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All Journal Indonesian Journal of Chemistry Jurnal Ilmu Kefarmasian Indonesia Proceeding of Mulawarman Pharmaceuticals Conferences AMMA : Jurnal Pengabdian Masyarakat al Kimiya : Jurnal Ilmu Kimia dan Terapan Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm
Baso Didik Hikmawan
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Optimalisasi Produksi Fikosianin pada Sianobakteria Laut BTM 11 dan Uji Aktivitas Antioksidannya Baso Didik Hikmawan; Swastika Praharyawan; Kintoko Kintoko
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1198

Abstract

Phycocyanin (PC)-producing cyanobacteria has shown many pharmaceutical applications, the main one is the antioxidant properties. Biosynthesis of PC-producing cyanobacteria is affected by many factors like nitrogen availability and light intensity during cultivation. This study aims to analyze the optimum concentration of nitrogen and light intensity during the cultivation of PC biosynthesis of marine cyanobacteria BTM 11 and identify its antioxidant properties This study was an experimental laboratory method and the PC level was determined through the variation of sodium nitrate (NaNO3) as a source of nitrogen dissolved in media and using different light intensities. The most optimum nitrogen and light intensity values of PC were measured by its antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical capture method. Data was analyzed by one-way ANOVA and the post-hoc Duncan to see whether p<0.05. The result showed that there was a significant difference in the PC level that was cultivated with the variation of NaNO3 concentrations. The highest PC level was observed in media containing 525 mg of NaNO3 and the optimum light intensity of 4500 lux. The result of the antioxidant activity assay showed that the BTM11’s PC’s antioxidant activity had its IC50 at 91.89 μg/mL and the IC50 of ascorbic acid was 2.39 μg/mL
Penyuluhan Pemanfaatan Limbah Kulit Buah Nanas Sebagai Alternatif Pembuatan Sabun Cuci Piring Di Kelurahan Bukit Pinang, Samarinda, Kalimantan Timur Muhammad Nuzul Azhim Ash Siddiq; Baso Didik Hikmawan; Hajrah; Noviyanty Indjar Gama; Nur Masyitah Zamruddin; Akhmad Jaizzur Rijai; Viriyanata Wijaya
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 9 : Oktober (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Domestic waste is a global problem that is growing along with population growth and changes in consumption patterns. Domestic waste, if not handled properly, can cause environmental and health problems. Pineapple peel as a type of domestic waste has the potential to be used as an alternative pharmaceutical product because it still contains compounds in it, such as enzymes and bioactive compounds. Utilizing this waste not only reduces negative impacts on the environment, but also creates high-value products that are beneficial to society. Utilizing pineapple peel waste as a dishwashing soap product is the focus of our community service. The use of fruit peel waste represents a progressive step towards sustainability, small-scale home industry innovation and waste reduction which are increasingly important in efforts to preserve the environment and create products that are more beneficial to humans.
Formulasi Sediaan Sabun Cair Ekstrak Etanol Daun Afrika (Vernonia Amygdalina Delile) dan Aktivitas Antibakterinya: Formulation of Liquid Soap with Ethanol Extract from African Leaves (Vernonia Amygdalina Delile) and Its Antibacterial Activity Ervina Irmaya Sagita; Baso Didik Hikmawan; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.704

