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Insidensi dan Karakteristik Hepatotoksisitas Obat Antituberkulosis pada Penderita Tuberkulosis dengan dan tanpa Infeksi HIV Sumantri, Agung Firmansyah; Djumhana, Ali; Wisaksana, Rudi; Sumantri, Rachmat
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstrak Â Salah satu penyulit dalam pengobatan tuberkulosis (Tb) adalah hepatotoksisitas obat antituberkulosis (OAT). Pasien Tb dengan infeksi human immunodeficiency virus (HIV) meningkatkan risiko kejadian hepatotoksisitas OAT. Hal ini menjadi tantangan dalam menghadapi pasien Tb-HIV. Penelitian ini bertujuan mengetahui insidensi dan karakteristik penderita hepatotoksisitas OAT pada Tb dengan dan tanpa infeksi HIV. Penelitian ini adalah penelitian Â epidemiologi Â klinik Â yang Â bersifatÂ deskriptifÂ observasional. Â Penelitian dilaksanakan di Â ruang Â rawat jalan dan rawat inap RSUP Dr. Hasan Sadikin (RSHS) Bandung serta ruang rawat jalan RS Bungsu periode Juniâ Oktober 2012. Terdapat 120 subjek terdiri atas 18 penderita dengan infeksi HIV dan 102 penderita tanpa infeksi HIV. Mayoritas usia penderita Tb dengan infeksi HIV yaitu â¤35 tahun (17/18 penderita), laki-laki (12/18 penderita), indeks massa tubuh <18,5 kg/m2 (10/18 penderita), dan Tb paru (16/18 penderita). Penderita Tb dengan infeksi HIV yang mengalami hepatotoksisitas terhadap OAT lebih banyak daripada penderita Tb tanpa infeksi HIV (9/18 vs 19/102 penderita). Insidensi hepatotoksisitas OAT sebesar 23,3%. Hepatotoksisitas OAT pada penderita Tb dengan dan tanpa infeksi HIV terjadi pada 2 minggu pengobatan OAT dengan derajat ringan. Simpulan, insidensi hepatotoksisitas OAT pada penderita Tb dengan infeksi HIV lebih tinggi daripada tanpa infeksi HIV. Kata kunci: Hepatotoksisitas OAT, HIV, tuberkulosis Â Incidence and Characteristics of Hepatotoxicity Anti-tuberculosis Drugs in Tuberculosis Patients with and without HIV Infection Â Abstract Hepatotoxicity is one of the complications in the treatment of tuberculosis (Tb). Tuberculosis patient with HIV infection has higher risk in hepatotoxicity, and this is a clinical obstacle in dealing with Tb-HIV treatment. The aims of this study were to find the incidence and characateristic of anti-tuberculosis hepatotoxicity in tuberculosis patients with and without HIV infection. A descriptive observational study was conducted in outpatient/inpatient RSUP Dr. Hasan Sadikin (RSHS) Bandung, and outpatient RS Bungsu period JuneâOctober 2012. There were 120 Tb patients consisted of 18 patients with HIV and 102 patients without HIV. Most of Tb patients with HIV occured in age â¤35 years (17/18 patients), male (12/18 patients), body mass index <18.5 kg/m2 (10/18 patients), and pulmonal Tb (16/18 patients). Tb patients with HIV had hepatotoxicity more than without HIV (9/18 vs 19/102 patients). The incidence of hepatotoxicity was 23.3%. Hepatotoxicity anti-tuberculosis drugs in Tb patients with and without HIV infection mostly occured in second week therapy with mild degree. In conclusion, anti-tuberculosis hepatotoxicity is higher in TB patients co-infected with HIV than non-HIV infections. Key words: Anti-tuberculosis hepatotoxicity, HIV, tuberculosis

