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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Tropical and Infectious Disease Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal PAEDAGOGIA Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) AcTion: Aceh Nutrition Journal SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal of Community Empowerment for Health Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Abdidas Indonesian Journal of Global Health research JURNAL ETIKA KEDOKTERAN INDONESIA Nusantara Science and Technology Proceedings Jurnal Pengabdian Masyarakat Sasambo Proceedings of the International Conference on Nursing and Health Sciences Jurnal Sehat Indonesia (JUSINDO) Proceeding Muhammadiyah International Public Health and Medicine Conference The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Smart Society Empowerment Journal Media Dermato-Venereologica Indonesiana Media Penelitian dan Pengembangan Kesehatan Journal of Midwifery in Community Jurnal Epidemiologi Kesehatan Indonesia

Tri Nugraha Susilawati

Department Of Microbiology, Faculty Of Medicine, Sebelas Maret University, Surakarta

Author-ID : 1465041

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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The role of genital tract infection inpreterm delivery: aretrospective study Satria, Yohanes Aditya Adhi; Budihastuti, Uki Retno; Susilawati, Tri Nugraha
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Preterm delivery is associated with higher mortality and morbidity of neonates, also increasestheir risk of having growth and development impairment.This study aimed toidentify the role ofgenital tract infection in preterm delivery. A retrospective study was conducted on medical records of mothers who had preterm delivery in a tertiary hospital in Surakarta, Indonesia during 2017. The data collected were mothers’ age and their gestational age, the history of current pregnancy, the number of previous abortion(s), mothers’ body temperature, the extent of abnormal vaginal discharge, and laboratory findings (white blood cell count, platelet count, red blood cell count, hemoglobin count, hematocrit level, urinalysis and microbiology results). The statistical differences amongst categorical and numerical data were analyzed using the Chi-Square test and the Mann-Whitney test. Based on the patient’s history and the examination results, we suspected genital tract infections in22.52% (25/111)of subjects. All of them had abnormal vaginal discharge despite only one case had been confirmed as streptococcal infection. This study found that the majority of mothers with probable genital tract infection hadpreterm premature rupture of the membrane whilst preeclampsiawas more evident in those without genital tract infection. We conclude that genital tract infection during pregnancy is a significant contributor to the occurence of premature birth so that microbiological testing is needed to confirm the diagnosis.

TNF-α and TGF-β Contributes in Recurrent Otorrhea of Active Mucosal Chronic Otitis Media Dewi Pratiwi; Marisa Rizqiana; Adisetya Wicaksono; Defitaria Permatasari; Ratna Dwi Restuti; Tri Nugraha Susilawati; Sutarno Sutarno
The Indonesian Biomedical Journal Vol 14, No 1 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i1.1759

BACKGROUND: Active mucosal chronic otitis media (COM) is prevalent in lower-income countries and is associated with recurrent episodes of otorrhea due to chronic inflammation of the middle ear. Cytokines, which are well-known for their effects on the immune system, play an important role in the inflammatory response and tissue remodeling. The specific contributions of proinflammatory and immunoregulatory cytokines in the pathophysiology of active mucosal COM remain unclear. This study aimed to compare the levels of serum tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β in patients with active mucosal COM vs. healthy subjects.METHODS: Total 20 subjects with active mucosal COM and 20 healthy subjects participated in this study. The levels of serum TNF-α and TGF-β were measured using enzyme-linked immunosorbent assay (ELISA).RESULTS: The average level of serum TNF-α in subjects with active mucosal COM was significantly higher compare to the healthy subjects (46.373±41.76 pg/mL vs. 15.021±7.16 pg/mL; p=0.004). In contrast, the average level of serum TGF-β in subjects with active mucosal COM was lower compared to the healthy subjects, although the difference is not statistically significant (9.963±3.2 ng/mL vs. 11.78±8.48 ng/mL; p=0.552). Further analysis showed that in subjects with active mucosal COM, the levels of serum TNF-α had a medium positive correlation with the level of TGF-β (r=0.525; p=0.018).CONCLUSION: TNF-α and TGF-β, which are proinflammatory and immunoregulatory cytokines, may contribute to the pathogenesis of recurrent episodes of otorrhea in an active mucosal COM.KEYWORDS: tumor necrosis factor-α, transforming growth factor-β, active mucosal chronic otitis media

