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Hertanto W Subagio, Hertanto W
Fakultas Kedokteran Universitas Diponegoro
Health Professions

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Determinan kejadian stunting pada bayi usia 6 bulan di Kota Semarang Mustikaningrum, Ardian Candra; Subagio, Hertanto W; Margawati, Ani
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 4, No 2 (2016)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.003 KB) | DOI: 10.14710/jgi.4.2.82-88

Abstract

Background: Stunting is an indicator of chronic nutrition problems. Districts with the highest prevalence of stunting is the District Gunungpati (16,93%), Mijen (13,75%), and Tembalang (10,11%). The prevalence of stunting are more difficult to overcome with increasing age there should be a study to determine the incidence of stunting the determinant.Objective: To identify determinants of stunting in infants aged 6 months in the city of Semarang.Methods: case-control study, composed of 91 infants stunting and 91 normal infants. The sample selection using purposive sampling. Determinants studied were low birth weight, exclusive breastfeeding, complementary feeding Giving early, the incidence of diarrhea, ISPA, the allocation of parenting time mother, maternal height, maternal education, family economic level, and head circumference. The research instrument with a questionnaire, digital baby scales, infantometer, and metline. Data were analyzed with the value of odds ratios  and multiple logistic regression.Results:The proportion of stunting was 39.6% in male babies and 60.4% in girls. Result of bivariate are low birth weight, the incidence of diarrhea, ISPA, maternal education, and family economic level association with stunting, but result in multivariate determinant incidence of stunting is the family's economic level (OR = 5,39, 95% CI = 2,73; 10,63, p<0,001), the incidence of acute respiratory infection (OR = 2,29, 95% CI = 1,16; 4,51, p=0,016). The family's economic level, the incidence of acute respiratory infection, and the incident of diarrhea contribute to stunting by 30%..Conclusion: The main determinants of stunting in infants 6 months is the  family’seconomic level.
Efek pemberian Chlorophyllin terhadap kadar nitric oxide dan malondialdehida tikus hiperkolesterolemia Pontang, Galeh S; Johan, Andrew; Subagio, Hertanto W
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 3, No 1 (2014)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (495.158 KB) | DOI: 10.14710/jgi.3.1.115-120

Abstract

Background : Endothelial dysfunction is well-known as an early stage of atherosclerosis. Increased oxidative stress inhypercholesterolemia triggers endothelial dysfunction that is characterized by decreased biological availability ofnitric oxide (NO). Experimental studies showed that chlorophyllin had an effective antioxidant activity.Objectives : To determine the effect of chlorophyllin on nitric oxide (NO) and malondialdehyde (MDA) level ofhypercholesterolemic rats.Methods : Post test only randomized control groupusedtwenty four male Sprague Dawley rats were randomly dividedinto four groups: without treatment (technical control/K1), hypercholesterolemic (negative control/K2),hypercholesterolemic with chlorophyllin at dose of 1,8 mg/200 g/d (P1) and hypercholesterolemic with chlorophyllin atdose of 3,34 mg/200g/d (P2). Chlorophyllin was dissolved in water and was given via nasogastric tube for 21 days afterthe rats got hypercholesterolemia. Total cholesterol level of blood was measured by CHOD-PAP method, level of NOplasma was measured by Griess reaction and level of MDA plasma was measured by TBARS method. Hypothesis testwas analyzed by One Way Anova continued by Post hoc LSD test and Kruskall Wallis by significant level of 0,05.Results :NO plasma level was the lowest in group P2 (0.203+0.015 μM) and the highest in the group K2 (0,224±0,001μM), but no difference of NO plasma level among groups (p = 0.118). There were differences in MDA plasma levelamong the groups (p = 0.001). P1 and P2 groups had lower MDA plasma level than K2 (2.40+0.11 nmol/ml), indicatedby (1.94 +0.07 nmol/ml, p=0.0001) and (1,37 +0.13 nmol/ml, p=0.0001) respectively, but still higher than K1(0.94+0.05 nmol/ml, p=0.0001).Conclusion : The treatment of chlrophyllin does not have an effect of NO plasma level, but gives an effect of lowerMDA plasma level.
Co-Authors Andrew Johan Ani Margawati Ardian Candra Mustikaningrum Galeh S Pontang, Galeh S