Therapeutic Responses of Imatinib and Nilotinib among CML Patients in Hasan Sadikin Hospital Bandung Sumantri, Agung Firmansyah; Oehadian, Amaylia; Wijaya, Indra; Vidyaniati, Putri; Rahmaniati, Rahmaniati
Indonesian Journal of Cancer Vol 12, No 3 (2018): July-September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Chronic Myeloid Leukemia (CML) is a myeloproliferative malignancy with an estimated incidence in the world of 1-2 cases per 100,000 adults. The use of Tyrosine Kinase Inhibitors (TKI) as a therapy for CML is still the first choice for treatment, but some cases show a high level of resistance or intolerance to TKI therapy. This study aims to identify the therapeutic responses of imatinib and nilotinib among CML patients in Bandung.Method: This study is an analytical descriptive study of CML patients at Hasan Sadikin Hospital’s Hematology and Medical Oncology Outpatient Clinic in 2017. The total number of samples in this study is 244 patients, consisting of 199 patients with Imatinib therapy and 45 patients with Nilotinib therapy. The data is processed using SPSS Statistics 22.0 software.Result: The results showed that CML patients had a median age of 42 years, sex ratio of 1: 1 and the highest prevalence was in Bandung City (21.3%). Hematologic response is dominated by complete hematologic response, as high as 72.86% with Imatinib and 66.67% with Nilotinib. Molecular response 3-6 months post therapy is dominated by suboptimal response in as many as 36,8% with Imatinib and failure in as many as 50% with Nilotinib. Molecular response 12-18 months post therapy is dominated by failure in as high as 69,4% with Imatinib and 52,4% with Nilotinib.Conclusion: Based on the molecular response, the rates of suboptimal response and resistance are quite high. Regular monitoring standards of therapy for CML patients are needed to identify TKI resistance so alternative therapies can be provided to improve the outcomes.

Insidensi dan Karakteristik Hepatotoksisitas Obat Antituberkulosis pada Penderita Tuberkulosis dengan dan tanpa Infeksi HIV Agung Firmansyah Sumantri; Ali Djumhana; Rudi Wisaksana; Rachmat Sumantri
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Universitas Islam Bandung

Salah satu penyulit dalam pengobatan tuberkulosis (TB) adalah hepatotoksisitas obat antituberkulosis (OAT). Pasien TB dengan infeksi human immunodeficiency virus (HIV) meningkatkan risiko kejadian hepatotoksisitas OAT. Hal ini menjadi tantangan dalam menghadapi pasien TB-HIV. Penelitian ini bertujuan mengetahui insidensi dan karakteristik penderita hepatotoksisitas OAT pada TB dengan dan tanpa infeksi HIV. Penelitian ini adalah penelitian epidemiologi klinik yang bersifat deskriptif observasional. Penelitian dilaksanakan di ruang rawat jalan dan rawat inap RSUP Dr. Hasan Sadikin (RSHS) Bandung serta ruang rawat jalan RS Bungsu periode Juni–Oktober 2012. Terdapat 120 subjek terdiri atas 18 penderita dengan infeksi HIV dan 102 penderita tanpa infeksi HIV. Mayoritas usia penderita TB dengan infeksi HIV yaitu ≤35 tahun (17/18 penderita), laki-laki (12/18 penderita), indeks massa tubuh <18,5 kg/m2 (10/18 penderita), dan TB paru (16/18 penderita). Penderita TB dengan infeksi HIV yang mengalami hepatotoksisitas terhadap OAT lebih banyak daripada penderita TB tanpa infeksi HIV (9/18 vs 19/102 penderita). Insidensi hepatotoksisitas OAT sebesar 23,3%. Hepatotoksisitas OAT pada penderita TB dengan dan tanpa infeksi HIV terjadi pada 2 minggu pengobatan OAT dengan derajat ringan. Simpulan, insidensi hepatotoksisitas OAT pada penderita TB dengan infeksi HIV lebih tinggi daripada tanpa infeksi HIV. INCIDENCE AND CHARACTERISTICS OF HEPATOTOXICITY ANTI-TUBERCULOSIS DRUGS IN TUBERCULOSIS PATIENTS WITH AND WITHOUT HIV INFECTIONHepatotoxicity is one of the complications in the treatment of tuberculosis (TB). Tuberculosis patient with HIV infection has higher risk in hepatotoxicity, and this is a clinical obstacle in dealing with TB-HIV treatment. The aims of this study were to find the incidence and characateristic of anti-tuberculosis hepatotoxicity in tuberculosis patients with and without HIV infection. A descriptive observational study was conducted in outpatient/inpatient RSUP Dr. Hasan Sadikin (RSHS) Bandung, and outpatient RS Bungsu period June–October 2012. There were 120 TB patients consisted of 18 patients with HIV and 102 patients without HIV. Most of TB patients with HIV occured in age ≤35 years (17/18 patients), male (12/18 patients), body mass index <18.5 kg/m2 (10/18 patients), and pulmonal TB (16/18 patients). TB patients with HIV had hepatotoxicity more than without HIV (9/18 vs 19/102 patients). The incidence of hepatotoxicity was 23.3%. Hepatotoxicity anti-tuberculosis drugs in TB patients with and without HIV infection mostly occured in second week therapy with mild degree. In conclusion, anti-tuberculosis hepatotoxicity is higher in TB patients co-infected with HIV than non-HIV infections.

