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All Journal Majalah Kedokteran Bandung Althea Medical Journal
Nucki Nursjamsi Hidajat, Nucki Nursjamsi
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung
Medicine & Pharmacology

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Profile of Hand Compartment Syndrome in Dr. Hasan Sadikin General Hospital, West Java, 2008−2012 Manogaran, Kajendaran; Hidajat, Nucki Nursjamsi; Soenggono, Arifin
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Althea Medical Journal

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Background: Compartment syndrome is a serious disorder caused by elevated pressure in a muscle compartment that can progress to muscle and nerve damage. This disorder can happen to anyone but more frequently in young adults. The occurrence frequency of hand compartment syndrome is relatively low. The aim of this study is to identify the profile of compartment syndrome in patients handMethods: A descriptive study was perfomed to 15 cases that were collected from medical records from 2008-2012, in Dr. Hasan Sadikin General Hospital. The profile of the case consisted of age, sex, symptoms and signs, etiology, facsiotomy schedule after admission, length of stay and patient’s outcome. The collected data were presented using tables.Results: The study showed that 12 out of 15 cases were males and 7 out of 15 cases were 20−39 years oldpatients. The common clinical findings were swelling, pain, limited range of motion and normal sensibility. The faciotomy procedure was conducted 1 day after the admission with length of stay more than 1 week. The patients condition were improved after operation. Conclusions: Hand compartment syndrome is a rare case, mostly affects younger adults and male. Most of the symptoms and signs are swelling, limitation of movement, pain in the location area with normal sensibility. The faciotomy procedure is conducted 1 day after admission. The length of stay is more than 1 week with an improved outcome. [AMJ.2015;2(4):497–501] DOI: 10.15850/amj.v2n4.634
Herniated Nucleus Pulposus in Dr. Hasan Sadikin General Hospital Bandung Indonesia Ikhsanawati, Annisa; Tiksnadi, Bambang; Soenggono, Arifin; Hidajat, Nucki Nursjamsi
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

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Background: Herniated nucleus pulposus (HNP) is one of the most common diseases of the spine. For an optimal management and prevention, there’s a need for data on factors related to the onset of complaints because this disease lowers the quality of life and increases morbidity. This study is aimed to see the scale and pattern of the HNP in Dr. Hasan Sadikin General Hospital, Bandung.Methods: This is a descriptive study with the design of case series, data was obtained from medical records of patients with the diagnosis of HNP in the inpatient care of Dr. Hasan Sadikin General Hospital in the period of 2007–2011.Results: According to the study on 79 patients, with 43 men and 36 women, the highest incidence was at the age group of 51–60 years old (31.6%) and most common occupation was civil servant (11.4%). The most common clinical symptoms were sciatica (51.9%) and low back pain (51.9%). Most frequent location was in the lumbar vertebrae at the level of L5–S1 (58.2%). Trauma was found to be the highest relatable history in the patients (39.2%). Therapy of choice was primarily conservative (58.2%) and most patients went home after the progression (84.8%). The year 2007 showed the highest prevalence of HNP at 25.3%. The most common clinical symptoms were sciatica (51.9%) and low back pain (51.9%)Conclusions: The most common clinical symptoms were sciatica and low back pain. Most frequent location was in the lumbar vertebrae at the level L5–S1. [AMJ.2015;2(1):179–85]
Femur Fracture Patient Characteristics in Dr. Hasan Sadikin General Hospital Bandung Indonesia January–December 2011 Firdaus, Mohamad; Hidajat, Nucki Nursjamsi; Murniati, Nani
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

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 Background: Femur fracture is one of the most common orthopedic cases which may occur in all age groups. Its incidence can be characterized by several aspects, such as patient’s age, sex, causes, location and many more. The aim of this study was to understand the characteristics of femur fracture patients in Dr. Hasan Sadikin General Hospital Bandung Indonesia during the period of January to December 2011.Methods: A descriptive study was conducted using 89 medical records of femur fracture patients in the Department of Orthopedic and Traumatology Dr. Hasan Sadikin General Hospital Bandung from January to December 2011. The inclusion criteria of the study were medical records containing patient aged 20-59 years data who were diagnosed with femur fracture, sex, cause of fracture, type of fracture, location of fracture, type of treatments given, and the length of hospitalization. Data were analyzed using frequency distribution.Results: Of 60 cases of motor vehicle accidents, there were more male (77.53%) than female who suffered from fracture. Closed fracture was more common with 52 cases of closed fracture compared to 29 cases of proximal fracture. Of 35 patients accepted treatment, 30 patients were treated by surgery  and hospitalized for 21–30 days.Conclusion: Young male adults are the most common group suffering from femur fracture. A continuous epidemiology study must be carried out on annual basis so that a better view of the incidence and the location of femur fracture as well as the type of treatment given to patients can be observed.Keywords: Adults, characteristics, femur fracture  DOI: 10.15850/amj.v2n1.428 
Histopathological Effects of Ageratum Leaf Extract (Ageratum Conyzoides) on Wound Healing Acceleration After Acute Excisional Wound on Epidermis in Type 2 Diabetes Mellitus Model of Sprague Dawley Rats (Rattus norvegicus) Yudhantoro, Liliek; Hidajat, Nucki Nursjamsi; Ismiarto, Yoyos Dias; Ismono, Darmadji
Majalah Kedokteran Bandung Vol 51, No 3 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v51n3.1652

