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All Journal Althea Medical Journal Neurona
Wulantika Nurhayati, Wulantika
Unknown Affiliation
Health Professions Medicine & Pharmacology Neuroscience

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Anti-inflammatory Effect of Trigona spp. Propolis in Restricting Edema Volume Nurhayati, Wulantika; Dewi, Vycke Yunivita Kusumah; Djajakusumah, Teguh Marfen
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (729.705 KB)

Abstract

  Background: Inflammation is a normal response that potentially harmful if it is uncontrolled. On the other hand, it is necessary to find an alternative anti-inflammatory as most anti-inflammatory drugs available nowadays still have adverse effects. Trigona spp. propolis is one of the potential anti-inflammatory alternatives because of its flavonoid, especially caffeic acid phenethyl ester, which is known as an active compound in anti-inflammatory process. This study aimed to understand the anti-inflammatory effect of Trigona spp. prolisin reducing edema volume in rat’s paw.Methods: An experimental study was performed on 20 male wistar rats. The rats were divided into control and experimental groups with 10 rats in each group. Control group was treated by propylene glycol 1 ml/day and experimental group was treated by Trigona spp. propolis 200 mg/kg body weight/day. The inflammation was induced by subcutaneous injection of λ-carrageenan 1% at plantar one hour after the treatment. Edema volumes were measured by plethysmometer every hour at 1 to 6 hours and once at 24 hours after induction. The difference in edema volumes was calculated in percentage. This study was conducted during October 2012 at the Pharmacology and Therapy Laboratory, Faculty of Medicine, Universitas Padjadjaran Bandung.Results: The increase of edema volume (in percentage) in control group and Trigona spp. propolis treated group are 100.64±32.22 and 56.46±20.38 respectively (p value=0.000). Multiple comparisons using Dunnet and Duncan post hoc test showed significant differences that were observed at 3, 4, 5, and 6 hours after inflammatory induction.Conclusion: Trigona spp. propolis has an anti-inflammatory effect in reducing edema volume in rat’s paw. The most significant effect was observed at 3, 4, 5, and 6 hours after inflammatory induction. Trigona spp. propolis might have a potential to be developed as a future anti-inflammatory drug.Keywords: Edema volume, inflammation, propylene glycol, Trigona spp, propolisDOI: 10.15850/amj.v2n1.440 
PERBEDAAN LUARAN MOTORIK PASIEN SINDROMA GUILLAIN BARRE DENGAN TERAPI IVIG DAN PLASMAFERESIS Nurhayati, Wulantika
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 2 (2025): Vol 41 No 2 (2025): Volume 41, No 2 - Maret 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i2.744

Abstract

ABSTRACT Introduction Guillain-Barré syndrome (GBS) is an acute autoimmune polyneuropathy characterized by progressive motor weakness and potentially fatal complications. In severe cases (disability scale ≥3), the standard immunotherapies are intravenous immunoglobulin (IVIg) and plasmapheresis. Studies on populations dominated by demyelinating subtype reported equal efficacy between both treatments, whereas studies on the axonal subtype indicated better motor outcomes with IVIg. However, to the best of our knowledge, such research has not been conducted in Indonesia. Aim To evaluate the difference motor outcomes between GBS patients treated with IVIg and plasmapheresis. Methods A retrospective cross-sectional study was performed using medical records of adult GBS patients admitted between November 2020 and September 2024. Clinical characteristics and Medical Research Council (MRC) motor scores at admission and discharge were analyzed. Motor outcome was categorized as “good” (MRC ≥36) or “poor” (MRC <36). Results Among 141 GBS patients, 12 received IVIg and 47 underwent plasmapheresis, and the rest were given supportive therapy and roborantia. The largest proportion was axonal subtype (43,3%). The proportion of good motor outcomes was higher in the IVIg group (83.3%) compared to the plasmapheresis group (59.6%), although this was not statistically significant (p>0.05). Lower initial MRC scores and higher mEGOS and EGRIS scores were associated with poorer outcomes. Discussion IVIg tends to yield better motor outcomes, particularly in GBS axonal subtype. Early identification of GBS subtype is beneficial for treatment decision. Bigger sample sizes and prospective studies are needed to confirm these results. Keywords Guillain-Barré Syndrome, IVIg, Motor Outcome, MRC Score, Plasmapheresis
Co-Authors Teguh Marfen Djajakusumah, Teguh Marfen Vycke Yunivita Kusumah Dewi