Karakteristik Pekerja Industri Tekstil yang Terdiagnosis Kanker di Purwakarta Tiara Oktaviani; Riri Risanti; Agung Firmansyah Sumantri
Jurnal Integrasi Kesehatan dan Sains Vol 3, No 2 (2021): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v3i2.7356

Pekerja industri berisiko terkena kecelakaan, kecacatan, dan kematian akibat kerja. Hasil survei dari International Labour Organization menunjukkan bahwa prevalensi terbesar penyebab kematian yang berhubungan dengan pekerjaan disebabkan oleh kanker sebesar 8%. Kanker merupakan pertumbuhan sel yang tidak terkontrol diikuti proses invasi ke jaringan sekitar dan penyebaran ke bagian tubuh yang lain. Penyakit ini diketahui berhubungan dengan lingkungan kerja salah satunya industri tekstil karena terpapar oleh zat-zat karsinogenik. Penelitian ini bertujuan mengetahui karakteristik pasien kanker yang bekerja di industri tekstil berdasar atas usia, jenis kelamin, dan jenis kanker yang terdiagnosis di RSUD Bayu Asih dan RS Dr. Abdul Radjak Purwakarta tahun 2018–2019. Penelitian ini menggunakan metode observasional deskriptif dengan melihat data rekam medis pasien kanker di RSUD Bayu Asih dan RS Dr. Abdul Radjak Purwakarta selama bulan Maret–Desember 2020 dengan rancangan cross-sectional. Didapatkan kejadian kanker pada pekerja industri tekstil lebih tinggi pada perempuan 61% daripada laki-laki 39%. Berusia 46–55 tahun 58%, usia 36–45 tahun 35%, dan jenis kankernya, yaitu kanker paru 26%, kanker payudara 23%, dan kanker kulit 13%. Simpulan penelitian ini adalah mayoritas pekerja industri tekstil yang terdiagnosis kanker adalah perempuan, berusia 46–55 tahun, serta jenis kanker adalah kanker paru dan kanker payudara. CHARACTERISTICS OF TEXTILE INDUSTRY WORKERS DIAGNOSED WITH CANCER IN PURWAKARTAIndustrial workers are at high risk of accidents, injuries, and death due to work. The survey results from the International Labor Organization show that the highest prevalence of work-related deaths is cancer at 8%. Cancer is an uncontrolled growth of cells following the invasion of surrounding tissues and spread to the other parts of the body. These diseases are known related to the work environment, one of them being the textile industry because it is exposed to carcinogenic substances. This study aims to determine the characteristics of cancer patients who work in the textile industry based on age, gender, and type of cancer diagnosed at the Bayu Asih Regional General Hospital and Dr. Abdul Radjak Hospital Purwakarta in 2018–2019. This study used a descriptive observational method by looking at the medical record data of cancer patients at Bayu Asih Regional General Hospital and Dr. Abdul Radjak Hospital Purwakarta during March–December 2020 with a cross-sectional design. It found that the cancer incidence in textile industry workers was 61% higher for women than 39% for men. Age 46–55 years 58%, age 36–45 years 35%, and the type of cancer, namely lung cancer 26%, breast cancer 23%, and skin cancer 13%. This study concludes that the textile industry workers majority diagnosed with cancer are women, aged 46–55 years, and the types of cancer are lung and breast cancer.

