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All Journal Majalah Kedokteran Bandung Althea Medical Journal
Teguh Marfen Djajakusumah, Teguh Marfen
Department of Surgery, Faculty of Medicine, Universitas Padjadjran, Dr.Hasan Sadikin General Hospital, Bandung
Medicine & Pharmacology

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Anti-inflammatory Effect of Trigona spp. Propolis in Restricting Edema Volume Nurhayati, Wulantika; Dewi, Vycke Yunivita Kusumah; Djajakusumah, Teguh Marfen
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

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Abstract

  Background: Inflammation is a normal response that potentially harmful if it is uncontrolled. On the other hand, it is necessary to find an alternative anti-inflammatory as most anti-inflammatory drugs available nowadays still have adverse effects. Trigona spp. propolis is one of the potential anti-inflammatory alternatives because of its flavonoid, especially caffeic acid phenethyl ester, which is known as an active compound in anti-inflammatory process. This study aimed to understand the anti-inflammatory effect of Trigona spp. prolisin reducing edema volume in rat’s paw.Methods: An experimental study was performed on 20 male wistar rats. The rats were divided into control and experimental groups with 10 rats in each group. Control group was treated by propylene glycol 1 ml/day and experimental group was treated by Trigona spp. propolis 200 mg/kg body weight/day. The inflammation was induced by subcutaneous injection of λ-carrageenan 1% at plantar one hour after the treatment. Edema volumes were measured by plethysmometer every hour at 1 to 6 hours and once at 24 hours after induction. The difference in edema volumes was calculated in percentage. This study was conducted during October 2012 at the Pharmacology and Therapy Laboratory, Faculty of Medicine, Universitas Padjadjaran Bandung.Results: The increase of edema volume (in percentage) in control group and Trigona spp. propolis treated group are 100.64±32.22 and 56.46±20.38 respectively (p value=0.000). Multiple comparisons using Dunnet and Duncan post hoc test showed significant differences that were observed at 3, 4, 5, and 6 hours after inflammatory induction.Conclusion: Trigona spp. propolis has an anti-inflammatory effect in reducing edema volume in rat’s paw. The most significant effect was observed at 3, 4, 5, and 6 hours after inflammatory induction. Trigona spp. propolis might have a potential to be developed as a future anti-inflammatory drug.Keywords: Edema volume, inflammation, propylene glycol, Trigona spp, propolisDOI: 10.15850/amj.v2n1.440 
Frequency of Chronic Venous Disease among Nurses Martanegara, Cendy; Ekowati, RA Retno; Djajakusumah, Teguh Marfen
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

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 Background: Chronic vein diseases are quite common and its prevalence is also quite high in community. One of the risk factors is occupation with prolonged standing. Quality of life and work efficacy may become risk factors. This disease has not received any special consideration and response. Methods: This is a cross-sectional study performed on nurses working in Dr. Hasan Sadikin General Hospital Bandung (n=98; women=76, men=22). The study was conducted in November 2012 through collecting data on prevalence, risk factors, and clinical symptoms by using questionnaire. Chronic venous disease was observed by direct inspection in lower extremities. Diagnosis was concluded according to the Clinical Etiology Anatomy Pathophysiological criteria. Results: There was a high frequency, i.e. 86.7% (n=71), of chronic venous disease among nurses, with the age group of 20–29 years old (34.1%) as the age group that was mostly affected. Among female nurses, almost all of them experienced the disease (93.4%; n=71). Clinical symptoms felt by most nurses were heavy feeling on legs (82.3%) and cramps (55.3%).Conclusion: The frequency of chronic venous disease among nurses is high, 86.7% and almost all of the female nurses suffer from the disease. The high frequency in females could be caused by risk factors such as parity and hormonal contraception. Those who are mostly affected by the disease are  within range of age 20–29 years old of age. Heavy legs and cramps are the most frequent clinical symptoms felt. Keywords: Chronic vein disease, frequency, nursesDOI: 10.15850/amj.v2n1.432   
Peripheral Arterial Disease among Diabetic Patients in Dr. Hasan Sadikin General Hospital Bandung 2012 Azkiyah, Feriska Fairuz; Djajakusumah, Teguh Marfen; Ekowati, RA. Retno
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