Abstract

Diabetic wound healing problem often occurs if proper care is not given which will lead to the development of a chronic wound. Ageratum (Ageratum conyzoides L.) leaves is one of the most common plants in tropical areas, including Indonesia, which are frequently used in traditional treatment due to its anti-bacterial properties. This experimental study aimed to identify the effects of topical application of Ageratum leaf extract on wound healing based on histopathological examination of the reepithelization, ulceration, neovascularization, and the presence of inflammatory cells. This study was performed in the period of September to December 2017 at the Pharmacology and Pathology Anatomy laboratories of Dr. Hasan Sadikin General Hospital Bandung, Indonesia. Excisions were made on the back of the 36 rats that were divided into control and test groups. The test group then received a topical application of Ageratum leaf extract. The resulting histopathologic appearance of the wound was then examined. The test group showed better wound healing in all parameters inspected when compared to the control group. Mann-Whitney Test with 95% confidence interval (p<0.05) showed that the re-epithelialization, ulceration, neovascularization, and presence of inflammatory cells reflected a statistically significant improvement in the test group (p=0.319, p=0.290, p=0.251, and p=0.245, respectively). This study concludes that the topical application of Ageratum leaf extract has a statistically significant benefit on diabetic wound healing.Pengaruh Histopatologis Ekstrak Daun Ageratum (Ageratum Conyzoides) terhadap Akselerasi Penyembuhan Luka Setelah Luka Eksisi Akut pada Epidermis pada Model 2 Diabetes Mellitus Tikus Sprague Dawley (Rattus norvegicus) Luka diabetes sering menyebabkan luka kronik jika tidak mendapat penanganan yang tepat. Ageratum (Ageratum conyzoides) merupakan tanaman khas daerah tropis termasuk Indonesia, yang daunnya digunakan untuk pengobatan tradisional karena mengandung zat anti bakteri. Penelitian eksperimental ini menggunakan desain kelompok kontrol post-test untuk mengidentifikasi efek aplikasi topical dari ekstrak daun Ageratum pada penyembuhan luka dengan pemeriksaan histopatologis dari reepitelialisasi, ulserasi, neovaskularisasi, dan sel radang. Penelitian ini dilakukan antara September hingga Desember 2017 di laboratorium Farmakologi dan Patologi Anatomi Rumah Sakit Umum Dr. Hasan Sadikin Bandung. Eksisi dilakukan pada tiap-tiap tikus dari 36 tikus yang dibagi menjadi kelompok kontrol dan kelompok uji di mana kelompok uji dilakukan perawatan dengan ekstrak etanol daun ageratum secara topikal. Setelah diaplikasikan ekstrak daun Ageratum, luka diperiksa secara histopatologi. Observasi pada kelompok uji menunjukkan penyembuhan luka eksisional tikus diabetes yang lebih baik daripada kelompok control untuk semua parameter. Uji Mann-Whitney dengan interval kepercayaan 95% (p <0,05) menunjukkan bahwa nilai p untuk reepitelisasi, ulserasi, neovaskularisasi, dan sel radang adalah p=0,319, p=0,290, p=0,251, dan p=0,245. Aplikasi topikal dari ekstrak daun Ageratum memiliki manfaat pada penyembuhan luka diabetes dan hasilnya signifikan secara statistik. 
POTENSI FRAKSINASI SARANG SEMUT PAPUA (MYRMECODIA PENDANS) PADA PENURUNAN TNF-α DAN PERBAIKAN SECARA HISTOPATOLOGI KARTILAGO OSTEOARTRITIS LUTUT KELINCI Hidajat, Nucki Nursjamsi; Mulyadi, Dicky; Tandjung, Fachry A.; Sulaeman, Asep
Majalah Kedokteran Bandung Vol 50, No 3 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v50n3.1320

