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All Journal Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) JIMR - Journal of Islamic Medicine Research Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Kedokteran Komunitas (Journal of Community Medicine) Borneo Journal of Pharmacy
Risandiansyah, Rio
Faculty Of Medicine, Universitas Islam Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Perbandingan Kuantitas dan Kualitas DNA Bacillus sp. antara Heat Treatment dan Filter berbasis Kit Durrotun Ni'mah; Muhammad Zainul Fadli; Rio Risandiansyah
Jurnal Ilmiah Biosaintropis (Bioscience -Tropic) Vol 6 No 2 (2021): Memperjelas Fenomena
Publisher : Fakultas Matematika & Ilmu Pengetahuan Alam - Universitas Islam Malang

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Diagnosis of bacterial infection can be done quickly with simplified DNA isolation methods, such as Heat Treatment, which is a simple and inexpensive DNA isolation method, but detection and quantification levels of Bacillus sp. still unknown. This study aims to compare the quantity and quality of DNA isolates from Bacillus sp. using Heat Treatment etraction method and Filter Based isolation method. This research used in vitro experiment method. Heat Treatment is compared to Filter Based Kit according to Limit of Detection (LoD) and Limit of Quantification (LoQ). Data analyzed with ANOVA and Honesty Significant Difference (HSD). DNA yield obtained by Heat Treatment at the highest concentration was 5 µg/ml, whereas Filter Based Kit was 3.67 µg/ml. LoD of the Heat treatment and Filter Based Kit were 1.61 and 5.72 µg/ml, while LoQ of the Heat treatment and Filter Based Kit were 4.87 and 17.34 µg/ml. The number of bacteria that exceeded the LoD and LoQ of Heat Treatment was 101 and 104 CFU/ml, whereas the LoD and LoQ of Filter Based Kit was >104 CFU/ml. The quantitiy of Bacillus sp. DNA with Heat Treatment method is better than Filter Based Kit. The quality of Bacillus sp. DNA both the Heat Treatment and Filter Based Kit methods are not good. Keywords: DNA isolation, Bacillus sp., heat treatment, Filter Based Kit ABSTRAK Penegakkan diagnosis infeksi bakteri dapat dilakukan secara cepat dengan metode isolasi DNA yang telah disederhanakan, seperti Heat Treatment yang merupakan metode ekstraksi DNA sederhana dan ekonomis, namun tingkat deteksi dan kuantifikasi terhadap Bacillus sp. masih belum diketahui. Penelitian ini bertujuan membandingkan kuantitas dan kualitas DNA dari Bacillus sp. dengan menggunakan metode ekstraksi Heat Treatment dan metode isolasi Filter Based Kit. Penelitian ini menggunakan metode penelitian eksperimen secara in vitro. Heat Treatment dibandingkan dengan Filter Based Kit berdasarkan Limit of Detection (LoD) and Limit of Quantification (LoQ). Analisa data menggunakan uji ANOVA serta uji Honesty Significant Diference (HSD). Yield DNA yang didapatkan Heat Treatment pada konsentrasi terbesar adalah 5 µg/ml, sedangkan dengan Filter Based Kit adalah 3.67 µg/ml. Nilai LoD Heat treatment dan Filter Based Kit adalah 1.61 µg/ml dan 5.72 µg/ml, sedangkan nilai LoQ Heat treatment dan Filter Based Kit adalah 4.87 µg/ml dan 17.34 µg/ml. Jumlah bakteri yang melebihi nilai LoD dan LoQ Heat treatment adalah 101 CFU/ml dan 104 CFU/ml, sementara LoD dan LoQ Filter Based Kit adalah >104 CFU/ml. Kuantitas DNA Bacillus sp. dengan metode Heat Treatment lebih baik dibandingkan dengan Filter Based Kit. Kualitas DNA Bacillus sp. baik dengan metode Heat Treatment maupun Filter Based Kit tidak baik. Kata kunci: isolasi DNA, Bacillus sp., heat treatment, Filter Based Kit
Pengaruh Dekokta Eceng gondok (Eichhornia crassipes) terhadap Kadar Malondialdehid (MDA) dan Nekrosis Sel Tubulus Proksimal Ginjal Tikus Wistar Jantan dengan Induksi Oral Kadmium Klorida (CdCl2) Subkronis Dosis Rendah Wika Yuli Deakandi; Rio Risandiansyah; Arif Yahya
JIMR - Journal of Islamic Medicine Research Vol 1, No 1 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

