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All Journal Urecol Journal. Part C: Health Sciences
Dwi Bagus Pambudi
Universitas Muhammadiyah Pekajangan Pekalongan, Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Test of ?-Amylase Inhibition Activity in Ethanol Extract of Fennel Leaves (Foeniculum vulgare Mill.) Using Elisa Reader Dwi Bagus Pambudi; Nuniek Nizmah Fajriyah; Retno Aulia Maharisti
Urecol Journal. Part C: Health Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (191.263 KB) | DOI: 10.53017/ujhs.1

Abstract

Fennel has been cultivated in Indonesia as a spice and medicinal plant. Fennel can produce fennel oil, which is the result of distillation from dry and ripe fennel fruit powder, while fennel leaves are mainly cooked to make vegetables. The ?-amylase enzyme plays an important role in the breakdown of oligosaccharides and disaccharides into monosaccharides so that they are ready for absorption. Inhibition of the ?-amylase enzyme can delay and prolong the digestion time of carbohydrates, causing a decrease in the rate of glucose absorption and preventing an increase in postpandrial plasma glucose levels. Therefore, this study aims to investigate the ethanol extract of fennel leaves (Foeniculum vulgare Mill.) Against the inhibitory activity of the ?-amylase enzyme using Elisa Reader. The experimental research method was applied to test the ethanol extract of secondary metabolite compounds from fennel leaves against the inhibition of ?-amylase enzyme activity. The results showed that the IC50 value in the fennel leaf extract was 1.432 ?g/mL while the IC50 acarbose as a comparison was 3.340 ?g/mL. In conclusion, the ethanol extract of fennel leaves can be used to reduce blood sugar levels.
Test of ?-Amylase Inhibition Activity in Ethanol Extract of Fennel Leaves (Foeniculum vulgare Mill.) Using Elisa Reader Dwi Bagus Pambudi; Nuniek Nizmah Fajriyah; Retno Aulia Maharisti
Urecol Journal. Part C: Health Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53017/ujhs.1

Abstract

Fennel has been cultivated in Indonesia as a spice and medicinal plant. Fennel can produce fennel oil, which is the result of distillation from dry and ripe fennel fruit powder, while fennel leaves are mainly cooked to make vegetables. The ?-amylase enzyme plays an important role in the breakdown of oligosaccharides and disaccharides into monosaccharides so that they are ready for absorption. Inhibition of the ?-amylase enzyme can delay and prolong the digestion time of carbohydrates, causing a decrease in the rate of glucose absorption and preventing an increase in postpandrial plasma glucose levels. Therefore, this study aims to investigate the ethanol extract of fennel leaves (Foeniculum vulgare Mill.) Against the inhibitory activity of the ?-amylase enzyme using Elisa Reader. The experimental research method was applied to test the ethanol extract of secondary metabolite compounds from fennel leaves against the inhibition of ?-amylase enzyme activity. The results showed that the IC50 value in the fennel leaf extract was 1.432 ?g/mL while the IC50 acarbose as a comparison was 3.340 ?g/mL. In conclusion, the ethanol extract of fennel leaves can be used to reduce blood sugar levels.
Optimation of Red Ginger (Zingiberofficinale Roxb) Extract Lozenges with Various Concentrations of Binding and Disintegrant Materials Dwi Bagus Pambudi; St. Rahmatullah; Novel Umarella; Hilda Fitria Wulandari; Dewi Safitri
Urecol Journal. Part C: Health Sciences Vol. 2 No. 2 (2022): August-Dec
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53017/ujhs.173

Abstract

The red ginger plant through several studies is known to have potential as a medicinal plant because it contains oleoresin and flavonoid that can relieve symptoms of coughs and are also effective in curing symptoms of sore throat, especially sore throat. The use of medicinal plants are active ingredients in herbal medicinal preparations has been widely used, especially in tablet preparations. In this study, tablets were formulated in 3 formulations with varying concentrations of binder and disintegrant. The method used in the wet granulation’s method because the selection of the method is adjusted to the nature of the extract and excipients to be used. Based on the tablet evaluation results, it was shown that the 3 formulas only met the requirements for the size uniformity test and the disintegration time test.
Co-Authors Dewi Safitri Hilda Fitria Wulandari Novel Umarella Nuniek Nizmah Fajriyah Retno Aulia Maharisti St. Rahmatullah