PEMBERDAYAAN YAYASAN SEBAGAI PELOPOR GERAKAN MASYARAKAT HIDUP SEHAT DALAM UPAYA PENCEGAHAN PENYAKIT HIPERTENSI Dono Indarto; Setyo Sri Rahardjo; Sinu Andhi Jusup; Sri Wulandari; Niniek Purwaningtyas; Heru Sulastomo; Ratna Kusumawati; Tri Nugraha Susilawati
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 6, No 1 (2022): Maret
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v6i1.7284

ABSTRAKPenyakit Tidak Menular (PTM) merupakan penyebab kematian tertinggi di dunia, termasuk di Indonesia. Salah satu PTM yang cukup tinggi prevalensinya adalah hipertensi. Kabupaten Karanganyar merupakan salah satu kabupaten di provinsi Jawa Tengah dengan jumlah kasus hipertensi yang cukup tinggi dan prevalensinya terus meningkat dari tahun ke tahun. Pemerintah Indonesia dan pemerintah kabupaten setempat telah mencanangkan Gerakan Masyarakat Hidup Sehat (Germas) sebagai upaya pengendalian PTM. Yayasan Usaha Umat Karanganyar (YUUK), sebuah organisasi masyarakat yang berlokasi di Tasikmadu, Karanganyar, telah memiliki program kegiatan pendidikan dan pelatihan yang diperlukan oleh masyarakat setempat, namun program pendidikan dan pelatihan tersebut belum menjamah aspek kesehatan masyarakat. Untuk mengoptimalkan kesehatan masyarakat setempat melalui pemberdayaan organisasi kemasyarakatan, tim pengabdian masyarakat yang tergabung dalam grup riset Human Proteomics Fakultas Kedokteran Universitas Sebelas Maret (FK UNS) melakukan kegiatan penyuluhan dan konsultasi tentang hipertensi dan serta pelatihan penggunaan tensimeter digital dan oximeter. Kegiatan tersebut bertujuan untuk meningkatkan peran serta YUUK dalam pencegahan dan deteksi dini penyakit hipertensi. Sasaran kegiatan ini adalah para remaja di sekitar masjid Al Walidah Tasikmadu Karanganyar. Hasil dari kegiatan tersebut adalah meningkatnya pemahaman peserta mengenai hipertensi dan keterampilan memantau kesehatan kardiovaskuler melalui penggunaan tensimeter digital. Evaluasi kegiatan ini dilakukan dengan cara menghubungi pengurus YUUK untuk mendapatkan laporan tentang implementasi pemanfaatan 2 unit tensimeter digital dan 1 unit oximeter yang diberikan oleh tim pengabdi kepada pengelola Yayasan untuk dimanfaatkan sebaik-baiknya bagi masyarakat sekitar. Tim pengabdi juga terus memonitor prevalensi hipertensi dari tahun ke tahun di Kabupaten Karanganyar. Kata kunci: hipertensi; pemberdayaan masyarakat; penyakit tidak menular ABSTRACT Non-communicable diseases (NCD) are the major causes of mortality in the world, including in Indonesia. One of the most prevalent type of NCD is hypertension. Karanganyar is a district in Central Java province with high incidence of hypertension and its prevalence continues to rise over years. Both central and local governments have established "Gerakan Masyarakat Hidup Sehat (Germas)", a community-based movement to promote healthy lifestyle, to control NCD. "Yayasan Usaha Umat Karanganyar (YUUK)", a community organization located in Tasikmadu, Karanganyar, provides education and training for locals but their main focus has not reached health programs. To optimize the locals' health through empowerment of community organizations, we conducted education and counseling about hypertension as well as training on using digital sphygmomanometer and oxymeter. The activities aimed to increase YUUK's roles in the prevention and early detection of hypertension. The activities involved teenagers living in the catchment area of Al Walidah mosque, Tasikmadu, Karanganyar. The activites resulted in an increased understanding about hypertension and skills to monitor cardiovascular health by using a digital sphygmomanometer, Evaluation was performed by contacting the YUUK manager who is responsible for reporting the use of 2 units of digital sphygmomanometers and 1 unit of oxymeter that were given during the occasion so that the equipment can be used by locals. We also continuosly monitor the annual prevalence of hypertension in Karanganyar district. Keywords: hypertension; community empowerment; non-communicable diseases