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Abstract

Introduction: Cadmium is a heavy metal pollutant which has high toxicity. Long term exposure to cadmium at low dose is able to induce kidney damage, possibly due to an increase in ROS. Water hyacinth (E. crassipes) is known to contain antioxidants that can prevent free radical damage. The purpose of the research is to investigate the effect of water hyacinth in preventing kidney damage, characterized by a decreasein MDA levels and renal proximal tubular cell necrosis of male wistar rats induced using subchronic CdCl2 at low dosage, administered orally.Methods: This is an in vivo laboratory experiments using 30 male wister rats (Rattus norvegicus), which were divided into 5 treatment groups (6 rats/groups). The negative control group was fed by standard food and drink while the positive control are treatment groups were given CdCl2 (5 mg/KgBB) orally for 28 days. The treatment groups were also given water hyacinth decocta with a dosage of 200 mg/KgBB, 400 mg/kgBB and 800 mg/kgBB for 28 days. On the 29th day of treatment, the rats have to be sacrificed and its kidney tissue were examined for histopathology and MDA.Results : Oral administration of CdCl2 (5 mg/kg) for 28 days significantly induced kidney damage which was evident from the increased levels of MDA (1,131 ± 0,135 ng/200mg ) and the proportion of necrosis of the kidney proximal tubule cells(73,189 ± 10,556 %), which was higher than the negative control group (MDA:0,179±0,021, kidney necrosis:35,777±2,593%). The addition of water hyacinth decoction at the doses of 200 mg/kg, 400 mg/kg and 800 mg/kg significantly decrease the MDA levels of kidney tissue(0,456±0,067 ng/200mg, 0,394±0,054 ng/200mg, 0,528±0,141 ng/200mg, respectively) and the percentage of proximal renal necrosis (53,729±4,875 %, 49,755±6,892%, 50,552±4,566%, respectively) compared to positive control group (MDA:1,131±0,135ng/200mg, kidney necrosis:73,189±10,556%).Conclusions: Decocta of water hyacinth at the doses of 200mg/KgBB, 400 mg/KgBB and 800 mg/KgBB were able to prevent renal organ damage due to subchronic exposure CdCl2. Keywords: Water Hyacinth, E. Crassipes, Cadmium Chloride, Subcronic, MDA, kidney necrosis
Frekuensi Resistensi pada Enterococcus faecalis Terhadap Dekokta Rosella (Hibiscus sabdariffa Linn) dan Antibiotik Amoksisilin Putri Lissanawidya; Rio Risandiansyah; Hardadi Airlangga
JIMR - Journal of Islamic Medicine Research Vol 1, No 1 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

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Abstract

Introduction: The inappropriate use of antibiotics leads to antibiotic resistance. This can be supported by measuring resistance frequency of bacteria to antibiotics. Antibacterial activity is also found in many herbal medicines consumed as a traditional medicine, therefore resistance is suspected to occur in herbal medicine. This study aims to measure the frequency of resistance in Enterococcus faecalis applied to againts Rosella (Hibiscus sabdariffa Linn) decocta. The method used will also be applied to Amoxicillin as a control. Method: Disc diffusion method was used to the measure inhibition zone (ZOI). Dilusion method used for minimum inhibition concentration (MIC). Resistance frequency was tested using Luria-Delbrück method, using 5 plates and 2 controls performed in 3 repetitions. Results were measured statistically using Mann Whitney U Test (p ≤ 0.05). Results: The ZOI from Rosella decocta and Amoxicillin was 20 mm at each concentration of 250 mg/ml and 200 mg/ml, respecticly MIC from Rosella decocta was 3,125 mg/ml, whereas Amoxicillin used the MIC from literature (0,00902 mg/ml). From 3 repetition, 1 coloni was found to be resistance to Rosella decocta on repetition 2 and the resistance frequency was 7,8 x 10-12 mutant per total population cell. Amoxicillin was calculated the resistance frequency from 3 repetition which was 1,2-1,8 x 10-2mutant per total population cell. The data was tested statistically and showed that there is a significant difference between the resistance frequency of Enterococcus faecalis towards Rosella decocta resistance and Amoxicillin resistance. Conclusion: From this study it can be concluded that the use of Rosella herbal as a traditional medicine, especially for antibacterials has a low resistance frequency of mutation. Therefore, resistance to Rosella decocta cannot occurred in short term. Keywords: Resistance, Luria-Delbrück Method, Resistance Frequency, Rosella (Hibiscus sabdariffa Linn).
The growth rate of S. aureus when treated with Azithromycin alone and combined with Syzygium cumini decoctation Rio Risandiansyah; Yoni Rina Bintari
JIMR - Journal of Islamic Medicine Research Vol 1, No 2 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

