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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Triyanta Yuli Pramana
Department of Internal Medicine, Dr. Moewardi Hospital/ Faculty of Medicine, Universitas Sebelas Maret, Surakarta
Immunology & microbiology Medicine & Pharmacology Neuroscience

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The Prevalence of T Cells Population in the Liver of Patients with Viral Hepatitis Tri Nugraha Susilawati; Triyanta Yuli Pramana; Brian wasita
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 1 (2020): VOLUME 21, NUMBER 1, April 2020
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.418 KB) | DOI: 10.24871/211202033-37

Abstract

Background: It has been widely known that viral hepatitis is a major cause of liver disease that can cause chronic inflammation and carcinoma. This study aimed to describe the frequencies of CD4+ and CD8+ T cells, as well as regulatory T cells (CD25+ and Foxp3+ T cells) in the liver of patients with viral hepatitis in order to understand the comprehensive role of T lymphocytes in the progression of liver diseases attributed to viral hepatitis.Method: Liver biopsies were performed on adult patients presenting to a tertiary hospital in Surakarta, Indonesia with viral hepatitis from 2017 to 2018. Immunohistochemical staining was performed to identify cells expressing CD4+, CD8+, CD25+and Foxp3+ which represent T helper, T cytotoxic, and T regulatory cells, respectively. Additional data were retrieved from the patients’ medical records, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, viral load, and results of ultrasonography and fibroscan.Results: A total of 25 liver samples were collected from patients with chronic HBV infection (n = 21), chronic HCV infection (n = 2), acute HBV infection (n = 1), and from a with multiple liver nodules. The liver injury is minimum in all patients. The study found that CD8+ and CD4+ T cells were predominant whilst the frequency of T regulatory cells is generally low.Conclusions: The findings indicate the involvement of intrahepatic T helper and T cytotoxic in the pathogenesis of viral hepatitis. These liver infiltrating T cell subsets may be readily differentiated into regulatory T cells expressing CD25+ and Foxp3+ in order to prevent severe inflammation and maintain disease chronicity.
Characteristics of patients with Hepatitis B and C at Dr. Moewardi General Hospital in Surakarta, Indonesia Benedictus Aditya Satya Laksana Adji; Triyanta Yuli Pramana; Tri Nugraha Susilawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 54, No 3 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005403202207

Abstract

Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remain a significant health burden in the world, which is mainly attributed to patients who develop chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). The epidemiology of hepatitis B and C in Surakarta, Central Java Province, Indonesia has never been reported. This study aimed to investigate the demographic, clinical, and laboratory characteristics of patients with hepatitis B and C who were admitted to Dr. Moewardi General Hospital, Surakarta in 2019. The medical records of patients with hepatitis B (n=94) and hepatitis C (n=75) were examined, and the data were analyzed using the chi-square and Mann-Whitney tests. The patients with hepatitis C were generally older, more likely to develop jaundice and ascites, and had higher levels of serum urea, creatinine, AST, and total bilirubin compared to those with hepatitis B. In conclusion, patients with HCV infection had worse clinical presentation and laboratory profiles than those with HBV infection. However, further research is needed on a wider scale to confirm this result.
Co-Authors Benedictus Aditya Satya Laksana Adji Brian wasita Tri Nugraha Susilawati