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PENGARUH FAKTOR-FAKTOR RISIKO PENUAAN DINI DI KULIT PADA REMAJA WANITA USIA 18-21 TAHUN Dewiastuti, Marlina; Hasanah, Irma Fathul
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 10, No 1 (2016): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Skin aging process is a dynamic process. Skin aging process causes histologic change in skin layer. There are 2 factors causing skin aging process, intrinsic factor (nutritional status) and extrinsic factor (UV light).Tis research was conducted in a population of medical students of UPN Veteran Jakarta. The objective of this study was to ascertain prevalence of skin aging process and whether there was a relationship between the intrinsic and extrinsic factors and skin aging process. The design in this study was a cross-sectional study of the 136 research subjects. The collected data were analyzed by univariate, bivariate, and multivariate analysis. The incidence of skin aging process is 57.35%. Chi-square test showed that there was a relationship between the application of sunscreen and skin aging process (p = 0.001). There was no signifcant relationship between nutritional status (p=0,246) and skin aging process. From that result, skin aging process has occurred in late adolescent and most inﬂuence factor is application of sunscreen.

PENGARUH FAKTOR-FAKTOR RISIKO PENUAAN DINI DI KULIT PADA REMAJA WANITA USIA 18-21 TAHUN Marlina Dewiastuti; Irma Fathul Hasanah
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 10, No 1 (2016): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Skin aging process is a dynamic process. Skin aging process causes histologic change in skin layer. There are 2 factors causing skin aging process, intrinsic factor (nutritional status) and extrinsic factor (UV light).Tis research was conducted in a population of medical students of UPN Veteran Jakarta. The objective of this study was to ascertain prevalence of skin aging process and whether there was a relationship between the intrinsic and extrinsic factors and skin aging process. The design in this study was a cross-sectional study of the 136 research subjects. The collected data were analyzed by univariate, bivariate, and multivariate analysis. The incidence of skin aging process is 57.35%. Chi-square test showed that there was a relationship between the application of sunscreen and skin aging process (p = 0.001). There was no signifcant relationship between nutritional status (p=0,246) and skin aging process. From that result, skin aging process has occurred in late adolescent and most inﬂuence factor is application of sunscreen.

Efek Suplementasi Vitamin D terhadap Perbaikan Klinis dan Laboratorium Pasien Penyakit Hati Kronik Marlina Dewiastuti; Ryan Herardi
Cermin Dunia Kedokteran Vol 49 (2022): CDK Suplemen-2
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i0.1970

Sekitar 844 juta penduduk dunia menderita penyakit hati kronik yang dapat berkembang menjadi sirosis hati. Komplikasi penyakit hati kronik adalah keadaan malnutrisi dan defisiensi antara lain defisiensi vitamin D. Vitamin D merupakan vitamin larut dalam lemak yang disintesis di hati, sehingga penyakit hati berkaitan dengan defisiensi vitamin D, padahal vitamin D memiliki peran dalam pencegahan progresivitas penyakit hati. Beberapa penelitian mencoba suplementasivitamin D untuk perbaikan klinis dan laboratorium, serta mengurangi risiko kematian akibat penyakit hati. Telaah sistematis laporan kasus berbasis bukti ini tidak mendapatkan perbedaan hasil klinis antara suplementasi vitamin D dan plasebo, namun tidak ada efek samping serius pada suplementasi vitamin D. EASL menyarankan pemeriksaan kadar vitamin D dan suplementasi pada pasien dengan defisiensi vitamin D. Around 844 million people worldwide have a chronic liver disease, which can progress to liver cirrhosis. Complications of chronic liver disease such as malnutrition and deficiency states, including vitamin D deficiency. Vitamin D is a fat-soluble vitamin synthesized in the liver, whereas vitamin D has a role in preventing the progression of liver disease. Several studies investigated vitamin D supplementation for clinical and laboratory improvement and reducing mortality from liver disease. This systematic review resulted in no clinical difference between vitamin D supplementation and placebo-treated subjects, but no serious side effects of vitamin D supplementation were observed.