Therapeutic Responses of Imatinib and Nilotinib among CML Patients in Hasan Sadikin Hospital Bandung Agung Firmansyah Sumantri; Amaylia Oehadian; Indra Wijaya; Putri Vidyaniati; Rahmaniati Rahmaniati
Indonesian Journal of Cancer Vol 12, No 3 (2018): July-September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Chronic Myeloid Leukemia (CML) is a myeloproliferative malignancy with an estimated incidence in the world of 1-2 cases per 100,000 adults. The use of Tyrosine Kinase Inhibitors (TKI) as a therapy for CML is still the first choice for treatment, but some cases show a high level of resistance or intolerance to TKI therapy. This study aims to identify the therapeutic responses of imatinib and nilotinib among CML patients in Bandung.Method: This study is an analytical descriptive study of CML patients at Hasan Sadikin Hospital’s Hematology and Medical Oncology Outpatient Clinic in 2017. The total number of samples in this study is 244 patients, consisting of 199 patients with Imatinib therapy and 45 patients with Nilotinib therapy. The data is processed using SPSS Statistics 22.0 software.Result: The results showed that CML patients had a median age of 42 years, sex ratio of 1: 1 and the highest prevalence was in Bandung City (21.3%). Hematologic response is dominated by complete hematologic response, as high as 72.86% with Imatinib and 66.67% with Nilotinib. Molecular response 3-6 months post therapy is dominated by suboptimal response in as many as 36,8% with Imatinib and failure in as many as 50% with Nilotinib. Molecular response 12-18 months post therapy is dominated by failure in as high as 69,4% with Imatinib and 52,4% with Nilotinib.Conclusion: Based on the molecular response, the rates of suboptimal response and resistance are quite high. Regular monitoring standards of therapy for CML patients are needed to identify TKI resistance so alternative therapies can be provided to improve the outcomes.

Hubungan Personal Hygiene dan Tingkat Pengetahuan dengan Kejadian Skabies pada Santri Pesantren Miftahul Huda Al-Hadi Tasikmalaya Shafira Nefananda Kariza; Herry Garna; Agung Firmansyah Sumantri
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.1302

Abstract. Scabies is an infectious skin disease due to the infestation and sensitization of the mite Sarcoptes scabiei (S. scabiei) which is a parasite that can tunnel through the skin. Scabies is often in inhabited places such as boarding schools, dormitories, prisons, and areas, occurring in association with poor hygiene and behavior. The purpose of this study was to determine the relationship between personal hygiene and knowledge level with the incidence of scabies in male students at Miftahul Huda Al-Hadi Islamic Boarding School Tasikmalaya. This study used an observational method with a cross-sectional design using a questionnaire and related patient data forms. The number of respondents in this study amounted to 65 people who were taken using purposive sampling. Data collection was carried out in the period March–October 2021. The results showed that the majority of students at Miftahul Huda Al-Hadi Islamic Boarding School Tasikmalaya 40 students (62%) experienced scabies. The majority of students' hygiene was sufficient (51%) and the level of knowledge was poor (65%). The results of the bivariate chi-square analysis showed that there was a relationship between personal hygiene and level of knowledge with the incidence of scabies (p-value = 0.001 > 0.05). In conclusion that there is a relationship between personal hygiene and level of knowledge with the incidence of scabies in students at Miftahul Huda Al-Hadi Islamic Boarding School Tasikmalaya. Abstrak. Skabies adalah penyakit kulit menular yang disebabkan oleh infeksi tungau (S. scabiei), parasit yang dapat menyerang kulit. Skabies sering terjadi di tempat berpenghuni banyak seperti pondok pesantren, asrama, penjara, dan daerah kumuh, yang berhubungan dengan kebersihan dan perilaku penghuni yang buruk. Tujuan penelitian ini adalah memperjelas hubungan personal hygiene dan tingkat pengetahuan dengan kejadian skabies pada santri di Pondok Pesantren Miftahul huda Al Hadi Tasikmalaya. Penelitian ini adalah metode observasional dengan rancangan cross sectional menggunakan kuesioner dan formulir data santri terkait. Responden penelitian ini berjumlah 65 orang yang diambil dengan teknik purposive sampling. Pengambilan data dilakukan periode bulan Maret hingga Oktober 2021. Hasil penelitian menunjukkan mayoritas santri di Pondok Pesantren Miftahul Huda Al-Hadi Tasikmalaya 40 orang santri (62%) mengalami kejadian skabies. Mayoritas personal hygiene santri cukup (51%) dan tingkat pengetahuan buruk (65%). Hasil analisis bivariat chi-square menunjukkan hubungan personal hygiene dan tingkat pengetahuan dengan kejadian skabies (p = 0,001 > 0,05). Simpulan, terdapat hubungan personal hygiene dan tingkat pengetahuan dengan kejadian skabies pada santri di Pondok Pesantren Miftahul Huda Al-Hadi Tasikmalaya.

