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All Journal Medical Journal of Indonesia Padjadjaran Journal of Dentistry Majalah Kesehatan Pharmamedika Narra J Jurnal Penyakit Dalam Indonesia
Samsuridjal Djauzi
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Interleukin-18 levels in adult dengue fever and dengue hemorrhagic fever Pohan, Herdiman T.; Suhendro, Suhendro; Bur, Rika; Matondang, Asnath; Djauzi, Samsuridjal; Inada, Katsuya; Endo, Shigeatsu
Medical Journal of Indonesia Vol 13, No 2 (2004): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.037 KB) | DOI: 10.13181/mji.v13i2.136

Abstract

Interleukin (IL)-18 ( interferon-γ inducing factor) is one of cytokines, produced by macrophage, take part in differentiation T-helper (Th) to Th1 and interferon γ producing. T helper1 play role in cellular immunity especially in viral infection include dengue. A descriptive correlative study has done to know the correlation between IL-18 levels and disease severity in admitted dengue fever (DF) and dengue hemorrhagic fever (DHF) patients. In 42 subjects consist of 20 (47.6%) DF and 22 (53.3%) DHF (grade I to IV WHO criteria, 1999) showed that IL-18 levels significantly higher in DHF than DF patients. There are significant correlation between IL-18 levels and hematocrit and low platelet value. This study supports the possible role of IL-18 in pathogenesis DHF in adults. (Med J Indones 2004; 13: 86-9)Keywords: dengue, dengue hemorrhagic fever, IL-18, cytokine, pathogenesis
Highly active antiretroviral therapy adherence and its determinants in selected regions in Indonesia Widjaja, Felix F.; Puspita, Caroline G.; Daud, Ferdi; Yudhistrie, Ienag; Tiara, Marita R.; Suwita, Christopher S.; Zain, Ekachaeryanti; Husna, Lailatul; Djauzi, Samsuridjal
Medical Journal of Indonesia Vol 20, No 1 (2011): February
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.509 KB) | DOI: 10.13181/mji.v20i1.429

Abstract

Background: Highly active antiretroviral therapy (HAART) can reduce morbidity and mortality of HIV-infected patients. However, it depends upon adherence to medication. The objective of this study was to examine the adherence to HAART and to evaluate individual patient characteristics i.e. self-efficacy, depression level, and social support and to finally determine HAART adherence in selected regions in Indonesia.Methods: This cross-sectional study was conducted in Jakarta, Malang, Bandung, Makasar and Banda Aceh. The subject of the study was HIV-infected patients who were older than 13 years old and had taken HAART for at least a month. They were recruited consecutively then asked how many pills they had missed during the previous month. Poor adherence can be stated if the percentage of adherence rate is below 95%. HIV treatment adherence self-efficacy scale  (HIVASES), Beck Depression Inventory (BDI-II) and Interpersonal Support Evaluation List (ISEL) was adapted to assess self-efficacy, depression level and social support, respectively.Results: We found that 96% (n=53) of the subjects adhered to HAART. There were no associations between adherence with self-efficacy, depression level, and social support. The main cause of non-adherence in this study was ‘simply  forget’.Conclusion: Adherence to HAART was found to be high and not associated with self-efficacy, depression level and social support in some central regions in Indonesia. (Med J Indones 2011; 20:50-5)Keywords: adherence, depression, HAART, HIV, self-efficacy, social support
Development of multiplex-PCR assay for rapid detection of Candida spp. Tarini, Ni Made A.; Wahid, Mardiastuti H.; Ibrahim, Fera; Yasmon, Andi; Djauzi, Samsuridjal
Medical Journal of Indonesia Vol 19, No 2 (2010): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.411 KB) | DOI: 10.13181/mji.v19i2.387

