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All Journal Global Medical and Health Communication Indonesian Journal of Cancer Jurnal Integrasi Kesehatan dan Sains
Agung Firmansyah Sumantri
Bagian Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Islam Bandung/RSUD Al-Ihsan Provinsi Jawa Barat Bandung
Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Insidensi dan Karakteristik Hepatotoksisitas Obat Antituberkulosis pada Penderita Tuberkulosis dengan dan tanpa Infeksi HIV Sumantri, Agung Firmansyah; Djumhana, Ali; Wisaksana, Rudi; Sumantri, Rachmat
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak   Salah satu penyulit dalam pengobatan tuberkulosis (Tb) adalah hepatotoksisitas obat antituberkulosis (OAT). Pasien Tb dengan infeksi human immunodeficiency virus (HIV) meningkatkan risiko kejadian hepatotoksisitas OAT. Hal ini menjadi tantangan dalam menghadapi pasien Tb-HIV. Penelitian ini bertujuan mengetahui insidensi dan karakteristik penderita hepatotoksisitas OAT pada Tb dengan dan tanpa infeksi HIV. Penelitian ini adalah penelitian  epidemiologi  klinik  yang  bersifat  deskriptif  observasional.  Penelitian dilaksanakan di  ruang  rawat jalan dan rawat inap RSUP Dr. Hasan Sadikin (RSHS) Bandung serta ruang rawat jalan RS Bungsu periode Juni– Oktober 2012. Terdapat 120 subjek terdiri atas 18 penderita dengan infeksi HIV dan 102 penderita tanpa infeksi HIV. Mayoritas usia penderita Tb dengan infeksi HIV yaitu ≤35 tahun (17/18 penderita), laki-laki (12/18 penderita), indeks massa tubuh <18,5 kg/m2 (10/18 penderita), dan Tb paru (16/18 penderita). Penderita Tb dengan infeksi HIV yang mengalami hepatotoksisitas terhadap OAT lebih banyak daripada penderita Tb tanpa infeksi HIV (9/18 vs 19/102 penderita). Insidensi hepatotoksisitas OAT sebesar 23,3%. Hepatotoksisitas OAT pada penderita Tb dengan dan tanpa infeksi HIV terjadi pada 2 minggu pengobatan OAT dengan derajat ringan. Simpulan, insidensi hepatotoksisitas OAT pada penderita Tb dengan infeksi HIV lebih tinggi daripada tanpa infeksi HIV. Kata kunci: Hepatotoksisitas OAT, HIV, tuberkulosis   Incidence and Characteristics of Hepatotoxicity Anti-tuberculosis Drugs in Tuberculosis Patients with and without HIV Infection   Abstract Hepatotoxicity is one of the complications in the treatment of tuberculosis (Tb). Tuberculosis patient with HIV infection has higher risk in hepatotoxicity, and this is a clinical obstacle in dealing with Tb-HIV treatment. The aims of this study were to find the incidence and characateristic of anti-tuberculosis hepatotoxicity in tuberculosis patients with and without HIV infection. A descriptive observational study was conducted in outpatient/inpatient RSUP Dr. Hasan Sadikin (RSHS) Bandung, and outpatient RS Bungsu period June–October 2012. There were 120 Tb patients consisted of 18 patients with HIV and 102 patients without HIV. Most of Tb patients with HIV occured in age ≤35 years (17/18 patients), male (12/18 patients), body mass index <18.5 kg/m2 (10/18 patients), and pulmonal Tb (16/18 patients). Tb patients with HIV had hepatotoxicity more than without HIV (9/18 vs 19/102 patients). The incidence of hepatotoxicity was 23.3%. Hepatotoxicity anti-tuberculosis drugs in Tb patients with and without HIV infection mostly occured in second week therapy with mild degree. In conclusion, anti-tuberculosis hepatotoxicity is higher in TB patients co-infected with HIV than non-HIV infections. Key words: Anti-tuberculosis hepatotoxicity, HIV, tuberculosis
Therapeutic Responses of Imatinib and Nilotinib among CML Patients in Hasan Sadikin Hospital Bandung Sumantri, Agung Firmansyah; Oehadian, Amaylia; Wijaya, Indra; Vidyaniati, Putri; Rahmaniati, Rahmaniati
Indonesian Journal of Cancer Vol 12, No 3 (2018): July-September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (843.37 KB) | DOI: 10.33371/ijoc.v12i3.615