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Abstract

Background: As one of the most devastating complication in diabetes mellitus, peripheral arterial disease is still under detected in health care services. This study aimed to reveal the frequency of peripheral arterial disease in diabetic patients in Endocrine and Metabolism Clinic in Dr. Hasan Sadikin General Hospital Bandung.Methods: A cross sectional descriptive study was conducted during the period of October to November 2012 in Endocrine and Metabolism Clinic in Dr. Hasan Sadikin General Hospital Bandung. As many as 54 patients who met the inclusion criteria and agreed to participate in this study signed the informed consent form then underwent history taking, simple physical examination of lower extremities, and Ankle-Brachial Index (ABI) measurement. Normality of the data distribution was calculated by Kolmogorov-Smirnov test.Results: From a total 54 diabetic patients enrolled, it was found 18 cases of peripheral arterial disease, consisted of 10 patients with Ankle-Brachial Index measurement ≤0.9 and 8 patients with Ankle-Brachial Index measurement >1.4. Most of the cases occurred in the elderly group (>60 years old) and had been diagnosed diabetes less than 10 years.Conclusions: The frequency of peripheral arterial disease in diabetic patients attended Dr. Hasan Sadikin General Hospital Bandung is 33.3% and more prevalent in elderly patients. It occurred mostly in patients diagnosed with diabetes less than 10 years. [AMJ.2015;2(1):287–90]
Public Opinion Regarding Information on Porcine-Contained Medications Wibowo, Anindhita Paramita; Syukriani, Yoni Fuadah; Djajakusumah, Teguh Marfen
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Althea Medical Journal

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Abstract

Background: Drugs are biological products, a single or combination of active and additives components. Some additional components are derived from porcine, a substance that is haraam for Muslims. Patient’s rights, such as medication information, are substantial in decision-making process. Medical decision-making in the Eastern culture is not only the patient’s affair, but also family’s interest. This study aimed to determine the public opinion on that matter. Methods: This study was conducted in October–November 2014 using qualitative methods. Data collection was performed in the District of Jatinangor, Sumedang Regency by using the purposive sampling method. Six respondents were selected. Data were collected through in-depth interview techniques and were analyzed using content analysis technique.Results: There were 3 main responses regarding the respondent’s opinions. First, respondents showed several attitudes toward drugs in general and also several attitudes toward porcine-contained drugs. Respondents showed concern for the medications used and wished either to be informed or not about the prohibited substance in the drugs. The decision-making process of respondents was performed by each individual or family, with the guidance of religious scholars. In a doctor-patient relationship, the doctors should be more active in providing information on the medications and the opportunity for patients to choose drugs. Respondents also had a high dependency to the physicians in making medical decisions.Conclusions: Public opinion on patient’s rights regarding porcine-contained drugs shows the people’s attitude towards drugs in general and porcine-contained drugs in particular, the decision-making process and the relationship between physicians and patients. 
Accuracy of Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score System as An Early Diagnostic Predictor of Necrotizing Fasciitis in A Tertiary Referral Hospital in Bandung, Indonesia Djajakusumah, Teguh Marfen; Septrina, Rani; Dwinanda, Arief
Althea Medical Journal Vol 11, No 3 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n3.3341

Abstract

Background: Necrotizing fasciitis (NF) is a serious infection that can rapidly kill tissue and potentially lead to multiple organ failure. Early diagnosis and treatment are essential for survival. The laboratory risk indicator for necrotizing fasciitis (LRINEC) score may aid in early detection of NF. Although initially promising, studies on the effectiveness of LRINEC have shown mixed results. This study aimed to investigate the accuracy of LRINEC in predicting NF.Methods: This was an observational prospective cohort study, including patients with NF as well as skin and soft tissue infection (SSTI) who were treated at a tertiary referral hospital in Bandung, Indonesia in 2022. The LRINEC scores was calculated to measure sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). The accuracy of LRINEC scores was specified in the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. Results: Of the total 70 patients, 33 were diagnosed with NF and 37 with SSTI. The LRINEC score with ≥6 points cut-off showed a sensitivity of 90.9% (95%CI; 75.67–98.08%), specificity of 75.60% (95%CI; 58.80–88.23%), PPV of 76.9% (95%CI; 60.67–88.87%), and NPV 90.30% (95%CI; 74.25–97.96%). The area under the ROC (AUROC) curve for the accuracy of the LRINEC scores was 0.895 (95%CI; 0.821–0.969).Conclusions: The laboratory risk indicator for necrotizing fasciitis (LRINEC) score is an accurate predictor and feasible early diagnostic indicator in NF. However, clinical judgment remains a crucial factor in diagnosing NF.
Histopathological Aspects as Predictor of Recurrency of Locally Advanced Breast Cancer Rizki, Kiki Akhmad; Djajakusumah, Teguh Marfen; Agustina, Hasrayati; Hidayat, Peri
Majalah Kedokteran Bandung Vol 56, No 2 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3193