Abstract

Aim Candida spp. infection commonly occur in immunocompromised patients. Biochemical assay for identification of Candida spp. is time-consuming and shows many undetermined results. Specific detection for antibody, antigen and metabolites of Candida spp. had low sensitivity and specificity. In this study, we developed a rapid diagnostic method, Multiplex-PCR, to identify Candida spp.Methods Five Candida spp. isolates were cultured, identifi ed with germ tube and API® 20 C AUX (BioMerieux® SA) kit. Furthermore, DNA was purified by QIAamp DNA mini (Qiagen®) kit for Multiplex-PCR assay.Results DNA detection limit by Multiplex-PCR assays for C. albicans, C. tropicalis, C. parapsilosis, C. krusei and C. glabrata were 4 pg, 0.98 pg, 0.98 pg, 0.5 pg and 16 pg respectively. This assay was also more sensitive than culture in that Multiplex-PCR could detect 2.6-2.9 x 100 CFU/ml, whereas culture 2.6-2.9 x 102 CFU/ml.Conclusion Multiplex-PCR is much more sensitive than culture and thus, can be recommended as a sensitive and specific assay for identification of Candida spp. (Med J Indones 2010; 19:83-7)Keywords: Candida spp., multiplex-PCR
Correlation between saliva IgA level and T cell CD4+ in HIV/AIDS patients Sufiawati, Irna; Sasanti, Harum; Djauzi, Samsuridjal
Padjadjaran Journal of Dentistry Vol 19, No 2 (2007): July
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (322.211 KB) | DOI: 10.24198/pjd.vol19no2.14169

Abstract

Background: HIV infection appears to have direct effects on oral mucosal immunity, cellular and humoral. Antibody secretion, especially salivary immunoglobulin A (IgA), is a useful indicator of mucosal immune function. This immune system component is recognized as an important first-line of defence against pathogens which colonize and invade mucosal surfaces in the oral cavity. Objectives: The purpose of this study was to investigate salivary IgA levels and to determine its correlation with CD4+ T-cell counts among HIV-infected patients in Pokdisus AIDS Cipto Mangunkusomo Hospital Jakarta. Methods: The design study was using a cross-sectional study. Whole paraffin-wax-stimulated saliva was collected from 103 HIV-infected patients and 30 healthy individuals. Saliva was collected using the spitting method. Salivary IgA levels were determined by the immunoturbidimetry method using the Behring Turbitimer Analyser. CD4+ T-cell counts were analyzed by flow cytometry. Results: Salivary IgA levels were 141.55 ± 83.23 (HIV group) and 97.24 ± 38.25 (healthy individuals). The Mann-Whitney U test showed salivary IgA levels were significantly higher in HIV/AIDS subjects compared with healthy individuals (p<0.1). Most of the subject has severe immunosuppression with CD4+ T-cell counts <200 cell/mm.3 Pearson’s correlation test between CD4+ T-cell counts and salivary IgA levels showed no significant correlation (r= 0.06, p>0.1). Conclusion: This study indicates that total salivary IgA levels were significantly higher in the HIV-infected patients compared to control, and salivary IgA level seems not to be related significantly to CD4+ T-cell counts.
Risk factors of sepsis after open congenital cardiac surgery in infants: a pilot study Fakhri, Dicky; Busro, Pribadi W.; Rahmat, Budi; Purba, Salomo; Mukti, Aryo A.P.; Caesario, Michael; Christy, Kelly; Santoso, Anwar; Djauzi, Samsuridjal
Medical Journal of Indonesia Vol 25, No 3 (2016): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.46 KB) | DOI: 10.13181/mji.v25i3.1450

Abstract

Background: Postsurgical sepsis is one of the main causes of the high mortality and morbidity after open congenital heart surgery in infants.  This study aimed to evaluate the role of cardiopulmonary bypass duration, thymectomy, surgical complexity, and nutritional status on postsurgical sepsis after open congenital cardiac surgery in infants.Methods: A total of 40 patients &lt;1 year of age with congenital heart disease, Aristotle Basic Score (ABS) ≥6 were followed for clinical and laboratory data before and after surgery until the occurrence of signs or symptoms of sepsis or until a maximum of 7 days after surgery. Bivariate analyses were performed. Variables with p≤0.200 were then included for logistic regression.Results: Duration of cardiopulmonary bypass ≥90 minutes was associated with 5.538 increased risk of postsurgical sepsis in comparison to those ≤90 minutes (80% vs 25%, RR=5.538, p=0.006). No association was observed between the incidence of postsurgical sepsis with poor nutritional status (86% vs 84%, RR=1.059, p=1.000), thymectomy (and 50% vs 76%, RR=0.481, p=0.157), and Aristotle Basic Score (p=0.870).Conclusion: Cardiopulmonary bypass time influences the incidence of sepsis infants undergoing open congenital cardiac surgery. Further studies are needed to elaborate a number of risk factors associated with the incidence of sepsis in this population.
Sunlight–derived vitamin D affects interleukin-4 level, T helper 2 serum cytokines, in patients with Graves’ disease: a prospective cohort study Purnamasari, Dyah; Soewondo, Pradana; Djauzi, Samsuridjal
Medical Journal of Indonesia Vol 24, No 4 (2015): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.046 KB) | DOI: 10.13181/mji.v24i4.1270