Abstract

Empirically, African leaves (Vernonia amygdalina delile) have been widely used by Indonesians as medicinal plants, especially for diseases caused by bacteria. Liquid soap is a soap that has a liquid form that produces more foam than solid soap so it is more attractive. This study aims to make the benefits of African leaves can be easily applied, so it is formulated in the form of liquid soap that meets the standards and also has an antibacterial effect. This research uses laboratory experimental qualitative and quantitative methods. The extract was obtained by maceration of simplisia with 96% ethanol, then variating the extract concentration to 5%, 10%, and 20% in the formula. The base formula is variating concentration of VCO, which are 20%, 25%, and 30%. The results showed that base formula 1 (F1) with 5% extract concentration had optimum characteristics, organoleptic test results of dark green color, liquid form that has a distinctive peppermint fragrance, pH value of 10.80, viscosity of 19 dpa.s, density of 1.086 g/mL, water content of 29.5%, foam stability of 95.56%, and free fatty acid content of 0.33%. Antibacterial test results against Staphylococcus aureus and Escerichia coli showed inhibition diameters of 23.8 mm and 25 mm respectively. Keywords: African leaves, Liquid soap, Antibacterial Abstrak Secara empiris daun afrika (Vernonia amygdalina delile) telah banyak digunakan oleh masyarakat Indonesia sebagai tumbuhan obat, salah satunya penyakit yang disebabkan oleh bakteri. Sabun cair merupakan sabun yang memiliki bentuk cairan menghasilkan busa lebih banyak daripada sabun padat sehingga lebih menarik. Penelitian ini, memiliki tujuan untuk membuat kemanfaatan daun afrika tersebut dapat dengan mudah untuk diaplikasikan, sehingga diformulasikan dalam bentuk sabun cair yang memenuhi standar juga memiliki efek antibakteri. Penelitian ini menggunakan metode kualitatif dan kuantitatif eksperimental laboratorium. Ekstrak didapatkan dengan maserasi simplisia dengan etanol 96%, lalu dibuat variasi konsentrasi 5%, 10%, dan 20% dalam sediaan. Basis formula dibuat dengan memvariasikan konsentrasi VCO yaitu 20%, 25%, dan 30%. Hasil penelitian menunjukkan bahwa formula basis 1 (F1) dengan konsentrasi ekstrak 5% memiliki karakteristik optimum, hasil uji organoleptik warna hijau tua, berbentuk cairan yang memiliki wangi khas peppermint, nilai pH 10,80, viskositas 19 dpa.s, bobot jenis 1,086 g/mL, kadar air 29,5%, stabilitas busa 95,56%, dan kadar asam lemak bebas 0,33%. Hasil uji antibakteri terhadap Staphylococcus aureus dan Escerichia coli menunjukkan diameter daya hambat sebesar 23,8 mm dan 25 mm berturut-turut. Kata Kunci: Daun Afrika, Sabun cair, Antibakteri
Naphthalene Derivates from Bawang Tiwai Bulb Eleutherine Bulbosa in Borneo Salam, Supriatno; Hikmawan, Baso Didik; Samsul, Erwin; Herman, Herman; Ahmad, Islamudin; Rijai, Laode; Nafiah, Mohd Azlan
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 1 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i1.35515

Abstract

Naphthalene derivative compounds named Eleutherol (1) and Eleutherol C (2) have been isolated from Bawang Tiwai Bulb Eleutherine bulbosa. We tested its cytotoxic activity against T47D breast cancer cells in vitro after isolating compounds 1 and 2 from the EtOH extract using conventional chromatography methods. Their chemical structures were elucidated based on spectroscopic analysis, including IR, HR-TOFMS, 1D, and 2D NMR, and by comparison to those related spectra previously reported. Compounds 1 and 2 were tested for their cytotoxic effects against T47D breast cancer cells and showed moderate cytotoxicity against T47D breast cancer cells with IC50 values of 117.15 and 80.21 µM, respectively, compared with cisplatin 24.07 µM.
Upaya Peningkatan Kesehatan Melalui Pemeriksaan Kesehatan Gratis pada Masyarakat Desa Bangun Rejo Kecamatan Tenggarong Seberang Kabupaten Kutai Kartanegara sebagai Upaya Deteksi Dini Penyakit Tidak Menular Arifuddin, Muhammad; Samsul, Erwin; Riki; Rija'i, Hifdzur Rashif; Rusli, Rolan; Ibrahim, Arsyik; Febrina, Lizma; Bone, Mahfuzun; Junaidin; Herman; Rusman, Arman; Hikmawan, Baso Didik; Ahmad, Islamudin
Jurnal Abdita Naturafarm Vol. 2 No. 1 (2025): J Abdita Naturafarm
Publisher : B-Creta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jan.v2i1.1925

