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All Journal Denta: Jurnal Kedokteran Gigi
Yoifah Rizka Wedarti
Periodonsia Fakultas Kedokteran Gigi Universitas Hang Tuah
Dentistry

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Daya Hambat Minyak Hati Ikan Hiu Terhadap Pertumbuhan Bakteri Porphyromonas gingivalis Felisitas Maria Agustina; Dian Mulawarmanti; Yoifah Rizka Wedarti
Denta Journal Kedokteran Gigi Vol 9 No 2 (2015): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Porphyromonas gingivalis is the dominant bacteria that found in chronic periodontitis. Conventional antibacterial (antibiotic) especially tetracycline mostly used for periodontal treatment, but antibiotic ussage often causes resistant, allergy, and toxic. Shark Liver Oil Cenctrophorus sp species have antibacterial effect through its contents, squalene and squalamine that can be developed as an antibacterial adjuvant therapy in periodontal disease. Purpose: To examine the inhibition effect of Shark Liver Oil to the growth of Porphyromonas gingivalis. Materials and Methods: This study used a research design post test only control group design. The research subject is Porphyromonas gingivalis strain ATCC 33277 which have total amount 30 samples, divided into 5 groups. Three groups were given the shark liver oil with different concentrations of 10%, 15%, and 20%. Positive control were given the tetracycline and negative control were given the DMSO 1%. The inhibition was examined using diffution method and was inoculated on MH agar. The inhibitory effect has been observed by measuring the diameter of clear area on the disk using digital calipersin milimeter. Result: Shark liver oil could inhibit the growth of Porphyromonas gingivalis in every concentrations. Concentration 10% with 9,06 mm, concentration 15% with 11,31 mm, concentration 20% with 13,2 mm, while the negative control with 6,01 mm, and positive control with 30,09 mm. Conclusion: Shark liver oil could inhibit the growth of Porphyromonas gingivalis.
Pengaruh Pemberian Ekstrak Nannochloropsis oculata Terhadap Penurunan Kadar TNF-α pada Tikus yang Diinduksi Bakteri Actinobacillus actinomycetemcomitans Peggie Octavia Halim; Syamsulina Revianti; Yoifah Rizka Wedarti
Denta Journal Kedokteran Gigi Vol 9 No 1 (2015): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Actinobacillus actinomycetemcomitans is a major periodontopathic bacterium with multiple virulence factors, including LPS. LPS is a potent stimulator cytokines proinflammatory such as TNF-α. Nannochloropsis oculata is a green micro algae that hasanti-inflammatory effects. Purpose: The aim of this study was to prove the effect of Nannochloropsis oculata extracts to decreased levels of TNF-α which induced by Actinobacillus actinomycetemcomitans bacteria. Materials and Methods: The experiment was held post test only control group design. 48 male wistar rats divided into 6 groups. K1 group was negative control group without any treatment, K2 group induced by Actinobacillus actinomycetemcomitans bacteria, K3 group treated with minocycline antibiotics 0.1%, and the other groups K4, K5, K6 were treated with Nannochloropsis oculata extract on various concentration that is 2.375%, 2.5%, 2.625%. After treatments on the 37th day, all groups of rats were euthanized and measured the levels of TNF-α in gingival tissue by ELISA. All of thedatas were analyzed by Kruskal Wallis dan Mann-Whitney U test. Result: This study showed the levels of TNF-α K2 group (36.9444) was significantly higher than K1 group(27.8889). K3 group (29.2778) showed no significant decreased compared to K2 group (36.9444). K4 (35.2778), K5 (33.1111) and K6 (29.2778)groups showed no significant decreased levels of TNF-α compared to K2 group (36.9444). Conclusion: Nannochloropsis oculata extracts can not reduce the levels of TNF-α in rats which induced by Actinobacillus actinomycetemcomitans bacteria.
Co-Authors Dian Mulawarmanti Felisitas Maria Agustina Peggie Octavia Halim Syamsulina Revianti