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All Journal Jurnal Ilmu Kefarmasian Indonesia
Swastika Praharyawan
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Optimalisasi Produksi Fikosianin pada Sianobakteria Laut BTM 11 dan Uji Aktivitas Antioksidannya Baso Didik Hikmawan; Swastika Praharyawan; Kintoko Kintoko
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1198

Abstract

Phycocyanin (PC)-producing cyanobacteria has shown many pharmaceutical applications, the main one is the antioxidant properties. Biosynthesis of PC-producing cyanobacteria is affected by many factors like nitrogen availability and light intensity during cultivation. This study aims to analyze the optimum concentration of nitrogen and light intensity during the cultivation of PC biosynthesis of marine cyanobacteria BTM 11 and identify its antioxidant properties This study was an experimental laboratory method and the PC level was determined through the variation of sodium nitrate (NaNO3) as a source of nitrogen dissolved in media and using different light intensities. The most optimum nitrogen and light intensity values of PC were measured by its antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical capture method. Data was analyzed by one-way ANOVA and the post-hoc Duncan to see whether p<0.05. The result showed that there was a significant difference in the PC level that was cultivated with the variation of NaNO3 concentrations. The highest PC level was observed in media containing 525 mg of NaNO3 and the optimum light intensity of 4500 lux. The result of the antioxidant activity assay showed that the BTM11’s PC’s antioxidant activity had its IC50 at 91.89 μg/mL and the IC50 of ascorbic acid was 2.39 μg/mL
Co-Authors Baso Didik Hikmawan Kintoko, Kintoko