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A Study on The Formulation of Plant Matrix Tablets From Coarse Botanical Materials Using Cinnamon Bark and Areca Nut as The Model Botanical Materials Veronica, Natalia; Ang, Xiu Hui; Ooi, Shing Ming; Liew, Celine Valeria; Heng, Paul Wan Sia
Pharmaceutical Sciences and Research Vol. 7, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: There is much interest in formulating botanical materials into tablets due to the compactness and ease of administration. However, tableting of coarse milled botanical materials poses a challenge due to poor tableting properties. Objective: To evaluate the feasibility of wet granulation to produce tablets from coarse milled botanical materials and to assess the effect of formulation on properties of the tablets. Materials and Methods: Cinnamon bark and areca nut were milled to obtain 1–2 mm particle size, which was subsequently used in wet granulation using maltodextrin solution as a granulating liquid. Two diluents were tried; microcrystalline cellulose (MCC) or mannitol at a different ratio to the botanical materials. Tablets were then produced from the granules and evaluated for tensile strength and surface roughness. Results: Tablets formulated with MCC had higher tensile strength than tablets formulated with mannitol. Additionally, granules prepared using mannitol were more friable than those with MCC. The effect of diluent to botanical material ratio was more prominently observed on tablet surface roughness. Tablets containing a higher ratio of botanical material had a rougher surface, which could have implications on the mouth-feel of the tablets. Conclusion: Wet granulation could be a viable pre-processing method to produce tablets from coarse milled botanical materials.
Literature Review on BRI Client’s Coffee Export and Competitive Advantage Through Sustainability Veronica, Natalia; Ramanda, Diar K.; Perdhana, Mirwan Surya
Economic and Business Horizon Vol. 4 No. 2 (2025): May
Publisher : LifeSciFi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54518/ebh.4.2.2025.684

Abstract

Micro, Small, and Medium Enterprises (MSMEs) in the coffee sector, particularly those supported by BRI Bank, hold significant potential to contribute to national coffee exports. Various structural and operational challenges are still encountered, such as limited access to financing, low levels of technology adoption, and difficulties in meeting international market standards. This study aims to develop an empowerment model that enables MSMEs to build long-term competitive advantage through sustainable business practices. Employing a literature review approach, this study synthesizes previous empirical findings to analyze the role of BRI’s empowerment initiatives such as training, mentoring, and financing in enhancing MSME performance. The findings reveal that sustainability-oriented empowerment focusing on market-driven training, digitalization of export processes, and inclusive financing access significantly enhances the competitiveness of MSMEs. The main contribution of this study is the formulation of an integrated empowerment model based on the Resource-Based View (RBV), emphasizing the development of valuable, rare, and inimitable resources as a foundation for sustainable competitive advantage.
Hubungan Tingkat Pengetahuan dan Faktor Lainnya dengan Tingkat Kepatuhan Pasien Hipertensi di RSAL Dr. Mintohardjo Jakarta Arrang, Sherly Tandi; Veronica, Natalia; Notario, Dion
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 13, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.84908

Abstract

Hypertension is a "silent killer". It is still one of the bigest challenges in Indonesia, where many cases are still found in primary health facilities. Hypertensive patients who require long-term therapy and adherence are very important factors to support the success of therapy. Based on the data from the Ministry of Health of the Republic of Indonesia (2018), 32.3% of hypertensive patients did not take medication regularly. Many factors influence medication adherence, such as level of knowledge, age, gender, working status, and length of illness. This study aimed to determine the effect of the level of knowledge and other factors on the level of medication adherence of hypertensive patients at the Dr. Mintohardjo Naval Hospital (RSAL). This research is a observasional study with a cross-sectional method and uses a questionnaire for data collection. Adherence level questionnaire uses MMAS-8. Analysis of the relationship between factors that influence the level of adherence uses logistic regression. The inclusion criteria of this study included hypertention outpatient aged ≤ 65 years old and are currently receiving antihypertensive therapy. The results of this study showed that out of 284 respondents, 92% of respondents had good knowledge regarding hypertension, while the level of adherence to taking medication was low at 47%. Factors that influence the level of patient adherence to taking medication in this study are gender (p-value = <0.001), education (p-value = <0.001), duration of hypertension (p-value = 0.033), and working status (p-value = <0.001). In contrast, the level of knowledge (p-value = 0.979) and age (p = 0.87) did not significantly influence the level of medication adherence. The Odds Ratio (OR) for working status was 5.73, OR for final education was 2.97, OR for the duration of hypertension was 2.24, and OR for gender was 0.34.