The Levels of Inhibitory Cytokines in the Serum of Patients with Hepatitis B and C Ainor Rohmah; Sigit Setyawan; Tri Nugraha Susilawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 27, No 3 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i3.1678

Hepatitis B and C Viruses (HBV dan HCV) can cause acute or chronic hepatitis that may develop into fibrosis, cirrhosis, and hepatocarcinoma. Previous studies have reported that hepatocyte damage is mainly due to overactive immune responses rather than viral infection. Cytokines are essential mediators in the immune response. This study aimed to determine the correlation between the levels of serum inhibitory cytokines, i.e., IL-4, IL-10, and TGF-β, and the development of liver disease in patients with hepatitis B and C. The levels of serum IL-4, IL-10, and TGF-β from 58 patients with hepatitis B or hepatitis C were determined by ELISA. The progression of liver disease is inferred from the levels of serum transaminases and the degree of liver fibrosis. Data were analyzed using the Spearman correlation test with a p-value of < 0.05 is considered statistically significant. This study showed no correlation between the levels of serum IL-4, IL-10, and TGF-β and the development of liver disease in patients with hepatitis B and C (p > 0.05). Therefore, cytokine testing using ELISA was unable to replace liver biopsy to assess liver disease progression in patients with hepatitis B and C.

Digitalisasi Layanan Kaji Etik: Sebuah Studi Tata Kelola Komite Etik Penelitian Tri Nugraha Susilawati; Erindra Budi Cahyanto; Usman Sudarmaji
Jurnal Etika Kedokteran Indonesia Vol 5, No 2 (2021): VOL 5, NO 2 (2021)
Publisher : Majelis Kehormatan Etik Indonesia PBIDI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstrak Perkembangan era digital yang pesat mempermudah rutinitas dan komunikasi sehari-hari, tetapi juga menciptakan tantangan tersendiri. Penyelesaian pekerjaan kelompok memerlukan pengetahuan dan keterampilan memadai agar dapat diselesaikan dengan lancar dan menghindari miskomunikasi. Penelitian ini bertujuan untuk mendeskripsikan karakteristik dan manajemen protokol penelitian yang dikaji Komite Etik Penelitian Kesehatan (KEPK) Fakultas Kedokteran Universitas Sebelas Maret (FK UNS). Studi retrospektif dilakukan dengan menganalisis protokol yang masuk ke KEPK FK UNS selama periode 2018-2020. Penelitian ini membandingkan proses kaji etik terhadap protokol penelitian serta mengidentifikasi permasalahan yang muncul ketika kaji etik dilakukan secara luring/ tatap muka maupun secara daring melalui aplikasi digital dan email resmi KEPK FK UNS. Data yang dikumpulkan berupa nomor identitas protokol, judul dan jenis penelitian, asal dan lembaga pemohon, serta jumlah hari yang diperlukan tim KEPK untuk menyelesaikan kaji etik (KE) hingga akhirnya menerbitkan surat keterangan laik etik (ethical clearance/ EC). Dari 405 protokol di tahun 2018, 302 protokol di tahun 2019, dan 188 protokol di tahun 2020, didapatkan jenis penelitian terbanyak adalah penelitian observasional, diikuti penelitian intervensi. Berdasarkan asal pemohonnya, mayoritas peneliti berasal dari lingkungan internal UNS, terutama mahasiswa S1. Jenis lembaga asal pemohon didominasi oleh institusi pendidikan, disusul rumah sakit dan litbang. Layanan KE secara manual (tahun 2018) dapat diselesaikan dalam waktu rerata 20 