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All Journal Jurnal Kedokteran Komunitas (Journal of Community Medicine) The International Journal of Medical Science and Health Research
Deanurva Calista Prima
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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EFEK KOMBINASI EKTRAK AIR DAUN JATI BELANDA, KEMUNING, MURBEI DAN RIMPANG BANGLE TERHADAP KADAR BUN DAN KREATININ SERUM PADA TIKUS WISTAR DENGAN DIET ATEROSKLEROSIS Deanurva Calista Prima
Jurnal Kedokteran Komunitas Vol 6, No 3 (2018)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (345.265 KB)

Abstract

Introduction: Chronic hyperlipidemia leads to the excessive production of ROS (Reactive Oxygen Spesies) and the formation of atherosclerosis, in which both lead to kidney impairment. The administration of combined water extract of Jati Belanda, Kemuning, Murbei leaves and Bangle rhizome (JKMB) was traditionally used as anti-hyperlipidemia and antioxidant. This research aims to study the effect of JKMB water extract on serum BUN and creatinine levels of wistar rats with atherosclerosis diet.Methods : Laboratory experimental in vivo research method with post test control group only design. This research used 30 male wistar rats aged 2 months old which were divided into 5 groups: Negative Control (KN), Positive Control (KP), Group treated with Dose 1 (189mg/200gBB), Dose 2 (378mg/200gBB) and Dose 3 (756mg/200gBB). KP group and treatment groups are given with DTLM to induce atherosclerosis condition. DTLM was given along with the administration of JKMB for 12 weeks. A spectrophotometer with a wavelength of 600 nm and 510 nm is used for the examination of serum BUN and creatinine levels. Data analysis using SPSS version 16.Results: Induction of DTLM in KP did not increase the serum BUN and creatinine levels compared to KN. The combination of JKMB water extract increased serum BUN levels significantly (p <0.05) in D1 and D2 compared to KP, and D1 compared to D3. Whereas on creatinine level examination, the administration of JKMB water extract did not give any improvement (p> 0.05).Conclusion: Induction of DTLM did not increase serum BUN and creatinine levels in the KP group. The given JKMB water extract did not reduce serum BUN and creatinine levels in DTLM-induced wistar rats.
The Analysis Study of Prevalence,  Management, and Outcome of Steven Johnson Syndrome and Toxic Epidermal Necrolysis in Pregnant Patients : A Comprehensive Systematic Review Deanurva Calista Prima; Wahyu Rhomadon
The International Journal of Medical Science and Health Research Vol. 8 No. 1 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/h3cyw230

Abstract

Background: Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are uncommon, potentially fatal cutaneous drug reactions that affect the skin and mucous membranes and are thought to be different manifestations of the same illness. The aim: The purpose of this study is to demonstrate the incidence, treatment, and prognosis of toxic epidermal necrolysis and Steven Johnson syndrome in pregnant individuals. Methods: The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 was utilized to demonstrate that this study complied with all applicable standards. With this search strategy, articles published between 2014 and 2024 were taken into consideration. This was accomplished by utilizing a number of distinct online reference sites, including Sciencedirect, Pubmed, and SagePub. It was determined that reviews, previously published works, and partially completed works would not be included. Result: Following a thorough three-level screening process, eight publications were determined to be closely connected to our ongoing systematic examination. Following that, an extensive examination of the entire text was carried out, and these articles were subjected to further inspection. Conclusion: SJS/TEN during pregnancy seems to be benign and is linked to good outcomes for both the mother and the fetus, with the exception of a higher risk of preterm birth. The extreme form of the illness, known as TEN, has been linked to worse outcomes for fetuses. Pregnant HIV-positive women do not have an increase in SJS/TEN-associated mortality. It doesn't appear that maternal SJS/TEN frequently shows up in the fetus.
Co-Authors Wahyu Rhomadon