Abstract

Non-communicable diseases (NCDs) have become a significant global health challenge. Conditions such as heart disease, diabetes, and hypertension contribute to more than 70% of deaths worldwide. This community service activity aims to provide free health screenings to the community, particularly to the residents of Desa Bangun Rejo, with the goal of early detection of NCDs. The community service activities involved health screenings followed by direct education to the participants. The results showed that 40 participants attended and gained knowledge about their current health conditions, including blood pressure, blood glucose levels, and uric acid levels. The findings from the health screenings will serve as a reference for participants to understand the importance of regular health check-ups in mitigating future risks Penyakit tidak menular (PTM) menjadi salah satu tantangan kesehatan global yang signifikan. termasuk penyakit jantung, diabetes, dan hipertensi menyumbang lebih dari 70% kematian di seluruh dunia. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan pemeriksaan Kesehatan gratis kepada masyarakat khususnya masyarakat Desa Bangun Rejo yang bertujuan untuk deteksi dini PTM. Metode kegiatan pengabdian yang dilakukan berupa pemeriksaan Kesehatan dan dilanjutkan pemberian edukasi langsung kepada peserta. Hasil kegiatan pengabdian kepada masyarakat ini menunjukkan peserta yang hadir sebanyak 40 orang mengetahui tentang kondisi saat ini berupa tekanan darah, kadar glukosa darah, dan asam urat. Hasil pemeriksaan yang didapatkan dijadikan sebagai rujukan untuk peserta lebih memahami pentingnya melakukan pemeriksaan kesehatan secara rutin guna menanggulangi resiko yang lebih besar untuk kedepannya
An Innovative Strategy for the Green Synthesis of Nanochitosan Using Plant Extracts and Their Possible Applications: A Review Riki, Riki; Ahmad, Islamudin; Herman, Herman; Ibrahim, Arsyik; Rusman, Arman; Samsul, Erwin; Rusli, Rolan; Arifuddin, Muhammad; Junaidin, Junaidin; Bone, Mahfuzun; Rijai, Hifdzur Rashif; Hikmawan, Baso Didik
Indonesian Journal of Chemistry Vol 25, No 2 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.100148

Abstract

The numerous applications of nanochitosan in a variety of sectors, including medicine, food, and agriculture, attract researchers to work toward the development of environmentally favorable, safe, and efficient synthesis methods. Currently, a biological approach is being developed to synthesize nanochitosan to address the limitations of conventional methods. The synthesis of biogenic pathways employs biological entities, including plant extracts and microorganisms, as nanoparticle-forming agents. The use of extracts is more desirable due to the simple working procedure, the absence of hazardous chemicals, the economic benefits, and the use of basic equipment. This article highlights the role of biomolecules in plant extracts, including polyphenols, terpenoids, citric acid, alkaloids, and polysaccharides, in the synthesis of nanochitosan. Nanoparticle preparation protocols and characterization using zeta potential analysis techniques, scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV-visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR) are briefly described. The potential applications of green nanochitosan are also discussed, considering the results of biological activity testing and the potential mechanisms associated with these activities. According to the results of numerous studies highlighted in this review, nanochitosan synthesis utilizing plant extracts appears to be a promising alternative approach to conventional methods.
Aktivitas Antihiperglikemia Infusa Daun Sambung Nyawa (Gynura Procumbens) dengan Metode Toleransi Glukosa pada Mencit Jantan (Mus Musculus): Antihyperglycemic Activities of Sambung Nyawa Leaves (Gynura Procumbens) Infusion using a Glucose Tolerance Method in Male Mice (Mus Musculus) Ridhotulloh, Yusuf Isro; Rijai, Laode; Mus, Nurul Muhlisa; Arifuddin, M.; Ibrahim, Arsyik; Ahmad, Islamudin; Herman, Herman; Hikmawan, Baso Didik; Junaidin, Junaidin; Febrina, Lizma; Faisal, Muhammad; Rusman, Arman; Riki, Riki; Almeida, Maria; Bone, Mahfuzun; Arifian, Hanggara; Samsul, Erwin
Jurnal Sains dan Kesehatan Vol. 7 No. 2 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i2.2421

