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All Journal Jurnal Kedokteran Komunitas (Journal of Community Medicine) The International Journal of Medical Science and Health Research
Wahyu Rhomadon
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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EFEK KOMBINASI INFUSA DAUN SAMBILOTO, SALAM, KAYU MANIS, DAN RIMPANG TEMULAWAK TERHADAP KADAR HDL DAN LDL SERUM TIKUS WISTAR JANTAN MODEL HIPERGLIKEMIA Wahyu Rhomadon
Jurnal Kedokteran Komunitas Vol 6, No 3 (2018)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (355.474 KB)

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Introduction: Diabetes mellitus (DM) is associated with impaired fat metabolism which causes an increase in VLDL, LDL and decreased HDL. Sambiloto, bay leaves, cinnamon, and ginger rhizome (SSKT) have the potential for antihyperlipidemia, antioxidants and antihyperglycemia. This study aims to determine the potential of SSKT as antihyperglycemia in DM.Methods: Experimental laboratory in vivo with the control group post test only design using male Wistar rats aged 2-3 months. Mice were divided into five groups: negative control, positive control, and treatment group. The combination of infusion is given per sonde for 30 days at a dose of 125 mg / kg, 250 mg / kg body weight, 500 mg / kg body weight per day. Examination of HDL levels using the Abx Pentra HDL direct Pentra C200 device, while for LDL level examination using the Abx pentra LDL direct Pentra C200 device. The results of HDL data were analyzed using Kruskal Wallis, and LDL was analyzed using One Way ANOVA followed by Post Hoc LSD test. The results are said to be significant if (p <0.05).Result: STZ 25 mg and 10% HFD could not reduce HDL levels and increase LDL levels significantly. There were no significant differences between the positive groups with treatment of serum HDL and LDL levels.. There is a tendency that the higher dose of SSKT extract given will reduce serum LDL levels in hyperglycemia mice.Conclusion: The apropriation of SSKT infusion combination extract could not increase HDL levels and reduce serum LDL levels in hyperglycemic mice.
The Analysis Study of Prevalence,  Management, and Outcome of Steven Johnson Syndrome and Toxic Epidermal Necrolysis in Pregnant Patients : A Comprehensive Systematic Review Deanurva Calista Prima; Wahyu Rhomadon
The International Journal of Medical Science and Health Research Vol. 8 No. 1 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/h3cyw230

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Background: Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are uncommon, potentially fatal cutaneous drug reactions that affect the skin and mucous membranes and are thought to be different manifestations of the same illness. The aim: The purpose of this study is to demonstrate the incidence, treatment, and prognosis of toxic epidermal necrolysis and Steven Johnson syndrome in pregnant individuals. Methods: The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 was utilized to demonstrate that this study complied with all applicable standards. With this search strategy, articles published between 2014 and 2024 were taken into consideration. This was accomplished by utilizing a number of distinct online reference sites, including Sciencedirect, Pubmed, and SagePub. It was determined that reviews, previously published works, and partially completed works would not be included. Result: Following a thorough three-level screening process, eight publications were determined to be closely connected to our ongoing systematic examination. Following that, an extensive examination of the entire text was carried out, and these articles were subjected to further inspection. Conclusion: SJS/TEN during pregnancy seems to be benign and is linked to good outcomes for both the mother and the fetus, with the exception of a higher risk of preterm birth. The extreme form of the illness, known as TEN, has been linked to worse outcomes for fetuses. Pregnant HIV-positive women do not have an increase in SJS/TEN-associated mortality. It doesn't appear that maternal SJS/TEN frequently shows up in the fetus.
Co-Authors Deanurva Calista Prima