Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

p-Index From 2021 - 2026

P-Index

This Author published in this journals

All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

Arnold Harahap

Department of Internal Medicine, Fatmawati General Hospital, Jakarta

Author-ID : 5436509

Medicine & Pharmacology

Published : 3 Documents Claim Missing Document

Claim Missing Document

Articles

Clinical Characteristics and Outcome of Acute on Chronic Liver Failure Patients at Fatmawati General Hospital Nikko Darnindro; Annela Manurung; Edi Mulyana; Arnold Harahap; Marlina Dewiastuti; Fenandri Fadillah Fedrizal; Mohammad Sadhyo Prabhasworo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 20, No 3 (2019): VOLUME 20, NUMBER 3, December 2019
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute liver decompensation with extrahepatic organ failure in patients with pre-existing liver disease causing high short-term mortality. A good knowledge about characteristics and diagnostic of ACLF will help us to give proper treatment. The aim of this study is to know the profile and characteristics of ACLF patientMethod: Retrospective study was conducted to find patient with ACLF between January 2017-January 2018 at Fatmawati General Hospital.Results: Ten patients were diagnosed with ACLF. Six patients admitted with a chief complaint: unconscious, 2 of them had hematemesis in the course-of-treatment. Three patients were admitted with abdominal pain, and 1 patient with hematemesis-melena. Seven patients had Hepatitis-B infection. Aspartate-transaminase to platelet-ratio index (APRI) values varied (median 8.1;minimum 2.81-maximum 34.67). Hepatic encephalopathy, ascites, and acute renal failure were found in 90% of patients. Jaundice can be found in all patients, with mean values of bilirubin levels in patients undergoing test for bilirubin level were 18.56 mg/dL (9/10). Coagulation disorders were found in 60% of patients undergoing haemostasis test. Four patients were diagnosed with grade 3 ACLF. All ACLF patients eventually died during treatment, including third-degree patients who all died within 7 days. Only 2 patients survived more than 7 days, and 4 patients died within 3 days of treatment. Conclusion: mortality rates of ACLF were very high, and are often found in patients with advanced liver disease characterized by high APRI values. The prognosis is related to the number of organ failures. Central nervous system, kidneys and liver are the organs that are often impaired. Because the current treatment method is still limited, further research is needed, especially on biomarkers for better prevention, diagnosis and treatment.

Prevalence of Gastroesophageal Reflux Disease (GERD) in Dyspepsia Patients in Primary Referral Hospital Nikko Darnindro; Annela Manurung; Edi Mulyana; Arnold Harahap
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 19, No 2 (2018): VOLUME 19, NUMBER 2, August 2018
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Gastroesophageal reflux disease (GERD) is caused by reflux of stomach contents into the esophagus and give the typical symptoms as heartburn. The prevalence of GERD was vary around the world. Prevalence of GERD by endoscopy in Jakarta was 22.8%. Limited data exist to determine the prevalence and related factors of gastroesophageal reflux disease (GERD) in the population without alarm symptoms. Validated GERDq questionnaire can be used easily to diagnose GERD in primary health care. This study aims to know the prevalence of GERD and related factors.Method: This cross-sectional study was conducted in adult dyspepsia patients at General Hospital District of Cilincing from January to March 2016. A validated GERDq questionnaire and a single proportion sample size calculation were used. Results: The prevalence of GERD was 49%, in elderly participants the prevalence was 44%. Of the 104 consecutive participants, 33.7% were male and 66.3% were female. The mean age was 47.6 ± 15.4 years old. The rate of GERD was higher in females than in males (53 vs. 40%, p = 0.189), increased as the age of the participants increased (p = 0.059) and also increased as the body mass index (BMI) of the participants increased (p 0.05). GERD was present in 50% of active or former smokers (p 0.05), 33.3% of daily coffee drinkers (p 0.05), 56.2% of active or former alcohol consumers (p 0.05), and 57.4% of daily tea drinkers (p = 0.049).Conclusion: The prevalence of GERD in dyspeptic patient was still high. There is a relation between GERD and tea consumption.

Association of Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) with Mortality in Patients with Coronavirus Disease 2019 (COVID-19) in Fatmawati General Hospital: A Preliminary Data Nikko Darnindro; M Ikhsan Mokoagow; Annela Manurung; Jerry Nasarudin; Elisabeth Yasmine Wardoyo; Anggraini Permata Sari; Aryan Yohanes Djojo; Martha Iskandar; Giri Aji; Radhiyatam Mardiyah; Nadya Magfira; Marina Epriliawati; Edi Mulyana; Arnold Harahap
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 2 (2020): VOLUME 21, NUMBER 2, August 2020
Publisher : The Indonesian Society for Digestive Endoscopy

Background: COVID-19, caused by SARS-CoV-2 virus, is a novel disease that has not been previously identified. The disease may result in multiple organ impairment leading to death. Liver is also affected by this viral infection. This study aimed to investigate the association of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) with mortality rate in these patients.Method: This is a retrospective cohort study of COVID-19 patients admitted in Fatmawati General Hospital during a period of March-April, 2020. Diagnosis of COVID-19 was established from real time Polymerase chain reaction (RT PCR). Association of AST and ALT levels with mortality was analyzed by using SPSS® version 16.0.Results: Forty-two patients were diagnosed as confirmed case of COVID-19, 52.3% of them were male. Mean age was 54.6±12 years. Median (IQR) value of AST and ALT levels were 55(48) U/L and 39(40) U/L, respectively. AST and ALT was elevated in 71.4% and 42.9%, respectively. Increased levels of AST and ALT 2 times above the upper normal limit (UNL), 2 times ULN, and 5 times ULN were found in 33.3% and 21.4%; 38.1% and 21.4%; 4.8% and 4.8%, respectively. Mortality was recorded in 45.1% of these confirmed cases, 50% occurred within 2 days of hospitalization. Higher mean value of AST is associated with an increased mortality risk (101 ± 147 U/L vs. 82.78 ± 173 U/L; p 0.032). Sub-analysis identified that abnormal AST 2 times above UNL has a higher mortality proportion compared with AST 2 times UNL and normal AST levels (62.5% vs. 50% vs. 16.7%; p 0.05). Mean value of ALT is not associated with mortality (p 0.479). Further sub-analysis found that in patients who succumbed to the disease, abnormal levels of AST and ALT is related to the time of death during hospitalization despite being statistically not significant.Conclusion: Mortality rate of COVID-19 in hospitalized patients remains high. Increased AST levels was significantly associated with higher mortality rate. This finding merit further investigation by incorporating larger sample size to discern the role of these factors’ contribution to mortality in COVID-19.

Co-Authors Anggraini Permata Sari Annela Manurung Aryan Yohanes Djojo Edi Mulyana Elisabeth Yasmine Wardoyo Fenandri Fadillah Fedrizal Giri Aji Jerry Nasarudin M Ikhsan Mokoagow Marina Epriliawati Marlina Dewiastuti, Marlina Martha Iskandar Mohammad Sadhyo Prabhasworo Nadya Magfira Nikko Darnindro Radhiyatam Mardiyah

Title

Found 3 Documents
Search

Abstract

Abstract

Abstract

Title Search

Found 3 Documents Search

Abstract

Abstract

Abstract

Title

Found 3 Documents
Search