hari. Adapun layanan KE melalui aplikasi digital diselesaikan dalam waktu lebih lama, yaitu rata-rata 58 hari (tahun 2019) dan 46 hari (tahun 2020). Layanan KE melalui email dapat diselesaikan dalam waktu rata-rata 27 hari (tahun 2019) dan 19 hari (tahun 2020). Layanan KE harus disesuaikan dengan dinamika perkembangan jaman dan situasi yang memudahkan penelaah maupun pemohon. Hal itu demi tercapainya proses kaji etik yang efisien, cepat, nyaman namun tetap memprioritaskan kualitas telaah. Untuk mencapai hal tersebut, KEPK dapat merancang program edukasi berupa in-house training kepada penelaah serta pelatihan kepada peneliti untuk meningkatkan pengetahuan dan keterampilan teknis dalam menyusun protokol penelitian agar dapat diterima baik secara etik maupun secara digital.Abstract Background: The rapid development of digital era simplifies daily tasks and communication despite creating challenges. For example, when the tasks involve team work, particular knowledge and skills are needed to complete the tasks smoothly without bringing up any miscommunication. This study aimed to describe the characteristics and the management of research protocols submitted for ethical reviews at the Health Research Ethics Committee (HREC) of Faculty of Medicine, Universitas Sebelas Maret (UNS). Method: A retrospective study was conducted to analyse research protocols submitted to the HREC during the period of 2018-2020. This study compared the process of ethical reviews and identified problems during the conventional review (board meeting) and digital review (via digital application and the HREC official email). The following data were collected: protocol numbers, research titles, type of research, researcher’s origins, and the number of days required for the HREC team to complete the review and finally issuing ethical approval; i.e., the Ethical Review (ER) service. Results: A total of 405 protocols in 2018, 302 protocols in 2019, and 188 protocols in 2020 were submitted to the HREC. Most of the research protocols were observational studies, followed by interventional studies. The majority of researchers were undergraduate students of UNS. The origins of researchers were mostly from educational institutions, followed by hospital and research and development (R&D) institutions. The mean duration to complete the ER service by conventional review in 2018 was 20 days. The use of a digital application delayed the ER service which on average took 58 days to complete in 2019 and 46 days in 2020. The mean duration for completing the ER service via emails was 27 days in 2019 and 19 days in 2020. Conclusion: The ER service should be customized in accordance with the dynamics of the times and the situations that enables reviewers and researchers to perform an efficient, rapid, and comfortable process of ethical review whilst prioritizing the review quality. In order to do this, the HERC could deliver educational programs such as inhouse training for reviewers as well as training for researchers to improve the knowledge and technical skills in composing research protocols that are ethically and digitally acceptable.

Antidiabetic Effects of Red Rice Bran in The Rat Models of Diabetes Diana Nurrohima; Brian Wasita; Tri Nugraha Susilawati
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 2: June 2022
Publisher : Universitas Aisyah Pringsewu