Abstract

The histopathological aspect of breast cancer has been established as one of the important prognostic factors of recurrence. This study aimed to determine whether histopathological examination can be used as a predictor of the incidence of recurrence in locally advanced breast cancer patients. This was a cohort retrospective observational study with a correlative analytical approach. Subjects of this study were breast cancer patients who have undergone mastectomy and/or received additional therapy at Dr. Hasan Sadikin General Hospital Bandung, Indonesia, between January 2017 and September 2019. Data were collected through medical records and anatomical histopathology data. Subjects were divided based on their recurrency status. A total of 62 breast cancer patients were included in the study with 31 recurrent patients and 31 non-recurrent patients. A total of 29 patients in the recurrent group (93.5%) had lymphovascular invasion. Histopathology grading showed a difference in both groups, in which recurrent group patients were mostly (74.2%) in the high histopathological grade while 51.6% of samples in non-recurrent group were categorized as moderate histopathological grade. Complete histopathological margins were found in both recurrent and non-recurrent groups for 54.8% and 87.1% respectively. There is a correlation between histopathologic grading, lymphovascular invasion, and incision margin with the recurrence of a locally advanced stage breast cancer. It can be concluded that some histopathological aspects can be used as a predictor of recurrence in locally advanced breast cancer.
Correlation between Duration of Placement of Non-tunneled Hemodialysis Catheter and Positive Bacterial Culture Incidence in Hemodialysis Patients Djajakusumah, Teguh Marfen; Hapsari, Putie; Yarman, Indra Prasetya; Utomo, Hafidh Seno Radi; Lukman, Kiki; Sulastri, Dian; Ulurrosyad, Muhammad Faiz
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3042

Abstract

Non-tunneling hemodialysis catheter is one of the most convenient vascular accesses for hemodialysis in End Stage Kidney Disease (ESRD) patients. However, these catheters have the highest morbidity among all available accesses. Current guidelines recommend that non-tunneled hemodialysis catheters be placed for no more than 2 weeks to prevent bacterial contamination. This study was conducted in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, throughout January-December 2021. A correlation test with a prospective observational analysis design was applied to find the link between the duration of non-tunneled hemodialysis catheter placement and the incidence of positive bacterial culture on the catheter. Pearson correlation test was used to see the strength of the correlation, with a significance limit of 0.05. This study involved 28 subjects. The most common location for catheter placement was in the jugular vein, and laboratory examinations showed no correlation between leukocyte values and positive bacterial culture results. Hypertension and diabetes mellitus were not significant risk factors (p-value 0.887). At ≤14 days of catheter placement, only 1 (6.7%) of the subjects presented a positive culture result. Most of the positive bacterial culture results were found at a duration of 15-30 days of placement, (n=8; 53.3%). The results of the Pearson test showed a p-value of 0.036 and an r-value of 0.399, indicating a significant result with a strong correlation between the two variables. The duration of placement of hemodialysis catheters has a positive correlation with the incidence of positive bacterial cultures, which can increase the risk of systemic infection associated with hemodialysis catheters.
Traumatic Brain Injury and Covid-19 Tinambunan, Nicholas Christian; Faried, Ahmad; Djajakusumah, Teguh Marfen; Yohana, Raden; Rizki, Kiki Ahmad; Sobana, Mirna
Majalah Kedokteran Bandung Vol 56, No 2 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3229