Abstract

Background: Graves’ disease (GD) is the most common autoimmune disease leading to hyperthyroidism. The role of Th1/Th2 pathways balance in GD is still controversial. Vitamin D is reported to have an effect on those pathways. This study aims to examine the effect of sunlight exposure on vitamin D 25(OH) level and Th1 and Th2 pathway-derived cytokines in GD patients. Methods: A prospective cohort study was conducted on 32 GD patients to compare the effect of sunlight exposure on vitamin D level and cytokines of Th1 and Th2 pathways between exposed and unexposed groups. Exposed group received sunlight exposure three times a week for 30 minutes each between 9–11 a.m for 1 month. Thyroid stimulating hormone (TSH), free thyroxin (fT4), vitamin D 25(OH), interferon-γ (IFN-γ) and interleukin-4 (IL-4) serum levels, were investigated before and after one month of sunlight exposure. Paired t-test or Mann Whitney test were used to analyze the difference between exposed and unexposed GD groups before and after sun exposure.Results: One month of sunlight exposure increased vitamin D 25(OH) level by 27.90% among exposed GD group (15.34 ng/mL to 19.62 ng/mL, p&lt;0.001). Meanwhile, unexposed GD group’s vitamin D 25(OH) level decreased from 20.48 ng/mL to 18.86 ng/mL (p&lt;0.001). Increased vitamin D 25(OH) level in exposed group was not accompanied by the increase of IL-4 level after sunlight exposure.Conclusion: Sunlight exposure increases vitamin D 25(OH) serum level and may affect the level of IL-4, Th2 pathway-derived cytokine, in patients with GD. However, the role of sunlight-derived vitamin D on IFN-γ in GD patients can not be concluded in this study.
Infeksi Protozoa Usua Memberikan Profil Respons Imun yang Berbeda Andri Damayanti, Ndaru; Wibowo, Heri; Djauzi, Samsuridjal
Majalah Kesehatan Pharmamedika Vol 9, No 1 (2017): JUNI 2017
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (131.769 KB) | DOI: 10.33476/mkp.v9i1.671

Abstract

Pajanan mikroorganisme yang bervariasi dan terjadi terus menerus di lingkungan tempattinggal berpengaruh terhadap respon imun individu yang mampu memberikan ketahanan seseorang terhadap suatu penyakit. Tujuan penelitian mengetahui pajanan protozoa usus di lingkungan tempat tinggal mempengaruhi profil respons imun individu. Subyek penelitian berjumlah 80 orang terdiri dari masyarakat yang tinggal di sekitar tempat pembuangan sampah terpadu (TPST) Bantar Gebang, Bekasi, dianggap sebagai populasi dengan kondisi sanitasi dan higiene yang kurang baik. Kelompok pembanding adalah populasi dari mahasiswa perguruan tinggi swasta, yang dianggap sebagai subyek dengan kondisi sanitasi dan higiene yang lebih baik, Sampel yang digunakan adalah darah dan feses. Seluruh data diolah berdasarkan program SPSS 17 for Window. Variasi pajanan mikroorganisme protozoa usus memodulasi ekspresi rasio sitokin proinflamasi (tnf-α, inf-γ,) dan antiinflamasi (IL-10) pada kultur sel darah subyek yang tinggal di lingkungan kumuh lebih rendah dibandingkan subyek yang tinggal di pemukiman nonkumuh (p 0,01).
Factors Associated with Retention in Care One Year after Deliveryin Patients Undergoing Prevention of Mother to Child Transmission(PMTCT) at RSCM Yulidar, Yulidar; Yunihastuti, Evy; Djauzi, Samsuridjal; Padmita, Astrid Citra; Koesnoe, Sukamto
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 2
Publisher : UI Scholars Hub