Clinical Characteristics and Outcome of Acute on Chronic Liver Failure Patients at Fatmawati General Hospital Nikko Darnindro; Annela Manurung; Edi Mulyana; Arnold Harahap; Marlina Dewiastuti; Fenandri Fadillah Fedrizal; Mohammad Sadhyo Prabhasworo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 20, No 3 (2019): VOLUME 20, NUMBER 3, December 2019
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute liver decompensation with extrahepatic organ failure in patients with pre-existing liver disease causing high short-term mortality. A good knowledge about characteristics and diagnostic of ACLF will help us to give proper treatment. The aim of this study is to know the profile and characteristics of ACLF patientMethod: Retrospective study was conducted to find patient with ACLF between January 2017-January 2018 at Fatmawati General Hospital.Results: Ten patients were diagnosed with ACLF. Six patients admitted with a chief complaint: unconscious, 2 of them had hematemesis in the course-of-treatment. Three patients were admitted with abdominal pain, and 1 patient with hematemesis-melena. Seven patients had Hepatitis-B infection. Aspartate-transaminase to platelet-ratio index (APRI) values varied (median 8.1;minimum 2.81-maximum 34.67). Hepatic encephalopathy, ascites, and acute renal failure were found in 90% of patients. Jaundice can be found in all patients, with mean values of bilirubin levels in patients undergoing test for bilirubin level were 18.56 mg/dL (9/10). Coagulation disorders were found in 60% of patients undergoing haemostasis test. Four patients were diagnosed with grade 3 ACLF. All ACLF patients eventually died during treatment, including third-degree patients who all died within 7 days. Only 2 patients survived more than 7 days, and 4 patients died within 3 days of treatment. Conclusion: mortality rates of ACLF were very high, and are often found in patients with advanced liver disease characterized by high APRI values. The prognosis is related to the number of organ failures. Central nervous system, kidneys and liver are the organs that are often impaired. Because the current treatment method is still limited, further research is needed, especially on biomarkers for better prevention, diagnosis and treatment.

Pencegahan Infeksi HIV Pada Wanita Subur Marlina dewiastuti
Segara : Jurnal Pengabdian Kepada Masyarakat Vol 1 No 1 (2023): Volume.1 No.1 Agustus (2023) - SEGARA : Jurnal Pengabdian Kepada Masyarakat
Publisher : Fakultas Kedokteran UPN "Veteran" Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/segara.v1i1.6069

Prevalensi infeksi Human Immunodeficiency Virus (HIV) di dunia meningkat 0.7% , walaupun peningkatan tidak sebesar pada tahun 1990-an diperkirakan saat ini 38 juta penduduk dunia terinfeksi HIV dan sebanyak 17.6 juta wanita usia subur terinfeksi HIV. Kasus infeksi HIV di Indonesia mengalami peningkatan, data tahun 2019 diperikirakan 50.282 terinfeksi HIV. Jawa Barat merupakan kota tertinggi ketiga populasi terinfeksi HIV. Indramayu salah satu kota di Jawa Barat mengalami peningkatan jumlah kasus infeksi HIV, berdasarkan data belum tercapai target sasaran bidang Kesehatan, yang mana target kasus baru HIV <0.05%. Meningkatnya kasus HIV meningkatkan masalah kesehatan. Infeksi HIV merupakan penyebab kematian pada wanita usia subur. Wanita usia subur merupakan jembatan epidemi infeksi HIV dari risiko rendah menjadi risiko tinggi. Selain itu wanita usia subur yang terinfeksi HIV akan berisiko menularkan ke anaknya kelak. Berbagai macam upaya sudah dilakukan dalam mencegah peningkatan infeksi HIV, baik pencegahan primer dan pencegahan sekunder. Upaya pencegahan dilakukan secara berkala dan mampu menjangkau semua lapisan masyarakat. Pemberian informasi mengenai HIV secara komprehensif , pencegahan dan transmisi, mencegah penularan ke anak, dan banyaknya miskonsepsi tentang HIV. Pengabdian kepada masyarakat ini bertujuan memberikan informasi yang komprehensif mengenai pencegahan infeksi HIV terutama pada wanita usia subur sebagai populasi kunci. Hasil dari pengabdian kepada masyarakat didapatkan pengetahuan yang rendah sebelum dilakukan edukasi dan setelah dilakukan terdapat peningkatan kemampuan. Edukasi berkala dapat meningkatkan pengetahuan dan diharapkan dapat menurunkan kejadian HIV.

Determinants of active aging affect healthy life expectation theresa, Ria Maria Theresa; dewiastuti, Marlina; Kristanti, Melly; cantika
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 17 No 1 (2023): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v17i1.5837

Life expectancy is an indicator of successful health development. It is estimated the elderly population will increase along with the increase in life expectancy, in 2050 there will be an increase 3 times in the number of elderly from 2013. The increase in the number of elderly raises a health sector complicated problem. The elderly group will experience a decrease in health status either naturally or due to illness. Goals of the health program focus on life expectancy. West Java is the largest proportion with Indramayu a city in West Java that has a target life expectancy that reaches the target. The government's efforts to improve the elderly welfare are realized in various programs so that an increase in the elderly population does not increase health problems. Indicators of elderly health can be measured by active aging (AA).. The determinants of the AA component, which include health and well-being, are indicators for assessing healthy life expectancy in the elderly. Assessment of healthy life expectancy is assessed from several determinants. Assessment of healthy life expectancy can determine health development targets, especially in the elderly. This study associated dietary patterns and smoking habits with increased healthy life expectancy.