Abstract

Introduction: Chronic Myeloid Leukemia (CML) is a myeloproliferative malignancy with an estimated incidence in the world of 1-2 cases per 100,000 adults. The use of Tyrosine Kinase Inhibitors (TKI) as a therapy for CML is still the first choice for treatment, but some cases show a high level of resistance or intolerance to TKI therapy. This study aims to identify the therapeutic responses of imatinib and nilotinib among CML patients in Bandung.Method: This study is an analytical descriptive study of CML patients at Hasan Sadikin Hospital’s Hematology and Medical Oncology Outpatient Clinic in 2017. The total number of samples in this study is 244 patients, consisting of 199 patients with Imatinib therapy and 45 patients with Nilotinib therapy. The data is processed using SPSS Statistics 22.0 software.Result: The results showed that CML patients had a median age of 42 years, sex ratio of 1: 1 and the highest prevalence was in Bandung City (21.3%). Hematologic response is dominated by complete hematologic response, as high as 72.86% with Imatinib and 66.67% with Nilotinib. Molecular response 3-6 months post therapy is dominated by suboptimal response in as many as 36,8% with Imatinib and failure in as many as 50% with Nilotinib. Molecular response 12-18 months post therapy is dominated by failure in as high as 69,4% with Imatinib and 52,4% with Nilotinib.Conclusion: Based on the molecular response, the rates of suboptimal response and resistance are quite high. Regular monitoring standards of therapy for CML patients are needed to identify TKI resistance so alternative therapies can be provided to improve the outcomes.
Insidensi dan Karakteristik Hepatotoksisitas Obat Antituberkulosis pada Penderita Tuberkulosis dengan dan tanpa Infeksi HIV Agung Firmansyah Sumantri; Ali Djumhana; Rudi Wisaksana; Rachmat Sumantri
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1574.585 KB) | DOI: 10.29313/gmhc.v3i2.1548

Abstract

Salah satu penyulit dalam pengobatan tuberkulosis (TB) adalah hepatotoksisitas obat antituberkulosis (OAT). Pasien TB dengan infeksi human immunodeficiency virus (HIV) meningkatkan risiko kejadian hepatotoksisitas OAT. Hal ini menjadi tantangan dalam menghadapi pasien TB-HIV. Penelitian ini bertujuan mengetahui insidensi dan karakteristik penderita hepatotoksisitas OAT pada TB dengan dan tanpa infeksi HIV. Penelitian ini adalah penelitian epidemiologi klinik yang bersifat deskriptif observasional. Penelitian dilaksanakan di ruang rawat jalan dan rawat inap RSUP Dr. Hasan Sadikin (RSHS) Bandung serta ruang rawat jalan RS Bungsu periode Juni–Oktober 2012. Terdapat 120 subjek terdiri atas 18 penderita dengan infeksi HIV dan 102 penderita tanpa infeksi HIV. Mayoritas usia penderita TB dengan infeksi HIV yaitu ≤35 tahun (17/18 penderita), laki-laki (12/18 penderita), indeks massa tubuh <18,5 kg/m2 (10/18 penderita), dan TB paru (16/18 penderita). Penderita TB dengan infeksi HIV yang mengalami hepatotoksisitas terhadap OAT lebih banyak daripada penderita TB tanpa infeksi HIV (9/18 vs 19/102 penderita). Insidensi hepatotoksisitas OAT sebesar 23,3%. Hepatotoksisitas OAT pada penderita TB dengan dan tanpa infeksi HIV terjadi pada 2 minggu pengobatan OAT dengan derajat ringan. Simpulan, insidensi hepatotoksisitas OAT pada penderita TB dengan infeksi HIV lebih tinggi daripada tanpa infeksi HIV. INCIDENCE AND CHARACTERISTICS OF HEPATOTOXICITY ANTI-TUBERCULOSIS DRUGS IN TUBERCULOSIS PATIENTS WITH AND WITHOUT HIV INFECTIONHepatotoxicity is one of the complications in the treatment of tuberculosis (TB). Tuberculosis patient with HIV infection has higher risk in hepatotoxicity, and this is a clinical obstacle in dealing with TB-HIV treatment. The aims of this study were to find the incidence and characateristic of anti-tuberculosis hepatotoxicity in tuberculosis patients with and without HIV infection. A descriptive observational study was conducted in outpatient/inpatient RSUP Dr. Hasan Sadikin (RSHS) Bandung, and outpatient RS Bungsu period June–October 2012. There were 120 TB patients consisted of 18 patients with HIV and 102 patients without HIV. Most of TB patients with HIV occured in age ≤35 years (17/18 patients), male (12/18 patients), body mass index <18.5 kg/m2 (10/18 patients), and pulmonal TB (16/18 patients). TB patients with HIV had hepatotoxicity more than without HIV (9/18 vs 19/102 patients). The incidence of hepatotoxicity was 23.3%. Hepatotoxicity anti-tuberculosis drugs in TB patients with and without HIV infection mostly occured in second week therapy with mild degree. In conclusion, anti-tuberculosis hepatotoxicity is higher in TB patients co-infected with HIV than non-HIV infections.
Karakteristik Pekerja Industri Tekstil yang Terdiagnosis Kanker di Purwakarta Tiara Oktaviani; Riri Risanti; Agung Firmansyah Sumantri
Jurnal Integrasi Kesehatan dan Sains Vol 3, No 2 (2021): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v3i2.7356