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Abstract

Introduction. Retention in care is important to the successful of HIV treatment. This study is aimed to analyze factors associated with retention in care one year after delivery in patients undergoing PMTCT at HIV integrated clinic of RSCM. Methods. A retrospective cohort study was conducted among post-partum HIV patients who were given ARV therapy for PMTCT at HIV intergrated clinic of Cipto Mangunkusumo Hospital from January 2004 to May 2014. Evaluation of one year retention in care after PMTCT was performed by observing medical records of the patient. The collected data were factors associated with one year after delivery retention in care including age of patients, level of initial CD4, ARV toxicity, injecting drug user, duration of ARV before delivery, having child with positive HIV status, having spouse with positive HIV status, distance from the residence to the hospital, and indication of ARV. Bivariate analysis was performed by using Chi Square and Mann Whitney test and multivariate anaysis was performed by using logistic regression to assess factors associated with retention in car after PMTCT program. Results. 253 subjects met the inclusion criteria. In One year after delivery, the retention in care rate was 55,3%. Multivariate analysis found that factors significantly associated with one year retention in care were indication of ARV initiation for therapy (OR =3,812 [95% CI: 1,825-7,966]), non-IDU patients (OR=3,055 [95% CI: 1,382-6,752]), duration of ARV before delivery for more than 6 months (OR = 2,657 [95% CI: 1,328-5,316]), and level of initial CD4 less than 200/mm3 (OR = 2,033 [95% CI: 1,061-3,894]). Conclusions. Factors significantly associated with one year after delivery retention in care are indication of ARV for therapy, duration of ARV before delivery, non-IDU patients, and level of initial CD4 less than 200/mm3 . and Mann Whitney test and multivariate anaysis was performed by using logistic regression to assess factors associated with retention in car after PMTCT program. Results. 253 subjects met the inclusion criteria. In One year after delivery, the retention in care rate was 55,3%. Multivariate analysis found that factors significantly associated with one year retention in care were indication of ARV initiation for therapy (OR =3,812 [95% CI: 1,825-7,966]), non-IDU patients (OR=3,055 [95% CI: 1,382-6,752]), duration of ARV before delivery for more than 6 months (OR = 2,657 [95% CI: 1,328-5,316]), and level of initial CD4 less than 200/mm3 (OR = 2,033 [95% CI: 1,061-3,894]). Conclusions. Factors significantly associated with one year after delivery retention in care are indication of ARV for therapy, duration of ARV before delivery, non-IDU patients, and level of initial CD4 less than 200/mm3 .
Predictors of Virological Failure in HIV Patients Receiving FirstLine Antiretroviral Therapy with Good Adherence Kurniawan, Farid; Djauzi, Samsuridjal; Yunihastuti, Evy; Nugroho, Pringgodigdo
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 1
Publisher : UI Scholars Hub

