasi data genetic dalam layanan kesehatan. Kesimpulan: Integrasi farmakogenomik ke dalam praktik klinis rutin menawarkan pendekatan yang transformatif dalam layanan kesehatan, dengan potensi untuk memperbaiki hasil terapeutik secara global.
Analisis Reporting Odds Ratio Efek Samping Gastrointestinal pada Metformin Berdasarkan Data FAERS 2025 Annisa Abdi Ghifari
Jurnal Riset Multidisiplin Edukasi Vol. 3 No. 2 (2026): Jurnal Riset Multidisiplin Edukasi (Februari 2026)
Publisher : PT. Hasba Edukasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71282/jurmie.v3i2.1714

Abstract

Latar Belakang: Metformin merupakan terapi lini pertama pada diabetes melitus tipe 2 dan diketahui memiliki efek samping gastrointestinal. Database FDA Adverse Event Reporting System (FAERS) dapat digunakan untuk mendeteksi sinyal farmakovigilans. Tujuan: Menganalisis hubungan antara penggunaan metformin dan kejadian efek samping gastrointestinal berdasarkan database FAERS. Metode: Studi observasional retrospektif menggunakan data FAERS kuartal pertama tahun 2025. Efek samping gastrointestinal didefinisikan sebagai laporan dengan Preferred Term (PT): nausea, vomiting, dan diarrhoea. Analisis dilakukan menggunakan metode disproporsionalitas melalui perhitungan Reporting Odds Ratio (ROR) dengan uji chi-square menggunakan aplikasi Uji Statistik. Hasil: Dari 2.008.162 laporan yang dianalisis, diperoleh nilai ROR sebesar 0,376 (IK95%: 0,371–0,382; p < 0,001). Kesimpulan: Terdapat hubungan signifikan antara metformin dan laporan efek samping gastrointestinal dalam database FAERS, dengan keterbatasan inheren sistem pelaporan spontan.
Dampak Variasi Genetik terhadap Respon Terapi dan Potensi Hemolisis Anemia dari Penggunaan Primakuin melalui Pendekatan Farmakogenetika Sianu, Rahman Sumani; Ghifari, Annisa Abdi; Ma’ruf, Muhammad; Nur Jannah, Eka Yuni; Lestari, Putri Ayu
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.219

Abstract

Primaquine is essential for radical cure of Plasmodium vivax malaria but poses hemolysis risk in G6PD-deficient individuals and shows variable therapeutic responses. Genetic polymorphisms in drug-metabolizing enzymes and transporters contribute to these inter-individual variations. To investigate genetic variants in G6PD, SLCO2B1, and MAOA genes that influence primaquine safety and efficacy, and to assess their clinical implications for personalized antimalarial therapy. Method the database used in this study is PhramGKB. Genetic polymorphisms in four candidate genes were analyzed for associations with hemolysis, anemia, therapeutic efficacy, and malaria recurrence. Statistical analyses determined the strength and significance of genotype-phenotype associations. Result G6PD variants rs1050828 and rs1050829 showed strong associations with hemolysis (p<0.01) and anemia (p=0.001). SLCO2B1 variant rs12422149 was associated with reduced chloroquine-primaquine efficacy (p=0.01). MAOA variant rs6323 increased malaria recurrence risk (p=0.03). Conclusion multiple genetic variants significantly impact primaquine safety and efficacy. These findings support pharmacogenetic-guided personalized antimalarial therapy to optimize outcomes and minimize adverse events, contributing to malaria elimination efforts.
Co-Authors Darmawi Dedi Afandi Fifia Chandra Ma’ruf, Muhammad Muhammad Yulis Hamidy Nur Jannah, Eka Yuni NURUL AZIZAH Putri Ayu Lestari Sianu, Rahman Sumani Syaifulanwar, Alauddin Wirawan Adikusuma