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All Journal Majalah Obat Tradisional
Desi Elvira Cindy Puspita, Desi Elvira Cindy
Faculty of Pharmacy, Universitas Gadjah Mada
Health Professions Medicine & Pharmacology Public Health

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OPTIMASI FORMULA TABLET HISAP EKSTRAK KULIT AKAR SENGGUGU (Clerodendrum serratum L. MOON) SEBAGAI SEDIAAN OBAT PENGENCER LENDIR (MUKOLITIK) DENGAN KOMBINASI BAHAN PENGISI MANNITOL-LAKTOSA-SUKROSA Sulaiman, T.N. Saifullah; Puspita, Desi Elvira Cindy; Wahyono, Wahyono
Majalah Obat Tradisional Vol 20, No 2 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (660.578 KB) | DOI: 10.14499/mot-TradMedJ20iss2pp87-95

Abstract

Senggugu root bark (Clerodendrum serratum L. Moon) is known as a mucolitics. Senggugu root bark is made in the dosage form of lozenges in combination with sucrose, mannitol and lactose in order to obtain good flavor and comfortable when consumed. The purpose of this study was to determine the effect of the combination of fillers on the physical properties of granules and tablets as well as the composition of the combination of excipients to produce lozenges of extract of senggugu root bark with optimum physical properties. Seven formulas were made with a combination of mannitol, lactose and sucrose as follows: FI (100%: 0%: 0%), FII (0%: 100%: 0%), FIII (0%: 0%: 100%), FIV (50 %: 50%: 0%), FV (50%: 0%: 50%), FVI (0%: 50%: 50%), and FVII (33.3%: 33.3%: 33.3% ). The results showed that the combination of mannitol, lactose and sucrose affected the physical properties of the granules and lozenges of extract of senggugu root bark i.e. flow rate, hardness, dissolved time, compactibility and perceptive sense. The dominant amount of sucrose and lactose can improve the physical properties of granules and tablets. The optimal composition of the combination of mannitol, lactose and sucrose obtained from Design Expert 7.1.5. program was 5.491%: 37.387%: 57.122%, respectively.
Co-Authors T.N. Saifullah Sulaiman, T.N. Saifullah Wahyono Wahyono