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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Cermin Dunia Kedokteran
FITRIANI MANGARENGI, FITRIANI
Bagian Ilmu Patologi Klinik FK UNHAS/ RSUP Wahidin Sudirohusodo Makassar.
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Kadar Asam Urat Berkorelasi dengan Kadar Hemoglobin Terglikolisasi (HbA1c) Pasien Diabetes Melitus tipe 2 Sanda, Arfandhy; Mangarengi, Fitriani; Pakasi, Ruland DN
Cermin Dunia Kedokteran Vol 45, No 6 (2018): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (128.276 KB) | DOI: 10.55175/cdk.v45i6.650

Abstract

Latar Belakang: Beberapa studi menunjukkan peranan asam urat dalam progresivitas prediabetes menuju diabetes. Tujuan : mengetahui hubungan kadar asam urat serum dengan HbA1c pada pasien DM tipe 2 di RSUP Dr. Wahidin Sudirohusodo Makassar. Metode: Penelitian retrospektif observasional cross sectional menggunakan data sekunder 107 pasien DM tipe 2 yang memenuhi kriteria inklusi dan menjalani pengobatan di poliklinik dan perawatan Interna RS Wahidin Sudirohusodo (RSWS) periode Januari-Desember 2016. Uji normalitas data menggunakan uji Kolgomorov Smirnov dengan hasil tidak terdistribusi normal. Korelasi kadar asam urat dengan HbA1c dianalisis menggunakan uji Spearman dengan p-value<0,05. Hasil: Dijumpai korelasi positif signifikan antara kadar asam urat dengan HbA1c pada pasien DM tipe 2 (r=0,229, p=0,018). Simpulan: Kadar asam urat serum memiliki korelasi positif dengan HbA1c pada pasien DM tipe 2.Background: Some studies suggest the role of uric acid in progression of prediabetes to diabetes. Objective: To determine the correlation between uric acid serum and glycated haemoglobin (HbA1c) among type 2 Diabetes Mellitus patients in Wahidin Sudirohusodo Hospital. Method: A cross-sectional observational retrospective study conducted on 107 type 2 DM patients who fulfilled the inclusion criteria and underwent treatment at Wahidin Sudirohusodo Hospital during January-December 2016. Data is not normally distributed. The correlation of uric acid with HbA1c was analyzed using Spearman test with p-value <0.05. Result: A significant positive correlation between uric acid levels and HbA1c in patients with type 2 DM (r = 0.229, p = 0.018).
Correlation of Serum Creatinine Based on Cockcroft-Gault and CKD-EPI in Diabetes Mellitus Hasna, Hasna; Kurniawan, Liong Boy; Mangarengi, Fitriani
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2327

Abstract

World Health Organization (WHO) predicts Indonesia's population with Type 2 Diabetes Mellitus (T2DM) will rise from 8.4 million in 2000 to 21.3 million in 2030. The primary cause of disability and death in people with Diabetes Mellitus (DM) is nephropathy. The early stages of diabetic nephropathy are characterized by glomerular hyperfiltration and an increase in the estimated-Glomerular Filtration Rate (eGFR). Other markers of diabetic nephropathy in addition to eGFR are increased creatinine, albuminuria, and proteinuria. The currently developed formulas for eGFR assessment are the Cockcroft-Gault (CG) formula, the Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI). This study aimed to determine the relationship between eGFR using the CKD-EPI formula for serum creatinine and CG in T2DM patients. Fifty-three DM patients participated in a cross-sectional study of the population of patients diagnosed with T2DM by clinicians at Hasanuddin University Hospital between March and June 2022. Version 25 of the Statistical Package for Social Science (SPSS) software was used to analyze the data. Statistical tests for the Normality of data distribution used the Kolmogorov-Smirnov test to determine the normality of data, the ANOVA test was used for comparison, and the Spearman test was used as a correlation test. The relationship between CKD-EPI and CG was highly correlated (r=0.868, p<0.001). Urine albumin levels and eGFR CKD EPI (r= -0.283, p=0.042) and CG (r= -0.282, p=0.043) showed a significant connection. There was a very strong relationship between CKD-EPI and CG.
Analysis of Serum Uric Acid to Albumin Ratio in Acute Kidney Injury Widiantara, Ade Kurniawan; Mangarengi, Fitriani; Widaningsih, Yuyun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2397

Abstract

Hypoalbuminemia and hyperuricemia are associated with the occurrence of Acute Kidney Injury (AKI), leading to increased mortality. Epidemiological studies have shown that AKI is related to disease severity, mortality, period of stay in the intensive care unit, and prolonged use of mechanical ventilation. This study aimed to analyze the uric acid-albumin ratio in AKI. A retrospective cross-sectional study was conducted using secondary data from subjects diagnosed with AKI and treated at the Dr. Wahidin Sudirohusodo Hospital, Makassar for four and a half years from January 2019 to July 2023. Statistical analysis was performed using the Kruskal-Wallis, Mann-Whitney, and Receiver Operating Characteristic (ROC) tests. A total of 93 subjects with an average age of 56.4+15.6 were included in the study, with a higher percentage of males, 63.4% (59). The mean uric acid/albumin ratio was higher in AKI stage 3 = 3.17 compared to stages 1 and 2, with a significant value of p=0.866. The mean uric acid/albumin ratio was higher in AKI patients who died = 4.46, compared to those who recovered, with a significant value of p<0.001. There was a considerable correlation between uric acid/albumin ratio and outcome AKI (p<0.001) with strong correlation strength. Value uric acid/albumin comparison with AKI (p<0.001) strong category (r=0.842). Based on the ROC curve coordinate values uric acid/albumin ratio, a cut-off > 2.79 was obtained for the AKI who died and < 2.79 for the outcome AKI who recovered, with sensitivity of 97.7% and specificity of 91.6%. There was a significant correlation between the uric acid/albumin ratio and the outcome of AKI, with high correlation strength. However, no statistically significant correlation was found between the uric acid/albumin ratio and the AKI stage.
Co-Authors Hasna, Hasna Liong Boy Kurniawan, Liong Boy RULAND DN PAKASI, RULAND DN Sanda, Arfandhy Widaningsih, Yuyun Widiantara, Ade Kurniawan