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Abstract

ABSTRACTIntroductiom: Resistance to antibiotics is the result of adaptive and spontaneous mutations, which can be suppressed by use of combinatory antibiotics. Synergistic effects between certain plants in combination with antibiotics is known, yet the mutation frequency of such combinations is still unexplored. Therefore, this study aims to measure the spontaneous mutational frequency of S. aureus for Azithromycin (AZM) resistance alone and in combination with Syzygium cumini decocta (SCD), known for its antimutagenic effect. Method: This study uses fluctuation analysis with 39 replicate cultures in selective media using AZM alone, SCD alone, and AZM combined with SCD at 1x MIC and analysing resistant strains based on its log phase delay in liquid media in a 24-hour period. AZM and SCD showed antibiotic activity against S. aureus. Results: Time-point growth comparison showed two cultures in AZM selective medium with no delayed log phase between S. aureus in non-selective medium and absorbance >1.0 after 24 hours, indicating resistance to AZM. Conclusion: Increased growth suppression was observed in combination between AZM combined with SCD, compared to AZM and SCD alone. The spontaneous mutation frequency of S. aureus against AZM was 0.182, while both SCD and AZM combined with SCD had zero mutational events for antibiotic resistance.Keywords:Antibiotic Resistance, Combinatorial Antibiotic Therapy (CAT), Mutation frequency, Syzygium cumini.
Perbandingan Frekuensi Resistensi Bakteri Bacillus subtilis terhadap Antibiotik Tetracycline Tunggal dan Kombinasi dengan Dekokta Hibiscus sabdariffa L. Nova Faisal Waber; Rio Risandiansyah; Hardadi Airlangga
JIMR - Journal of Islamic Medicine Research Vol 1, No 1 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

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Abstract

Introduction: The use of inappropriate antibiotics encourages the emergence of antibiotic resistance. It can be known by measuring the frequency of resistance. The use antibiotic combination has a low resistance, but the combination of antibiotic with herb is unknown.This study was conducted to prove the comparison frequency of bacterial resistance of Bacillus subtilis to Tetracycline and combination with dekokta Rosella (Hibiscus sabdariffa L.).Methods: This research uses laboratory experimental method in vitro. The method used is to measure the zone of inhibition which is then used to determine the minimum inhibitory (KHM). Then, the measurement of resistance frequency on the media with 3 times repetition.Results: Zone Inhibition of dekokta Rosella with the highest concentration (100%) is 15 mm, while the Tetracycline antibiotic is 40 mm. KHM Tetracycline antibiotic is 1/1024 which is equivalent to 0.0048 mg / ml and dekokta Rosella is 1/16 equivalent to 6.25 mg / ml. The frequency of resistance in Tetracycline is 0.69 x 10-9 to 9.72 x 10-9. Meanwhile, in Rosella dekokta not found any resistant bacteria. In combination between dekokta Rosella and Tetracycline antibiotics, there was no antibiotic resistant to B. Subtilis bacteria.Conclusion: From this research can be concluded that dekokta Rosella (Hibiscus sabdariffa L.) can be used as a combination with antibiotics to reduce resistance frequency of Bacillus subtilis to TetracyclineKeywords: Resistance, Resistance Frequency, Tetracycline, Rosella (Hibiscus sabdariffa L.)
Antibacterial potential of four herbal plants (Syzygium cumini, Piper ornatum, Anredera cordifolia, and Alpinia galangan) against Staphylococcus aureus and Escherichia coli Helmin Elyani; Rio Risandiansyah
JIMR - Journal of Islamic Medicine Research Vol 1, No 2 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