Abstract

Pekerja industri berisiko terkena kecelakaan, kecacatan, dan kematian akibat kerja. Hasil survei dari International Labour Organization menunjukkan bahwa prevalensi terbesar penyebab kematian yang berhubungan dengan pekerjaan disebabkan oleh kanker sebesar 8%. Kanker merupakan pertumbuhan sel yang tidak terkontrol diikuti proses invasi ke jaringan sekitar dan penyebaran ke bagian tubuh yang lain. Penyakit ini diketahui berhubungan dengan lingkungan kerja salah satunya industri tekstil karena terpapar oleh zat-zat karsinogenik. Penelitian ini bertujuan mengetahui karakteristik pasien kanker yang bekerja di industri tekstil berdasar atas usia, jenis kelamin, dan jenis kanker yang terdiagnosis di RSUD Bayu Asih dan RS Dr. Abdul Radjak Purwakarta tahun 2018–2019. Penelitian ini menggunakan metode observasional deskriptif dengan melihat data rekam medis pasien kanker di RSUD Bayu Asih dan RS Dr. Abdul Radjak Purwakarta selama bulan Maret–Desember 2020 dengan rancangan cross-sectional. Didapatkan kejadian kanker pada pekerja industri tekstil lebih tinggi pada perempuan 61% daripada laki-laki 39%. Berusia 46–55 tahun 58%, usia 36–45 tahun 35%, dan jenis kankernya, yaitu kanker paru 26%, kanker payudara 23%, dan kanker kulit 13%. Simpulan penelitian ini adalah mayoritas pekerja industri tekstil yang terdiagnosis kanker adalah perempuan, berusia 46–55 tahun, serta jenis kanker adalah kanker paru dan kanker payudara. CHARACTERISTICS OF TEXTILE INDUSTRY WORKERS DIAGNOSED WITH CANCER IN PURWAKARTAIndustrial workers are at high risk of accidents, injuries, and death due to work. The survey results from the International Labor Organization show that the highest prevalence of work-related deaths is cancer at 8%.  Cancer is an uncontrolled growth of cells following the invasion of surrounding tissues and spread to the other parts of the body. These diseases are known related to the work environment, one of them being the textile industry because it is exposed to carcinogenic substances. This study aims to determine the characteristics of cancer patients who work in the textile industry based on age, gender, and type of cancer diagnosed at the Bayu Asih Regional General Hospital and Dr. Abdul Radjak Hospital Purwakarta in 2018–2019. This study used a descriptive observational method by looking at the medical record data of cancer patients at Bayu Asih Regional General Hospital and Dr. Abdul Radjak Hospital Purwakarta during March–December 2020 with a cross-sectional design. It found that the cancer incidence in textile industry workers was 61% higher for women than 39% for men. Age 46–55 years 58%, age 36–45 years 35%, and the type of cancer, namely lung cancer 26%, breast cancer 23%, and skin cancer 13%. This study concludes that the textile industry workers majority diagnosed with cancer are women, aged 46–55 years, and the types of cancer are lung and breast cancer.
Co-Authors A.A. Ketut Agung Cahyawan W Ali Djumhana Ali Djumhana Amaylia Oehadian Putri Vidyaniati Rachmat Sumantri Rachmat Sumantri Rahmaniati, Rahmaniati Riri Risanti Rudi Wisaksana Rudi Wisaksana Tiara Oktaviani