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia than often requires antidiabetic drugs (AD) to control fasting blood glucose (FBG) levels. However, long-term use of AD has side effects. Red rice bran is a natural food containing flavonoids and anthocyanins, rich in antioxidants. However, the antidiabetic effect of rice bran is yet to be understood. This study aimed to determine the effect of ethanol extract of red rice bran (EERRB) on the levels of FBG, insulin, HOMA-IR, HOMA-B, and QUICKI on male rats induced by streptozotocin-nicotinamide (STZ-NA). This study was a pretest-posttest control group design. White male Wistar rats (Rattus norvegicus) (n=35) were divided into five groups randomly i.e P1 negative control (STZ-NA), P2 positive control (STZ-NA and acarbose 1.8 mg/200 g BW), P3, P4, P5 EERRB groups (STZ-NA and EERRB 165, 330, 660 mg/kg BW). The intervention was performed in 21 days. The data were analyzed using one way ANOVA test, paired t-test and Post Hoc test. EERRB effectively reduced FBG and HOMA-IR but increased insulin, HOMA-B and QUICKI in STZ-NA induced diabetic male rats. In conclusion, this shows that EERRB 330 and 660 mg/kgBW/day have the most potent antidiabetic effect. Abstrak: Diabetes melitus (DM) adalah penyakit metabolik yang ditandai dengan hiperglikemia kronis yang seringkali memerlukan obat antidiabetes (OAD) guna membantu mengontrol kadar glukosa darah puasa (GDP). Akan tetapi, penggunaan OAD dalam jangka panjang menimbulkan efek samping. Bekatul beras merah adalah bahan pangan alami dengan kandungan flavonoid dan antosianin yang kaya antioksidan. Namun, belum diketahui secara pasti efek antidiabetes dari bekatul beras merah tersebut. Penelitian ini bertujuan untuk mengetahui efek ekstrak etanol bekatul beras merah (EEBBM) terhadap kadar GDP, insulin, HOMA-IR, HOMA-B, dan QUICKI pada tikus jantan diabetes yang diinduksi Streptopzotocin-Nicotinamide (STZ-NA). Rancangan penelitian berupa pretest-posttest control group design. Tikus putih jantan Wistar (Rattus norvegicus) (n=35) terbagi menjadi lima kelompok secara acak: P1 kelompok kontrol negatif (diinduksi STZ-NA), P2 kelompok kontrol positif (diinduksi STZ-NA dan diberi akarbosa 1,8 mg/200 gBB), P3, P4, dan P5 kelompok EEBBM (diinduksi STZ-NA dan diberi EEBBM 165, 330, dan 660 mg/kgBB). Intervensi dilakukan selama 21 hari. Data dianalisis menggunakan uji one way ANOVA, paired t-test, dan uji Post Hoc. EEBBM efektif menurunkan GDP dan HOMA-IR serta meningkatkan insulin, HOMA-B, dan QUICKI pada tikus jantan model diabetes yang diinduksi STZ-NA. Kesimpulannya menunjukkan bahwa EEBBM330 dan 660 mg/kgBB/hari memiliki efek antidiabetik yang paling kuat.

A Systematic Review of the Frequency of Regulatory T Cells in Hepatitis B and Hepatitis C Tri Nugraha Susilawati; Atik Susianto
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 20, No 3 (2019): VOLUME 20, NUMBER 3, December 2019
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Regulatory T cells (Tregs) play an important role in sustaining the hepatitis B and C viruses (HBV and HCV) persistence and protecting the liver tissues from cytokine-associated detrimental effects through unclear mechanisms. This paper aims to review the frequency of Tregs during the course of HBV and HCV infection.Method: Electronic databases were searched to identify studies investigated the frequency of intrahepatic and peripheral Tregs of the patients infected with HBV and/ or HCV.Results: The majority of studies reported the increase of intrahepatic and peripheral Tregs in acute and chronic infection of HBV and HCV. The decrease of peripheral Tregs occurred in patients with chronic hepatitis B who respond to interferon α or nucleos(t)ide analogues treatment as well as those with chronic hepatitis C who were treated with interferon, ribavirin or liver transplantation.Conclusion: Infection with HBV and HCV appears to induce the production of Tregs in blood and hepatocytes whereas treatment may decrease Tregs levels. As the optimum balance between regulatory and effector T during HBV and HCV infection is crucial for preventing liver damage, further studies should be directed on the development of Tregs during HBV and HCV infection as well as their involvement in immunomodulatory strategies for combating HBV and HCV.

The Prevalence of T Cells Population in the Liver of Patients with Viral Hepatitis Tri Nugraha Susilawati; Triyanta Yuli Pramana; Brian wasita
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 1 (2020): VOLUME 21, NUMBER 1, April 2020
Publisher : The Indonesian Society for Digestive Endoscopy

