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All Journal Althea Medical Journal Sari Pediatri Paediatrica Indonesiana
Rodman Tarigan
Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/ RS Hasan Sadikin, Bandung
Health Professions Medicine & Pharmacology

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Journal : Althea Medical Journal

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The Role of Socioeconomic Factors Contributed to The Prevalence of Children under Five Years Old with Small Stature in Jatinangor Indari, Anggie; Setiawati, Elsa Pudji; Tarigan, Rodman
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (395.581 KB)

Abstract

Background: Indonesia  is on the fifth in world population for children with small stature. It could affect to their future, so growth disorders should be detected as early as possible. The influence of growth disorders is inseparable from the socioeconomic condition of the family.  This study aims to analyze the influence of socioeconomic based on education, occupation and family income towards small stature children under five years old in Jatinangor.Methods: This was a study of analytic cross sectional with multi-stage proportionate consecutive sampling. 110 samples of children under five years of age (12–59months) from 12 villages (6087 children) in Jatinangor sub district were taken on October and November 2012. Their height was measured using a microtoise based on WHO Growth Chart and the socioeconomic status was measured using questionnaire completed by their motherResults: There were 32 children (29,1%) with small stature. The relationship between maternal education with short stature (p=0.310), father’s education with small stature (p=0.368), mother’s occupation with small stature (p=0.774), father’s occupation with small stature (p=0.524) and family income with small stature (p=0.890) after it was examined using chi-squre test were not significant (p>0.05).Conclusion: In Jatinangor, there are still many children with small stature under five years old and the socioeconomic factors do not have any relationship with this condition. [AMJ.2015;2(1):298–303]
Safety and Preliminary Immunogenicity of Recombinant Hepatitis B (Bio Farma) Vaccine in Adults and Children: A Phase 1 Clinical Trial Fadlyana, Eddy; Tarigan, Rodman; Rusmil, Kusnandi; Sari, Rini Mulia; Kartasmita, Cissy B; Mardiah, Behesti Zahra; Dwi Putra, Muhammad Gilang
Althea Medical Journal Vol 10, No 4 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n4.3279

Abstract

Background: In order to fulfil the requirements of the national immunization program and sustain the production capacity of the monovalent Hepatitis B vaccine, this study aimed to assess the safety and immunogenicity of the recombinant Hepatitis B Vaccine (Bio Farma) using the new Hepatitis B bulk. Methods: This study was an experimental, randomized, double-blinded, and controlled Phase I clinical trial, with 100 healthy subjects divided into 50 adults and 50 adolescents. Subjects were randomly assigned to receive either the Bio Farma registered Recombinant Hepatitis B Vaccine (group A) or a new source of Hepatitis B bulk (group B). Subjects received one or three doses of vaccine, depending on the baseline anti-Hbs titer. Subjects were given diary cards to record solicited and unsolicited adverse events for 28 days following vaccination. Vaccine immunogenicity was assessed by measuring the level of HBsAg antibody titer elevation.Results: No serious adverse events were reported during clinical trials. The frequencies of adverse events were not significantly different between the two vaccine-randomized groups. The most immediately observed local reaction was local pain, reported by 35.7–42.8% of adults and 24.0–26.3% of adolescents, without any systemic reactions. Seroconversion in adults in group B reached 100% and 78.5% in group A, meanwhile in adolescent subjects in both groups it reached 100%. A substantial increase in geometric mean titer (GMT) was observed in the majority of subjects after immunization.Conclusion: Recombinant Hepatitis B Vaccine with a new source of HBsAg B bulk is safe, well tolerated, and highly immunogenic.
Co-Authors Ahmedz Widiasta Anggie Indari, Anggie Anggraini Alam, Anggraini Djatnika Setiabudi Dwi Putra, Muhammad Gilang Dzulfikar Djalil Lukmanul Hakim Eddy Fadlyana Elsa Pudji Setiawati Elsa Pudji Setiawati Fairuz Sani Inge Yasmien Irvan Afriandi Iskandar, Safira Atya Kartasmita, Cissy B Kusnandi Rusmil Lidya Chaidir Lynna Lidyana Mardiah, Behesti Zahra Meita Dhamayanti Nirwani, Bunga Nisita Widyastari Qory Aulia Sukma Rafa Fathia Suhud Rini Mulia Sari Siti Aminah Solek, Purboyo Tisnasari Hafsah Viramitha Kusnandi Rusmil