Studi Epidemiologi Penderita Leukemia Granulositik Kronis pada Komunitas ELGEKA di Jawa Barat Muhammad Sayyid Hidayatullah; Agung Firmansyah Sumantri
Jurnal Riset Kedokteran Volume 2, No.2, Desember 2022, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.vi.1536

Abstract. This research is a descriptive observational study, with a cross sectional research design. The number of subjects in this study was 63 people. The selection of subjects using non-probability purposive sampling techniques or research subjects met the inclusion criteria, using the Slovin formula. Data analysis using the SPSS statistical application. The characteristics to be described include domicile, age, sex, occupation, race, age at diagnosis, latest education, medication, initial and final BCR-ABL values, leukocytes, platelets and hemoglobin. The results showed the highest prevalence was in Bandung (20%), with an age range of 30-39 years (38.1%), suffered mostly by women (55.6%), most of them were private employees (28.6%), people with Sundanese race (68.3%), the average age of diagnosis was 34 years, the latest education was higher education graduate (57.1%), the most drug used was imatinib (81.3%), the initial dominant BCR-ABL value was > 10% and end dominant was < 0.1%, the results of a routine dominant hemoglobin blood test were 8-12 g/dL, the results of dominant leukocytes were 5000-10,000/mm3, and the yield of dominant platelets was 150,000 to 400,000 mm3. Abstrak. Penelitian ini bertujuan untuk mendiskripsikan karakteristik penderita leukemia granulositik kronis pada komunitas ELGEKA Jawa Barat. Penelitian ini adalah sebuah penelitian deskriptif observasional, dengan desain penelitian cross sectional. Jumlah Subjek dalam penelitian ini adalah 63 orang. Pemilihan subjek dengan teknik non probability purposive sampling atau subjek penilitian memenuhi kriteria inklusi, menggunakan rumus slovin. Analisis data menggunakan aplikasi statistik SPSS. Karakteristik yang akan digambarkan meliputi domisili, usia, jenis kelamin, pekerjaan, ras, usia diagnosis, pendidikan terakhir, pengobatan, nilai BCR-ABL awal dn akhir, leukosit, trombosit dan hemoglobin. Hasil menunjukan bahwa pravelensi tertinggi berada di Kota Bandung (20%), dengan rentang usia 30-39 tahun (38,1%), jenis kelamin terbanyak wanita (55,6%), pekerjaan terbanyak pegawai swasta (28,6%), Ras terbanyak sunda (68,3%), usia rata-rata diagnosis 34 tahun, pendidikan terakhir perguruan tinggi (57,1%), penggunaan obat terbanyak imatinib (81.3%), nilai BCR-ABL awal dominan >10% dan akhir dominan <0,1%, hasil pemeriksaan darah rutin dominan hemoglobin 8-12g/dL, leukosit dominan dengan hasil 5000-10.000/mm3 dan trombosit dominan dengan hasil 150.000-400.000 mm3.

Gambaran Tingkat Kecemasan dan Depresi pada Pasien Anak dengan Thalasemia Mayor di RSUD Al Ihsan Bandung Tahun 2021-2022 Wafa Haifa Nur Maula; Agung Firmansyah Sumantri; Harvi Puspa Wardani
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.5336