Abstract

Head trauma is a head injury caused by external forces in the head or body that results in disruption of the normal functioning of the brain. According to the CDC, deaths from head injuries were about 60,000 in 2016, and rose to more than 61,000 in 2017. The COVID-19 pandemic had caused poor non-COVID patient care, especially in low- and lower-middle-income countries with limited access to health facilities, resulting in increased morbidity and mortality, including among patients with head injuries. The purpose of this study was to understand the characteristics, duration of hospital stay, and difference of time to surgery interval in Traumatic Brain Injury patients in Dr. Hasan Sadikin General Hospital Bandung before and during the COVID-19 pandemic. This study was performed through analytical methods with a cross-sectional study design using analysis of medical records of head trauma patients treated in Dr. Hasan Sadikin General Hospital Bandung, Indonesia in the period before the pandemic (February 2018-February 2020) and during the pandemic (March 2020 - September 2021). Data analysis showed significant differences in length of hospitalization and operating intervals before and during the pandemic (p=0.04 and p=0.03), showing that there are differences in interval operation and duration of stay between patients with head trauma before the pandemic and during the pandemic.
Neutrophil Lymphocyte Ratio and Mortality in Patients with Acute Limb Ischemia Hapsari, Putie; Djajakusumah, Teguh Marfen; Nugroho, Hendri Bayu
Majalah Kedokteran Bandung Vol 57, No 1 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3848

Abstract

Acute Limb Ischemia (ALI) is a sudden decrease in limb perfusion with a potential of limb loss and is an indication for immediate vascular intervention. Apart from reducing the quality of life, the mortality rate in ALI is reported to be high, i.e., around 40%. Neutrophil Lymphocyte Ratio (NLR) can be used to reflect the inflammatory process in this condition. This study aimed to assess the correlation of NLR to mortality rate in ALI Rutherford Category III patients treated in Dr. Hasan Sadikin General Hospital Bandung, Indonesia. This was a cross-sectional analytical observative retrospective study on data collected from medical records of ALI Rutherford Category III patients treated in the hospital from 2019 to 2022. Sampling was performed consecutively and data were processed using the SPSS with univariate analysis and bivariate analysis using Kendall's tau b analysis test. Results demonstrated that of a total of 46 patients, the majority were female patients (n=31) and 28 patients died. The mean NLR levels in patients who survived was 5.8, in contrast with 9.7 observed among those who died. The statistical test results showed a significant correlation between the NLR and mortality rate of ALI Rutherford category III patients (p
Correlation of Nutritional Status, HbA1c, and Duration of Diabetes Mellitus with Amputation Incidence in Patients with Diabetic Foot Ulcers Hapsari, Putie; Kharisma, Surti Wulan; Yarman, Indra Prasetya; Faried, Ahmad; Djajakusumah, Teguh Marfen; Maryani, Euis
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4094

Abstract

Diabetic foot ulcer (DFU) is a severe complication of diabetes that significantly impairs quality of life and  may often lead to amputation, particularly when infections become extensive. This study investigated the correlation of nutritional status, HbA1c levels, and duration of diabetes exposure with the incidence of amputation in DFU patients. Using an observational analytic study with a retrospective cohort design, data from 47 DFU patients treated at the Vascular and Endovascular Surgery clinic and Emergency Room  of a hospital from 2019-2024 were analyzed. The majority of subjects were men aged 40-60 years (59.57%). Among the amputee group, 55.31% experienced neuropathy, primarily classified as Wagner's degree 4. Patients requiring amputation had significantly higher levels of urea, creatinine, and leukocytes compared to those who did not. A significant correlation was observed between the incidence of amputation and nutritional status—specifically, serum albumin (r=-0.616) and Body Mass Index (BMI) (r=0.823)—as well as HbA1c levels (r=0.806) and duration of diabetes exposure (r=0.445) (p<0.05). However, the Subjective Global Assessment (SGA) did not show a significant relationship with amputation incidence. The findings of this study suggest that nutritional status, HbA1c levels, and duration of diabetes exposure are significantly correlated with the likelihood of amputation in patients with diabetic foot ulcers (DFU).
Co-Authors Ahmad Faried Cendy Martanegara, Cendy Dwinanda, Arief Feriska Fairuz Azkiyah, Feriska Fairuz Hapsari, Putie Hasrayati Agustina Hidayat, Peri Kharisma, Surti Wulan Kiki Akhmad Rizki, Kiki Akhmad Kiki Lukman Maryani, Euis Nugroho, Hendri Bayu Raden Yohana, Raden Rani Septrina Retno Ekowati Rizki, Kiki Ahmad Sobana, Mirna Sulastri, Dian Tinambunan, Nicholas Christian Ulurrosyad, Muhammad Faiz Utomo, Hafidh Seno Radi Vycke Yunivita Kusumah Dewi Wibowo, Anindhita Paramita Wulantika Nurhayati, Wulantika Yarman, Indra Prasetya Yoni Fuadah Syukriani