Siti Nurhidayah
Department Of Midwifery Medicine Faculty, University Of Brawijaya, Malang, Indonesia

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Potential Benefit of Flavonoid in Papaya Leave Gel in Neutrophil, Angiogenesis, and Wound size in Rattus Norvegicus Siti Nurhidayah; Iin Tri Marlinawati; Sri Winarsih; Tatit Nurseta
Medical Laboratory Technology Journal Vol. 8 No. 2 (2022): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1710.305 KB) | DOI: 10.31964/mltj.v8i1.464

Abstract

An incision wound is the destruction of several cells in the skin area that has experienced an incision. Several factors influencing wound healing are neutrophils as causative agents of inflammation, angiogenesis, and wound closure. These three factors should undergo physiologically to obtain the optimal healing process. Currently, herbal products are preferred because they have lower side effects than synthetic ones. Papaya leaves contain flavonoids with various functions, including wound closure and anti-inflammatory and antioxidant effects. Topical intervention, especially gel, is good for healing because it can keep the wound moist. This research aimed to determine the effect of the administration of papaya leaf gel on wound closure, neutrophil, and angiogenesis. Thirty white rats were used as the model animals in a randomized experimental study divided into five groups comprising negative control (0,9% NaCl), positive control (10% Povidone-iodine), and three intervention groups treated with gel of Carica papaya leaves at a dosage 10%, 20%, and 30%. All groups were topically administered treatment once a day on the dorsal surface for seven days. Carica papaya leaves contain flavonoids, saponin, tannin, and alkaloids qualitatively and 7,734 mg/kg of the flavonoid quantitatively. There were no significant differences in wound size in all three groups on three days, but Carica papaya leave gel had a superior effect compared to 10% PI and 0,9% NaCl in the wound closure process. There were significant differences in all groups in neutrophil and angiogenesis. Nevertheless, 20% papaya leave gel showed the lowest number of neutrophils and had a superior effect on improving the new blood vessels significantly compared to negative and positive groups.
IMPLEMENTATION OF DIFFERENT CULTURES TO INFLUENCE POSTPARTUM DEPRESSION Siti Nurhidayah
Journal of Psychiatry Psychology and Behavioral Research Vol. 4 No. 1 (2023): Fight Against Depression and Embrace Equity in Mental Health
Publisher : Departemen Psikiatri Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (362.016 KB) | DOI: 10.21776/ub.jppbr.2023.004.01.7

Abstract

Background: Postpartum depression (PPD) is a big problem that could cause effect adversely on postnatal mother’s mental health and cognitive and physical development for their children even though it is well known, disabling, and treatable. The prevalence of postpartum depression in the Middle East hasthe highest number(26%) but in contrast, Europe is on the lowest (8%). Postpartum practices traditionally are utilized for providing care to mothers. However, there are some evidence-based regarding particular outcomes of postpartum depression.Objective: To know about different cultures contributing to postpartum depression.Method: A literature review was conducted across 5 databases including PubMed, MEDLINE, PMC, Science Direct, and Taylor FrancisOnline between 2015 and 2021 which related particularly to cultural belief in postpartum and postpartum depression. The result will be determined by literature review.Results: There are a wide range of different culture that were implemented upon postpartum period in Western country and Asian Country resulting postpartum depression. Idealized mother, multitasking, having a good financial, job, bonding with infant, is emphasized in Western Country while Asian Country have certain culture in every region. However, gender is common in both nations to cause depressionConclusion: Postpartum depression is psychological disorder which can suffer during postpartum period culture is one of the included causes of it and gender preference is the most issue which lead postpartum depression. Keywords: cultures, postpartum, depression.