Abstract. Thalassemia is a disease in Indonesia with a high incidence. Java is an area with a high incidence of thalassemia, especially in West Java. In 2019, thalassemia patients in Indonesia reached 10 thousand patients, of the 5 thousand patients around 35% came from West Java. Regular medication over a long period time and a lack of social support can have psychological effects such as anxiety and depression. The purpose of this study was to determine the description of anxiety and depression in children with thalassemia major at Al-Ihsan Hospital, West Java. The method used is a descriptive method with a cross-sectional approach. Subjects totaled 64 patients aged 8-18 years, who were selected by purposive sampling technique. Data collection was taken through primary data using the RCADS questionnaire. Processing data using descriptive analysis of frequency. The results showed that 64 patients (100%) had mild anxiety, 63 patients (98.4%) had mild depression, and 1 patient (1.6%) had moderate depression. The conclusion of this study shows that the anxiety and depression of children with thalassemia major in RSUD Al Ihsan, West Java Province, are at a mild level of severity. Abstrak. Thalasemia merupakan salah satu penyakit di Indonesia dengan angka kejadian yang tinggi. Jawa adalah daerah dengan angka kejadian thalasemia yang tinggi, khususnya di Jawa Barat. Pada tahun 2019, pasien thalasemia di Indonesia mencapai 10 ribu pasien, dari 5 ribu pasien sekitar 35% berasal dari Jawa Barat. Pengobatan rutin dalam jangka waktu yang lama, dan kurangnya dukungan sosial dapat menimbulkan efek terhadap psikologis seperti kecemasan dan depresi. Tujuan penelitian ini yaitu untuk mengetahui gambaran kecemasan dan depresi pada pasien thalasemia mayor anak-anak di RSUD Al-Ihsan Jawa Barat. Metode yang digunakan adalah metode deskriptif dengan pendekatan cross-sectional. Subjek berjumlah 64 pasien yang berusia 8-18 tahun, yang dipilih dengan teknik purposive sampling. Pengumpulan data diambil melalui data primer menggunakan kuesioner RCADS. Pengolahan data menggunakan analisis deskriptif frekuensi. Hasil penelitian menunjukkan bahwa pasien yang memiliki kecemasan dengan tingkat keparahan ringan sebanyak 64 orang (100%), depresi dengan tingkat keparahan ringan sebanyak 63 orang (98,4%), dan depresi dengan tingkat keparahan sedang sebanyak 1 orang (1,6%). Kesimpulan penelitian ini menunjukkan kecemasan dan deperesi pasien thalasemia mayor anak-anak di RSUD Al Ihsan Provinsi Jawa Barat berada pada tingkat keparahan ringan. Kata Kunci: Depresi, Kecemasan, Thalasemia Mayor.

Pengaruh Kepatuhan Minum Obat Kelasi Besi dengan Kadar Ferritin pada Pasien Thalassemia di RSUD Al-Ihsan Bandung Tahun 2021/2022 Raihan Saparizki; Agung Firmansyah Sumantri; Sadiah Achmad
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.5824

Abstract. Thalassemia is a hereditary blood disorder that is commonly found in the world. One of the reasons for the decreased quality of life of patients is the high level of serum ferritin in the body. Ferritin levels can affect various things, one of which is patient compliance with taking iron chelation drugs. This study aims to determine the relationship between the level of compliance with iron chelation drug consumption and serum ferritin levels in thalassemia patients at Al-Ihsan Hospital, Bandung. The sample in this study was 59 patients with thalassemia children to adolescents aged 1 to 18 years. This study used a purposive sampling technique and an analytic observational method with a cross-sectional study design. Adherence level data were measured using the MMAS 8 questionnaire, while data on serum ferritin levels were obtained from the patient's medical record. Data collection was carried out in 2021 – 2022. The results of this study indicate that the majority of thalassemia patients (58%) have a low level of adherence to taking iron chelating drugs and most have serum ferritin levels >2,500 ng/mL (56%). There was a statistically significant relationship between the level of adherence to taking iron-chelating drugs and serum ferritin levels in thalassemia patients at Al-Ihsan Hospital in Bandung (p=0.00). In this study there was a moderate level of compliance with ferritin levels > 2,500 because there were other factors that affected ferritin levels, therefore future researchers are expected to be able to study other factors that affect ferritin levels. Abstrak. Thalasemia merupakan kelainan darah herediter yang banyak ditemukan di dunia. Salah satu alasan menurunnya kualitas hidup pasien ialah tingginya kadar feritin serum pada tubuh. Kadar feritin tersebut dapat dipengaruhi berbagai hal, salah satunya ialah kepatuhan pasien dalam mengonsumsi obat kelasi besi. Penelitian ini bertujuan untuk mengetahui hubungan tingkat kepatuhan konsumsi obat kelasi besi dengan kadar feritin serum pada penderita thalassemia di RSUD Al – Ihsan Bandung. Sampel pada penelitian ini adalah pasien thalassemia anak sampai remaja berusia 1 sampai 18 tahun sebanyak 59 pasien. Penelitian ini menggunakan teknik purposive sampling dan metode analitik observasional dengan design penelitian cross-sectional. Data tingkat kepatuhan diukur dengan kuesioner Morisky Medication Adherence Scale-8 (MMAS-8) yang diisi dipandu oleh peneliti, sedangkan data kadar feritin serum didapatkan dari rekam medis pasien. Pengambilan data dilakukan pada tahun 2021 – 2022, Pengumpulan data dilakukan dengan pemeriksaan langsung, menggunakan uji chi – square, dan dianalisis dengan software SPSS. Hasil penelitian ini menunjukan bahwa mayoritas penderita thalassemia di RSUD Al – Ihsan Bandung (58%) memiliki tingkat kepatuhan rendah dalam konsumsi obat kelasi besi dan sebagian besar memiliki kadar feritin serum >2.500 ng/mL (56%). Terdapat hubungan bermakna secara statistik antara tingkat kepatuhan konsumsi obat kelasi besi dan kadar feritin serum pada penderita talasemia di RSUD Al-Ihsan Bandung (p=0,00). Pada penelitian ini terdapat tingkat kepatuhan sedang dengan kadar feritin >2.500 karena hal tersebut terdapat faktor faktor lain yang mempengaruhi kadar feritin, oleh karena itu peneliti selanjutnya diharapkan dapat meneliti faktor faktor lain yang mempengaruhi kadar feritin.