Pengabdian Kepada Masyarakat edukasi tentang nyeri kaki pada tenaga kependidikan Anisah Makkiyah, Feda; Dewiastuti, Marlina
Segara : Jurnal Pengabdian Kepada Masyarakat Vol 2 No 1 (2024): Vol. 2 No. 1 (2024): SEGARA : Jurnal Pengabdian Kepada Masyarakat (In Press)
Publisher : Fakultas Kedokteran UPN "Veteran" Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/segara.v2i1.7990

yeri kaki mengenai populasi lebih dari 20 persen populasi di dunia, terutama pada pekerja dengan penggunaan sepatu yang tidak tepat, peningkatan berat badan, jenis pekerjaan, serta lama bekerja pada posisi yang bertumpu pada kaki. Kegiatan kepada Masyarakat kali ini berupa pemeriksaan antropometri (berat badan, tinggi badan dan penghitungan indeks massa tubuh (IMT), pemeriksaan tekanan darah, dilakukan pemeriksaan ultrasonografi kaki disertai edukasi mengenai nyeri kaki, penyebab, penanggulangan serta pencegahan nyeri kaki. Hasil pengabdian. Kebanyakan (50%) berusia 50-54 tahun. Keluhan nyeri pada kaki kebanyakan pada usia 35-39 tahun yaitu 50% dari total. Keluhan nyeri kaki 75 % dirasakan pada penderita overweight dan obesitas. Keluhan nyeri kaki juga dirasakan pada 75% penderita yang mengalami keluhan di kaki, diantaranya terdapat kallus, kaki pecah-pecah, flat feet, varises dan bunion. Kebanyakan yang mengeluh nyeri kaki adalah laki-laki sebesar 75%. Kesimpulan. Nyeri kaki meningkat pada penambahan usia dan penambahan berat badan. Penggunaan alas kaki yang tepat serta penurunan berat badan dapat menurunkan risiko nyeri kaki.

Heart Rate Variability pada Mahasiswa Penyintas COVID-19 Theodore, Ishak Ramos; Bustamam, Nurfitri; Simanjuntak, Kristina; Dewiastuti, Marlina
Jurnal Kedokteran Meditek Vol 30 No 3 (2024): SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v30i3.3257

COVID-19 meningkatkan risiko penyakit pada sistem kardiovaskular dan sistem saraf otonom. Penelitian ini bertujuan untuk mengetahui heart rate variability (HRV), yang merupakan salah satu indikator fungsi sistem saraf otonom dan sistem kardiovaskular, pada mahasiswa penyintas COVID-19 di Fakultas Kedokteran Universitas Pembangunan Nasional “Veteran” Jakarta. Penelitian menggunakan desain case-control dan purposive sampling. Jumlah sampel 42 mahasiswa dengan kriteria inklusi mahasiswa dengan riwayat COVID-19 atau tanpa riwayat COVID-19 dan berusia 18—22 tahun. Mahasiswa dengan riwayat penyakit kardiovaskular, disotonomia, merokok, minum alkohol, melakukan aktivitas berat, dan memiliki tingkat stres sedang hingga berat dieksklusi dari penelitian. Penelitian menggunakan HRV Analyzer SA-3000P untuk mengukur HRV dan kuesioner. Dari hasil penelitian didapatkan tidak ada perbedaan usia, jenis kelamin, dan skor stres antara kelompok penyintas COVID-19 dan kelompok kontrol (p > 0,05). Terdapat perbedaan RMSSD dan VLF di antara kedua kelompok (p < 0,05). Hasil uji Chi-square menunjukkan, terdapat hubungan antara riwayat COVID-19 dan HRV pada domain waktu RMSSD > 40 (p = 0,029; OR = 5,2; CI = 1,4—19,8). Kelompok penyintas COVID-19 berisiko 5,2 kali lipat memiliki RMSSD > 40 dibandingkan kelompok kontrol, yang menunjukkan adanya peningkatan aktivitas sistem saraf parasimpatis

Rapid Progressive Glomerulonephritis In Drug-Induced Bullous Pemphigoid Dewiastuti, Marlina; Bonar, Maruhum
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v11i4.64174

Rapidly progressive glomerulonephritis (RPGN) is a nephrologic emergency characterized by a rapid decline in renal function over days to weeks and is often associated with active urinary abnormalities. Drug-induced bullous pemphigoid (DIBP) is an autoimmune subepidermal blistering disease triggered by medication exposure and typically shows complement involvement. We report a case of a 62-year-old man with diabetes mellitus who developed pruritic urticarial plaques and tense bullae with erosions and hemorrhagic crusts on the trunk and extremities, predominantly on the dorsal hands and forearms, two days after starting acarbose. During hospitalization, renal function deteriorated rapidly within days, accompanied by significant albuminuria. The Naranjo Adverse Drug Reaction Probability Scale score was 5, indicating a probable drug-related reaction. Acarbose was discontinued and the patient received high-dose systemic corticosteroids (500 mg/day for three days). After seven days of therapy, renal parameters improved. Although renal biopsy and comprehensive serologic work-up were not performed to confirm the exact subtype of crescentic glomerulonephritis, the temporal association, probable causality assessment, and clinical response support an immune-mediated process with concurrent skin and kidney involvement. This case highlights the importance of early renal evaluation and multidisciplinary management in patients with suspected DIBP, as prompt drug withdrawal and immunosuppressive therapy may prevent irreversible kidney damage.

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