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All Journal El-Hayah : Jurnal Biologi JIMR - Journal of Islamic Medicine Research Jurnal Kesehatan Islam : Islamic Health Journal
Hardadi Airlangga
Fakultas Kedokteran, Universitas Islam Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Peran Gender dan Interval Puasa pada Profil Lipid Tikus Wistar dengan Diet Atherogenik Triliana, Rahma; Airlangga, Hardadi
Jurnal Kesehatan Islam : Islamic Health Journal Vol 7, No 01 (2018): JURNAL KESEHATAN ISLAM
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

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Abstract

AbstractIntroduction: Atherogenic diet can induced.hyperlipidemia leading to abnormal lipid profile. Time restricted feeding is proposed as treatment for hyperlipidemia. However, the effect of gender and which type of time-restricted feeding is the best to alter lipid profile is unknown.Method: The study was conducted in female and male wistar rats which was devided into 5 groups, Negative Control (KN, n=8), Positive Control (KP, n=8), Daily restricted group (KRam, n=8), alternate restricted group (KDaud, n=8) and Monday-Thursday restricted group (KSeKa, n=8) respectively. Atherogenic diet were administrated for six weeks followed by 4 weeks of time-restricted feeding. At 15 weeks of age, all rats were humanely culled and serum samples were collected for analyses. Lipid profile were assesed using spectrophotometry and analysed using two way Anova followed by post hoc LSD and p < 0.05 is considered as statiscally significant.Results: Gender and time restricted feeding affects serum total cholesterol and non-HDL cholesterol levels while gender influenced HDL and time restricted feeding influenced LDL levels. Both gender and time restricted feeding did not altered trigliseride level. Interestingly, no significant differences were found in lipid profile of KN vs KP in male or female group. Time restricted feeding had no significant effect in male but significant effect on female with higher, undesireable lipid profile.Conclusion: Atherogenic diets did not lipid profile in male or female rats, but higher lipid profile were observed in female with atherogenic diet. Time restricted feeding has gender related effect cholesterol and non-HDL cholesterol level, but no gender effect on LDL. HDL is solely dependent on gender and not affected by atherogenic diet or time restricted feeding.Keywords: Atherogenic diet, Time-restricted feeding,HDL, LDL, Triglyceride, Cholesterol.
OBSERVASI EFEK EKSTRAK ETANOL DAUN BAMBU JAWA (Gigantochloa atter (Hassk.) Kurz) DENGAN PARAMETER FISIK DAN FISIOLOGI HEWAN UJI TIKUS (Rattus sp.)YANG DIINDUKSI BORAKS Airlangga, Hardadi; Safitri, Endand; Arfarita, Novi
El-Hayah : Jurnal Biologi Vol 5, No 2 (2015): EL-HAYAH (VOL 5, NO 2, Maret 2015)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v5i2.3023

Abstract

Bamboo Jawa leaves (Gigantochloa atter) is known to contain antioxidant compound sandhas been used as abeverage from generation to generation invarious Asiancountries. While in Indonesia, currently borax widely abusedas a food preservative and food additives. Borax produce exogenous free radicals that can lead to organ damage due to oxidative stress.This current study was to observe the effect of ethanolic extract of G. atter leaf using physiology and physical parameter onthe levels of SOD, MDA and the hepatosite necrosis totalof rats induced by borax. Borax will generate free radicals which cause cell damage through lipid peroxidation there by increasing the levels of MDA and lower SOD antioxidant. Borax metabolism occurs mostlyin theliver, therefore, one of the organs damaged by borax is liver The method of this research was experimental control group posttest only using wistar rats which divided into five groups. The negative control group was induced by aquades. The positive control group was induced by borax 1gr/kg BW and treatment group was induced by borax. Ethanolic extract of G. atter leaf was given with doses of 10mg/ml, 20mg/ml and 40mg/ml for 21 days. After 21 days of treatment, hepatocite necrosis was then observed and counted using microscope trinocular 1000x. SOD examination was conducted by the NBT test while the MDA using TBA test. Data analysis was using one way ANOVA test. G. atter ethanolic extract dosageof 10 mg/ml, 20 mg/ml and 40 mg/mlcould decrease the number of liver cells necrosis. They were 23%, 39% and 63% respectivelly when compared to positive control. Extract ethanolik of G.Atter leaf also could improve SOD and decrease MDA rats serum which induced by borax. The effective dose is 20mg/ml.
Perbandingan Frekuensi Resistensi Bakteri Bacillus subtilis terhadap Antibiotik Tetracycline Tunggal dan Kombinasi dengan Dekokta Hibiscus sabdariffa L. Nova Faisal Waber; Rio Risandiansyah; Hardadi Airlangga
JIMR - Journal of Islamic Medicine Research Vol 1, No 1 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

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Introduction: The use of inappropriate antibiotics encourages the emergence of antibiotic resistance. It can be known by measuring the frequency of resistance. The use antibiotic combination has a low resistance, but the combination of antibiotic with herb is unknown.This study was conducted to prove the comparison frequency of bacterial resistance of Bacillus subtilis to Tetracycline and combination with dekokta Rosella (Hibiscus sabdariffa L.).Methods: This research uses laboratory experimental method in vitro. The method used is to measure the zone of inhibition which is then used to determine the minimum inhibitory (KHM). Then, the measurement of resistance frequency on the media with 3 times repetition.Results: Zone Inhibition of dekokta Rosella with the highest concentration (100%) is 15 mm, while the Tetracycline antibiotic is 40 mm. KHM Tetracycline antibiotic is 1/1024 which is equivalent to 0.0048 mg / ml and dekokta Rosella is 1/16 equivalent to 6.25 mg / ml. The frequency of resistance in Tetracycline is 0.69 x 10-9 to 9.72 x 10-9. Meanwhile, in Rosella dekokta not found any resistant bacteria. In combination between dekokta Rosella and Tetracycline antibiotics, there was no antibiotic resistant to B. Subtilis bacteria.Conclusion: From this research can be concluded that dekokta Rosella (Hibiscus sabdariffa L.) can be used as a combination with antibiotics to reduce resistance frequency of Bacillus subtilis to TetracyclineKeywords: Resistance, Resistance Frequency, Tetracycline, Rosella (Hibiscus sabdariffa L.)
Co-Authors Endand Safitri, Endand Nova Faisal Waber Novi Arfarita Rahma Triliana Risandiansyah, Rio