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Abstract

ABSTRACTIntroduction: The lack of new antibiotics and the increasing rate of resistance on pathogens requires the discovery of bioactive compounds with antibacterial activity. Using etnopharmacology knowledge, several Indonesian herbs, in particular Juwet (Syzygium cumini), Sirih merah (Piper ornatum), Binahong (Anredera cordifolia) and Laos (Alpinia galangan) had been shown possess wound-healing, anti-inflammatory and gastroprotective activities. It was postulated that these plants would also have antibacterial activity. Method: This study aims to assess the potential for antibacterial activity of these plants, in which decoctation, methanolic and choloroform extraction was used against Staphylococcus aureus and Escherichia coli growth by measuring and comparing zone of inhibition (ZOI), minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). Results: All plants tested had some activity against S. aureus, but none were found to be active against E. coli. Furthermore, various extraction methods of S. cumini and A. galangan had antibacterial activity against S. aureus with a ZOI of 10 15 mm and 12 25 mm, respectively, with increased antibacterial activity found in non-polar extracts. Methanolic extract of S. cumini acts as a bactericidal at 0.391 mg/ml, whilst other extracts had a bactericidal activity at 6.25 mg/ml.Conclusion: From four plants tested, methanolic extracts of S. cumini and A. galangan has medium to strong antibacterial activity against clinical S. aureus strains.Keywords: Juwet, Sirih Merah, Binahong, Laos, Antibacterial, Antibiotic
Efek Kombinasi Fraksi Alkaloid Imperata Cylindrica L. Dengan Amoksisilin Atau Kloramfenikol Terhadap Daya Hambat Staphylococcus Aureus alma nur; arif yahya; rio risandiansyah
Jurnal Kesehatan Islam : Islamic Health Journal Vol 8, No 2 (2019): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v8i2.8887

Abstract

Alkaloid merupakan senyawa yang terkandung dalam Imperata cylindrica L. (alang – alang). Ekstrak metanolik I. cylindrica L. diketahui berinteraksi dengan beberapa jenis antibiotik. Namun, belum ada penelitian yang membuktikan bahwa alkaloid dari I.cylindrica L. dapat meningkatkan kinerja antibiotik.Penelitian ini mengisolasi senyawa alkaloid dan melihat pengaruh penambannya terhadap zona hambat amoksisilin dan kloramfenikol terhadap Staphylococcus aureus.Metode: Ekstraksi dilakukan dengan maserasi menggunakan kloroform dan soxhletasi menggunakan methanol. Fraksinasi dengan pelarut, yaitu aquadest, methanol dan etil asetat. Uji fitokimia secara kualitatif dengan melihat perubahan warna. Uji Zone of Inhibition (ZOI) dilakukan untuk mengetahui efek dari kombinasi fraksi alkaloid I.cylindrica L. dengan antibiotik terhadap S.aureus dengan metode Kirby-Bauer. Diameter zona bening diukur menggunakan jangka sorong, dan interpretasi hasil berdasarkan metode Ameri-Ziaei Double Antibiotic Synergism Test (AZDAST).Hasil : Fraksi – fraksi alkaloid I.cylindrica L. tunggal tidak membentuk zona bening terhadap S.aureus. Kombinasi fraksi alkaloid dengan kloramfenikol (F1C dan F2C) memiliki ZOI dengan rerata diameter 30.73 ± 0.9 mm dan 30.53 ± 0.55 mm, yang lebih besar dari ZOI kloramfenikol tunggal yaitu 28.6 ± 0.95 mm dan fraksi tunggal 0 ± 0 mm. Pada uji fitokimia ditemukan bahwa senyawa yang terkandung adalah alkaloid.Simpulan: Alkaloid merupakan senyawa aktif dari I.cylindrica L.. Fraksi alkaloid I.cylindrica L. bersifat potensiasi dengan antibiotik kloramfenikol terhadap S.aureus karena mampu meningkatkan kinerja antibiotik tersebut.
Efek Penambahan Fraksi Semi Polar (F15-F19) Ekstrak Metanol Tapak Liman Pada Daya Hambat Amoksisilin dan Kloramfenikol Terhadap Bakteri Staphylococcus aureus dan Escherichia coli Nurma Alifia Rakhma; Zainul Fadli; Rio Risandiansyah
Jurnal Kedokteran Komunitas Vol 8, No 1 (2020)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