Abstract

Reaksi seluler kondrosit osteoartritis pada lutut ditandai dengan peningkatan sitokin tumor necrosis factor-? (TNF-?).TNF-? mengaktifkan fibroblas dan makrofag sinovial untuk menyekresi enzim degradasi dan menekan sintesis proteoglikan rawan sendi sehingga memberikan gambaran histopatologik kartilago yang mengalami perubahan. Osteoartritis sekunder terjadi akibat trauma sendi yang menyebabkan nyeri. Terapi obat seperti non-steroidal anti-inflammatory drugs (NSAIDs) yang digunakan menyebabkan efek samping merugikan jika digunakan dalam jangka panjang. Fraksinasi sarang semut papua (Myrmecodia pendans) diketahui memiliki kandungan salah satunya flavonoid yang berfungsi sebagai anti-inflamasi, antioksidan dan pelindung sel. Berdasar hal tersebut maka ingin diketahui potensi fraksinasi sarang semut papua pada osteoartritis kartilago lutut kelinci dalam menghambat enzim proinflamasi, yaitu TNF-? dan memberikan perbaikan secara histopatologik dibanding dengan kontrol. Penelitian menggunakan uji eksperimental hewan dengan desain experimental comparative menggunakan 8 kelinci ras New Zealand yang dibagi menjadi 2 kelompok, yaitu kelompok kontrol dan kelompok yang diberikan fraksinasi sarang semut papua dengan dosis 2,5 mg/kgBB intra-artikular. Kemudian dilakukan pengukuran kadar TNF-? dan skoring secara histopatologik. Penelitian dilakukan di Fakultas Kedokteran, Universitas Padjadjaran periode Februari-Maret 2017. Pada Uji-t tidak berpasangan untuk TNF-? didapatkan nilai p=0,011; Uji Mann Whitney untuk skoring histopatologik dengan nilai p=0,034 pada kelompok yang diberian fraksinasi sarang semut papua. Terdapat penurunan TNF-? dan perbaikan secara histopatologik pada kartilago osteoartritis lutut kelinci yang diberikan fraksinasi sarang semut papua.Potential of Fractionated Papuan Ant Nest (Myrmecodia Pendans) to Decrease TNF-? and Improve Osteoarthritis Cartilage Histopathological Features in Rabbits Knee Condrocyte cellular reaction in knee with osteoarthritis is characterized by increased tumor necrosis factor-? (TNF-?) cytokine level. TNF-? activates fibroblasts and synovial macrophages to secrete degradation enzymes and supress cartilage proteoglycan synthesis, leading to histopathological changes in cartilages. Secondary osteoarthritis is triggered by a joint trauma that leads to pain. Long term drug therapy, such as non-steroidal anti-inflammatory drugs (NSAIDs), will lead to adverse effects. Fractionated Papuan ant nest (Myrmecodia Pendans) is known as containing flavonoid that plays a role as anti-inflamatory agent, antioxidang, and cell protector. This study aimed to identify the potential of fractionated Papuan ant nest to inhibit pro-inflamatory enzyme, i.e. TNF-?, and improve the histopathological features in rabbit knee cartilage with osteoarthritis. This was a comparative animal experiment on 8 New Zeland rabbits that were divided into 2 groups: control group and treatment group conducted at the Faculty of Medicine, Universitas Padjadjaran, in February-March 2017. The treatment group received 2.5 mm/kgBW fractionated Papuan ant nest as treatment. Measurement was then performed on TNF-? level and histopathological scoring. Statitical analysis was performed using unpaired t-test for TNF-? and Mann Whitney test for histopathological scoring. The results showed that the p-values for TNF-? and histopathological scoring were 0.011 and 0.034, respectively, in the group receiving fractionated Papuan ant nest. Reduction of TNF-? level and histopathological improvement are found in rabbit knee cartilage with arthritis when fractionated Papuan ant nest is given.  
Co-Authors Annisa Ikhsanawati, Annisa Arifin Soenggono, Arifin Asep Sulaeman, Asep Bambang Tiksnadi Darmadji Ismono, Darmadji Dicky Mulyadi Kajendaran Manogaran, Kajendaran Mohamad Firdaus, Mohamad Nani Murniati Tandjung, Fachry A. Yoyos Dias Ismiarto Yudhantoro, Liliek