Hubungan Usia Terdiagnosis dengan Status Gizi dan Pubertas Pasien Thalasemia Beta Mayor di Poli Anak RSUD Al Ihsan Annisa Berlia Maharani Kaka Nisa; Agung Firmansyah Sumantri; Yuliana Ratna Wati
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6075

Abstract. Thalassemia is a hereditary blood disorder that is commonly found in the world. It is estimated that thalassemia sufferers in West Java reach 40% of the total thalassemia patients in Indonesia. Most patients diagnosed with thalassemia are estimated at the age of 1-5 years. Growth and development disorders occur in patients with beta thalassemia major. Early diagnosis makes it possible to provide maximum management so as to minimize puberty delays and impaired nutritional status. This study aims to determine the relationship between diagnosed age and nutritional status and puberty in pediatric thalassemia patients at Al Ihsan General Hospital. The sample in this study were beta thalassemia major patients aged 13-18 years as many as 21 patients. This study used an observational analytic method with a cross-sectional study design. Data collection was carried out by direct examination and analyzed by fisher's exact test with SPSS software. The results showed that the diagnosed age was < 5 years 81% and > 5 years 19%, 23.8% poor nutritional status and 76.2% good nutrition, 19% late puberty and 81% not late. Bivariate results showed a relationship between age diagnosed and nutritional status (p=0.532) and puberty (p=0.546) in pediatric beta thalassemia patients at Al Ihsan Hospital. With adequate iron chelation therapy, it is hoped that thalassemic sufferers will experience the same growth and development as normal children. In this study, nutritional status and puberty did not show a relationship with the age at diagnosis because they were under control. Keywords: Age Diagnosed, Nutritional Status, Puberty, Thalassemia. Abstrak. Thalasemia merupakan kelainan darah herediter yang banyak ditemukan di dunia. Diperkirakan penderita thalasemia di Jawa Barat mencapai 40% dari total pasien thalasemia di Indonesia. Pasien yang terdiagnosis thalasemia terbanyak diperkirakan pada usia 1-5 tahun. Gangguan tumbuh kembang banyak terjadi pada pasien dengan thalasemia beta mayor. Diagnosis dini dimungkinkan pemberian tatalaksana yang maksimal sehingga meminimalisir keterlambatan pubertas dan gangguan status gizi. Penelitian ini bertujuan untuk mengetahui hubungan usia terdiagnosis dengan status gizi dan pubertas pada pasien thalasemia anak di RSUD Al Ihsan. Sampel pada penelitian ini adalah pasien thalasemia beta mayorberusia 13-18 tahun sebanyak 21 pasien. Penelitian ini menggunakan metode analitik observasional dengan desain penelitian cross-sectional. Pengumpulan data dilakukan dengan pemeriksaan secara langsung dan dianalisis dengan uji fisher exact dengan Software SPSS. Hasil penelitian menunjukkan usia terdiagnosis usia < 5 tahun 81% dan > 5 tahun 19%, status gizi kurang 23,8% dan gizi baik 76,2%, pubertas terlambat 19% dan tidak terlambat 81%. Hasil bivariat menunjukkan hubungan antara usia terdiagnosis dengan status gizi (p=0,532) dan pubertas (p=0,546) pada pasien thalasemia beta mayor anak di RSUD Al Ihsan. Dengan terapi kelasi besi adekuat diharapkan penderita thalasemia mengalami tumbuh kembang yang sama dengan anak normal. Pada penelitian ini status gizi dan pubertas tidak menunjukkan hubungan dengan usia terdiagnosis karena sudah terkendali. Kata Kunci: Status Gizi, Thalasemia, Usia Terdiagnosis, Pubertas.

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