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All Journal Medical Journal of Indonesia ISM (Intisari Sains Medis) : Jurnal Kedokteran
Ida Bagus Rangga Wibhuti
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, Udayana University, Denpasar
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Diastolic function in patients with preeclampsia during pre- and post-partum period using tissue doppler imaging Rangga Wibhuti, I B; Soesanto, Amiliana M.; Shahab, Fahmi
Medical Journal of Indonesia Vol 25, No 2 (2016): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (423.673 KB) | DOI: 10.13181/mji.v25i2.1410

Abstract

Background: Prior studies have compared the E/e’ elevation in preeclampsia patients to normal patients, however there are no data whether this elevation persists after birth. The aim of this study is to analyze diastolic function in preeclampsia patients during pre- and post-partum period using E/e’ parameter measurement.Methods: This is a prospective cohort study of pregnant women with preeclampsia who were hospitalized and planned for pregnancy termination. Basic clinical characteristics were obtained from all samples. Echocardiography was done prepartum, 48-72 hours after termination, and 40-60 days postpartum. Post hoc analysis using least significant difference method was used to compare the results between measurements.Results: 30 subjects were enrolled in the study. Analysis on E/e’ characteristics showed statistical difference between prepartum E/e’ and 40 days postpartum E/e’ (11.87±3.184 vs 9.43±2.529, p=0.001, CI=1.123-3.751), as well as between 48 hours post-partum and 40 days post-partum period (12.12±2.754 vs 9.43±2.529, p<0.001, CI=1.615-3.771). There were no statistical differences between pre-partum E/e’ and 48 hours post-partum E/e’ (11.87±3.184 vs 12.12±2.754, p=0.633, CI=-1.345-0.832).Conclusion: This study showed diastolic dysfunction in preeclampsia patients persists up until a few days after birth, but resolves in time (40 days after birth) as measured by tissue doppler imaging.
The relationship between the decrease in Glomerulus Filtration Rate (GFR) and the increase in amount of coronary artery lesions on coronary heart disease patients in Sanglah General Hospital, Denpasar-Indonesia I Nyoman Triaditya Kresna Putra; I Kadek Susila Dharma; Ida Bagus Rangga Wibhuti
Intisari Sains Medis Vol. 9 No. 2 (2018): (Available online: 1 August 2018)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.389 KB) | DOI: 10.15562/ism.v9i2.160

Abstract

Coronary heart disease or coronary artery disease is caused by the atherosclerosis process in the coronary blood vessels. The high number of patients with this condition is significantly due to the influence of modern and all instant lifestyle. Among the factors suspected to be capable of influencing the increase in the number of coronary artery lesions in coronary heart patients is the Glomerulus Filtration Rate (GFR). This result is related to the high mortality and morbidity of coronary heart patients. Aim: The purpose of this research is to determine the relationship between the decrease in glomerulus filtration rate (GFR), the disturbance variables (age, gender, hypertension history, diabetes mellitus history, smoking history) and the increase in the number of coronary artery lesions in Sanglah General Hospital. Methods: This research is an analytical observational design with the cross-sectional design using secondary data from the medical records in Sanglah General Hospital Denpasar. This study attains 196 sample. Results: A significant relationship is attained between GFR (<60 ml/ minute) and the increase in the total vessel score (p = 0.017) with an OR 2.47 (CI95% 1.014-6.041). Furthermore, there is a significant relationship between risky age (male >45, female >55) and the increase in total vessel score (p = 0.015) with an OR 3.54 (CI 95% 1.217-10.307). Diabetes mellitus and the increase in the total vessel score also shows a significant relationship  (p = 0.016) with an OR 2.99 (CI 95% 1.189-7.539). While other risk factors such as gender, hypertension, and smoking have an insignificant relationship (p > 0.05). In the multivariate analysis, GFR (<60 ml/ minute) is a predictor of the vessel score (p=0,050) with an adjusted value of OR 1.86 (CI 95% 0.735-4.725). There are some other variables in which are significant predictors of the increase in vessel score. Risky age (male >45, female >55) (p=0,048) with an adjusted OR value of 3.08 (CI 95% 1.012- 9.407) and also diabetes mellitus (p=0.044) with an adjusted OR value of 2.65 (CI 95% 0.145-0.973) are those predictors. Conclusion: Hence, it appears that GFR (<60 ml/ minute), risky age (male >45, female >55) and diabetes mellitus have a significant relationship with the increase in vessel score and are predictors of the increase in vessel score. While gender, hypertension, and smoking do not have significant relationships with the increase in the amount of vessel score.
Kadar low density lipoprotein (LDL) tinggi berhubungan dengan peningkatan severitas sindrom koroner akut Irma Ersalina Br Karo; Ida Bagus Rangga Wibhuti; I Nyoman Wiryawan
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (245.125 KB) | DOI: 10.15562/ism.v11i3.658

