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All Journal Padjadjaran Journal of Dentistry
Harum Sasanti, Harum
Department of Oral Medicine, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Herpes Labialis and Oral Candidiasis in HIV-infected intravenous drug users with poor hematologic status Sufiawati, Irna; Sasanti, Harum
Padjadjaran Journal of Dentistry Vol 20, No 3 (2008): November
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1479.773 KB) | DOI: 10.24198/pjd.vol20no3.14125

Abstract

Hematologic abnormalities are common in HIV-infected patient, particularly in individuals with more advanced HIV disease. Hematologic abnormalities and their association with HIV-associated oral lesions had been reported. Intravenous drug use has been associated with increased oral lesions too. We reported a case of oral lesions in a 24 years old man HIV-infected intravenous drug users. Poor hematologic status is a risk factor of Oral Candidiasis in HIV-infected person with clinical features appear generally. But the clinical feature of Herpes Labialis is not usually because of his poor hematologic status. It’s concluded that poor hematologic status and transmission of HIV through contaminated needlestick are the high-risk factors of oral lesions and appear not usually clinical features in ODHA. Correction of these hematologic abnormalities and appropriately management of oral lesions can minimize the severity and increase the better quality of life patient.
Correlation between saliva IgA level and T cell CD4+ in HIV/AIDS patients Sufiawati, Irna; Sasanti, Harum; Djauzi, Samsuridjal
Padjadjaran Journal of Dentistry Vol 19, No 2 (2007): July
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (322.211 KB) | DOI: 10.24198/pjd.vol19no2.14169

Abstract

Background: HIV infection appears to have direct effects on oral mucosal immunity, cellular and humoral. Antibody secretion, especially salivary immunoglobulin A (IgA), is a useful indicator of mucosal immune function. This immune system component is recognized as an important first-line of defence against pathogens which colonize and invade mucosal surfaces in the oral cavity. Objectives: The purpose of this study was to investigate salivary IgA levels and to determine its correlation with CD4+ T-cell counts among HIV-infected patients in Pokdisus AIDS Cipto Mangunkusomo Hospital Jakarta. Methods: The design study was using a cross-sectional study. Whole paraffin-wax-stimulated saliva was collected from 103 HIV-infected patients and 30 healthy individuals. Saliva was collected using the spitting method. Salivary IgA levels were determined by the immunoturbidimetry method using the Behring Turbitimer Analyser. CD4+ T-cell counts were analyzed by flow cytometry. Results: Salivary IgA levels were 141.55 ± 83.23 (HIV group) and 97.24 ± 38.25 (healthy individuals). The Mann-Whitney U test showed salivary IgA levels were significantly higher in HIV/AIDS subjects compared with healthy individuals (p<0.1). Most of the subject has severe immunosuppression with CD4+ T-cell counts <200 cell/mm.3 Pearson’s correlation test between CD4+ T-cell counts and salivary IgA levels showed no significant correlation (r= 0.06, p>0.1). Conclusion: This study indicates that total salivary IgA levels were significantly higher in the HIV-infected patients compared to control, and salivary IgA level seems not to be related significantly to CD4+ T-cell counts.
Correlation between saliva IgA level and T cell CD4+ in HIV/AIDS patients Sufiawati, Irna; Sasanti, Harum; Djauzi, Samsuridjal
Padjadjaran Journal of Dentistry Vol 19, No 2 (2007): July 2007
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (322.211 KB) | DOI: 10.24198/pjd.vol19no2.14169

Abstract

Background: HIV infection appears to have direct effects on oral mucosal immunity, cellular and humoral. Antibody secretion, especially salivary immunoglobulin A (IgA), is a useful indicator of mucosal immune function. This immune system component is recognized as an important first-line of defence against pathogens which colonize and invade mucosal surfaces in the oral cavity. Objectives: The purpose of this study was to investigate salivary IgA levels and to determine its correlation with CD4+ T-cell counts among HIV-infected patients in Pokdisus AIDS Cipto Mangunkusomo Hospital Jakarta. Methods: The design study was using a cross-sectional study. Whole paraffin-wax-stimulated saliva was collected from 103 HIV-infected patients and 30 healthy individuals. Saliva was collected using the spitting method. Salivary IgA levels were determined by the immunoturbidimetry method using the Behring Turbitimer Analyser. CD4+ T-cell counts were analyzed by flow cytometry. Results: Salivary IgA levels were 141.55 ± 83.23 (HIV group) and 97.24 ± 38.25 (healthy individuals). The Mann-Whitney U test showed salivary IgA levels were significantly higher in HIV/AIDS subjects compared with healthy individuals (p<0.1). Most of the subject has severe immunosuppression with CD4+ T-cell counts <200 cell/mm.3 Pearson’s correlation test between CD4+ T-cell counts and salivary IgA levels showed no significant correlation (r= 0.06, p>0.1). Conclusion: This study indicates that total salivary IgA levels were significantly higher in the HIV-infected patients compared to control, and salivary IgA level seems not to be related significantly to CD4+ T-cell counts.
Herpes Labialis and Oral Candidiasis in HIV-infected intravenous drug users with poor hematologic status Sufiawati, Irna; Sasanti, Harum
Padjadjaran Journal of Dentistry Vol 20, No 3 (2008): November 2008
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1479.773 KB) | DOI: 10.24198/pjd.vol20no3.14125

Abstract

Hematologic abnormalities are common in HIV-infected patient, particularly in individuals with more advanced HIV disease. Hematologic abnormalities and their association with HIV-associated oral lesions had been reported. Intravenous drug use has been associated with increased oral lesions too. We reported a case of oral lesions in a 24 years old man HIV-infected intravenous drug users. Poor hematologic status is a risk factor of Oral Candidiasis in HIV-infected person with clinical features appear generally. But the clinical feature of Herpes Labialis is not usually because of his poor hematologic status. It’s concluded that poor hematologic status and transmission of HIV through contaminated needlestick are the high-risk factors of oral lesions and appear not usually clinical features in ODHA. Correction of these hematologic abnormalities and appropriately management of oral lesions can minimize the severity and increase the better quality of life patient.
Co-Authors Irna Sufiawati Samsuridjal Djauzi