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All Journal Journal Of Widya Medika Junior
Niluh Suwasanti
Department of Clinical Pathology, Faculty of Medicine, Widya Mandala Surabaya Catholic University
Medicine & Pharmacology Public Health

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THE EFFECT OF PERORAL POLYVINYL CHLORIDE MICROPLASTIC ON THE VALUE OF PROTHROMBIN TIME AND ACTIVATED PARTIAL THROMBOPLASTIN TIME IN RATTUS NORVEGICUS WISTAR STRAIN David Karunia Jaya; Yudhiakuari Sincihu; Niluh Suwasanti
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 4, No 3 (2022): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v4i3.4092

Abstract

Introduction: Microplastics can enter the human digestive system as polyvinyl chloride (PVC). Microplastics ingested by humans will accumulate in several organs. Microplastic accumulation in the liver causes inflammation, which damages hepatocyte cells, impairing liver synthesis function, one of which is the synthesis of blood clotting factors.Purpose: The purpose of this study was to determine the effect of oral microplastic polyvinyl chloride on prothrombin time (PT) and activated partial thromboplastin time (APTT) in Rattus norvegicus strain Wistar (APTT).Method: The experimental design incorporated a post-test-only control group. There were 12 rats randomly assigned to the control (K) or experimental (E) groups. For 28 days, Group E was exposed to microplastic type PVC at a concentration of up to 0.5 mg/day in 1 cc of Aquabidest via an oral probe. Blood samples were analyzed using a coagulation analyzer at BBLK Surabaya. The statistical test used an independent t-test.Result: There was a significant difference in the mean PT value of group K (9.8 ± 0.99 seconds) compared to group E (14.23 ± 9 seconds) (p=0.024) and the mean APTT value of group K(18.32 ± 7.96 seconds) compared to group E(26.1 ± 18.15 seconds) (p=0.022).Discussion: These findings confirm the theory that exposure to polyvinyl chloride microplastics in the liver can induce hepatocyte cell inflammation and impair the liver's ability to synthesize blood clotting factors, resulting in prolonged PT and APTT values.Conclusion: Oral administration of PVC microplastic affects PT and APTT values.
LITERATURE REVIEW: ASSOCIATION BETWEEN MATERNAL SERUM ALBUMIN LEVELS AND LOW BIRTH WEIGHT (LBW)LITERATURE REVIEW: ASSOCIATION BETWEEN MATERNAL SERUM ALBUMIN LEVELS AND LOW BIRTH WEIGHT (LBW) Stefanny Andrea Williana; Sianti Dewi; Niluh Suwasanti
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 2 (2023): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i2.3679

Abstract

Background: There are physiological changes during pregnancy, one of which is an increase in mother’s nutritional needs, which is protein. The most abundant plasma protein component is albumin; hypoalbuminemia is serum albumin levels below the normal values, which it can occur due to malnutrition, inflammation, kidney or liver damage where albumin is synthesized. Good nutritional status in pregnant women can prevent Low Birth Weight (LBW), while hypoalbuminemia in pregnant women can increase the risk of LBW. LBW is neonatal birth weight <2500 grams that can cause neonatal death and increase the risk of other diseases. LBW is a global problem, and in Indonesia LBW was also the most common cause of neonatal death in 2019 with a percentage of 35.3%. In Surabaya, there were 703 LBW cases (1.6%) in 2019; moreover, there were 15 LBW cases (1.92%) at Jagir Health Center in 2020. Aim: The aim of this study was to determine the association between maternal serum albumin levels and LBW. Method: The method used in this thesis is literature review with 10 research journals. The literatures that used in this literature review are journals with topics that related to the association between maternal serum albumin levels and neonatal birth weight. Result: From this literature review, there are 5 research journals conclude that there is a significant association between maternal serum albumin levels and neonatal birth weight.Conclusion: In conclusion, there is a possible association between maternal serum albumin levels and neonatal birth weight. Keywords: maternal serum albumin, hypoalbuminemia, birth weight, LBW
Co-Authors David Karunia Jaya Sianti Dewi Sincihu, Yudhiakuari Stefanny Andrea Williana