Background: It has been widely known that viral hepatitis is a major cause of liver disease that can cause chronic inflammation and carcinoma. This study aimed to describe the frequencies of CD4+ and CD8+ T cells, as well as regulatory T cells (CD25+ and Foxp3+ T cells) in the liver of patients with viral hepatitis in order to understand the comprehensive role of T lymphocytes in the progression of liver diseases attributed to viral hepatitis.Method: Liver biopsies were performed on adult patients presenting to a tertiary hospital in Surakarta, Indonesia with viral hepatitis from 2017 to 2018. Immunohistochemical staining was performed to identify cells expressing CD4+, CD8+, CD25+and Foxp3+ which represent T helper, T cytotoxic, and T regulatory cells, respectively. Additional data were retrieved from the patients’ medical records, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, viral load, and results of ultrasonography and fibroscan.Results: A total of 25 liver samples were collected from patients with chronic HBV infection (n = 21), chronic HCV infection (n = 2), acute HBV infection (n = 1), and from a with multiple liver nodules. The liver injury is minimum in all patients. The study found that CD8+ and CD4+ T cells were predominant whilst the frequency of T regulatory cells is generally low.Conclusions: The findings indicate the involvement of intrahepatic T helper and T cytotoxic in the pathogenesis of viral hepatitis. These liver infiltrating T cell subsets may be readily differentiated into regulatory T cells expressing CD25+ and Foxp3+ in order to prevent severe inflammation and maintain disease chronicity.

Proinflammatory Cytokines and Its Correlation with Liver Injury Tri Nugraha Susilawati; Winda Rahayuningtyas; Triyanta Yuli Pramana
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 22, No 3 (2021): VOLUME 22, NUMBER 3, December 2021
Publisher : The Indonesian Society for Digestive Endoscopy

Background: A persistent infection of hepatitis B virus (HBV) can cause liver cirrhosis and hepatocarcinoma even though the virus itself is non-cytopathic and does not cause cell injury. It has been asserted that liver injury in chronic HBV infection is attributed to the host immune system responding to HBV infection. Cytokines have a critical role in mediating immune responses to viral infection. This study aimed to determine the correlation between the levels of serum IFN-γ, IL-2, IL-17, and TNF- α with the progress of chronic HBV infection that was determined through provisional diagnosis, patient’s age, and the levels of serum transaminases.Method: Blood samples were collected from patients with chronic hepatitis B and the levels of serum IFN-γ, IL-2, IL-17, and TNF-α were measured by using ELISA. The correlation between each cytokine levels and the provisional diagnosis, patient’s age, and serum transaminases were analyzed by using the Spearman correlation test with a p value of 0.05 is considered as statistically significant.Results: A total of 47 samples were collected from patients with chronic hepatitis B (n=38), chronic hepatitis B with liver cirrhosis (n = 6), and chronic hepatitis B with hepatocellular carcinoma (nc = 3). A significant correlation was found between the levels of serum IFN-γ and aspartate aminotransferase (AST) (p = 0.04).Conclusion: The increase of serum IFN-γ and AST levels may highlight the importance of these particular cytokine and liver transaminase in the immune response to chronic HBV infection since IFN-γ is capable to induce apoptotic cell death which promotes AST release and facilitates liver injury.

PEMBERDAYAAN KLUB PERSATUAN DIABETES INDONESIA (PERSADIA) DALAM UPAYA PENCEGAHAN KOMPLIKASI KARDIOVASKULER PADA PENDERITA DIABETES MELLITUS Setyo Sri Rahardjo; Sinu Andhi Jusup; Dono Indarto; Sri Wulandari; Niniek Purwaningtyas; Tri Nugraha Susilawati
Jurnal Pengabdian Masyarakat Sasambo Vol 4, No 1 (2022): November
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jpms.v4i1.931

