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All Journal Dentino: Jurnal Kedokteran Gigi Denta: Jurnal Kedokteran Gigi
Fika Faradillah Drakel
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Dentistry

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STEVEN JOHNSON SYNDROME DENGAN IMPLIKASI ORAL PARAH SERTA PENATALAKSANAANNYA : LAPORAN KASUS Fika Faradillah Drakel; Tenny Setiani Dewi
Denta Journal Kedokteran Gigi Vol 16 No 1 (2022): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v16i1.7

Abstract

Background: Steven Johnson Syndrome (SJS) is an acute mucocutaneous syndrome that predominantly involve the skin and mucous membranes. SJS is an immune-mediated disease that have been associated with erythema multiforme (EM). The most common triggers are viruses, food allergies, autoimmune reactions and medicine. The medicines that most commonly cause SJS are non-steroidal anti-inflammatory drugs, antibiotics, antifungals, and anticonvulsants. Case: A 32-year-old man was consulted from the Dermatology Department with a diagnosis of drug induce SJS and was given cetirizine and dexamethasone. The patient presented to the Oral Medicine Department complaining of mouth pain, dysphagia, ulcers, oedema and haemorrhagic of the lips, difficult eating, drinking and speaking. Extra-oral examination found that the surface of the lips was covered with a white layer, bloody and crusted, and erythematous rash on his neck, arm, abdomen, palms and feet, with a diameter of 2-6 mm. Intra-oral examination found multiple ulcers and erosive lesions that spread on the tongue, palate, buccal and labial mucosa. This condition established as an oral lesion related to SJS. Case Management: The management of the oral lesion was given corticosteroid mouthwash, 0.12% chlorhexidine digluconate, lip compress with 0.9% NaCl and 1% hydrocortisone ointment. Conclusion: Steroid mouthwash to suppress inflammation as well as a combination of 0.12% chlorhexidine digluconate antiseptic drug suppresses the infection process and complications that continue in the oral cavity and 0.9% NaCl solution as a moist wound healing. This therapy plays an important role in the healing process of oral lesions in patients with SJS.
A RARE CLINICAL SYPHILIS ORAL MANIFESTATION DUE TO SEXUALLY TRANSMITTED DISEASE AMONG HOMOSEXUAL: CASE REPORT Agustin Ninintowe T. Santo; Riani Setiadhi; Fika Faradillah Drakel
Dentino : Jurnal Kedokteran Gigi Vol 8, No 2 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i2.17529

Abstract

Background: Syphilis is a sexually transmitted disease caused by Treponema pallidum, often found in Human Immunodeficiency Virus (HIV) patients and homosexuals. The oral manifestations are chancres, mucous patches, focal epithelial hyperplasia (FEH) and papilloma/condyloma. FEH is a rare oral mucosa disorder that occurs in immunocompromised patient. Objective: To present a rare oral manifestation in syphilis patient due to sexually transmitted infections. Case: A 25-year-old homosexual male came to Oral Medicine Department complaining of sores on the palate for 3 weeks and 2 weeks later a painless lump appeared. He was an HIV patient and had been taking ARVs since 6 months ago. Pain when opening the mouth, itching on his face and genital area. Intraoral revealed a soft, pedunculated, non-bleeding, mobile mass at the palate with a diameter about 2 cm, had the same color as the surrounding tissue. There was a reddish band-like area on the maxillary anterior gingival margin, suspected as Linear Gingival Erythema (LGE). Case management: 0.2% Chlorhexidine gluconate mouthwash was administered to prevent secondary infection and he was referred to Dermatovenereology and Periodontology Department. HBsAg Immunochromatography (negative), VDRL titer (reactive), TPHA titer (reactive) therefore diagnosis of syphilis was made and he was treated with a single dose Benzathine penicillin G 2.4 million units intramuscular. The oral lesions healed after 1 month therapy. Conclusion: FEH is a rare oral mucosa disorder in syphilis patients. Knowledge of the signs and symptoms of the disease is needed to make a diagnosis and a multidisciplinary approach to achieve successful treatment. Keywords: Oral manifestation, Sexual transmission, Syphilis, Treponemal infection
Oral Complications Due to Medication in Stevens-Johnson Syndrome Patient with Systemic Involvement Rahmi Harmiyati; Fika Faradillah Drakel; Riani Setiadhi
Denta Journal Kedokteran Gigi Vol 18 No 2 (2024): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v18i2.6

Abstract

Background: Stevens-Johnson Syndrome (SJS) is a drug-induced hypersensitivity reaction involving mucocutaneous with various trigger factors including drugs and herpes simplex virus. Objective: This case report aimed to discuss oral complications due to medication in SJS patients with systemic disease involvement. Case: A 51-year-old man was referred to the Department of Oral Medicine, Faculty of Dentistry, Padjadjaran University, at Hasan Sadikin Hospital from the dermatology and venereology department complaining of pain in the oral cavity, especially when eating and drinking two months before, with a history of phenytoin, salbutamol and theophylline therapy. Extraoral examination showed erosive lesions and tended to bleed serosanguinolenta crusts on the lips. Intraoral there were erosive lesions and white plaque on the tongue, buccal mucosa, labial mucosa, and palate, as well as dental caries and calculus. Blood examination showed low hemoglobin, hematocrit, erythrocytes, lymphocytes, monocytes, SGOT, and sodium levels, while HbA1c, random, fasting, and 2 HPP glucose levels were high. Reactive Anti-HSV-1 IgG and rheumatoid factor. KOH examination showed positive spores, hyphae, pseudohypha, and budding cells. The diagnosis was SJS-associated oral lesions with HSV-1 virus infection, oral candidiasis accompanied with diabetes mellitus. For diabetes mellitus treatment, he was referred to the internal medicine department. Case Management: The therapy was 0.9% NaCl for lip compress, acyclovir tablet, nystatin oral suspension, chlorhexidine digluconate 0,12% mouthwash, folic acid, and vitamin B12. Oral lesions were improved significantly after diabetes mellitus was treated. Conclusion: The SJS patient was susceptible to complications in the oral cavity, especially fungal and viral infections due to the received medication.
Co-Authors Agustin Ninintowe T. Santo Rahmi Harmiyati Riani Setiadhi Tenny Setiani Dewi