Abstract

Background: Acute coronary syndrome (ACS) is a collection of symptoms that caused by disruption of coronary arteries so that decreasing the oxygen levels to the heart muscle (myocardium). Low-density Lipoprotein (LDL) is a lipid-carrying lipoprotein with the strongest predisposing factor compared to other cholesterol in supporting the formation of atheroma plaques in blood vessels that flow through the heart muscle in patients with acute coronary syndrome.Methods: This study is an analytic cross-sectional observational study aimed at seeing whether there is a relationship between levels of Low Density Lipoprotein (LDL) with an increase in severity of acute coronary syndrome. The population of this study were patients with a diagnosis of acute coronary syndrome at Sanglah Hospital Denpasar from July 2018 – January 2019. The relationship between LDL levels and severity of acute coronary syndrome was analyzed using Spearman correlation test and multivariate analysis in the form of discriminant analysis to analyze the relationship of LDL levels with severity of acute coronary syndrome compared with other risk factors as confounding variables.Results: Spearman correlation test showed that there was a significant positive relationship between LDL levels and severity of acute coronary syndrome with p = 0.01 and Spearman’s correlation coefficient of +0.365. The result of the study of discriminant analysis test also showed that there was a significant positive relationship between LDL levels and severity of acute coronary syndrome after being analyzed along with confounding variables with a value of p = 0.004.Conclusions: There was a significant positive relationship between LDL levels and severity of acute coronary syndrome at RSUP Sanglah Latar Belakang: Sindrom koroner akut merupakan suatu sekumpulan gejala yang disebabkan adanya gangguan pada arteri koronaria sehingga kadar oksigen menuju otot jantung (miokardium) mengalami penurunan. Low-Density Lipoprotein (LDL) merupakan lipoprotein pengangkut lipid dengan faktor predisposisi terkuat dibandingkan kolesterol lain dalam mendukung pembentukan plak ateroma pada pembuluh darah yang mengaliri otot jantung pada penderita sindrom koroner akut. Metode: Penelitian ini bersifat observasional cross-sectional analitik yang bertujuan untuk melihat apakah terdapat hubungan antara kadar Low Density Lipoprotein (LDL) dengan peningkatan severitas sindrom koroner akut.  Populasi dari penelitian ini merupakan pasien dengan diagnosis sindrom koroner akut di RSUP Sanglah Denpasar pada Juli 2018 – Januari 2019. Hubungan antara kadar LDL dengan severitas sindrom koroner akut dianalisis menggunakan uji korelasi Spearman serta analisis multivariat berupa uji analisis diskriminan untuk menganalisis hubungan kadar LDL dengan severitas sindrom koroner akut dibandingkan dengan faktor resiko lain sebagai variabel perancu.Hasil: uji korelasi Spearman menunjukkan terdapat hubungan positif bermakna antara kadar LDL dengan severitas sindrom koroner akut dengan nilai p = 0.01 serta koefisien korelasi Spearman sebesar +0,365. Hasil penelitian pada uji analisis diskriminan juga menunjukkan terdapat hubungan positif bermakna antara kadar LDL dengan severitas sindrom koroner akut setelah dianalisis bersama variabel perancu, dengan nilai p = 0,004.Simpulan: Terdapat hubungan yang positif yang bermakna antara kadar LDL dan severitas sindrom koroner akut pada pasien sindrom koroner akut di RSUP Sanglah
Rheumatic mitral stenosis based on Wilkins score and echo score revisited for patients undergoing balloon mitral valvuloplasty Prayoga Setiawan; Ni Made Ayu Wulan Sari; Luh Oliva Saraswati Suastika; Ida Bagus Rangga Wibhuti
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (280.614 KB) | DOI: 10.15562/ism.v12i1.888

Abstract

Background: An important factor for obtaining good results with good clinical outcomes from BMV procedure in rheumatic mitral stenosis is selecting the right candidate. This study aimed to determine rheumatic mitral stenosis characteristics based on conventional scoring system and echo score revisited for patients undergoing balloon mitral valvuloplasty.Method: This was a retrospective descriptive study with a cross-sectional approach. The study was conducted at the Department of Cardiology and Vascular Medicine, Sanglah Hospital Denpasar. Data were collected between January 1, 2019 and December 31, 2019 from registry and medical records.Result: Both groups had the same median age, which is 43 years old. The majority of research subjects were female, namely 16 people or 94.4%. There were no subjects from the failed group who had low echo score revisited. A total of 3 subjects (100.0%) with Wilkins score of 7 and high echo score revisited categorized as failed because of occurrence of significant mitral regurgitation post-procedure. In the successful group with Wilkins score of 8, there were no subjects who had a low echo score revisited value. In subjects with a Wilkins score of 8 and high echo score revisited value, 3 subjects categorized as failed and 1 subject obtained significant mitral regurgitation post-procedure.Conclusion: Patients with a low Wilkins score, but a high echo score revisited had a higher procedure failure rate.
Co-Authors Amiliana M. Soesanto I Kadek Susila Dharma I Nyoman Triaditya Kresna Putra I Nyoman Wiryawan Irma Ersalina Br Karo Luh Oliva Saraswati Suastika Ni Made Ayu Wulan Sari Prayoga Setiawan Shahab, Fahmi