Diabetes mellitus (DM) merupakan penyakit tidak menular (PTM) dengan prevalensi yang cukup tinggi di Kabupaten Karanganyar, Jawa Tengah. Pengendalian gula darah merupakan faktor utama untuk mencegah berbagai komplikasi penyakit DM. Tujuan dari pengabdian masyarakat ini adalah mengaktifkan gerakan masyarakat hidup sehat (Germas) dalam upaya pencegahan komplikasi kardiovaskuler pada penderita DM. Sasaran kegiatan ini adalah masyarakat yang tergabung dalam klub Persatuan Diabetes Indonesia (Persadia) Perumnas Palur, Kecamatan Jaten, Kabupaten Karanganyar, Jawa Tengah dimana kegiatan senam diabetes yang rutin diselenggarakan oleh klub tersebut sempat vakum dikarenakan pandemi Covid-19. Kegiatan pengabdian masyarakat berlangsung pada tanggal 7 Juni 2022 dan diikuti oleh 32 anggota klub. Metode pengabdian adalah edukasi, pelatihan, serta pemeriksaan tekanan darah dan gula darah sewaktu (GDS). Hasil dari kegiatan tersebut adalah meningkatnya pemahaman peserta mengenai penyakit DM dan keterampilan dalam memantau kesehatan melalui penggunaan tensimeter digital dan alat pengukur gula darah. Dari hasil pencatatan tekanan darah dan GDS didapatkan 1 kasus komorbid DM dan hipertensi, 14 kasus hipertensi, dan 2 kasus DM. Dapat disimpulkan bahwa kegiatan ini bermanfaat bagi klub Persadia dan masyarakat di sekitarnya dalam upaya pencegahan dan deteksi penyakit hipertensi dan DM.

Co-Authors 'Ulwiyah, Nuuriyah Adi Magna Patriadi Nuhriawangsa Adiby, Zulfi Azam Adisetya Wicaksono Ainor Rohmah Ardhi, Tunggul Armita Asri Apsari Atik Susianto Basaria, Kevyn Benedictus Aditya Satya Laksana Adji Bernarda, Clarisca Calcafiorentina Bhisma Murti Billah, Muhammad Muayyad Brian wasita Brian Wasita Brian Wasita Buamona, Nur Sitra Budiyanti Wiboworini Cahyaningrum, Nabilla Fitria Cahyanto, Erindra Budi Darmayanti, Aquartuti Tri Defitaria Permatasari Dewi Pratiwi Diana Nurrohima Dono Indarto Eriana Melinawati Erindra Budi Cahyanto Fahmi, Muhammad Izzul Widad Grhasta Dian Perestroika Harioputro, Dhani Redhono Hasibuan, Wahyu Aulia Heru Priyanto Heru Sulastomo Hilmy, Farhan Indallah, Nabila Wajihan Ismanta, Anestasia Darmastuti Jusup, Sinu Andhi Kezia Elian Devina Kusmadewi Eka Damayanti Kusmadewi Eka Damayanti Kusumastuti, Wijayanti Larasati, Riska Leli Saptawati Leli Saptawati Lutfinayati, Sofia Marisa Rizqiana Maryani Maryani Mashuri, Yusuf Ari Mufidah, Amatullah Nandyantami, Farah Fauziah Nazili, Muhammad Haqin Niamuzisilawati, Eva Niniek Purwaningtyas Nofia, Yasinta Nugraha, Yanika Tiara Nurgajayanti, Cendi Prastyoningsih, Aris Pratiwi Pratiwi Wulandari Purwaningtyas, Niniek Puspitasari, Reni Nur Putra, Wahyu Pratama Putri, Noviyati Rahardjo Radityastuti Rahardjo, Setyo Sri Rahmat Sugianto Ramadhan, Ahmad Rizqi Ratna Dwi Restuti Ratna Kusumawati Ratna Kusumawati Ratnasari, Affi Angelia Rauf, Muhammad Abdul Ridha Setiawati Riska Larasati Saputri, Nurul Aini Suria Satria, Yohanes Aditya Adhi Satria, Yohanes Aditya Adhi Septiana, Yesika Cahya Setyo Sri Rahardjo Sigit Setyawan Sinu Andhi Jusup, Sinu Andhi Sri Wulandari Sri Wulandari Sudarmaji, Usman Suhartono Sulastomo, Heru Suselo, Yuliana Heri Susianto, Atik Susilawati, Eva Sutarno Sutarno Syaputri, Dwi Triyanta Yuli Pramana Triyanta Yuli Pramana Uki Retno Budihastuti Usman Sudarmaji Vitri Widyaningsih Widiasih, Ghina Widyaningrum, Sherly Asri Wijiwinarsih, Amallia Winda Rahayuningtyas Winda Rizki Pebrina Batubara Yasmin, Thania Zahida, Sarah

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