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Introduction: Elephantopus scabr linn contains various compounds which have antibacterial activity. The addition of antibiotic with herbs may increase antibiotic activity. However previous studies on Elephantopus scabr linn  was in the form of crude extract. Therefore, this study  separates compounds these into Semi polar fraction to determine the antibiotic activity and what compounds were contained therein.Methods: Methanol extract was fractionated using silica gel stationary phase and mobile phase 75 ml of ethyl acetate: 25 ml of  methanol. Phytochemical test were carried out with dragendorff spray, FeCl3 and Formaldehyde on Thin layer Chromatography. The interaction between herbs and antibiotics was assessed based on the AZDAST method and the inhibitory assessment using the Kirby bauer method.Result: Five fractions (f15-f19) were obtained using fractionation. Fraction 15 contain alkaloids, and fraction 16-19 contains alkaloids and phenol. On a single test, fraction 16 had clear zones against S.aureus with a value  6,66 ± 0,57 mm. In the combination test, fraction 18 and 19  had an antagonistic interaction with amoxicillin in S.aureus. Combination of fractions 16-19 had antagonistic interaction with chloramphenicol in S.aureus.Conclusion: Fraction 16 of Elephantopus Scabr Linn metanolic extract  was sinergistic with amoxicillin against S.aureus.Keywords: Semi Polar Fraction, Elephantopus scabr linn, S. aureus, E.coli
Efek Penambahan Fraksi Semi Polar (F1-F7) Ekstrak Metanolik Phyllanthus niruri, L. Terhadap Daya Hambat Amoxicillin atau Chloramphenicol pada Staphylococcus aureus atau Escherichia coli Wahyuni Dwi Permata Sari; Rio Risandiansyah; Hardadi Airlangga
Jurnal Kedokteran Komunitas Vol 9, No 1 (2021)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

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Abstract

Pendahuluan: Tingginya angka kejadian infeksi bakteri diterapi menggunakan antibiotik dapat meningkatkan risiko resistensi antibiotik. Untuk menanggulangi resistensi antibiotik dapat menggunakan kombinasi herbal seperti meniran (Phyllanthus niruri, L.) dengan antibiotik oleh karena itu, kombinasi tersebut perlu didalami lebih lanjut untuk menjadi alternatif yang tepat dalam menurunkan angka resistensi. Namun, belum diketahui senyawa spesifik yang mempengaruhi aktivitas herbal pada kinerja antibiotik. Oleh sebab itu, perlu penelitian lebih lanjut tentang efek penambahan fraksi meniran pada antibotik dalam menghambat pertumbuhan bakteri S. aureus dan E. coli.Metode: Fraksi 1-7 didapatkan dari proses fraksinasi ekstrak metanolik simplisia Phyllanthus niruri, L. menggunakan resin silica dengan eluen etil asetat 100%. Uji Zona Inhibisi (ZOI) menggunakan metode Kirby-Bauer. Efek interaksinya dihitung berdasarkan metode Ameri-Ziaei Double Antibiotic Synergism Test (AZDAST). Uji fitokimia menggunakan Kromatografi Lapis Tipis (KLT) dengan reagen FeCl3, dragendorff, dan formaldehyde Uji statistik dilakukan dengan Mann-Whitney dengan signifikan p<0,05.Hasil: Fraksi dengan eluen etil asetat 100% menghasilkan 7 fraksi yaitu F1-F7. Fraksi F3 memiliki interaksi sinergis dengan chloramphenicol dalam mebunuh E.coli dengan ZOI kombinasi 11,3 ± 0,57 mm dan ZOI antibiotik tunggal 11 ± 0 mm. Fraksi F6 memilki interaksi sinergis dengan amoxicillin dalam membunuh S.aureus dengan ZOI kombinasi 15,3 ± 0,57 mm dan ZOI antibiotik tunggal 14 ± 0 mm. Sedangkan pada fraksi lain memiliki interaksi not distinguishable. Fraksi F5, F6 dan F7 memiliki senyawa fenol dengan jenis senyawa yang berbeda.Kesimpulan: Fraksi F3 bersifat sinergis dengan chloramphenicol dalam membunuh E. coli. F6 bersifat sinergis dengan amoxicillin dalam membunuh S.aureus. Fraksi F1, F2, F4, F5 dan F7 memiliki interaksi not distinguishable. Fraksi F5, F6 dan F7 mengandung senyawa aktif fenol.Kata Kunci: Phyllanthus niruri,L.,Amoxicillin, Chloramphenicol, Uji Fitokimia, Zona Inihibisi, Kombinasi Antibiotik dan Herbal.
PENGARUH KAYU MANIS (Cinnamomum burmannii) PADA EFEKTIFITAS Amoksisilin TERHADAP Helicobacter pylori Cahya Dhimas Triatmojo Putra; Arif Yahya; Rio Risandiansyah
Jurnal Kedokteran Komunitas Vol 10, No 1 (2022)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

