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Enggar Wijayanti, Enggar
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Chemistry Medicine & Pharmacology

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Efek Dua Sediaan Ramuan Jamu pada Pasien Obesitas: Studi Klinis dengan Desain Paralel, Random dan Tidak Tersamar Zulkarnain, Zuraida; Nisa, Ulfatun; Wijayanti, Enggar; Fitriani, Ulfa
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.1596

Abstract

Obesity is a co-morbidity of cardiovascular disease, diabetes, and other metabolic diseases, which the prevalence increases every year. The use of herbal medicine is an alternative choice to overcome obesity. Clinical observation of decoction of herbal medicine (Dutch teak, kemuning, rhei radix and tempuyung) has been conducted for obesity therapy which has been proven to be effective in reducing body weight and body mass index (BMI). Innovation in steeping form is considered more practical than stew. Randomized open label pararel design research was carried out to assess the equal efficacy of the herbs in stew and steeping form. The number of subjects in each group were 30 subjects, they were patients of of Rumah Riset Jamu (RRJ) Hortus Medicus during June-October 2016 who met the inclusion criteria. BW and BMI are measured on Day-0, 28 and 56, while body height is measured once at Day-0. Both stew and steeping groups drank herbs twice a day for 56 days. At the end of the study, it was found that the mean of declining BW of the decoction group was 67.35 kg to 66.37 kg, while the steeping group 67.41 kg to 66.45 kg. BMI of stew group was decreased 26.85 kg / m2 to 26.46 kg / m2, while in steeping group 26.67 kg / m2 to 26.29 kg / m2. Statistic test result to compare BW and BMI of both two groups before and after treatment showed no significant differences in the two groups (p> 0.05). The ability of herbal medicines in steeping or stew forms can reduce the BW and BMI equally.
Aktivitas Ramuan Daun Salam, Herba Pegagan, Akar Alang-Alang dan Biji Pala pada Tikus Hipertensi yang Diinduksi Prednison dan Garam Nisa, Ulfatun; Fitriani, Ulfa; Wijayanti, Enggar
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 2, AGUSTUS 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i2.3496

Abstract

The prevalence of hypertension in Indonesia was 25,8%. As much as 70% types of hypertensive patients were mild hypertension. There were some medicinal plants contain single formulation could be used for lowering blood pressure but not in a herbal formulation. This study determined the efficacy of antihypertension herbal formulation that consists of Indonesian bay leaves, Centella herbs, blady grass roots and nutmeg seeds. This study was an experimental laboratory research with pre and post-test controlled design, used thirty Sprague-Dawley rats that were classified randomly into five groups (negative control group which didn't have treatment, positive control group which consumed captopril 0,25 mg, and three groups which consumed antihypertension herbal formulation with doses of 0,08 g; 0,16 g; and 0,32 g. The rats were induced by prednisone and NaCl 2,5 % for 21 days. The data were analysed using ANOVA test with CI 95%. After two weeks observation, the results showed that the blood pressure in the negative control group increased, but in the positive control and treatment groups decreased significantly (p=0,001). In conclusion, the herbal formulation could decrease rat's blood pressure
Co-Authors Ulfa Fitriani Ulfatun Nisa, Ulfatun Zuraida Zulkarnain, Zuraida