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Abstract

Introduction. Antiretroviral therapy (ART) effectively suppress HIV replication. Viral load (VL) measurement is better predictor than clinical or immunological criteria to evaluate success or failure of ART. However, in country with limited resources, viral load measurement is not easily accessible by HIV patients receiving ART. Therefore, it is necessary to know which factors that can predict virological failure. In previous studies, adherence was an important factor for suppression of HIV viral load. This study is aimed to know predictors of virological failure in HIV patients receiving recent first line ART regimen with good adherence in Indonesia. Methods. A retrospective cohort study was conducted among adult HIV patients in Out-patient Clinic of Cipto Mangunkusumo Hospital that started ART during periode of January 2011-June 2014. HIV patients with good adherence that had viral load data 6-9 months after initiation of ART were included in this study. Virological failure was defined as viral load ≥ 400 copies/ mL after minimum of 6 months therapy with good adherence. Age at starting ART, risk factor for HIV infection, HIV clinical stage, HIV-TB co-infection, baseline CD4 value, CD4 count increase, baseline hemoglobin level and body mass index, weight changes during therapy, and ART based regimen were analyzed in this study. Results. A total of 197 patients were included in this study. Virological failure was found in 21 patients (10,7%). CD4 increase /mm3 after minimum 6 months of ART was predictor of virological failure (p = 0,003; OR 5,802, 95%CI 1,842-18,270). Conclusion. CD4 increase /mm3 after minimum 6 months therapy can predict virological failure in HIV patients receiving first line ART with good adherence
A novel diastolic dysfunction score: A proposed diagnostic predictor for left ventricular dysfunction in obese population Kamelia, Telly; Rumende, Cleopas M.; Makmun, Lukman H.; Timan, Ina S.; Djauzi, Samsuridjal; Prihartono, Joedo; Fardizza, Fauziah; Tabri, Nur A.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1564

Abstract

Obesity-related diastolic dysfunction is an emerging contributor to heart failure and cardiovascular mortality. However, effective and accessible diagnostic tools are still limited. Current methods for assessing diastolic dysfunction are often invasive or technologically demanding, making them impractical for routine clinical use and community settings. The aim of this study was to develop a novel, non-invasive scoring system designed to predict diastolic dysfunction in obese adults, addressing this diagnostic gap. This community-based, prospective cross-sectional study was conducted in Jakarta, Indonesia, from March to November 2021, and included 82 participants aged 18 to 60 years, all with a body mass index (BMI) ≥25 kg/m². Patients with acute or critical illnesses, valvular heart diseases, or acute confusional states were excluded. Each participant underwent blood tests, polysomnography, and echocardiography. Of the study population, 80.5% were diagnosed with obstructive sleep apnea (OSA), and 12.2% exhibited diastolic dysfunction, all within the OSA group. The novel scoring system integrates four predictors: oxygen desaturation index (ODI) ≥39 (score 1; prevalence ratio: 4.31 (95% confidence interval (CI): 1.58–11.75)), HbA1C ≥5.95% (score 2; prevalence ratio: 6.32 (95%CI: 2.84–14.06)), pulmonary artery wedge pressure (PAWP) ≥10 mmHg (score 1; prevalence ratio: 5.95 (95%CI: 2.30–15.39)), and global longitudinal strain (GLS) ≥-16.95% (score 1; prevalence ratio: 4.32 (95%CI: 1.87–9.99)). A score of ≥2 predicted diastolic dysfunction with 90% sensitivity, with positive predictive value and negative predictive value of 40.91% and 98.33%, respectively. In conclusion, the diastolic dysfunction score is a simple and practical tool for the early detection of diastolic dysfunction in obese individuals without cardiovascular symptoms.
Co-Authors Alida Harahap Andi Yasmon Andri Damayanti, Ndaru Anwar Santoso Asmarinah Asmarinah Asnath Matondang Astrid Citra Padmita, Astrid Citra Budi Rahmat Busro, Pribadi W. Caroline G. Puspita Christopher S. Suwita Christy, Kelly Dicky Fakhri Dyah Purnamasari Ekachaeryanti Zain Evy Yunihastuti Fardizza, Fauziah Farid Kurniawan, Farid Fatimah Eliana, Fatimah Felix F. Widjaja Fera Ibrahim Ferdi Daud Harum Sasanti, Harum Herdiman T. Pohan Ienag Yudhistrie Ina S. Timan, Ina S. Irna Sufiawati Joedo Prihartono Katsuya Inada Lailatul Husna Luh Putu Ratna Sundari Lukman H. Makmun Mardiastuti H Wahid Marita R. Tiara Michael Caesario Mukti, Aryo A.P. Ni Made Adi Tarini Pradana Soewondo Pradana Suwondo Pringgodigdo Nugroho, Pringgodigdo Purba, Salomo Rika Bur Rumende, Cleopas M. Shigeatsu Endo Suhendro Suhendro Sukamto Koesnoe Tabri, Nur A. Telly Kamelia Tjokorda Gde Dalem Pemayun Yulidar Yulidar