Abstract

Hyperglycemia is a condition where blood sugar increases significantly which can lead to diabetes mellitus. Sambung Nyawa (Gynura Procumbens) leaves are a plant that is empirically believed to reduce hyperglycemia and has been scientifically proven based on several studies, however there has been no research that provides information about sembung nyawa leaves in infusion form. This study aims to determine the content of secondary metabolites in the infusion of the leaves of Gynura Procumbens and its antihyperglycemia activity in male males. This study consisted of phytochemical and antihyperglycemia screening using a tolerance method induced by glucose monohydrate at a dose of 2g/kgBW. The test group consisted of a negative control group (Na CMC 1%), a positif group (Glibenclamide), and 3 groups of sambung nyawa leaf infusion (5%, 10%, 15%). The results of the research showed that the infusion of sembung nyawa leaves contained secondary metabolites, namely tannins, phenolics, flavonoids and saponins. The effect of reducing blood sugar levels in test animals showed a significant reduction (0.00<0.05) at a 10% concentration infusion compared to the negative control and not significant to the positive control. The conclusion shows that the infusion of sambung nyawa leaves has an antihyperglycemic effect. Keywords:          Antihyperglycemic, Sambung Nyawa Leaves, Glucose Monohydrate   Abstrak Hiperglikemia merupakan kondisi peningkatan gula darah yang cukup signifikan yang akan berubah menjadi kondisi diabetes mellitus. Daun sambung nyawa (Gynura Procumbens) merupakan tumbuhan yang dipercaya secara empiris menurunkan hiperglikemia dan terbukti secara ilmiah berdasarkan beberapa penelitian dalam bentuk ekstrak. Penelitian ini bertujuan mengetahui kandungan metabolit sekunder pada infusa daun sambung nyawa dan aktivitas antihiperglikemia pada mencit jantan. Penelitian ini terdiri dari skrining fitokimia dan antihiperglikemia menggunakan metode toleransi yang dinduksi glukosa monohidrat dengan dosis 2g/kgBB. Kelompok uji terdiri dari kelompok kontrol negatif (Na CMC 1%), positif (Glibenklamid), dan 3 kelompok infusa daun sembung nyawa (5%, 10%, 15%). Hasil penelitian menunjukkan infusa daun sambung nyawa mengandung metabolit sekunder yaitu tanin, fenolik, flavonoid dan saponin. Efek penurunan kadar gula darah pada hewan uji menunjukkan penurunan yang signifikan (0,00<0,05) pada infusa konsentrasi 10% dibandingkan dengan kontrol negatif dan tidak signifikan terhadap kontrol positif. Kesimpulan menunjukkan bahwa infusa daun sambung nyawa mempunyai efek antihiperglikemia. Kata Kunci:         Antihiperglikemia, Daun Sambung Nyawa, Glukosa Monohidrat  
Co-Authors Akhmad Jaizzur Rijai Almeida, Maria Arifian, Hanggara Arifuddin, Muhammad Bone, Mahfuzun Ervina Irmaya Sagita Febrina, Lizma Hajrah Herman Herman Ibrahim, Arsyik Islamudin Ahmad Islamudin Ahmad Junaidin, Junaidin Kintoko, Kintoko Laode Rijai M. Arifuddin, M. Mohd Azlan Nafiah, Mohd Azlan Muhammad Faisal Muhammad Nuzul Azhim Ash Siddiq Mus, Nurul Muhlisa Noviyanty Indjar Gama Nur Masyitah Zamruddin Ridhotulloh, Yusuf Isro Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Riki RIKI RIKI, RIKI Rolan Rusli Rusman, Arman Salam, Supriatno Samsul, Erwin Swastika Praharyawan Wijaya, Viriyanata