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ABSTRAKPendahuluan: Gastritis disebabkan oleh infeksi bakteri Helicobacter pylori yang dapat diterapi dengan amoksisilin. Fitofarmaka kayu manis sering digunakan sebagai obat gastiris karena karena dapat melindungi lambung dan memiliki aktivitas antibakteri. Pada kayu manis ditemukan bahwa kombinasi sinamaldehida dengan antibiotik mempunyai efek sinergis dalam menghambat bakteri E. coli secara in vitro. Namun, efek terhadap bakteri H. pylori belum diketahui, oleh karena itu penelitian ini akan menguji daya hambat antibotik amoksisilin secara tunggal maupun kombinasi dengan obat herbal berbahan kayu manis terhadap bakteri Helicobacter pylori.Metode: Penelitian dilakukan secara eksperimental laboratorium in vitro. Penentuan dosis berupa rentang dari dosis hambat minimum yang ditambahkan dua dosis tambahan pada ambang atas dan ambang bawah dosis. Apabila tidak didapatkan zona  hambat dalam uji eksplorasi atau rata-rata zona hambat <14 mm, maka dosis yang dipilih untuk pengujian adalah dosis 100×103 ppm. Fitofarmaka kayu manis dilarutkan dengan akuades hingga 5 variasi dosis 400×103 ppm, 200×103 ppm, 100×103 ppm, 50×103 ppm, dan 25×103 ppm. Zona hambat kombinasi fitofarmaka kayu manis dan amoksisilin 25 µg dilakukan dengan metode Kirby-Bauer Disk Diffusion Susceptibility Test dan diukur dengan jangka sorong. Nilai interaksi dilakukan dengan metode Ameri-Ziaei Double Antibiotic Synergism Test (AZDAST). Signifikansi ditentukan dengan p<0,05.Hasil: Kombinasi fitofarmaka kayu manis dengan amoksisilin didapatkan hasil antagonis pada dosis 400×103  ppm (34,80±0,87 mm). Untuk dosis yang lain interaksi bersifat not-distinguishable dengan amoksisilin. Hal ini terjadi karena semakin tinggi dosis ekstrak maka semakin tinggi zona hambat yang terbentuk.Kesimpulan: Dosis 400×103 ppm fitofarmaka kayu manis berinteraksi antagonis dengan antibakteri amoksisilin terhadap bakteri Helicobacter pylori.Kata Kunci: Cinnamomum burmannii, Amoksisilin, ZOI, Kombinasi Antibiotik dan Herbal
Co-Authors alma nur anisa, rizki Annur Affin Niswah Arif Yahya Brillian Nur Muhammad Cahya Dhimas Triatmojo Putra Difa Rizqi Akmalia Durrotun Ni'mah EKO HARI PRASETYO Evilya Fitra Indriana Faiqo Nabila Faris Akbar Maulana Ghazi Ghazi Hardadi Airlangga Hardadi Airlangga Hardadi Airlangga Helmin Elyani Ibrahim Ashri Iqbal Ismail Mochsen Isna Aulia Zamzamy Khalfia Abdan Firani Marindra Firmansyah Muhamad Hudaya Setio Utari Muhammad Sandy Ali Yafie Muhammad Zainul Fadli Nina Oktavia Noer Aini Nova Faisal Waber Nurma Alifia Rakhma Putri Lissanawidya Putri, Amanita Dias Ezha Reza Hakim Riza Ma’rufin Riza Ma’rufin Rizky Fajar Imam Asshiddiq Sasi Purwanti Shabrina Yasyfi Hanifati Wahyuni Dwi Permata Sari Wika Yuli Deakandi Yoni Rina Bintari Yulia Resty