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All Journal Makara Journal of Health Research
Iskender, Hatice
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Determination of the Nutritional Habits and Anxiety Levels in Individuals with COVID-19 in Turkey Iskender, Hatice; Dokumacioglu, Eda; Yalap, Osman
Makara Journal of Health Research Vol. 25, No. 2
Publisher : UI Scholars Hub

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Background: Coronavirus disease 2019 (COVID-19), which has spread worldwide since December 2019, has infected and claimed the lives of millions of people. This study aimed to investigate the relationship between anxiety levels and nutritional habits of patients with COVID-19. Methods: This cross-sectional study enrolled patients diagnosed with COVID-19 between February 1, 2021 and May 1, 2021. The study population included a total of 108 individuals with COVID-19 residing in Artvin, Turkey. This study used a self-administered online questionnaire, containing 40 questions from the State and Trait Anxiety Scale. Results: The state anxiety score was 37.26, and the trait anxiety score was 39.98. A strong, positive, and significant relationship was found between the state and trait anxiety levels of the participants (r = 0.588; p < 0.001). Conclusions: Many individuals who recovered from COVID-19 still suffer and struggle with the residual symptoms of COVID-19 for several months. Symptoms such as fatigue, weakness, pain, and malnutrition may occur even after recovery.
Association Between Cigarette Smoking and Breast Milk Levels of Nesfatin-1, Irisin, and Oxidative Stress Markers Yildiz, Nesibe; Yilmaz, Adnan; Iskender, Hatice; Dokumacioglu, Eda
Makara Journal of Health Research Vol. 25, No. 3
Publisher : UI Scholars Hub

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Background: Breast milk is a very important functional food in the prevention of metabolic and chronic diseases. This study aimed to investigate the effects of smoking during pregnancy on the concentrations of nesfatin-1, irisin, and oxidative stress markers in breast milk. Methods: This study included two groups of 14 smoking and 14 nonsmoking mothers. Malondialdehyde (MDA) level and superoxide dismutase (SOD) activity were measured according to the spectrophotometric method in breast milk samples. Nesfatin and irisin levels were measured by enzyme-linked immunosorbent assay. Results: Levels of nesfatin-1 and MDA of the smoking group were significantly higher than those in the control group (p < 0.001). The SOD activity of the smoking group was significantly lower than that of the control group (p < 0.001). No significant difference was found in the breast milk irisin level between the study groups (p > 0.050). Conclusions: Cigarette smoking increases MDA level and decreases SOD activity in breast milk. Nesfatin-1 levels would increase in accordance with increased oxidative stress, and nesfatin-1 acts as a protective mechanism to limit oxidative damage.
Protective Effect of Betulinic Acid Administration on Kidney Damage in Acetaminophen-Induced Nephrotoxicity Model Dokumacioglu, Eda; İskender, Hatice; Hayirli, Armagan; Yenice, Guler; Kapakin, Kubra Asena Terim; Bolat, Ismail; Kirman, Esra Manavoglu
Makara Journal of Health Research Vol. 27, No. 1
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Background: Acetaminophen (APAP) is the most widely used analgesic drug worldwide, but it may induce renal toxicity. Betulinic acid (BA) ameliorates the oxidative stress and inflammatory response to renal damage. The present study aimed to investigate the potential protective effects of BA treatment through an experimental kidney damage rat model administered with APAP. Methods: Sprague–Dawley male rats were randomly divided into four groups: control, BA (25 mg/kg for 15 days), APAP (1 g/kg), and APAP + BA groups. BA was administered via oral gavage at a dose of 25 mg/kg for 15 days. APAP was dissolved in hot saline and administered on the last day to produce nephrotoxicity via a single oral gavage at a dose of 1 g/kg. Kidney tissue samples were analyzed for human cartilage glycoprotein 39 (YKL-40), kidney injury molecule 1 (KIM-1), interleukin 18 (IL-18), superoxide dismutase (SOD), and malondialdehyde (MDA). Data were subjected to one-way analysis of variance and the Wilcoxon rank-sum test Results: Renal tissue YKL-40, KIM-1, IL-18, and MDA levels in the APAP group were significantly higher than those in the control group (p < 0.05). The BA treatment completely restored renal KIM-1, YKL-40, and MDA levels and partially restored renal IL-18 and SOD levels in the rats subjected to renal damage induction (p < 0.05). The intertubular regions of rats administered with APAP had degeneration, necrosis, and infiltration of inflammatory cells and were immunopositive for IL-1 beta and 8-hydroxy-2′-deoxyguanosine. Conclusions: BA can be used in the prevention and replacement treatment of nephrotoxicity due to its inhibitory properties in multiple pathways and powerful antioxidant effects.
Co-Authors Bolat, Ismail Dokumacioglu, Eda Hayirli, Armagan Kapakin, Kubra Asena Terim Kirman, Esra Manavoglu Yalap, Osman Yenice, Guler Yildiz, Nesibe Yilmaz, Adnan