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All Journal The Indonesian Biomedical Journal Paediatrica Indonesiana ISM (Intisari Sains Medis) : Jurnal Kedokteran
Made Sukmawati
Departement Of Pediatrics, Faculty Of Medicine, Udayana University, Sanglah Hospital, Denpasar, Bali
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Presepsin Levels and Neutrophil-to-Lymphocyte Ratio are Positively Correlated with Procalcitonin Levels in Early Onset Neonatal Sepsis Ni Putu Sukma Sumantri Prabandari; Ni Kadek Mulyantari; Made Sukmawati; Anak Agung Ngurah Subawa; I Wayan Gede Artawan Eka Putra; Anak Agung Wiradewi Lestari; I Nyoman Wande; Ni Nyoman Mahartini
The Indonesian Biomedical Journal Vol 15, No 2 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i2.2135

Abstract

BACKGROUND: Early-onset neonatal sepsis (EONS) is an acute infection and sepsis occurring within the first 24 hours of new-born life. An increase in procalcitonin levels, presepsin levels, and neutrophil-to-lymphocyte ratio (NLR) in EONS subjects have been reported. However, whether presepsin levels and NLR affect the procalcitonin levels in EONS patients who have received antibiotic therapy has not been certainly known. This study was conducted to determine the correlation between presepsin levels and NLR with procalcitonin levels in EONS subjects.METHODS: A cross-sectional study involving 52 EONS subjects were conducted, and blood samples from subjects were collected. Presepsin levels were examined by enzyme-linked immunosorbent assay (ELISA) method, NLR was calculated from the absolute number of neutrophils divided by the absolute number of lymphocytes, and procalcitonin levels were examined by chemiluminescent microparticle immunoassay (CMIA) method. RESULTS: Median of procalcitonin levels and presepsin levels were 0.435 (0.12-9.11) ng/mL and 108.33 (71.43-1287.76) ng/L, respectively. While NLR value was 1.68 (0.2-7.52). There was significant difference between procalcitonin and presepsin levels (p=0.000), and so does between procalcitonin levels and NLR (p=0.001). Based on the multivariate analysis, presepsin levels also affected the procalcitonin levels (p=0.000; 95% CI: 0.001-0.004).CONCLUSION: The results of the study showed that there was significant correlation between presepsin levels and NLR with procalcitonin levels in EONS patients, suggesting that presepsin levels, NLR, and procalcitonin levels are potential candidates for EONS biomarkers.KEYWORDS: EONS, NLR, presepsin, procalcitonin
Co-Authors Anak Agung Ngurah Subawa Anak Agung Wiradewi Lestari Dyah Kanya Wati Gusti Ayu Nyoman Yulia Sitta Dewi Hendra Santoso I Gede Deden Susma Sugara I Made Kardana I Nyoman Wande I Putu Gede Danika Adikarya I Wayan Darma Artana I Wayan Darma Artana I Wayan Dharma Artana I Wayan Gede Artawan Eka Putra Ida Bagus Subanada Kadek Deddy Ariyanta Kadek Deddy Ariyanta Ketut Suarta Ketut Suarta Suarta Made Darmajaya Made Gede Dwi Lingga Utama N. K. Niti Susila, N. K. Ni Kadek Mulyantari Ni Made Sukewanti Ni Nyoman Mahartini Ni Nyoman Metriani Nesa Ni Putu Siadi Purniti Ni Putu Sukma Sumantri Prabandari Novita Purnamasari Assa Novita Purnamasari Assa Nyoman Gina Henny Kristianti Pramita Gayatri Putu Junara Putra Rinawati Rohsiswatmo Rulina Suradi Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Wayan Sulaksmana Sandhi Parwata