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All Journal International Journal of Integrated Health Sciences Jurnal Anestesi Perioperatif Althea Medical Journal
Indra Wijaya
Departemen Anestesiologi Dan Terapi Intensif Fakultas Kedokteran Universitas Padjadjaran/RSUP Dr. Hasan Sadikin Bandung
Education Health Professions Medicine & Pharmacology

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Malnutrition in Non-Hodgkin Lymphoma Patients at Dr. Hasan Sadikin General Hospital Bandung Azizah Puspitasari Ardinal; Siska Wiramihardja; Indra Wijaya
Althea Medical Journal Vol 6, No 1 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (56.609 KB) | DOI: 10.15850/amj.v6n1.1521

Abstract

Background: Non-hodgkin lymphoma (NHL) has the highest prevalence among hematologic malignancies. The prognosis and response to therapy in NHL patients may worsen in the presence of malnutrition. The aim of the study was to describe the malnutrition status in NHL patients. Methods: This was a cross-sectional descriptive study. Nutritional status was assessed using Subjective Global Assessment (SGA) obtained from the medical records of all NHL patients at Dr. Hasan Sadikin General Hospital registered in 2017.Results: In total, there were 78 medical records of NHL patients that fulfilled the inclusion criteria. All NHL patients had experienced malnutrition, categorized as mild-moderate malnutrition (70.5%) and severe malnutrition (29.5%). In NHL patients with mild-moderate malnutrition, 29% had 5–10% weight loss; 60% had suboptimal solid diet; 56.4% experienced anorexia; and 50.9% had subcutaneous fat loss. In NHL patients with severe malnutrition, 78.3% had more than 10% weight loss; 73.9% had suboptimal solid diet; 78.3% experienced anorexia; and 100% had subcutaneous fat loss.Conclusions: Based on subjective assessment, all NHL patients were malnourished and experienced change of food intake and loss of subcutaneous fat, therefore, a better nutritional support scheme are crucial for NHL patients.
Global Longitudinal Strain of Chronic Granulocytic Leukemia Patients treated with Imatinib and Nilotinib Indra Wijaya; Arief Sumarna; Eliza Nurazizah; Evan Susandi; Erwan Martanto
International Journal of Integrated Health Sciences Vol 9, No 2 (2021)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v9n2.2217

Abstract

Objective: To determine left ventricular function of patients with Chronic Granulocytic Leukemia in Chronic Phase (CGL-CP) who received imatinib and nilotinib by using Global Longitudinal Strain (GLS) examination.Methods: This was a descriptive study involving 46 CGL-CP patients who received imatinib and nilotinib therapy at the Hemato-Oncology Clinic of the Internal Medicine Departement of Dr. Hasan Sadikin General Hospital,, Bandung, Indonesia. Sampling was performed consecutively during the period of October to December 2019. Variables assessed in this study were age, gender, BMI, length of treatment, hemoglobin level, Left Ventricular Ejection Fraction (LVEF) value, and Global Longitudinal Strain (GLS). Primary data were tested for normality  using the Saphiro-Wilk test. Statistical analysis was performed using SPSS software version 25.0.Results: Thirty-nine patients (seventeen males and twenty-two females with a mean age of 42±11) who had been in therapy for about 8 to 179 months at the time of the study were included as subjects. On average, the GLS results for both treatment groups indicated a normal value based on the classification of the American Society of Echocardiography. The imatinib group gained a score of -22.4% (average range = -16.4% to (-28.1%)), while the nilotinib group gained a score of -21.6% (average range = -18.0% to (-25.9%)). Conclusion: This study described the left ventricular function based on results of GLS in CGL-CP patients receiving imatinib and nilotinib.
Hiperkapnia Sebagai Prediktor Mortalitas Pasien COVID-19 di Ruang Rawat Intensif Indra Wijaya; Ezra Oktaliansah; M. Erias Erlangga; Iwan Fuadi; Erwin Pradian; Indriasari Indriasari
Jurnal Anestesi Perioperatif Vol 10, No 3 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15851/jap.v10n3.3048

Abstract

Virus SARS-CoV-2 menyebabkan penyakit pernapasan akut yang disebut COVID-19 dan menyebabkan pandemi global. Proses aktivasi trombosis intravaskular pada COVID-19 menyebabkan komplikasi trombosis mikrovaskular dan makrovaskular sehingga terjadi peningkatan ruang mati paru dan meningkatkan kadar PaCO2. Hiperkapnia menyebabkan banyak perubahan fisiologis dalam tubuh meliputi sirkulasi paru dan sistemik dan meningkatkan risiko mortalitas pasien ARDS. Penelitian ini bertujuan mengetahui apakah hiperkapnia merupakan prediktor mortalitas pasien COVID-19. Penelitian dilakukan berdasarkan data pasien pada periode Maret 2020–Desember 2021. Penelitian ini adalah penelitian analitik observasional dengan rancangan kohort retrospektif. Data PaCO2 pasien diambil saat hari pertama pasien dirawat di ICU RSUP Dr. Hasan Sadikin dan status mortalitas pasien di hari rawat ke-7 dan 28 hari. Analisis statistik yang digunakan adalah analisis bivariabel simple regression logistic. Hasil analisis statistik diperoleh nilai p< 0,05 dengan OR = 7,07 (CI 2,519–19,850) pada mortalitas hari ke-7, dan nilai p< 0,05 OR 44,33 (CI 9,182–214,062) pada mortalitas hari ke-28. Simpulan penelitian ini menunjukkan bahwa hiperkapnia merupakan prediktor mortalitas hari ke-7 dan ke-28 perawatan pada pasien COVID-19 yang dirawat di ruang rawat intensif isolasi.Hypercapnia as Mortality Predictor in COVID-19 PatientsThe SARS-CoV-2 virus causes COVID-19, an acute respiratory illness that caused a global pandemic. The activation of intravascular thrombosis in COVID-19 results in microvascular and macrovascular thrombosis complications, which increase lung dead space and PaCO2 levels. The hypercapnia condition causes many physiological changes in the body, including pulmonary and systemic circulation. It is known to increase the mortality risk in ARDS patients admitted to the Intensive Care Unit (ICU). This study aimed to determine if hypercapnia was a mortality predictor in COVID-19 patients treated in the isolation intensive care unit at Hasan Sadikin Hospital in Bandung. This observational analytic study used an observational analytic design with a retrospective cohort. The patient's PaCO2 data was collected on the first day of hospitalization in the ICU, and the patient's mortality status was collected on the 7th and 28th days of hospitalization. According to the statistical analysis, hypercapnia was associated with higher mortality, OR 7.07 (CI 2.519–19.850) on the 7th-day mortality and 44.33 (CI 9.182–214.062) on the 28th-day mortality, P value < 0.05. In conclusion, hypercapnia is a mortality predictor on the 7th and 28th days of treatment in COVID-19 patients treated in the isolation intensive care unit. 
Co-Authors Arief Sumarna Azizah Puspitasari Ardinal Eliza Nurazizah Erwan Martanto Erwin Pradian Evan Susandi Ezra Oktaliansah Indriasari Indriasari Iwan Fuadi M. Erias Erlangga Siska Wiramihardja, Siska